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  1. Article ; Online: Prednisolone induced pneumatosis coli and pneumoperitoneum.

    Goh, Serene S N / Shelat, Vishal

    World journal of gastroenterology

    2021  Volume 28, Issue 28, Page(s) 3739–3742

    Abstract: Pneumatosis intestinalis (PI) is defined as the presence of gas within the submucosal or subserosal layer of the gastrointestinal tract. It is a radiologic sign suspicious for bowel ischemia, hence non-viable bowel must be ruled out in patients with PI. ... ...

    Abstract Pneumatosis intestinalis (PI) is defined as the presence of gas within the submucosal or subserosal layer of the gastrointestinal tract. It is a radiologic sign suspicious for bowel ischemia, hence non-viable bowel must be ruled out in patients with PI. However, up to 15% of cases with PI are not associated with bowel ischemia or acute abdomen. We described an asymptomatic patient with prednisolone-induced PI and modified the Naranjo score to aid in a surgeon's decision-making for emergency laparotomy
    MeSH term(s) Humans ; Ischemia ; Laparotomy ; Pneumatosis Cystoides Intestinalis/chemically induced ; Pneumatosis Cystoides Intestinalis/diagnostic imaging ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology ; Prednisolone/therapeutic use
    Chemical Substances Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i28.3739
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  2. Article: Anxiety and Morale in Front-Line Healthcare Workers During the Coronavirus Disease 2019 (COVID-19) Outbreak at the National Screening Centre in Singapore.

    Goh, Serene S N / Chia, Michael Y C

    Annals of the Academy of Medicine, Singapore

    2020  Volume 49, Issue 4, Page(s) 259–262

    MeSH term(s) Anxiety/epidemiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Health Personnel/psychology ; Humans ; Mass Screening/organization & administration ; Morale ; Pandemics ; Pneumonia, Viral/epidemiology ; Singapore/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
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  3. Article ; Online: Oncologic outcomes after breast-conserving surgery with radiotherapy versus mastectomy in patients with Paget's disease of the breast: systematic review and meta-analysis.

    Goh, Serene S N / Syn, Nicholas L X / Lim, Cheryl J E / Lee, Rui En / Samuel, Miny / Ng, Celene W Q

    The British journal of surgery

    2023  Volume 110, Issue 11, Page(s) 1451–1457

    Abstract: Background: The conventional approach to treatment for Paget's disease of the breast has been mastectomy, but there is an increasing trend to consider breast-conserving surgery (BCS) followed by radiotherapy (RT) in these patients. This study aimed to ... ...

    Abstract Background: The conventional approach to treatment for Paget's disease of the breast has been mastectomy, but there is an increasing trend to consider breast-conserving surgery (BCS) followed by radiotherapy (RT) in these patients. This study aimed to provide an updated systematic review and meta-analysis comparing outcomes after BCS with RT versus mastectomy in the treatment of Paget's disease of the breast.
    Methods: Studies before May 2021 were included. Primary outcomes were overall survival and local recurrence. Separate analyses of Paget's disease associated with ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) were undertaken. Meta-regression was used to adjust for imbalance in the proportion of IDC among patients selected to undergo BCS versus mastectomy.
    Results: Overall survival in patients with Paget's disease who underwent BCS with RT was higher than for those who underwent mastectomy with pooled mortality hazard ratio (HR) of 0.68, (95% per cent c.i. 0.45 to 1.01). Patients with Paget's disease with DCIS had higher overall survival after BCS with or without RT versus mastectomy, with adjusted HR of 0.14 (0.10 to 0.20) and 0.28 (0.22 to 0.36), respectively. For patients with Paget's disease and IDC, overall survival was lower for BCS with or without RT versus mastectomy, with adjusted HR of 0.84 (0.57 to 1.25) and 1.64 (1.04 to 2.58), respectively. In Paget's disease and IDC, local recurrence risk was much higher for BCS with RT, RR 26.8 (1.60 to 456) versus without RT, RR 51.8 (6.80 to 391). In patients with Paget's disease and DCIS, risk of local recurrence versus mastectomy was lower for BCS with RT 0.72 (0.11 to 4.50) but slightly higher for BCS alone 1.38 (0.09 to 21.20).
    Conclusion: BCS with RT may be a comparable treatment alternative to mastectomy for patients with Paget's disease with DCIS, and for selected patients with Paget's disease and IDC.
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad199
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  4. Article: Anxiety and Morale in Front-Line Healthcare Workers During the Coronavirus Disease 2019 (COVID-19) Outbreak at the National Screening Centre in Singapore

    Goh, Serene S N / Chia, Michael Y C

    Ann Acad Med Singapore

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32419010
    Database COVID19

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  5. Article ; Online: Early laparoscopic cholecystectomy by a dedicated emergency surgical unit confers excellent outcomes in acute cholecystitis presenting beyond 72 hours.

