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  1. Article ; Online: Synthesis of triazole bridged

    Tiwari, Ghanshyam / Mishra, Vinay Kumar / Kumari, Priti / Khanna, Ashish / Sharma, Sunil / Sagar, Ram

    RSC advances

    2024  Volume 14, Issue 2, Page(s) 1304–1315

    Abstract: In the pursuit of novel therapeutic agents, we present a comprehensive study on the design, synthesis, and evaluation of a diverse library of triazole ... ...

    Abstract In the pursuit of novel therapeutic agents, we present a comprehensive study on the design, synthesis, and evaluation of a diverse library of triazole bridged
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra06993a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recent progress in the synthesis of natural product inspired bioactive glycohybrids.

    Singh, Kavita / Sharma, Sunil / Tyagi, Rajdeep / Sagar, Ram

    Carbohydrate research

    2023  Volume 534, Page(s) 108975

    Abstract: Carbohydrates are a basic structural component that are indispensable to all cellular processes. In addition to being employed as chiral starting materials in the synthesis of a variety of natural products, carbohydrates are recognized as naturally ... ...

    Abstract Carbohydrates are a basic structural component that are indispensable to all cellular processes. In addition to being employed as chiral starting materials in the synthesis of a variety of natural products, carbohydrates are recognized as naturally occurring molecules having an enormous variety of functional, stereochemical, and structural properties. The understanding and biological roles of carbohydrate derived molecules can be greatly improved by selectively synthesizing functional carbohydrates through incorporating them with privileged scaffolds. For a deeper understanding of their roles and the development of functional materials based on sugar, it is crucial to develop new techniques for efficiently synthesizing, functionalizing, and modifying carbohydrates. Glycohybrids have a wide range of structural and functional characteristics along with protein-carbohydrate interactions that are crucial to mammalian biology and a number of disease states. This review, consisting the literature from January 2017 to July 2023 and provide an overview of recent developments in the chemical synthesis of glycohybrids based on natural product scaffolds of coumarin, quinolone, naphthalene diimide, indole, isatin, naphthoquinone, imidazole and pyrimidine. The biological activity of active glycohybrids are discussed in this review.
    MeSH term(s) Animals ; Biological Products/chemistry ; Carbohydrates/chemistry ; Quinolones ; Mammals
    Chemical Substances Biological Products ; Carbohydrates ; Quinolones
    Language English
    Publishing date 2023-10-13
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2023.108975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2002/704: Show issues
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  3. Article: A Rare Phenomenon of Stercoral Ileal Perforation in a Pregnant Woman.

    Das, Snehasis / Prakash, Sagar / Sunil, Julia / Shaikh, Oseen / Balasubramanian, Gopal

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41529

    Abstract: Perforation peritonitis is one of the most common emergency presentations in Indian hospitals. Stercoral perforations are rare due to increased intraluminal pressure on the gut wall from impacted feces. This is associated with transmural necrosis. We ... ...

    Abstract Perforation peritonitis is one of the most common emergency presentations in Indian hospitals. Stercoral perforations are rare due to increased intraluminal pressure on the gut wall from impacted feces. This is associated with transmural necrosis. We present a 31-year-old pregnant woman who reported abdominal pain and vomiting at 34 weeks of gestation. The diagnosis was unclear from examination and imaging studies, and a provisional diagnosis of acute appendicitis was made. The patient underwent laparotomy and was found to have fecal contamination and multiple stercoral ileal perforations. The bowel segment was resected and exteriorized as a stoma.
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cardiac Arrest Due to Anaphylactic Shock Following Vecuronium Injection.

    Das, Snehasis / Prakash, Sagar / Sunil, Julia / Shaikh, Oseen / Balasubramanian, Gopal

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40931

    Abstract: Anaphylaxis under anesthesia is a rare but potentially severe disease. Although anaphylaxis is rare, it can be lethal if not diagnosed and treated appropriately. We present the case of a 43-year-old male with no prior allergy history who experienced a ... ...

