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Article ; Online: Retraction Note: Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. Leaves in streptozotocin induced diabetic rats.

Kumar, Vikas / Ahmed, Danish / Gupta, Pushpraj S / Anwar, Firoz / Mujeeb, Mohd

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 159

Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Retraction of Publication
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03996-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Scope of Wnt signaling in the precise diagnosis and treatment of breast cancer.

Patel, Dilip K / Kesharwani, Roohi / Verma, Amita / Al-Abbasi, Fahad A / Anwar, Firoz / Kumar, Vikas

Drug discovery today

2023 Volume 28, Issue 7, Page(s) 103597

Abstract: Malignant breast cancers are responsible for a growing number of deaths among women globally. The latest research has demonstrated that Wnt signaling is pivotal in this disease, regulating a safe microenvironment for the growth and proliferation of ... ...

Abstract	Malignant breast cancers are responsible for a growing number of deaths among women globally. The latest research has demonstrated that Wnt signaling is pivotal in this disease, regulating a safe microenvironment for the growth and proliferation of cancer cells, sustained stemness, resistance to therapy, and aggregate formation. The three highly conserved Wnt signaling pathways, Wnt-planar cell polarity (PCP), Wnt/β-catenin signaling and Wnt-Ca
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Wnt Signaling Pathway ; Wnt Proteins/metabolism ; Cell Proliferation ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103597
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Zs.A 4725: Show issues

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Article ; Online: Epigenetic Impact of Curcumin and Thymoquinone on Cancer Therapeutics.

Kumar, Vikas / Kesharwani, Roohi / Patel, Dilip K / Verma, Amita / Mehanna, Mohamed Gamil / Mohammad, Ayman / Bawadood, Azizah Salim / Alabassi, Fahad A / Anwar, Firoz

Current medicinal chemistry

2024

Abstract: Today, one of the most prevalent reasons for death among people is carcinoma. Because it is still on the increase throughout the world, there is a critical need for in- -depth research on the pathogenic mechanisms behind the disease as well as for ... ...

Abstract	Today, one of the most prevalent reasons for death among people is carcinoma. Because it is still on the increase throughout the world, there is a critical need for in- -depth research on the pathogenic mechanisms behind the disease as well as for efficient treatment. In the field of epigenetics, gene expression alterations that are inherited but not DNA sequence changes are investigated. Three key epigenetic changes, histone modifications, DNA methylation and non-coding RNA (ncRNA) expression, are principally responsible for the initiation and progression of different tumors. These changes are interconnected and constitute many epigenetic changes. A form of polyphenolic chemical obtained from plants called curcumin has great bioactivity against several diseases, specifically cancer. A naturally occurring substance called thymoquinone is well-known for its anticancer properties. Thymoquinone affects cancer cells through a variety of methods, according to preclinical studies. We retrieved information from popular databases, including PubMed, Google Scholar, and CNKI, to summarize current advancements in the efficiency of curcumin against cancer and its epigenetic regulation in terms of DNA methylation, histone modifications, and miRNA expression. The present investigation offers thorough insights into the molecular processes, based on epigenetic control, that underlie the clinical use of curcumin and thymoquinone in cancerous cells.
Language	English
Publishing date	2024-04-04
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673288542240327112351
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Zs.A 4432: Show issues

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Article: Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment.

Nadeem, Muhammad Shahid / Kazmi, Imran / Ullah, Inam / Muhammad, Khushi / Anwar, Firoz

Antioxidants (Basel, Switzerland)

2021 Volume 11, Issue 1

Abstract: Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic ( ...

Abstract	Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic (
Language	English
Publishing date	2021-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010087
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Article ; Online: Natural sea salt in diet ameliorates better protection compared to table salt in the doxorubicin-induced cardiac remodeling

Anwar, Firoz / Omar Asar, Turky / Al-Abassi, Fahad A. / Kumar, Vikas / Alhayyani, Sultan

Journal of Taibah University for Science. 2022 Dec. 31, v. 16, no. 1 p.1213-1224

2022

Abstract: Cardiac dysfunction can be prevented by addressing risk factors including unhealthy diet with other lifestyle modifications. The present study demonstrates the effect of diet mixed with sea and table salts on cardiac remodeling with respect to CKMB, ... ...

Abstract	Cardiac dysfunction can be prevented by addressing risk factors including unhealthy diet with other lifestyle modifications. The present study demonstrates the effect of diet mixed with sea and table salts on cardiac remodeling with respect to CKMB, renin, angiotensin II, interleukin-6 and 10. Animals divided into six groups. Normal control, Table salt (0.3%), Natural sea salt (0.3%), Doxorubicin-induced cardiac remodeling control (2 mg/kg), + Normal table salt (0.3%) and Doxorubicin + Natural sea salt (0.3%) . Serum analysis and histopathology of heart, liver and kidney was performed. Significant variation (P < .05) observed in in CKMB for Natural sea salt group compared to Normal. Significant (P < .05) variation in renin for Normal table salt group compared to Normal. Variation in interleukin-6, 10, renin and angiotensin II give new insight in these parameters with marked variation in cellular architecture of the heart, liver and kidney. Observations suggest diet with natural sea salt demonstrated significant beneficial effect on cardiac dysfunction.
Keywords	blood serum ; diet ; doxorubicin ; heart ; histopathology ; interleukin-6 ; kidneys ; lifestyle ; liver ; renin ; risk ; table salt ; Cardiac dysfunction ; sea salt ; CKMB ; renin-angiotensin system ; interleukins
Language	English
Dates of publication	2022-1231
Size	p. 1213-1224.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2834710-9
ISSN	1658-3655
ISSN	1658-3655
DOI	10.1080/16583655.2022.2154491
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction: Ashraf et al. Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches.

