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Article ; Online: Journal of Traumatic Stress p Value Guidelines.

Hyland, Philip / Shevlin, Mark / Kerig, Patricia K

2019 Volume 32, Issue 5, Page(s) 651–652

MeSH term(s)	Editorial Policies ; Humans ; Periodicals as Topic ; Statistics as Topic/standards
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Editorial
ZDB-ID	639478-4
ISSN	1573-6598 ; 0894-9867
ISSN (online)	1573-6598
ISSN	0894-9867
DOI	10.1002/jts.22460
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Book ; Online ; E-Book: The doctor's world

Hyland, Paul

the life and times of Claver Morris, 1659-1727

2023

Abstract: This is the story of the extraordinary life of Claver Morris and the society in which he lived. After his marriage at Chelsea in 1685, Claver Morris moved to Somerset where he established an outstanding reputation for his work as a physician. His ... ...

Author's details	Paul Hyland
Abstract	"This is the story of the extraordinary life of Claver Morris and the society in which he lived. After his marriage at Chelsea in 1685, Claver Morris moved to Somerset where he established an outstanding reputation for his work as a physician. His diaries show us how he worked with apothecaries and surgeons, and travelled widely to treat all kind of patients, from the children of the poor to those of the landed gentry. The diaries also tell us about the joys and pains of Claver's personal and family life, and of his various intrigues. Claver Morris was a man of many talents: immensely enterprising, knowledgeable, sociable and loving. His house was always filled with music, guests and entertainments. Yet he was often faced with disputes and troubles partly of his own making - as when he courted a bishop's daughter, or stole some land to build his Queen Anne house. The Doctor's World provides a unique portrait of a physician living and working through the political and religious turmoils that beset the nation at the turn of the eighteenth century. Tales of medical treatments, clandestine marriages and self-serving priests are entwined with famous acts of treason and rebellion, and the pleasures and tragedies of daily life. This meticulously researched book will appeal to all readers of social, political, medical and family history"--
Keywords	Physicians ; Great Britain
Subject code	610.69/5
Language	English
Size	1 online resource (309 pages)
Publisher	Routledge
Publishing place	London, England ; New York, New York
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-00-333365-6 ; 1-000-79013-4 ; 1-003-33365-6 ; 1-000-79021-5 ; 9781032367644 ; 978-1-00-333365-4 ; 978-1-000-79013-9 ; 978-1-003-33365-4 ; 978-1-000-79021-4 ; 1032367644
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: impact of butyrate and fructo-oligosaccharide-inulin.

Walsh, Jacinta / Gheorghe, Cassandra E / Lyte, Joshua M / van de Wouw, Marcel / Boehme, Marcus / Dinan, Timothy G / Cryan, John F / Griffin, Brendan T / Clarke, Gerard / Hyland, Niall P

The Journal of pharmacy and pharmacology

2020 Volume 72, Issue 8, Page(s) 1072–1081

Abstract: ... Mdr1b to conventional levels. Butyrate upregulated Cyp2b10 in conventional mice (P < 0.05) but overall ... the opposite effect on Mdr1a expression in young adult mice (P < 0.05). Age, on the other hand, influenced ... the prebiotic effect on Cyp2a4 expression (P < 0.01).: Conclusion: The expression of hepatic genes implicated ...

Abstract	Objectives: Our objective was to demonstrate microbial regulation of hepatic genes implicated in drug metabolism and transport using germ-free (GF) mice and to explore the impact of a microbial metabolite, butyrate, and a prebiotic dietary intervention on hepatic gene expression in mice. Methods: Using reverse-transcriptase PCR, we investigated cytochrome P450 (CYP) and multidrug-resistance protein 1 (MDR1) expression in conventional, GF and colonised GF mice. To investigate the effects of butyrate, sodium butyrate (3 g/l) was administered for 21 days to conventional or GF mice. In the prebiotic study, young adult and middle-aged mice received diet enriched with 10% fructo-oligosaccharide (FOS)-inulin for 14 weeks. Key findings: Colonisation of GF animals normalised expression of Cyp3a11 and Mdr1b to conventional levels. Butyrate upregulated Cyp2b10 in conventional mice (P < 0.05) but overall did not induce widespread changes in hepatic genes. FOS-inulin increased Cyp3a13 expression and had the opposite effect on Mdr1a expression in young adult mice (P < 0.05). Age, on the other hand, influenced the prebiotic effect on Cyp2a4 expression (P < 0.01). Conclusion: The expression of hepatic genes implicated in drug metabolism and transport displays sensitivity to the microbiome, microbiome-derived metabolites and a microbial-targeted intervention. Our study may provide the impetus to explore microbiota-targeted interventions in normalising host metabolic activity and reducing inter-individual variability in drug pharmacokinetics.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Age Factors ; Animals ; Bacteria/drug effects ; Bacteria/metabolism ; Butyrates/pharmacology ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gastrointestinal Microbiome/drug effects ; Gene Expression Regulation, Enzymologic ; Germ-Free Life ; Intestines/drug effects ; Intestines/microbiology ; Inulin/pharmacology ; Isoenzymes ; Liver/drug effects ; Liver/enzymology ; Male ; Mice, Inbred C57BL ; Oligosaccharides/pharmacology ; Prebiotics ; ATP-Binding Cassette Sub-Family B Member 4
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B ; Butyrates ; Isoenzymes ; Oligosaccharides ; Prebiotics ; fructooligosaccharide ; Inulin (9005-80-5) ; Cytochrome P-450 Enzyme System (9035-51-2) ; multidrug resistance protein 3 (9EI49ZU76O)
Language	English
Publishing date	2020-04-26
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1111/jphp.13276
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Book ; Online: Studious Drift

