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Article ; Online: Extra-striatal D

Jaworska, Natalia / Cox, Sylvia M L / Tippler, Maria / Castellanos-Ryan, Natalie / Benkelfat, Chawki / Parent, Sophie / Dagher, Alain / Vitaro, Frank / Boivin, Michel / Pihl, Robert O / Côté, Sylvana M / Tremblay, Richard E / Séguin, Jean R / Leyton, Marco

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2020 Volume 45, Issue 9, Page(s) 1498–1505

Abstract: The neurobiological traits that confer risk for addictions remain poorly understood. However, dopaminergic function throughout the prefrontal cortex, limbic system, and upper brainstem has been implicated in behavioral features that influence addiction ... ...

Abstract	The neurobiological traits that confer risk for addictions remain poorly understood. However, dopaminergic function throughout the prefrontal cortex, limbic system, and upper brainstem has been implicated in behavioral features that influence addiction vulnerability, including poor impulse control, and altered sensitivity to rewards and punishments (i.e., externalizing features). To test these associations in humans, we measured type-2/3 dopamine receptor (DA
MeSH term(s)	Adolescent ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Humans ; Impulsive Behavior ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism
Chemical Substances	Receptors, Dopamine D2 ; Receptors, Dopamine D3
Language	English
Publishing date	2020-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-020-0662-7
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Article ; Online: Biological activity of human IgE monoclonal antibodies targeting Der p 2, Fel d 1, Ara h 2 in basophil mediator release assays.

Pena-Castellanos, Glorismer / Smith, Bryan R E / Pomés, Anna / Smith, Scott A / Stigler, Maria A / Widauer, Hannah L / Versteeg, Serge A / van Ree, Ronald / Chapman, Martin D / Aglas, Lorenz

Frontiers in immunology

2023 Volume 14, Page(s) 1155613

Abstract: ... harvested from the blood of allergic donors, targeting three allergens (Der p 2, Fel d 1 and Ara h 2) was ... investigated.: Methods: Three Der p 2-, three Fel d 1- and five Ara h 2-specific hIgE mAb produced by human ... pairs of Der p 2-, Fel d 1- and Ara h 2-specific hIgE mAb, respectively, produced significant mediator ...

Abstract	Background: Human Immunoglobulin E monoclonal antibodies (hIgE mAb) are unique tools for investigating IgE responses. Here, the biological activity of hIgE mAb, derived from immortalized B cells harvested from the blood of allergic donors, targeting three allergens (Der p 2, Fel d 1 and Ara h 2) was investigated. Methods: Three Der p 2-, three Fel d 1- and five Ara h 2-specific hIgE mAb produced by human B cell hybridomas, were combined in pairs and used to passively sensitize humanized rat basophilic leukemia cells and compared with sensitization using serum pools. Sensitized cells were stimulated with corresponding allergens (recombinant or purified), allergen extracts or structural homologs, having 40-88% sequence similarity, and compared for mediator (β-hexosaminidase) release. Results: One, two and eight pairs of Der p 2-, Fel d 1- and Ara h 2-specific hIgE mAb, respectively, produced significant mediator release (>50%). A minimum hIgE mAb concentration of 15-30 kU/L and a minimum antigen concentration between 0.01-0.1 µg/mL were sufficient to induce a pronounced mediator release. Individual sensitization with one Ara h 2-specific hIgE mAb was able to induce crosslinking independently of a second specific hIgE mAb. Der p 2- and Ara h 2-specific mAb showed a high allergen specificity when compared to homologs. Mediator release from cells sensitized with hIgE mAb was comparable to serum sensitization. Conclusion: The biological activity of hIgE mAb reported here provides the foundation for novel methods of standardization and quality control of allergen products and for mechanistic studies of IgE-mediated allergic diseases, using hIgE mAb.
MeSH term(s)	Animals ; Humans ; Rats ; Allergens ; Antibodies, Monoclonal ; Basophils ; Immunoglobulin E ; Paraproteins
Chemical Substances	Allergens ; Antibodies, Monoclonal ; Dermatophagoides pteronyssinus antigen p 2 ; Immunoglobulin E (37341-29-0) ; Paraproteins ; Fel d 1 protein, Felis domesticus (G408EE88II) ; Ara h 2 allergen, Arachis hypogaea
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1155613
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Article ; Online: (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.

Bloos, Frank / Held, Jürgen / Kluge, Stefan / Simon, Philipp / Kogelmann, Klaus / de Heer, Geraldine / Kuhn, Sven-Olaf / Jarczak, Dominik / Motsch, Johann / Hempel, Gunther / Weiler, Norbert / Weyland, Andreas / Drüner, Matthias / Gründling, Matthias / Meybohm, Patrick / Richter, Daniel / Jaschinski, Ulrich / Moerer, Onnen / Günther, Ulf /

Schädler, Dirk / Weiss, Raphael / Putensen, Christian / Castellanos, Ixchel / Kurzai, Oliver / Schlattmann, Peter / Cornely, Oliver A / Bauer, Michael / Thomas-Rüddel, Daniel

Intensive care medicine

2022 Volume 48, Issue 7, Page(s) 865–875

Abstract: Purpose: To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal ...

