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  1. Article: Deep Unlearning via Randomized Conditionally Independent Hessians.

    Mehta, Ronak / Pal, Sourav / Singh, Vikas / Ravi, Sathya N

    Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition

    2022  Volume 2022, Page(s) 10412–10421

    Abstract: Recent legislation has led to interest ... ...

    Abstract Recent legislation has led to interest in
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 1063-6919
    ISSN 1063-6919
    DOI 10.1109/cvpr52688.2022.01017
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  2. Article ; Online: Advanced 3D

    Jain, Nipun / Shashi Bhushan, B L / Natarajan, M / Mehta, Ravi / Saini, Deepak Kumar / Chatterjee, Kaushik

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 3, Page(s) 1235–1261

    Abstract: Fibrosis has been characterized as a global health problem and ranks as one of the primary causes of organ dysfunction. Currently, there is no cure for pulmonary fibrosis, and limited therapeutic options are available due to an inadequate understanding ... ...

    Abstract Fibrosis has been characterized as a global health problem and ranks as one of the primary causes of organ dysfunction. Currently, there is no cure for pulmonary fibrosis, and limited therapeutic options are available due to an inadequate understanding of the disease pathogenesis. The absence of advanced
    MeSH term(s) Humans ; Pulmonary Fibrosis/pathology ; Lung/pathology ; Cell Culture Techniques
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01499
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  3. Article ; Online: A Rare Clinical and Radiological Presentation of Neurosyphilis.

    Jakhar, Ravi / Mehta, Sahil / Chakravarty, Kamalesh / Ahuja, Chirag K / Lal, Vivek

    Movement disorders clinical practice

    2023  Volume 10, Issue 8, Page(s) 1207–1210

    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13830
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  4. Article: Trifocal Injury of the Patellar Tendon- An Exceedingly Rare Case Report.

    Deore, Sandeep / Kale, Sachin / Chalak, Ajit / Ghodke, Rahul / Mehta, Nrupam / Modi, Ravi

    Journal of orthopaedic case reports

    2024  Volume 14, Issue 2, Page(s) 145–149

    Abstract: Introduction: Distal pole of patella avulsion fracture with tibial tuberosity avulsion has been frequently reported as a bifocal patellar tendon injury. However, an osteochondral lateral patella facet fracture with a longitudinal split in the patella ... ...

    Abstract Introduction: Distal pole of patella avulsion fracture with tibial tuberosity avulsion has been frequently reported as a bifocal patellar tendon injury. However, an osteochondral lateral patella facet fracture with a longitudinal split in the patella tendon in addition to these avulsion fractures has never been documented previously. Hence, we now report this trifocal patellar tendon injury.
    Case report: An adolescent with a trifocal patella tendon injury underwent a fixation with a combination of transosseous pull- through sutures, suture tape, and knotless anchor. The patient was rehabilitated with gradual increase in 30° of knee flexion weekly and has now attained full knee range of motion.
    Conclusion: Fixation of the small avulsion fracture can be challenging using conventional methods such as cannulated cancellous screws especially in an immature skeleton as it can crush the fragments. Suture tape, transosseous tunnels, and knotless suture anchors have more flexibility, they avoid the physis and provide adequate strength in such situations compared to metallic implants.
    Language English
    Publishing date 2024-01-26
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2024.v14.i02.4250
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  5. Article ; Online: SARS-CoV-2 infection severity and mortality is modulated by repeat-mediated regulation of alternative splicing.

    Mehta, Priyanka / Chattopadhyay, Partha / Ravi, Varsha / Tarai, Bansidhar / Budhiraja, Sandeep / Pandey, Rajesh

    Microbiology spectrum

    2023  , Page(s) e0135123

    Abstract: Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 ... ...