Hyland, Peter / Lewis, Tyson E.

Movements and Protocols for a Postdigital Education

2022

Keywords	Higher & further education, tertiary education
Language	0\|e
Size	1 electronic resource (98 pages)
Publisher	University of Minnesota Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021616748
ISBN	9781452967080 ; 1452967083
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: Impact of butyrate and fructo-oligosaccharide-inulin

Walsh, Jacinta / Gheorghe, Cassandra E. / Lyte, Joshua Mark / Wouw, Marcel / Boehme, Marcus / Dinan, Timothy G. / Cryan, J. F. / Griffin, Brendan T. / Clarke, Gerard / Hyland, Naill P.

Journal of pharmacy and pharmacology. 2020, v. 72, no. 8 p.1072-1081

2020

Abstract: ... on Cyp2b10. Butyrate upregulated Cyp2b10 in conventional mice (p<0.05) and normalised Mdr1b expression in GF ... in young-adult mice (p<0.05) while age influenced the prebiotic effect on Cyp2a4 expression (p<0.01). Conclusion ...

Abstract	Objectives: We aimed to confirm the microbial regulation of hepatic genes implicated in drug metabolism and transport, to explore the mechanistic basis for this host-microbe interaction and to examine if a more clinically relevant microbiota-directed intervention alters hepatic gene expression. Methods: Using reverse-transcriptase PCR, we investigated cytochrome P450 (CYP) and multidrug-resistance protein 1 (MDR1) expression in conventional, germ-free (GF), and colonised GF mice. Sodium butyrate (3 g/L), or sodium chloride for sodium-matched controls, was administered via the drinking water for 21 days to conventional or GF C57BL/6 mice (n=13-15/group). Young adult (approx. 2 months at start of treatment) and middle-aged (approx. 10 months at start of treatment) conventional C57BL/6 mice received diet-enriched with 10% Oligofructose-inulin or standard diet for 14 weeks. Key findings: The colonisation of GF animals normalised the altered expression of Cyp3a11 and Mdr1b to conventional levels but did not exert the same effect on Cyp2b10. Butyrate upregulated Cyp2b10 in conventional mice (p<0.05) and normalised Mdr1b expression in GF mice. FOS-inulin increased Cyp3a13 expression but had the opposite effect on Mdr1a expression in young-adult mice (p<0.05) while age influenced the prebiotic effect on Cyp2a4 expression (p<0.01). Conclusion: Manipulation of the gut microbiome alters the expression of hepatic genes implicated in drug metabolism and transport. The overall effect of butyrate and FOS-inulin on CYP and MDR expression is gene-specific, and FOS-inulin alters CYP and MDR1 expression in an age-dependent manner.
Keywords	P-glycoproteins ; cytochrome P-450 ; fructooligosaccharides ; gene expression ; gene expression regulation ; germ-free animals ; intestinal microorganisms ; inulin ; liver ; mice ; microbiome ; pharmacokinetics ; prebiotics ; sodium butyrate
Language	English
Size	p. 1072-1081.
Document type	Article ; Online
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1111/jphp.13276
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Modified expression of the KEL2 (k) blood group antigen attributed to p.Leu196Val amino acid change three residues from the K/k antigen polymorphism site: implications for donor screening.