Abstract	Purpose: To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk of invasive Candida infection (ICI). Methods: Multicenter, randomized, controlled trial carried out between September 2016 and September 2019 in 18 intensive care units enrolling adult sepsis patients at high risk for ICI. Patients in the control group received targeted antifungal therapy driven by culture results. In addition to targeted therapy, patients in the BDG group received antifungals if at least one of two consecutive BDG samples taken during the first two study days was ≥ 80 pg/mL. Empirical antifungal therapy was discouraged in both groups. The primary endpoint was 28-day-mortality. Results: 339 patients were enrolled. ICI was diagnosed in 48 patients (14.2%) within the first 96 h after enrollment. In the BDG-group, 48.8% (84/172) patients received antifungals during the first 96 h after enrollment and 6% (10/167) patients in the control group. Death until day 28 occurred in 58 of 172 patients (33.7%) in the BDG group and 51 of 167 patients (30.5%) in the control group (relative risk 1.10; 95% confidence interval, 0.80-1.51; p = 0.53). Median time to antifungal therapy was 1.1 [interquartile range (IQR) 1.0-2.2] days in the BDG group and 4.4 (IQR 2.0-9.1, p < 0.01) days in the control group. Conclusions: Serum BDG guided antifungal treatment did not improve 28-day mortality among sepsis patients with risk factors for but unexpected low rate of IC. This study cannot comment on the potential benefit of BDG-guidance in a more selected at-risk population.
MeSH term(s)	Adult ; Antifungal Agents/therapeutic use ; Candidiasis, Invasive/drug therapy ; Glucans/therapeutic use ; Humans ; Sensitivity and Specificity ; Sepsis/complications ; Sepsis/drug therapy ; beta-Glucans
Chemical Substances	Antifungal Agents ; Glucans ; beta-Glucans
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-022-06733-x
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Zs.A 1089: Show issues

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Article ; Online: Measurements of Groomed-Jet Substructure of Charm Jets Tagged by D^{0} Mesons in Proton-Proton Collisions at sqrt[s]=13 TeV.

Acharya, S / Adamová, D / Adler, A / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akindinov, A / Al-Turany, M / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R / Ali, B / Ali, Y / Alici, A /