    Abstract Anaphylaxis under anesthesia is a rare but potentially severe disease. Although anaphylaxis is rare, it can be lethal if not diagnosed and treated appropriately. We present the case of a 43-year-old male with no prior allergy history who experienced a severe anaphylactic reaction that resulted in cardiac arrest after the intravenous injection of vecuronium. His surgery was postponed, and the patient required intensive care with ventilator support and other supportive measures. Post-reaction dermal sensitivity tests revealed a clear allergic reaction to vecuronium which confirmed the diagnosis retrospectively. Eventually, the patient made a full recovery and was rescheduled for surgery at a later date.
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40931
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  5. Article: Incidental Meckel's Diverticulum in Umbilical Hernia.

    Prakash, Sagar / Sunil, Julia / Shivakumar, Madan / Shaikh, Oseen / Balasubramanian, Gopal

    Cureus

    2023  Volume 15, Issue 6, Page(s) e41115

    Abstract: The presence of a Meckel's diverticulum in the hernial sac is called a Littre's hernia. It is a rare complication of Meckel's diverticulum. We present a 56-year-old male patient who complained of swelling in the umbilical region. After the clinical ... ...

    Abstract The presence of a Meckel's diverticulum in the hernial sac is called a Littre's hernia. It is a rare complication of Meckel's diverticulum. We present a 56-year-old male patient who complained of swelling in the umbilical region. After the clinical examination and imaging studies, we diagnosed the patient with a partially reducible umbilical hernia. The patient underwent exploration and was found to have omentum, Meckel's diverticulum, and part of the ileum within the sac. The patient underwent segmental resection of the bowel, primary repair of the hernial defect, and onlay meshplasty. Postoperatively, the patient did not develop any complications.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41115
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  6. Article: Myocardial Infarction after ChAdOx1 nCoV-19 in a Young Male.

    Sagar, V V S S / Wanjari, Anil / Kumar, Sunil / Acharya, Sourya

    Journal of emergencies, trauma, and shock

    2022  Volume 15, Issue 2, Page(s) 112–113

    Language English
    Publishing date 2022-06-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2461111-6
    ISSN 0974-519X ; 0974-2700
    ISSN (online) 0974-519X
    ISSN 0974-2700
    DOI 10.4103/jets.jets_20_22
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  7. Article: Attempts to Develop Vaccines Against Alzheimer's Disease: A Systematic Review of Ongoing and Completed Vaccination Trials in Humans.

    Thakur, Ajit / Bogati, Sunil / Pandey, Sagar

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40138

    Abstract: In this systematic review, we evaluate the safety, tolerability, and immunogenicity of vaccination efforts against Alzheimer's disease (AD) in human subjects from both ongoing and completed vaccination trials. Databases like PubMed, Embase, and Scopus ... ...

    Abstract In this systematic review, we evaluate the safety, tolerability, and immunogenicity of vaccination efforts against Alzheimer's disease (AD) in human subjects from both ongoing and completed vaccination trials. Databases like PubMed, Embase, and Scopus were used to identify relevant articles on completed vaccination trials whereas the clinicaltrials.gov database was used for identifying ongoing clinical trials for vaccination against AD in humans until January 2022. Only interventional randomized or non-randomized clinical trials which reported on the safety and immunogenicity of vaccine against AD in humans were included. Cochrane risk of bias tool-2 (RoB-2) or risk of bias in non-randomized studies- of intervention (ROBINS-I) was used for risk of bias assessment as appropriate. A narrative descriptive synthesis of the findings was done. Sixteen randomized/non-randomized clinical trials (phase I: six and phase II: 10) for seven different types of vaccines against AD were identified comprising a total of 2080 participants. Apart from the development of meningoencephalitis in 6% of patients receiving AN1792 in an interrupted phase II trial, the rest of the trial reported promising results on the safety and immunogenicity of vaccines. While only a subset of reported adverse events was treatment related, none of the fatalities reported during the trial were considered related to vaccine administration. The serological response rate ranged from 100% (4/16 trials) to 19.7% in an interrupted trial. Although current trials show promising results, adequately powered phase III studies are needed to conclusively establish the safety, immunogenicity and therapeutic efficacy of vaccines.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40138
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  8. Article ; Online: Radial artery pseudoaneurysm following pediatric arterial cannulation.