    Abstract Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery for its own replication. Numerous traditional differential gene expression-based investigations have examined the diverse clinical symptoms caused by SARS-CoV-2 infection. The virus, on the other hand, also affects the host splicing machinery, causing host transcriptional dysregulation, which can lead to diverse clinical outcomes. Hence, in this study, we performed host transcriptome sequencing of 125 hospital-admitted COVID-19 patients to understand the transcriptomic differences between the severity sub-phenotypes of mild, moderate, severe, and mortality. We performed transcript-level differential expression analysis, investigated differential isoform usage, looked at the splicing patterns within the differentially expressed transcripts (DET), and elucidated the possible genome regulatory features. Our DTE analysis showed evidence of diminished transcript length and diversity as well as altered promoter site usage in the differentially expressed protein-coding transcripts in the COVID-19 mortality patients. We also investigated the potential mechanisms driving the alternate splicing and discovered a compelling differential enrichment of repeats in the promoter region and a specific enrichment of SINE (Alu) near the splicing sites of differentially expressed transcripts. These findings suggested a repeat-mediated plausible regulation of alternative splicing as a potential modulator of COVID-19 disease severity. In this work, we emphasize the role of scarcely elucidated functional role of alternative splicing in influencing COVID-19 disease severity sub-phenotypes, clinical outcomes, and its putative mechanism. IMPORTANCE The wide range of clinical symptoms reported during the COVID-19 pandemic inherently highlights the numerous factors that influence the progression and prognosis of SARS-CoV-2 infection. While several studies have investigated the host response and discovered immunological dysregulation during severe infection, most of them have the common theme of focusing only up to the gene level. Viruses, especially RNA viruses, are renowned for hijacking the host splicing machinery for their own proliferation, which inadvertently puts pressure on the host transcriptome, exposing another side of the host response to the pathogen challenge. Therefore, in this study, we examine host response at the transcript-level to discover a transcriptional difference that culminates in differential gene-level expression. Importantly, this study highlights diminished transcript diversity and possible regulation of transcription by differentially abundant repeat elements near the promoter region and splicing sites in COVID-19 mortality patients, which together with differentially expressed isoforms hold the potential to elaborate disease severity and outcome.
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01351-23
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  6. Article ; Online: Stereotypies in a Patient With Wilson Disease.

    Mehta, Sahil / Mahajan, Surbhi / Singh, Jagdeep / Jakhar, Ravi K / Baishya, Jitupam / Lal, Vivek

    Neurology

    2023  Volume 101, Issue 17, Page(s) 763

    MeSH term(s) Humans ; Hepatolenticular Degeneration/complications ; Stereotyped Behavior ; Stereotypic Movement Disorder
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207641
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  7. Article ; Online: Evaluation of an Interventional Health Education Project: Screening of Breast Cancer and Health Education (SHE).

    Khapre, Meenakshi / Ravi, Bina / Sharda, Prateek / Mehta, Aparajita / Kumari, Ranjeeta

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 7, Page(s) 2361–2366

    Abstract: There is an increasing incidence of breast cancer in India, especially among younger women. The study's main objective was to create awareness related to breast cancer and breast self-examination by community health workers and assess the effectiveness ... ...

    Abstract There is an increasing incidence of breast cancer in India, especially among younger women. The study's main objective was to create awareness related to breast cancer and breast self-examination by community health workers and assess the effectiveness of improving knowledge and practice. Secondary objective was to conduct clinical breast examination (CBE) of women and prompt referral.
    Methods: An outcome evaluation of the Educational Interventional project was conducted in a hilly district of Uttarakhand. Twenty Accredited Social Health Activists (ASHA) were identified and trained in breast cancer awareness, the procedure of breast self-examination, and screening methods. These ASHA's further created awareness among study participants (women above 30 years). A structured questionnaire on knowledge and practice was administered before and after educational intervention by ASHA workers. Clinical Breast Examination (CBE) camps were held for women at high risk for breast cancer who were referred to the Division of Breast Surgery, AIIMS Rishikesh, for further management.
    Result: One thousand sixty-one females participated in health education sessions by ASHAs. There was an improvement in knowledge and practice regarding Breast Self-examination after health education intervention. A low prevalence of risk factors for breast cancer was found among attendees of the CBE camp. 3.2% of participants had abnormalities on breast examination needing further workup.
    Conclusion: In the pre-test assessment, we found a low awareness and practice regarding breast cancer which increased significantly among women after behavioral change intervention. The prevalence of risk factors for breast cancer was very low. Trained community health workers were found to be effective in raising awareness, selective screening, and prompt referral.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/prevention & control ; Breast Self-Examination ; Community Health Workers/education ; Early Detection of Cancer/methods ; Female ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans
    Language English
    Publishing date 2022-07-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.7.2361
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  8. Article ; Online: Four-Year Nutritional Outcomes in Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Patients: an Australian Experience.