Ashraf, Ghulam Md / DasGupta, Debarati / Alam, Mohammad Zubair / Baeesa, Saleh S / Alghamdi, Badrah S / Anwar, Firoz / Alqurashi, Thamer M A / Sharaf, Sharaf E / Al Abdulmonem, Waleed / Alyousef, Mohammed A / Alhumaydhi, Fahad A / Shamsi, Anas

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 2

Abstract: The updated affiliation information can be seen in the affiliation part of this correction [ ... ]. ...

Abstract	The updated affiliation information can be seen in the affiliation part of this correction [...].
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020600
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Zs.MO 81: Show issues

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Article ; Online: In Vitro and In Vivo Preventive Effects of Thymoquinone against Breast Cancer: Role of DNMT1.

Kaleem, Mohammed / Kayali, Asaad / Sheikh, Ryan A / Kuerban, Abudukadeer / Hassan, Mohammed A / Almalki, Naif Abdullah R / Al-Abbasi, Fahad A / Anwar, Firoz / Omran, Ziad / Alhosin, Mahmoud

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 2

Abstract: Breast cancer (BC) is one of the most common cancers in women and is a major cause of female cancer-related deaths. BC is a multifactorial disease caused by the dysregulation of many genes, raising the need to find novel drugs that function by targeting ... ...

Abstract	Breast cancer (BC) is one of the most common cancers in women and is a major cause of female cancer-related deaths. BC is a multifactorial disease caused by the dysregulation of many genes, raising the need to find novel drugs that function by targeting several signaling pathways. The antitumoral drug thymoquinone (TQ), found in black seed oil, has multitargeting properties against several signaling pathways. This study evaluated the inhibitory effects of TQ on the MCF7 and T47D human breast cancer cell lines and its antitumor activity against BC induced by a single oral dose (65 mg/kg) of 7,12-dimethylbenzanthracene (DMBA) in female rats. The therapeutic activity was evaluated in DMBA-treated rats who received oral TQ (50 mg/kg) three times weekly. TQ-treated MCF7 and T47D cells showed concentration-dependent inhibition of cell proliferation and induction of apoptosis. TQ also decreased the expression of DNA methyltransferase 1 (DNMT1) in both cancer cell types. In DMBA-treated animals, TQ inhibited the number of liver and kidney metastases. These effects were associated with a reduction in DNMT1 mRNA expression. These results indicate that TQ has protective effects against breast carcinogens through epigenetic mechanisms involving DNMT1 inhibition.
MeSH term(s)	Female ; Humans ; Animals ; Rats ; Breast Neoplasms/chemically induced ; Breast Neoplasms/drug therapy ; Benzoquinones/pharmacology ; 9,10-Dimethyl-1,2-benzanthracene/toxicity ; Apoptosis
Chemical Substances	thymoquinone (O60IE26NUF) ; Benzoquinones ; 9,10-Dimethyl-1,2-benzanthracene (57-97-6)
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020434
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Zs.MO 81: Show issues

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Article ; Online: Nanomedicines: intervention in inflammatory pathways of cancer.

Anwar, Firoz / Naqvi, Salma / Shams, Saiba / Sheikh, Ryan Adnan / Al-Abbasi, Fahad A / Asseri, Amer H / Baig, Mirza Rafi / Kumar, Vikas

Inflammopharmacology

2023 Volume 31, Issue 3, Page(s) 1199–1221

Abstract: Inflammation is a complex defense process that maintains tissue homeostasis. However, this complex cascade, if lasts long, may contribute to pathogenesis of several diseases. Chronic inflammation has been exhaustively studied in the last few decades, for ...

Abstract	Inflammation is a complex defense process that maintains tissue homeostasis. However, this complex cascade, if lasts long, may contribute to pathogenesis of several diseases. Chronic inflammation has been exhaustively studied in the last few decades, for its contribution in development and progression of cancer. The intrinsic limitations of conventional anti-inflammatory and anti-cancer therapies triggered the development of nanomedicines for more effective and safer therapies. Targeting inflammation and tumor cells by nanoparticles, encapsulated with active therapeutic agents, offers a promising outcome with patient survival. Considerable technological success has been achieved in this field through exploitation of tumor microenvironment, and recognition of molecules overexpressed on endothelial cells or macrophages, through enhanced vascular permeability, or by rendering biomimetic approach to nanoparticles. This review focusses on the inflammatory pathways in progression of a tumor, and advancement in nanotechnologies targeting these pathways. We also aim to identify the gaps that hinder the successful clinical translation of nanotherapeutics with further clinical studies that will allow oncologist to precisely identify the patients who may be benefited from nanotherapy at time when promotion or progression of tumor initiates. It is postulated that the nanomedicines, in near future, will shift the paradigm of cancer treatment and improve patient survival.
MeSH term(s)	Humans ; Nanomedicine ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/metabolism ; Drug Delivery Systems ; Endothelial Cells/metabolism ; Neoplasms/metabolism ; Nanoparticles ; Inflammation/drug therapy ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01217-w
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Zs.A 3274: Show issues