Millard, Glenda M / Lopez, Genghis H / Turner, Elise M / Lizarazu, Maria E / Roots, Naomi M / Liew, Yew-Wah / Flower, Robert L / Hyland, Catherine A

Transfusion

2018 Volume 59, Issue 3, Page(s) 1156–1158

MeSH term(s)	Antigens, Bacterial/chemistry ; Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Antigens, Surface/chemistry ; Antigens, Surface/genetics ; Antigens, Surface/immunology ; Blood Donors/statistics & numerical data ; Blood Group Antigens/immunology ; Donor Selection/methods ; Erythrocytes/immunology ; Erythrocytes/metabolism ; Female ; Genotype ; Humans ; Phenotype
Chemical Substances	Antigens, Bacterial ; Antigens, Surface ; Blood Group Antigens ; K antigens
Language	English
Publishing date	2018-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.15106
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Article: Comment on “Paleosol-based paleoclimate reconstruction of the Paleocene-Eocene Thermal Maximum, northern Argentina” by Andrews, E., White, T., and del Papa, C. [Palaeogeography, Palaeoclimatology, Palaeoecology, v. 471, p. 181–195]

Hyland, Ethan G / Nathan D. Sheldon

Palaeogeography, palaeoclimatology, palaeoecology. 2018 Dec. 15, v. 511

2018

Abstract: Andrews et al. (2017) present a paleosol-based paleoclimate reconstruction of the Paleocene-Eocene Thermal Maximum from localities in northern Argentina. We suggest that the age model presented for these localities is incorrect based on recently ... ...

Abstract	Andrews et al. (2017) present a paleosol-based paleoclimate reconstruction of the Paleocene-Eocene Thermal Maximum from localities in northern Argentina. We suggest that the age model presented for these localities is incorrect based on recently published magnetostratigraphy from the area, and that the studied Maiz Gordo and Lumbrera Formations instead represent a paleoclimate record of the early to middle Eocene. This record, combined with previously published data from these formations provide a more comprehensive regional reconstruction of paleoclimate and paleoenvironmental conditions during the peak of early Eocene warmth, including the early Eocene climatic optimum and possibly the middle Eocene climatic optimum.
Keywords	Eocene epoch ; models ; palaeogeography ; paleoclimatology ; paleoecology ; Argentina
Language	English
Dates of publication	2018-1215
Size	p. 639-642.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2017.05.031
Database	NAL-Catalogue (AGRICOLA)

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Article: Human hepatocytes in primary culture predict lack of cytochrome P-450 3A4 induction by eletriptan in vivo.

Pichard-Garcia, L / Hyland, R / Baulieu, J / Fabre, J M / Milton, A / Maurel, P

Drug metabolism and disposition: the biological fate of chemicals

2000 Volume 28, Issue 1, Page(s) 51–57

Abstract: ... potency of eletriptan in vitro compared with well characterized cytochrome P-450 (CYP) inducers ... by 25 microM eletriptan was significantly lower, with a mean of 19 (P =.0015) and 26% (P =.0002 ...

Abstract	Eletriptan (Relpax) is a novel 5-hydroxytryptamine (serotonin)(1D/1B) agonist currently in development for the acute treatment of migraine. The aim of this work was to evaluate the relative induction potency of eletriptan in vitro compared with well characterized cytochrome P-450 (CYP) inducers with primary cultures of human hepatocytes and to relate this to the situation in vivo. Eletriptan was a weak inducer of CYP3A4 protein and cyclosporin A oxidation in four of the six cultures used, whereas rifampicin was a potent inducer in all cultures. Induction was concentration dependent and not detectable at eletriptan concentrations of 5 microM and lower. The amplitude of the increase in CYP3A4 protein and activity by 25 microM eletriptan was significantly lower, with a mean of 19 (P =.0015) and 26% (P =.0002), respectively, of that observed in response to 25 microM rifampicin. CYP2A6, a protein with minor pharmacological implication, also was induced by eletriptan and rifampicin in two cultures but was not detected in the others. The levels of other CYP proteins, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, were not affected by eletriptan. Because the maximum blood concentration of eletriptan in humans after a therapeutic dose (maximum 80 mg) is 0.5 microM, the in vitro model would predict no clinically significant induction of CYP3A4 protein in vivo. This has been confirmed subsequently in a clinical study, with 6beta-hydroxycortisol/cortisol ratios as marker of CYP3A4 activity. Eletriptan is therefore not an inducer of CYP3A4 at clinical doses.
MeSH term(s)	Adult ; Aged ; Cells, Cultured ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/drug effects ; DNA Fragmentation ; DNA Primers ; Enzyme Induction/drug effects ; Female ; Humans ; Hydrocortisone/urine ; Indoles/pharmacology ; Indoles/therapeutic use ; Liver/cytology ; Liver/drug effects ; Liver/enzymology ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Middle Aged ; Migraine Disorders/drug therapy ; Mixed Function Oxygenases/biosynthesis ; Mixed Function Oxygenases/drug effects ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Serotonin Receptor Agonists/pharmacology ; Serotonin Receptor Agonists/therapeutic use ; Tryptamines
Chemical Substances	DNA Primers ; Indoles ; Pyrrolidines ; Serotonin Receptor Agonists ; Tryptamines ; eletriptan (22QOO9B8KI) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Mixed Function Oxygenases (EC 1.-) ; CYP3A protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2000-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	186795-7
ISSN	1521-009X ; 0090-9556
ISSN (online)	1521-009X
ISSN	0090-9556
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Article ; Online: Stability of social jetlag and sleep timing into the second year of the Covid-19 pandemic: Results from a longitudinal study of a nationally representative adult sample in Ireland.