    Chia, Clement L K / Lu, Junde / Goh, Serene S N / Lee, Daniel J K / Rao, Anil D / Lim, Woan Wui / Tan, Kok-Yang / Goo, Jerry T T

    ANZ journal of surgery

    2019  Volume 89, Issue 11, Page(s) 1446–1450

    Abstract: Background: Early laparoscopic cholecystectomy (ELC) within 72 h of symptom onset is preferred for management of acute cholecystitis (AC). Beyond 72 h, acute-on-chronic fibrosis sets in rendering surgery challenging. This study aims to compare the ... ...

    Abstract Background: Early laparoscopic cholecystectomy (ELC) within 72 h of symptom onset is preferred for management of acute cholecystitis (AC). Beyond 72 h, acute-on-chronic fibrosis sets in rendering surgery challenging. This study aims to compare the outcomes of ELC for AC within and beyond 72 h of symptom onset by a dedicated acute surgical unit.
    Methods: This is a single-centre retrospective study of 217 patients with AC who underwent ELC by an acute surgical unit from January 2017 to August 2018. Outcomes collected include post-operative morbidity, length of hospitalization and operation duration. A subgroup analysis for the same outcomes was performed for elderly patients.
    Results: Of the 217 patients, 88 were operated within 72 h of symptom onset while 129 were operated beyond 72 h. Twenty-six patients received ELC after 7 days. There was no occurrence of bile duct injury. There was no statistical difference in conversion rates, wound infections and post-operative collections. Patients receiving ELC beyond 72 h had longer duration of operation (125.4 versus 116 min, P = 0.035) and length of hospitalization (4.59 versus 3.09 days, P = 0.001) without increase in morbidity. Patients older than 75 years had a higher incidence of post-operative collection (P < 0.001).
    Conclusion: Patients with AC undergoing ELC by a dedicated acute surgical unit can have good outcomes even beyond 72 h of symptom onset. Meticulous haemostasis should be performed for the elderly subgroup of patients.
    MeSH term(s) Aged ; Cholecystectomy, Laparoscopic ; Cholecystitis, Acute/surgery ; Emergency Service, Hospital ; Emergency Treatment ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Time-to-Treatment ; Treatment Outcome
    Language English
    Publishing date 2019-09-03
    Publishing country Australia
    Document type Comparative Study ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.15398
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  6. Article ; Online: Clinical assessment for pulmonary hypertension in interstitial lung disease.

    Chan, Roseanne K / Horrigan, Mark / Goh, Nicole S L / Khor, Yet H

    Internal medicine journal

    2022  Volume 53, Issue 8, Page(s) 1415–1422

    Abstract: ... for methods of PH assessment with transthoracic echocardiography (TTE), serum N-terminal pro-brain ... serum NT-proBNP levels during the first year were observed in 47 (38.8%) patients. Only 14 (8.6 ...

    Abstract Background: Pulmonary hypertension (PH) is an important complication of interstitial lung disease (ILD), as its development confers a poor prognosis. There are no specific recommendations for methods of assessment for PH in ILD populations.
    Aims: To determine current assessment practices for PH in an Australian ILD centre.
    Methods: In the Austin Health ILD database, 162 consecutive patients with idiopathic pulmonary fibrosis or connective tissue disease-associated ILD were identified and retrospectively evaluated for methods of PH assessment with transthoracic echocardiography (TTE), serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and right heart catheterisation (RHC) in relation to patient demographic and physiological parameters.
    Results: The median follow-up was 30 (14.4-56.4) months. At baseline, vital capacity was 80.0 ± 18.4% predicted, and diffusing capacity for carbon monoxide was 59.6 ± 15.2% predicted. Evaluation for PH was performed in 147 (90.7%) patients, among whom 105 (64.8%) had TTE performed at least once. At the initial TTE, 33.7% patients had high probability of PH, defined as RVSP >40 mmHg + RAp and/or right ventricular dysfunction. At the time of the most recent TTE, these criteria were met in 45 (52.3%) patients. Elevated serum NT-proBNP levels during the first year were observed in 47 (38.8%) patients. Only 14 (8.6%) patients had RHC.
    Conclusion: Our institutional PH assessment practice in ILD demonstrates a substantial prevalence of probable PH at baseline. As new therapies emerge for the treatment of PH in ILD, well-defined screening practices are important in this population for early identification and optimal management.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/etiology ; Retrospective Studies ; Australia/epidemiology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/epidemiology ; Echocardiography
    Language English
    Publishing date 2022-08-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15887
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    Zs.MO 424: Show issues

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  7. Article ; Online: Physiological and electroencephalographic changes in goats subjected to transportation, lairage, and slaughter.