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Article ; Online: Mass Spectrometry-Based Detection of Mycotoxins in Imported Meat and Their Perspective Role on Myocardial Apoptosis.

Ansari, Maged Al / Abbasi, Fahad A Al / Hosawi, Salman / Baig, Mirza Rafi / Alhayyani, Sultan / Kumar, Vikas / Asar, Turky Omar / Anwar, Firoz

Current medicinal chemistry

2023

Abstract: Background: Fungal mycotoxins are the secondary metabolite and are harmful to plants, animals, and humans. Common aflatoxins present and isolated from feeds and food comprises aflatoxins B1, B2, G1, and G2. Public health threats or risk of foodborne ... ...

Abstract	Background: Fungal mycotoxins are the secondary metabolite and are harmful to plants, animals, and humans. Common aflatoxins present and isolated from feeds and food comprises aflatoxins B1, B2, G1, and G2. Public health threats or risk of foodborne disease posed by mycotoxins, especially the export or import of such meat products are of primary concern. This study aims to determine the concentration of the level of aflatoxins B1, B2, G1, G2 M1, and M2 respectively in imported burger meat. Method: The present work is designed to select and collect the various sample of meat products from different sources and subjected to mycotoxin analysis by LCMS/MS. Random selection was made on sites of burger meat that was for sale. Results: Simultaneous presence of several mycotoxins in the same sample of imported meat under the set conditions of LCMS/MS detected 26% (18 samples) were positive for various mycotoxins. The most frequent mycotoxins proportion in the analyzed samples was aflatoxin B1 (50%) followed by aflatoxin G1 (44%), aflatoxin G2 (38.8%), aflatoxin B2 (33%) respectively were least among all with 16.66 and 11.11%. Discussion: A positive correlation is deduced between CVD and mycotoxin present in burger meat. Isolated mycotoxins initiate death receptor-mediated apoptosis, death receptor-mediated necrosis, mitochondrial-mediated apoptosis, mitochondrial-mediated necrosis, and immunogenic cell deaths through various pathways that can damage the cardiac tissues. Conclusion: The presence of these toxins in such samples is just the tip of the iceberg. Further investigation is necessary for complete clarifications of toxins on human health especially on CVD and other related metabolic complications.
Language	English
Publishing date	2023-06-09
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867330666230609100707
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Article ; Online: Therapeutic Potential of Nanomedicine in Management of Alzheimer's Disease and Glioma.

Anwar, Firoz / Al-Abbasi, Fahad A / Naqvi, Salma / Sheikh, Ryan Adnan / Alhayyani, Sultan / Asseri, Amer H / Asar, Turky Omar / Kumar, Vikas

International journal of nanomedicine

2023 Volume 18, Page(s) 2737–2756

Abstract: Neoplasm (Glioblastoma) and Alzheimer's disease (AD) comprise two of the most chronic psychological ailments. Glioblastoma is one of the aggressive and prevalent malignant diseases characterized by rapid growth and invasion resulting from cell migration ... ...

Abstract	Neoplasm (Glioblastoma) and Alzheimer's disease (AD) comprise two of the most chronic psychological ailments. Glioblastoma is one of the aggressive and prevalent malignant diseases characterized by rapid growth and invasion resulting from cell migration and degradation of extracellular matrix. While the latter is characterized by extracellular plaques of amyloid and intracellular tangles of tau proteins. Both possess a high degree of resistance to treatment owing to the restricted transport of corresponding drugs to the brain protected by the blood-brain barrier (BBB). Development of optimized therapies using advanced technologies is a great need of today. One such approach is the designing of nanoparticles (NPs) to facilitate the drug delivery at the target site. The present article elaborates the advances in nanomedicines in treatment of both AD as well as Gliomas. The intention of this review is to provide an overview of different types of NPs with their physical properties emphasizing their importance in traversing the BBB and hitting the target site. Further, we discuss the therapeutic applications of these NPs along with their specific targets. Multiple overlapping factors with a common pathway in development of AD and Glioblastoma are discussed in details that will assist the readers in developing the conceptual approach to target the NP for an aging population in the given circumstances with limitations of currently designed NPs, and the challenges to meet and the future perspectives.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Nanomedicine ; Glioma/drug therapy ; Brain/metabolism ; Blood-Brain Barrier/metabolism ; Drug Delivery Systems ; Nanoparticles/therapeutic use
Language	English
Publishing date	2023-05-22
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S405454
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