    Rao, Ravi / Mehta, Munish / Sheth, Devesh Ramesh / Hogan, Gabrielle

    Obesity surgery

    2023  Volume 33, Issue 3, Page(s) 750–760

    Abstract: Nutritional deficiencies following malabsorptive surgeries are a major concern.: Purpose: To present clinical-based, mid-term nutritional outcomes in single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) patients using a nutritional ...

    Abstract Nutritional deficiencies following malabsorptive surgeries are a major concern.
    Purpose: To present clinical-based, mid-term nutritional outcomes in single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) patients using a nutritional supplement based on the American Society for Metabolic & Bariatric Surgery (ASMBS) guidelines.
    Setting: Single private institute, Australia.
    Materials and methods: Data from 196 patients who underwent a primary SADI-S by a single surgeon from January 2017 through March 2022 were retrospectively analysed. All patients received either original or altered formulated nutritional supplementation throughout the study. In total, three formulae, slightly different from each other, were used at three different time points to formulate the supplement.
    Results: In total, 196 patients were included. The average age and preoperative body mass index were 44.9 ± 6.7 years and 43.6 ± 22.5 kg/m
    Conclusion: Factors, like preoperative and postoperative early, aggressive correction of nutritional deficiencies, regular laboratory monitoring and follow-ups with the multidisciplinary team, and adherence to our formulated nutritional supplement, have contributed to favourable nutritional outcomes at 4 years.
    MeSH term(s) Humans ; Obesity, Morbid/surgery ; Retrospective Studies ; Australia/epidemiology ; Malnutrition/epidemiology ; Malnutrition/etiology ; Anastomosis, Surgical/adverse effects ; Gastrectomy/adverse effects ; Gastric Bypass/adverse effects
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06461-1
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    Zs.A 3381: Show issues Location:
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  9. Article: Real-World Evaluation of the Safety and Effectiveness of 2.3% Hypertonic Saline Soft Mist Spray for Sino-Nasal Symptoms.

    Gandhi, Dipak / Semwal, Alok / Agrawal, Vikas / Jain, Ravindra / Srivastava, Harsh / Shetty, Preeth / Chopra, Ravindra / Mehta, Ravi / Pilliwar, Chaitali / Jaiswal, Ashok

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55302

    Abstract: Introduction and aims Mildly hypertonic saline is more effective in relieving symptoms of nasal congestion compared to placebo or isotonic saline. Recently, a unique device, delivering a soft mist of 2.3% hypertonic sea-salt saline (Nasoclear ... ...

    Abstract Introduction and aims Mildly hypertonic saline is more effective in relieving symptoms of nasal congestion compared to placebo or isotonic saline. Recently, a unique device, delivering a soft mist of 2.3% hypertonic sea-salt saline (Nasoclear PureHale
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55302
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  10. Article: Management of a case of oil drowning with whole lung lavage - Challenges and solutions.

    Thondebhavi, S Muralidhar / Himashweta, G / Agarwal, Dharmesh / Mehta, Ravi

    Indian journal of anaesthesia

    2021  Volume 65, Issue 9, Page(s) 705–706

    Language English
    Publishing date 2021-10-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.IJA_1_21
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