    Othman, Azalea-Hani / Goh, Yong Meng / Mohamed Mustapha, Noordin / Raghazli, Razlina / Kaka, Ubedullah / Imlan, Jurhamid Columbres / Abubakar, Ahmed Abubakar / Abdullah, Rasedee

    Animal science journal = Nihon chikusan Gakkaiho

    2022  Volume 92, Issue 1, Page(s) e13610

    Abstract: ... transported for 6 h and kept at lairage for 3, 6, or 16 h (n = 3). Blood samples were collected at pre- (pre-T ... and post-transportation (post-T), and post-slaughter (post-S) for determination of hematological ... at pre-T, post-T, pre-slaughter (pre-S), and post-S to determine the median frequency (F ...

    Abstract This preliminary trial investigated the effect of transportation and lairage periods on physiological parameters of goats subjected to slaughter. Nine male Boer cross goats aged 8-12 months were transported for 6 h and kept at lairage for 3, 6, or 16 h (n = 3). Blood samples were collected at pre- (pre-T) and post-transportation (post-T), and post-slaughter (post-S) for determination of hematological parameters, serum enzyme, protein, and cortisol concentrations. Electroencephalogram readings were taken at pre-T, post-T, pre-slaughter (pre-S), and post-S to determine the median frequency (F
    MeSH term(s) Abattoirs ; Animals ; Electroencephalography ; Goats ; Hydrocortisone ; Male ; Stress, Physiological ; Transportation
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-06-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2095161-9
    ISSN 1740-0929 ; 1344-3941
    ISSN (online) 1740-0929
    ISSN 1344-3941
    DOI 10.1111/asj.13610
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  8. Article ; Online: Defects in protective cytokine profiles in spontaneous miscarriage in the first trimester.

    Ku, Chee Wai / Ong, Lay See / Goh, Jody Paige / Allen, John / Low, Louise Wenyi / Zhou, Jieliang / Tan, Thiam Chye / Lee, Yie Hou

    F&S science

    2022  Volume 4, Issue 1, Page(s) 36–46

    Abstract: ... walk-in clinic (n = 58).: Intervention(s): None.: Main outcome measure(s): Sixty-five serum ... Patient(s): In this prospective cohort study, 155 pregnant women, comprising normal pregnant women ... recruited from antenatal clinics (n = 97) and women with threatened miscarriage recruited from an emergency ...

    Abstract Objective: To study differences in cytokine expression profiles between women with ongoing pregnancy and those experiencing spontaneous miscarriage, among women who presented with threatened miscarriage before week 16 of gestation.
    Design: Prospective cohort study.
    Setting: Academic hospital.
    Patient(s): In this prospective cohort study, 155 pregnant women, comprising normal pregnant women recruited from antenatal clinics (n = 97) and women with threatened miscarriage recruited from an emergency walk-in clinic (n = 58).
    Intervention(s): None.
    Main outcome measure(s): Sixty-five serum cytokines quantified using multiplex immunoassay correlated with miscarriage outcomes.
    Result(s): Among women presenting with threatened miscarriage, those who eventually miscarried had significantly lower levels of interleukin (IL)-2, IL-12p70, IL-17A, B-cell-activating factor, B lymphocyte chemoattractant, basic nerve growth factor, interferon-γ, tumor necrosis factor-related apoptosis-inducing ligand, thymic stromal lymphopoietin, and tumor necrosis factor-α and higher levels of vascular endothelial growth factor A, IL-21, and stromal cell-derived factor 1α than those with ongoing pregnancy. Comparisons between normal pregnancies and women with threatened miscarriage who eventually miscarried revealed significant differences across 7 cytokines: B-cell-activating factor; B lymphocyte chemoattractant; basic nerve growth factor; IL-17A; fractalkine/CX3CL1; vascular endothelial growth factor A; and CCL22. Vascular endothelial growth factor A exhibited a negative correlation with the progesterone level (r = -0.270). The cluster of significant cytokines alludes to T cell proliferation, B-cell proliferation, natural killer cell-mediated cytotoxicity, and apoptosis as important pathways that determine pregnancy outcomes. Bioinformatic analysis further revealed alteration of the suppressor of cytokine signaling proteins family of Janus kinase-signal transducer and activator of transcription signaling axis by cytokines as a plausible key molecular mechanism in spontaneous miscarriage.
    Conclusion(s): This study demonstrates that the regulated balance between the proinflammatory and anti-inflammatory pathways is crucial to maintaining pregnancy. A better understanding of the cytokines associated with immunomodulatory effects may lead to novel targets for the prediction and treatment of spontaneous miscarriage.
    MeSH term(s) Female ; Pregnancy ; Humans ; Abortion, Spontaneous ; Pregnancy Trimester, First ; Vascular Endothelial Growth Factor A ; Interleukin-17 ; Abortion, Threatened ; Prospective Studies ; Cytokines ; Tumor Necrosis Factor-alpha ; Nerve Growth Factors
    Chemical Substances Vascular Endothelial Growth Factor A ; Interleukin-17 ; Cytokines ; Tumor Necrosis Factor-alpha ; Nerve Growth Factors
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-335X
    ISSN (online) 2666-335X
    DOI 10.1016/j.xfss.2022.09.003
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  9. Article ; Online: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