Alizadehvandchali, N / Alkin, A / Alme, J / Alocco, G / Alt, T / Altsybeev, I / Anaam, M N / Andrei, C / Andronic, A / Anguelov, V / Antinori, F / Antonioli, P / Anuj, C / Apadula, N / Aphecetche, L / Appelshäuser, H / Arata, C / Arcelli, S / Aresti, M / Arnaldi, R / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Azmi, M D / Badalà, A / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Bala, R / Balbino, A / Baldisseri, A / Balis, B / Banerjee, D / Banoo, Z / Barbera, R / Barile, F / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Barreto, L / Bartels, C / Barth, K / Bartsch, E / Baruffaldi, F / Bastid, N / Basu, S / Batigne, G / Battistini, D / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Becht, P / Behera, D / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Belyaev, V / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / Bhasin, A / Bhat, M A / Bhattacharjee, B / Bianchi, L / Bianchi, N / Bielčík, J / Bielčíková, J / Biernat, J / Bigot, A P / Bilandzic, A / Biro, G / Biswas, S / Bize, N / Blair, J T / Blau, D / Blidaru, M B / Bluhme, N / Blume, C / Boca, G / Bock, F / Bodova, T / Bogdanov, A / Boi, S / Bok, J / Boldizsár, L / Bolozdynya, A / Bombara, M / Bond, P M / Bonomi, G / Borel, H / Borissov, A / Bossi, H / Botta, E / Bouziani, Y E M / Bratrud, L / Braun-Munzinger, P / Bregant, M / Broz, M / Bruno, G E / Buckland, M D / Budnikov, D / Buesching, H / Bufalino, S / Bugnon, O / Buhler, P / Buthelezi, Z / Butt, J B / Bysiak, S A / Cai, M / Caines, H / Caliva, A / Calvo Villar, E / Camacho, J M M / Camerini, P / Canedo, F D M / Carabas, M / Carnesecchi, F / Caron, R / Castillo Castellanos, J / Catalano, F / Ceballos Sanchez, C / Chakaberia, I / Chakraborty, P / Chandra, S / Chapeland, S / Chartier, M / Chattopadhyay, S / Chavez, T G / Cheng, T / Cheshkov, C / Cheynis, B / Chibante Barroso, V / Chinellato, D D / Chizzali, E S / Cho, J / Cho, S / Chochula, P / Christakoglou, P / Christensen, C H / Christiansen, P / Chujo, T / Ciacco, M / Cicalo, C / Cifarelli, L / Cindolo, F / Ciupek, M R / Clai, G / Colamaria, F / Colburn, J S / Colella, D / Colocci, M / Concas, M / Conesa Balbastre, G / Conesa Del Valle, Z / Contin, G / Contreras, J G / Coquet, M L / Cormier, T M / Cortese, P / Cosentino, M R / Costa, F / Costanza, S / Crkovská, J / Crochet, P / Cruz-Torres, R / Cuautle, E / Cui, P / Cunqueiro, L / Dainese, A / Danisch, M C / Danu, A / Das, P / Das, S / Dash, A R / Dash, S / David, R M H / De Caro, A / de Cataldo, G / de Cuveland, J / De Falco, A / De Gruttola, D / De Marco, N / De Martin, C / De Pasquale, S / Deb, S / Debski, R J / Deja, K R / Del Grande, R / Dello Stritto, L / Deng, W / Dhankher, P / Di Bari, D / Di Mauro, A / Diaz, R A / Dietel, T / Ding, Y / Divià, R / Dixit, D U / Djuvsland, Ø / Dmitrieva, U / Dobrin, A / Dönigus, B / Dubey, A K / Dubinski, J M / Dubla, A / Dudi, S / Dupieux, P / Durkac, M / Dzalaiova, N / Eder, T M / Ehlers, R J / Eikeland, V N / Eisenhut, F / Elia, D / Erazmus, B / Ercolessi, F / Erhardt, F / Ersdal, M R / Espagnon, B / Eulisse, G / Evans, D / Evdokimov, S / Fabbietti, L / Faggin, M / Faivre, J / Fan, F / Fan, W / Fantoni, A / Fasel, M / Fecchio, P / Feliciello, A / Feofilov, G / Fernández Téllez, A / Ferrer, M B / Ferrero, A / Ferrero, C / Ferretti, A / Feuillard, V J G / Filova, V / Finogeev, D / Fionda, F M / Flor, F / Flores, A N / Foertsch, S / Fokin, I / Fokin, S / Fragiacomo, E / Frajna, E / Fuchs, U / Funicello, N / Furget, C / Furs, A / Fusayasu, T / Gaardhøje, J J / Gagliardi, M / Gago, A M / Galvan, C D / Gangadharan, D R / Ganoti, P / Garabatos, C / Garcia, J R A / Garcia-Solis, E / Garg, K / Gargiulo, C / Garibli, A / Garner, K / Gautam, A / Gay Ducati, M B / Germain, M / Ghosh, C / Ghosh, S K / Giacalone, M / Gianotti, P / Giubellino, P / Giubilato, P / Glaenzer, A M C / Glässel, P / Glimos, E / Goh, D J Q / Gonzalez, V / González-Trueba, L H / Gorgon, M / Gotovac, S / Grabski, V / Graczykowski, L K / Grecka, E / Grelli, A / Grigoras, C / Grigoriev, V / Grigoryan, S / Grosa, F / Grosse-Oetringhaus, J F / Grosso, R / Grund, D / Guardiano, G G / Guernane, R / Guilbaud, M / Gulbrandsen, K / Gundem, T / Gunji, T / Guo, W / Gupta, A / Gupta, R / Guzman, S P / Gyulai, L / Habib, M K / Hadjidakis, C / Hamagaki, H / Hamid, M / Han, Y / Hannigan, R / Haque, M R / Harris, J W / Harton, A / Hassan, H / Hatzifotiadou, D / Hauer, P / Havener, L B / Heckel, S T / Hellbär, E / Helstrup, H / Hemmer, M / Herman, T / Herrera Corral, G / Herrmann, F / Herrmann, S / Hetland, K F / Heybeck, B / Hillemanns, H / Hills, C / Hippolyte, B / Hofman, B / Hohlweger, B / Honermann, J / Hong, G H / Horzyk, A / Hosokawa, R / Hou, Y / Hristov, P / Hughes, C / Huhn, P / Huhta, L M / Hulse, C V / Humanic, T J / Hushnud, H / Hutson, A / Hutter, D / Iddon, J P / Ilkaev, R / Ilyas, H / Inaba, M / Innocenti, G M / Ippolitov, M / Isakov, A / Isidori, T / Islam, M S / Ivanov, M / Ivanov, V / Izucheev, V / Jablonski, M / Jacak, B / Jacazio, N / Jacobs, P M / Jadlovska, S / Jadlovsky, J / Jaelani, S / Jaffe, L / Jahnke, C / Jakubowska, M J / Janik, M A / Janson, T / Jercic, M / Jevons, O / Jimenez, A A P / Jonas, F / Jones, P G / Jowett, J M / Jung, J / Jung, M / Junique, A / Jusko, A / Kabus, M J / Kaewjai, J / Kalinak, P / Kalteyer, A S / Kalweit, A / Kaplin, V / Karasu Uysal, A / Karatovic, D / Karavichev, O / Karavicheva, T / Karczmarczyk, P / Karpechev, E / Kashyap, V / Kebschull, U / Keidel, R / Keijdener, D L D / Keil, M / Ketzer, B / Khan, A M / Khan, S / Khanzadeev, A / Kharlov, Y / Khatun, A / Khuntia, A / Kileng, B / Kim, B / Kim, C / Kim, D J / Kim, E J / Kim, J / Kim, J S / Kim, M / Kim, S / Kim, T / Kimura, K / Kirsch, S / Kisel, I / Kiselev, S / Kisiel, A / Kitowski, J P / Klay, J L / Klein, J / Klein, S / Klein-Bösing, C / Kleiner, M / Klemenz, T / Kluge, A / Knospe, A G / Kobdaj, C / Kollegger, T / Kondratyev, A / Kondratyuk, E / Konig, J / Konigstorfer, S A / Konopka, P J / Kornakov, G / Koryciak, S D / Kotliarov, A / Kovalenko, O / Kovalenko, V / Kowalski, M / Králik, I / Kravčáková, A / Kreis, L / Krivda, M / Krizek, F / Krizkova Gajdosova, K / Kroesen, M / Krüger, M / Krupova, D M / Kryshen, E / Kučera, V / Kuhn, C / Kuijer, P G / Kumaoka, T / Kumar, D / Kumar, L / Kumar, N / Kumar, S / Kundu, S / Kurashvili, P / Kurepin, A / Kurepin, A B / Kushpil, S / Kvapil, J / Kweon, M J / Kwon, J Y / Kwon, Y / La Pointe, S L / La Rocca, P / Lai, Y S / Lakrathok, A / Lamanna, M / Langoy, R / Larionov, P / Laudi, E / Lautner, L / Lavicka, R / Lazareva, T / Lea, R / Legras, G / Lehrbach, J / Lemmon, R C / León Monzón, I / Lesch, M M / Lesser, E D / Lettrich, M / Lévai, P / Li, X / Li, X L / Lien, J / Lietava, R / Lim, B / Lim, S H / Lindenstruth, V / Lindner, A / Lippmann, C / Liu, A / Liu, D H / Liu, J / Lofnes, I M / Loizides, C / Loncar, P / Lopez, J A / Lopez, X / López Torres, E / Lu, P / Luhder, J R / Lunardon, M / Luparello, G / Ma, Y G / Maevskaya, A / Mager, M / Mahmoud, T / Maire, A / Malaev, M / Malfattore, G / Malik, N M / Malik, Q W / Malik, S K / Malinina, L / Mal'Kevich, D / Mallick, D / Mallick, N / Mandaglio, G / Manko, V / Manso, F / Manzari, V / Mao, Y / Margagliotti, G V / Margotti, A / Marín, A / Markert, C / Martinengo, P / Martinez, J L / Martínez, M I / Martínez García, G / Masciocchi, S / Masera, M / Masoni, A / Massacrier, L / Mastroserio, A / Mathis, A M / Matonoha, O / Matuoka, P F T / Matyja, A / Mayer, C / Mazuecos, A L / Mazzaschi, F / Mazzilli, M / Mdhluli, J E / Mechler, A F / Melikyan, Y / Menchaca-Rocha, A / Meninno, E / Menon, A S / Meres, M / Mhlanga, S / Miake, Y / Micheletti, L / Migliorin, L C / Mihaylov, D L / Mikhaylov, K / Mishra, A N / Miśkowiec, D / Modak, A / Mohanty, A P / Mohanty, B / Khan, M Mohisin / Molander, M A / Moravcova, Z / Mordasini, C / Moreira De Godoy, D A / Morozov, I / Morsch, A / Mrnjavac, T / Muccifora, V / Muhuri, S / Mulligan, J D / Mulliri, A / Munhoz, M G / Munzer, R H / Murakami, H / Murray, S / Musa, L / Musinsky, J / Myrcha, J W / Naik, B / Nair, R / Nambrath, A I / Nandi, B K / Nania, R / Nappi, E / Nassirpour, A F / Nath, A / Nattrass, C / Neagu, A / Negru, A / Nellen, L / Nesbo, S V / Neskovic, G / Nesterov, D / Nielsen, B S / Nielsen, E G / Nikolaev, S / Nikulin, S / Nikulin, V / Noferini, F / Noh, S / Nomokonov, P / Norman, J / Novitzky, N / Nowakowski, P / Nyanin, A / Nystrand, J / Ogino, M / Ohlson, A / Okorokov, V A / Oleniacz, J / Oliveira Da Silva, A C / Oliver, M H / Onnerstad, A / Oppedisano, C / Ortiz Velasquez, A / Oskarsson, A / Otwinowski, J / Oya, M / Oyama, K / Pachmayer, Y / Padhan, S / Pagano, D / Paić, G / Palasciano, A / Panebianco, S / Park, H / Park, J / Parkkila, J E / Patra, R N / Paul, B / Pei, H / Peitzmann, T / Peng, X / Pennisi, M / Pereira, L G / Pereira Da Costa, H / Peresunko, D / Perez, G M / Perrin, S / Pestov, Y / Petráček, V / Petrov, V / Petrovici, M / Pezzi, R P / Piano, S / Pikna, M / Pillot, P / Pinazza, O / Pinsky, L / Pinto, C / Pisano, S / Płoskoń, M / Planinic, M / Pliquett, F / Poghosyan, M G / Politano, S / Poljak, N / Pop, A / Porteboeuf-Houssais, S / Porter, J / Pozdniakov, V / Prasad, S K / Prasad, S / Preghenella, R / Prino, F / Pruneau, C A / Pshenichnov, I / Puccio, M / Pucillo, S / Pugelova, Z / Qiu, S / Quaglia, L / Quishpe, R E / Ragoni, S / Rakotozafindrabe, A / Ramello, L / Rami, F / Ramirez, S A R / Rancien, T A / Raniwala, R / Raniwala, S / Rasa, M / Räsänen, S S / Rath, R / Ravasenga, I / Read, K F / Reckziegel, C / Redelbach, A R / Redlich, K / Rehman, A / Reidt, F / Reme-Ness, H A / Rescakova, Z / Reygers, K / Riabov, A / Riabov, V / Ricci, R / Richert, T / Richter, M / Riedel, A A / Riegler, W / Riggi, F / Ristea, C / Rodríguez Cahuantzi, M / Røed, K / Rogalev, R / Rogochaya, E / Rogoschinski, T S / Rohr, D / Röhrich, D / Rojas, P F / Rojas Torres, S / Rokita, P S / Romanenko, G / Ronchetti, F / Rosano, A / Rosas, E D / Rossi, A / Roy, A / Roy, P / Roy, S / Rubini, N / Rueda, O V / Ruggiano, D / Rui, R / Rumyantsev, B / Russek, P G / Russo, R / Rustamov, A / Ryabinkin, E / Ryabov, Y / Rybicki, A / Rytkonen, H / Rzesa, W / Saarimaki, O A M / Sadek, R / Sadhu, S / Sadovsky, S / Saetre, J / Šafařík, K / Saha, S K / Saha, S / Sahoo, B / Sahoo, R / Sahoo, S / Sahu, D / Sahu, P K / Saini, J / Sajdakova, K / Sakai, S / Salvan, M P / Sambyal, S / Saramela, T B / Sarkar, D / Sarkar, N / Sarma, P / Sarritzu, V / Sarti, V M / Sas, M H P / Schambach, J / Scheid, H S / Schiaua, C / Schicker, R / Schmah, A / Schmidt, C / Schmidt, H R / Schmidt, M O / Schmidt, M / Schmidt, N V / Schmier, A R / Schotter, R / Schukraft, J / Schwarz, K / Schweda, K / Scioli, G / Scomparin, E / Seger, J E / Sekiguchi, Y / Sekihata, D / Selyuzhenkov, I / Senyukov, S / Seo, J J / Serebryakov, D / Šerkšnytė, L / Sevcenco, A / Shaba, T J / Shabetai, A / Shahoyan, R / Shangaraev, A / Sharma, A / Sharma, D / Sharma, H / Sharma, M / Sharma, N / Sharma, S / Sharma, U / Shatat, A / Sheibani, O / Shigaki, K / Shimomura, M / Shirinkin, S / Shou, Q / Sibiriak, Y / Siddhanta, S / Siemiarczuk, T / Silva, T F / Silvermyr, D / Simantathammakul, T / Simeonov, R / Singh, B / Singh, R / Singh, S / Singh, V K / Singhal, V / Sinha, T / Sitar, B / Sitta, M / Skaali, T B / Skorodumovs, G / Slupecki, M / Smirnov, N / Snellings, R J M / Solheim, E H / Song, J / Songmoolnak, A / Soramel, F / Sorensen, S / Spijkers, R / Sputowska, I / Staa, J / Stachel, J / Stan, I / Steffanic, P J / Stiefelmaier, S F / Stocco, D / Storehaug, I / Storetvedt, M M / Stratmann, P / Strazzi, S / Stylianidis, C P / Suaide, A A P / Suire, C / Sukhanov, M / Suljic, M / Sumberia, V / Sumowidagdo, S / Swain, S / Szarka, I / Tabassam, U / Taghavi, S F / Taillepied, G / Takahashi, J / Tambave, G J / Tang, S / Tang, Z / Tapia Takaki, J D / Tapus, N / Tarasovicova, L A / Tarzila, M G / Tassielli, G F / Tauro, A / Telesca, A / Terlizzi, L / Terrevoli, C / Tersimonov, G / Thakur, S / Thomas, D / Tikhonov, A / Timmins, A R / Tkacik, M / Tkacik, T / Toia, A / Tokumoto, R / Topilskaya, N / Toppi, M / Torales-Acosta, F / Tork, T / Torres Ramos, A G / Trifiró, A / Triolo, A S / Tripathy, S / Tripathy, T / Trogolo, S / Trubnikov, V / Trzaska, W H / Trzcinski, T P / Turrisi, R / Tveter, T S / Ullaland, K / Ulukutlu, B / Uras, A / Urioni, M / Usai, G L / Vala, M / Valle, N / Vallero, S / van Doremalen, L V R / van Leeuwen, M / van Veen, C A / van Weelden, R J G / Vande Vyvre, P / Varga, D / Varga, Z / Varga-Kofarago, M / Vasileiou, M / Vasiliev, A / Vázquez Doce, O / Vechernin, V / Vercellin, E / Vergara Limón, S / Vermunt, L / Vértesi, R / Verweij, M / Vickovic, L / Vilakazi, Z / Villalobos Baillie, O / Vino, G / Vinogradov, A / Virgili, T / Vislavicius, V / Vodopyanov, A / Volkel, B / Völkl, M A / Voloshin, K / Voloshin, S A / Volpe, G / von Haller, B / Vorobyev, I / Vozniuk, N / Vrláková, J / Wagner, B / Wang, C / Wang, D / Wegrzynek, A / Weiglhofer, F T / Wenzel, S C / Wessels, J P / Weyhmiller, S L / Wiechula, J / Wikne, J / Wilk, G / Wilkinson, J / Willems, G A / Windelband, B / Winn, M / Wright, J R / Wu, W / Wu, Y / Xu, R / Yadav, A / Yadav, A K / Yalcin, S / Yamaguchi, Y / Yamakawa, K / Yang, S / Yano, S / Yin, Z / Yoo, I-K / Yoon, J H / Yuan, S / Yuncu, A / Zaccolo, V / Zampolli, C / Zanoli, H J C / Zanone, F / Zardoshti, N / Zarochentsev, A / Závada, P / Zaviyalov, N / Zhalov, M / Zhang, B / Zhang, S / Zhang, X / Zhang, Y / Zhang, Z / Zhao, M / Zherebchevskii, V / Zhi, Y / Zhigareva, N / Zhou, D / Zhou, Y / Zhu, J / Zhu, Y / Zinovjev, G / Zurlo, N