Raman, Sudha / Hyland, Philip / Coogan, Andrew N

Chronobiology international

2024 Volume 41, Issue 1, Page(s) 29–37

Abstract: The early phase of the COVID-19 pandemic has previously been associated with marked changes in sleep/wake timing arising from the imposition of society-wide infection mitigation measures. Such observations are considered of broader significance as they ... ...

Abstract	The early phase of the COVID-19 pandemic has previously been associated with marked changes in sleep/wake timing arising from the imposition of society-wide infection mitigation measures. Such observations are considered of broader significance as they reveal the social pressures that sleep timing normally operates under. In order to assess how persistent such changes were as the COVID-19 pandemic developed, we assessed sleep timing and quality in a longitudinal study of a nationally-representative sample of Irish adults with data collected at two time-points (December 2021 and March 2021). Data on social jetlag and chronotype was derived from the micro Munich Chronotype Questionnaire from 830 and 843 participants who provided data in December 2020 and March 2021 respectively, of which 338 contributed data to both timepoints. Demographics and measures of insomnia symptoms, anxiety, depression and loneliness were also collected, and data was analysed both within-subjects and cross-sectionally within data waves. Social jetlag (the mismatch between sleep timing on "work" and "free" days) and other measures of sleep timing were stable across the two time-points, although insomnia symptoms improved slightly from December 2020 to March 2021. The mean social jetlag at both timepoints was ~ 30 minutes, considerably lesser than reported pre-pandemic levels in similar populations. Multiple regression analysis of cross-sectional data reveals that the timing of midsleep on "free" days was only a weak-to-moderate predictor of social jetlag, whilst hours worked per week was the strongest predictor of social jetlag. Requirement for "face-to-face" contact with the public at work and urban location of residence also emerged as predictors of social jetlag, although insomnia, anxiety and depression symptoms and loneliness rating did not. We conclude that sleep timing changes that occurred during the initial phase of the COVID-19 pandemic persisted into the second year of the pandemic, and these results further illustrate the key roles working practices and other social factors have in shaping social jetlag.
MeSH term(s)	Adult ; Humans ; Circadian Rhythm ; Pandemics ; Sleep Initiation and Maintenance Disorders/epidemiology ; Cross-Sectional Studies ; Ireland ; Longitudinal Studies ; Social Behavior ; COVID-19 ; Sleep ; Jet Lag Syndrome ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2023.2292098
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Article ; Online: Making Sense of Quorum Sensing at the Intestinal Mucosal Interface.

Uhlig, Friederike / Hyland, Niall P

Cells

2022 Volume 11, Issue 11

Abstract: The gut microbiome can produce metabolic products that exert diverse activities, including effects on the host. Short chain fatty acids and amino acid derivatives have been the focus of many studies, but given the high microbial density in the ... ...

Abstract	The gut microbiome can produce metabolic products that exert diverse activities, including effects on the host. Short chain fatty acids and amino acid derivatives have been the focus of many studies, but given the high microbial density in the gastrointestinal tract, other bacterial products such as those released as part of quorum sensing are likely to play an important role for health and disease. In this review, we provide of an overview on quorum sensing (QS) in the gastrointestinal tract and summarise what is known regarding the role of QS molecules such as auto-inducing peptides (AIP) and acyl-homoserine lactones (AHL) from commensal, probiotic, and pathogenic bacteria in intestinal health and disease. QS regulates the expression of numerous genes including biofilm formation, bacteriocin and toxin secretion, and metabolism. QS has also been shown to play an important role in the bacteria-host interaction. We conclude that the mechanisms of action of QS at the intestinal neuro-immune interface need to be further investigated.
MeSH term(s)	Acyl-Butyrolactones/chemistry ; Acyl-Butyrolactones/metabolism ; Bacteria/metabolism ; Gastrointestinal Microbiome ; Quorum Sensing/genetics ; Symbiosis
Chemical Substances	Acyl-Butyrolactones
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11111734
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