    Ho, Lena / van Dijk, Marie / Chye, Sam Tan Jian / Messerschmidt, Daniel M / Chng, Serene C / Ong, Sheena / Yi, Ling Ka / Boussata, Souad / Goh, Grace Hui-Yi / Afink, Gijs B / Lim, Chin Yan / Dunn, N Ray / Solter, Davor / Knowles, Barbara B / Reversade, Bruno

    Science (New York, N.Y.)

    2017  Volume 357, Issue 6352, Page(s) 707–713

    Abstract: Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA ( ... ...

    Abstract Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta.
    MeSH term(s) Animals ; Apelin/genetics ; Apelin/metabolism ; Birth Weight ; Cardiovascular Abnormalities/genetics ; Carrier Proteins/administration & dosage ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Carrier Proteins/pharmacology ; Female ; Mice ; Mice, Knockout ; Neovascularization, Physiologic/genetics ; Peptide Hormones ; Placenta/blood supply ; Placenta/metabolism ; Placental Hormones/genetics ; Placentation/genetics ; Pre-Eclampsia/genetics ; Pregnancy ; Proteinuria ; Signal Transduction
    Chemical Substances Apela protein, mouse ; Apelin ; Apln protein, mouse ; Carrier Proteins ; Peptide Hormones ; Placental Hormones
    Language English
    Publishing date 2017-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aam6607
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  10. Article ; Online: Influence of Co-morbidities During SARS-CoV-2 Infection in an Indian Population

    Adrian Matysek / Aneta Studnicka / Wade Menpes Smith / Michał Hutny / Paweł Gajewski / Krzysztof J. Filipiak / Jorming Goh / Guang Yang

    Frontiers in Medicine, Vol

    2022  Volume 9

    Abstract: ... and used for calculation of eGFR, SII index and N/L ratio. Spearman’s rank correlation coefficient ... ResultsThe parameters which showed the highest correlation coefficient were age, random serum glucose, serum ... urea, gender and serum cholesterol, whereas the highest inverse correlation coefficient was assessed ...

    Abstract BackgroundSince the outbreak of COVID-19 pandemic the interindividual variability in the course of the disease has been reported, indicating a wide range of factors influencing it. Factors which were the most often associated with increased COVID-19 severity include higher age, obesity and diabetes. The influence of cytokine storm is complex, reflecting the complexity of the immunological processes triggered by SARS-CoV-2 infection. A modern challenge such as a worldwide pandemic requires modern solutions, which in this case is harnessing the machine learning for the purpose of analysing the differences in the clinical properties of the populations affected by the disease, followed by grading its significance, consequently leading to creation of tool applicable for assessing the individual risk of SARS-CoV-2 infection.MethodsBiochemical and morphological parameters values of 5,000 patients (Curisin Healthcare (India) were gathered and used for calculation of eGFR, SII index and N/L ratio. Spearman’s rank correlation coefficient formula was used for assessment of correlations between each of the features in the population and the presence of the SARS-CoV-2 infection. Feature importance was evaluated by fitting a Random Forest machine learning model to the data and examining their predictive value. Its accuracy was measured as the F1 Score.ResultsThe parameters which showed the highest correlation coefficient were age, random serum glucose, serum urea, gender and serum cholesterol, whereas the highest inverse correlation coefficient was assessed for alanine transaminase, red blood cells count and serum creatinine. The accuracy of created model for differentiating positive from negative SARS-CoV-2 cases was 97%. Features of highest importance were age, alanine transaminase, random serum glucose and red blood cells count.ConclusionThe current analysis indicates a number of parameters available for a routine screening in clinical setting. It also presents a tool created on the basis of these parameters, useful for ...
    Keywords SARS-CoV-2 ; blood biomarkers ; COVID-19 ; machine learning ; vitamin D ; Medicine (General) ; R5-920
    Subject code 630 ; 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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