Physical review letters

2023 Volume 131, Issue 19, Page(s) 192301

Abstract: ... fraction of the first splitting in charm jets, tagged by a reconstructed D^{0} meson. The measurement is ...

Abstract	Understanding the role of parton mass and Casimir color factors in the quantum chromodynamics parton shower represents an important step in characterizing the emission properties of heavy quarks. Recent experimental advances in jet substructure techniques have provided the opportunity to isolate and characterize gluon emissions from heavy quarks. In this Letter, the first direct experimental constraint on the charm-quark splitting function is presented, obtained via the measurement of the groomed shared momentum fraction of the first splitting in charm jets, tagged by a reconstructed D^{0} meson. The measurement is made in proton-proton collisions at sqrt[s]=13 TeV, in the low jet transverse-momentum interval of 15≤p_{T}^{jet ch}<30 GeV/c where the emission properties are sensitive to parton mass effects. In addition, the opening angle of the first perturbative emission of the charm quark, as well as the number of perturbative emissions it undergoes, is reported. Comparisons to measurements of an inclusive-jet sample show a steeper splitting function for charm quarks compared with gluons and light quarks. Charm quarks also undergo fewer perturbative emissions in the parton shower, with a reduced probability of large-angle emissions.
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.192301
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Article ; Online: Corrigendum: Biological activity of human IgE monoclonal antibodies targeting Der p 2, Fel d 1, Ara h 2 in basophil mediator release assays.

Pena-Castellanos, Glorismer / Smith, Bryan R E / Pomés, Anna / Smith, Scott A / Stigler, Maria A / Widauer, Hannah L / Versteeg, Serge A / van Ree, Ronald / Chapman, Martin D / Aglas, Lorenz

Frontiers in immunology

2023 Volume 14, Page(s) 1296381

Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1155613.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2023.1155613.].
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1296381
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Article ; Online: β-(1→3)-D-glucan- and mannan-guided early termination of antifungal therapy in ICU patients: a randomized controlled study.

Erb, Timothy / Mihai, Sidonia / Strauß, Richard / Herbst, Larissa / Castellanos, Ixchel / Diesch, Katharina / Cipa, Franziska / Bihlmaier, Karl / Lang, Anne-Katharina / Ganslmayer, Marion / Willam, Carsten / Bremer, Frank / Fürst, Julia / Beyer, Christian / Bogdan, Christian / Rath, Anca / Held, Jürgen

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 11, Page(s) e0072523

Abstract: ... ...

Abstract	Candida
MeSH term(s)	Adult ; Humans ; Antifungal Agents/therapeutic use ; Mannans ; Glucans ; Prospective Studies ; beta-Glucans ; Candidiasis, Invasive/drug therapy ; Intensive Care Units ; Biomarkers
Chemical Substances	Antifungal Agents ; Mannans ; Glucans ; beta-Glucans ; Biomarkers
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00725-23
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Article ; Online: Submicron 3-D mass spectrometry imaging reveals an asymmetric molecular distribution on chemotaxing cells.

Castellanos, Anthony / Gomer, Richard H / Fernandez-Lima, Francisco

F1000Research

2022 Volume 11, Page(s) 1017

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Dictyostelium ; Spectrometry, Mass, Secondary Ion/methods ; Imaging, Three-Dimensional ; Eukaryotic Cells ; Ions
Chemical Substances	Ions
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.124273.1
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Article ; Online: Measurement of Prompt D^{0}, Λ_{c}^{+}, and Σ_{c}^{0,++}(2455) Production in Proton-Proton Collisions at sqrt[s]=13 TeV.

Acharya, S / Adamová, D / Adler, A / Adolfsson, J / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akbar, Z / Akindinov, A / Al-Turany, M / Alam, S N / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R /