    Munaf, Mamatha / Gadhinglajkar, Shrinivas / N Nayanar, V Krishna / Dash, Prasanta K / Puthuvasserry, Suneel / Sagar, Sunil

    Annals of cardiac anaesthesia

    2023  Volume 26, Issue 3, Page(s) 359–360

    MeSH term(s) Humans ; Child ; Radial Artery/diagnostic imaging ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Catheterization, Peripheral/adverse effects ; Ultrasonography, Interventional
    Language English
    Publishing date 2023-07-19
    Publishing country India
    Document type Letter
    ZDB-ID 2106866-5
    ISSN 0974-5181 ; 0971-9784
    ISSN (online) 0974-5181
    ISSN 0971-9784
    DOI 10.4103/aca.aca_171_22
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  9. Article ; Online: Duodeno-duodenal intussusception presenting as upper gastrointestinal bleed.

    Das, Snehasis / Sunil, Julia / Prakash, Sagar / Shaikh, Oseen Hajilal / Reddy, Abhinaya / Kumbhar, Uday Shamrao

    BMJ case reports

    2023  Volume 16, Issue 8

    Abstract: Duodeno-duodenal intussusception (DDI) is the type of intestinal intussusception in which a segment of the duodenum invaginates into the next part of the duodenum. We present a case of a male patient in his 50s presenting with right upper abdominal pain ... ...

    Abstract Duodeno-duodenal intussusception (DDI) is the type of intestinal intussusception in which a segment of the duodenum invaginates into the next part of the duodenum. We present a case of a male patient in his 50s presenting with right upper abdominal pain with multiple episodes of vomiting and a history of melena for 1 month. Imaging studies showed the presence of DDI without apparent growth. The patient underwent upper gastrointestinal endoscopy, which showed a doubtful growth in the duodenum, and the biopsy, was suggestive of adenocarcinoma. The patient underwent Whipple's procedure, and postoperative histology was diagnostic of Brunner's gland adenoma. The patient improved well without any complications.
    MeSH term(s) Humans ; Male ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Intussusception/surgery ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Melena ; Abdominal Pain ; Adenocarcinoma/diagnosis ; Adenocarcinoma/diagnostic imaging
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Isolated pancreatic tuberculosis masquerading pancreatic malignancy.

    Shaikh, Oseen Hajilal / Sunil, Julia / Prakash, Sagar / Vijaykumar, Chellappa / Kumbhar, Uday Shamrao

    BMJ case reports

    2023  Volume 16, Issue 7

    Abstract: Pancreatic tuberculosis is the rarest form of abdominal and extrapulmonary tuberculosis. We present a patient in his 40s who presented with pain abdomen and a fever. On examination, the patient had mild jaundice and right hypochondriac tenderness. Blood ... ...

    Abstract Pancreatic tuberculosis is the rarest form of abdominal and extrapulmonary tuberculosis. We present a patient in his 40s who presented with pain abdomen and a fever. On examination, the patient had mild jaundice and right hypochondriac tenderness. Blood investigation was suggestive of obstructive jaundice. Imaging studies were representative of pancreatic head lesion, causing mild intrahepatic biliary radical dilatation. Endoscopic ultrasound-guided fine-needle aspiration done from the pancreatic head lesion was diagnostic of tuberculosis. The patient was started on antitubercular medications and responded well.
    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/drug therapy ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/pathology ; Antitubercular Agents/therapeutic use ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Pancreatic Neoplasms
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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