Ali, B / Ali, Y / Alici, A / Alizadehvandchali, N / Alkin, A / Alme, J / Alt, T / Altenkamper, L / Altsybeev, I / Anaam, M N / Andrei, C / Andreou, D / Andronic, A / Angeletti, M / Anguelov, V / Antinori, F / Antonioli, P / Anuj, C / Apadula, N / Aphecetche, L / Appelshäuser, H / Arcelli, S / Arnaldi, R / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Aziz, S / Azmi, M D / Badalà, A / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Bala, R / Balbino, A / Baldisseri, A / Balis, B / Ball, M / Banerjee, D / Barbera, R / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Bartels, C / Barth, K / Bartsch, E / Baruffaldi, F / Bastid, N / Basu, S / Batigne, G / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Belyaev, V / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / Bhasin, A / Bhat, M A / Bhattacharjee, B / Bhattacharya, P / Bianchi, L / Bianchi, N / Bielčík, J / Bielčíková, J / Biernat, J / Bilandzic, A / Biro, G / Biswas, S / Blair, J T / Blau, D / Blidaru, M B / Blume, C / Boca, G / Bock, F / Bogdanov, A / Boi, S / Bok, J / Boldizsár, L / Bolozdynya, A / Bombara, M / Bond, P M / Bonomi, G / Borel, H / Borissov, A / Bossi, H / Botta, E / Bratrud, L / Braun-Munzinger, P / Bregant, M / Broz, M / Bruno, G E / Buckland, M D / Budnikov, D / Buesching, H / Bufalino, S / Bugnon, O / Buhler, P / Buthelezi, Z / Butt, J B / Bysiak, S A / Caffarri, D / Cai, M / Caines, H / Caliva, A / Calvo Villar, E / Camacho, J M M / Camacho, R S / Camerini, P / Canedo, F D M / Carnesecchi, F / Caron, R / Castillo Castellanos, J / Casula, E A R / Catalano, F / Ceballos Sanchez, C / Chakraborty, P / Chandra, S / Chapeland, S / Chartier, M / Chattopadhyay, S / Chauvin, A / Chavez, T G / Cheshkov, C / Cheynis, B / Chibante Barroso, V / Chinellato, D D / Cho, S / Chochula, P / Christakoglou, P / Christensen, C H / Christiansen, P / Chujo, T / Cicalo, C / Cifarelli, L / Cindolo, F / Ciupek, M R / Clai, G / Cleymans, J / Colamaria, F / Colburn, J S / Colella, D / Collu, A / Colocci, M / Concas, M / Conesa Balbastre, G / Conesa Del Valle, Z / Contin, G / Contreras, J G / Coquet, M L / Cormier, T M / Cortese, P / Cosentino, M R / Costa, F / Costanza, S / Crochet, P / Cuautle, E / Cui, P / Cunqueiro, L / Dainese, A / Damas, F P A / Danisch, M C / Danu, A / Das, I / Das, P / Das, S / Dash, S / De, S / De Caro, A / de Cataldo, G / De Cilladi, L / de Cuveland, J / De Falco, A / De Gruttola, D / De Marco, N / De Martin, C / De Pasquale, S / Deb, S / Degenhardt, H F / Deja, K R / Dello Stritto, L / Delsanto, S / Deng, W / Dhankher, P / Di Bari, D / Di Mauro, A / Diaz, R A / Dietel, T / Ding, Y / Divià, R / Dixit, D U / Djuvsland, Ø / Dmitrieva, U / Do, J / Dobrin, A / Dönigus, B / Dordic, O / Dubey, A K / Dubla, A / Dudi, S / Dukhishyam, M / Dupieux, P / Dzalaiova, N / Eder, T M / Ehlers, R J / Eikeland, V N / Eisenhut, F / Elia, D / Erazmus, B / Ercolessi, F / Erhardt, F / Erokhin, A / Ersdal, M R / Espagnon, B / Eulisse, G / Evans, D / Evdokimov, S / Fabbietti, L / Faggin, M / Faivre, J / Fan, F / Fantoni, A / Fasel, M / Fecchio, P / Feliciello, A / Feofilov, G / Fernández Téllez, A / Ferrero, A / Ferretti, A / Feuillard, V J G / Figiel, J / Filchagin, S / Finogeev, D / Fionda, F M / Fiorenza, G / Flor, F / Flores, A N / Foertsch, S / Foka, P / Fokin, S / Fragiacomo, E / Frajna, E / Fuchs, U / Funicello, N / Furget, C / Furs, A / Gaardhøje, J J / Gagliardi, M / Gago, A M / Gal, A / Galvan, C D / Ganoti, P / Garabatos, C / Garcia, J R A / Garcia-Solis, E / Garg, K / Gargiulo, C / Garibli, A / Garner, K / Gasik, P / Gauger, E F / Gautam, A / Gay Ducati, M B / Germain, M / Ghosh, P / Ghosh, S K / Giacalone, M / Gianotti, P / Giubellino, P / Giubilato, P / Glaenzer, A M C / Glässel, P / Goh, D J Q / Gonzalez, V / González-Trueba, L H / Gorbunov, S / Gorgon, M / Görlich, L / Gotovac, S / Grabski, V / Graczykowski, L K / Greiner, L / Grelli, A / Grigoras, C / Grigoriev, V / Grigoryan, A / Grigoryan, S / Groettvik, O S / Grosa, F / Grosse-Oetringhaus, J F / Grosso, R / Guardiano, G G / Guernane, R / Guilbaud, M / Gulbrandsen, K / Gunji, T / Gupta, A / Gupta, R / Guzman, S P / Gyulai, L / Habib, M K / Hadjidakis, C / Halimoglu, G / Hamagaki, H / Hamar, G / Hamid, M / Hannigan, R / Haque, M R / Harlenderova, A / Harris, J W / Harton, A / Hasenbichler, J A / Hassan, H / Hatzifotiadou, D / Hauer, P / Havener, L B / Hayashi, S / Heckel, S T / Hellbär, E / Helstrup, H / Herman, T / Hernandez, E G / Herrera Corral, G / Herrmann, F / Hetland, K F / Hillemanns, H / Hills, C / Hippolyte, B / Hofman, B / Hohlweger, B / Honermann, J / Hong, G H / Horak, D / Hornung, S / Horzyk, A / Hosokawa, R / Hristov, P / Hughes, C / Huhn, P / Humanic, T J / Hushnud, H / Husova, L A / Hutson, A / Hutter, D / Iddon, J P / Ilkaev, R / Ilyas, H / Inaba, M / Innocenti, G M / 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Morozov, I / Morsch, A / Mrnjavac, T / Muccifora, V / Mudnic, E / Mühlheim, D / Muhuri, S / Mulligan, J D / Mulliri, A / Munhoz, M G / Munzer, R H / Murakami, H / Murray, S / Musa, L / Musinsky, J / Myrcha, J W / Naik, B / Nair, R / Nandi, B K / Nania, R / Nappi, E / Naru, M U / Nassirpour, A F / Nath, A / Nattrass, C / Neagu, A / Nellen, L / Nesbo, S V / Neskovic, G / Nesterov, D / Nielsen, B S / Nikolaev, S / Nikulin, S / Nikulin, V / Noferini, F / Noh, S / Nomokonov, P / Norman, J / Novitzky, N / Nowakowski, P / Nyanin, A / Nystrand, J / Ogino, M / Ohlson, A / Okorokov, V A / Oleniacz, J / Oliveira Da Silva, A C / Oliver, M H / Onnerstad, A / Oppedisano, C / Ortiz Velasquez, A / Osako, T / Oskarsson, A / Otwinowski, J / Oyama, K / Pachmayer, Y / Padhan, S / Pagano, D / Paić, G / Palasciano, A / Pan, J / Panebianco, S / Pareek, P / Park, J / Parkkila, J E / Pathak, S P / Patra, R N / Paul, B / Pazzini, J / Pei, H / Peitzmann, T / Peng, X / Pereira, L G / Pereira Da Costa, H / Peresunko, D / Perez, G M / Perrin, S / Pestov, Y / Petráček, V / Petrovici, M / Pezzi, R P / Piano, S / Pikna, M / Pillot, P / Pinazza, O / Pinsky, L / Pinto, C / Pisano, S / Płoskoń, M / Planinic, M / Pliquett, F / Poghosyan, M G / Polichtchouk, B / Politano, S / Poljak, N / Pop, A / Porteboeuf-Houssais, S / Porter, J / Pozdniakov, V / Prasad, S K / Preghenella, R / Prino, F / Pruneau, C A / Pshenichnov, I / Puccio, M / Qiu, S / Quaglia, L / Quishpe, R E / Ragoni, S / Rakotozafindrabe, A / Ramello, L / Rami, F / Ramirez, S A R / Ramos, A G T / Rancien, T A / Raniwala, R / Raniwala, S / Räsänen, S S / Rath, R / Ravasenga, I / Read, K F / Redelbach, A R / Redlich, K / Rehman, A / Reichelt, P / Reidt, F / Reme-Ness, H A / Renfordt, R / Rescakova, Z / Reygers, K / Riabov, A / Riabov, V / Richert, T / Richter, M / Riegler, W / Riggi, F / Ristea, C / Rode, S P / Rodríguez Cahuantzi, M / Røed, K / Rogalev, R / Rogochaya, E / Rogoschinski, T S / Rohr, D / Röhrich, D / Rojas, P F / Rokita, P S / Ronchetti, F / Rosano, A / Rosas, E D / Rossi, A / Rotondi, A / Roy, A / Roy, P / Roy, S / Rubini, N / Rueda, O V / Rui, R / Rumyantsev, B / Russek, P G / Rustamov, A / Ryabinkin, E / Ryabov, Y / Rybicki, A / Rytkonen, H / Rzesa, W / Saarimaki, O A M / Sadek, R / Sadovsky, S / Saetre, J / Šafařík, K / Saha, S K / Saha, S / Sahoo, B / Sahoo, P / Sahoo, R / Sahoo, S / Sahu, D / Sahu, P K / Saini, J / Sakai, S / Sambyal, S / Samsonov, V / Sarkar, D / Sarkar, N / Sarma, P / Sarti, V M / Sas, M H P / Schambach, J / Scheid, H S / Schiaua, C / Schicker, R / Schmah, A / Schmidt, C / Schmidt, H R / Schmidt, M O / Schmidt, M / Schmidt, N V / Schmier, A R / Schotter, R / Schukraft, J / Schutz, Y / Schwarz, K / Schweda, K / Scioli, G / Scomparin, E / Seger, J E / Sekiguchi, Y / Sekihata, D / Selyuzhenkov, I / Senyukov, S / Seo, J J / Serebryakov, D / Šerkšnytė, L / Sevcenco, A / Shaba, T J / Shabanov, A / Shabetai, A / Shahoyan, R / Shaikh, W / Shangaraev, A / Sharma, A / Sharma, H / Sharma, M 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Topilskaya, N / Toppi, M / Torales-Acosta, F / Tork, T / Cruz-Torres, R / Torres, S R / Trifiró, A / Tripathy, S / Tripathy, T / Trogolo, S / Trombetta, G / Trubnikov, V / Trzaska, W H / Trzcinski, T P / Trzeciak, B A / Tumkin, A / Turrisi, R / Tveter, T S / Ullaland, K / Uras, A / Urioni, M / Usai, G L / Vala, M / Valle, N / Vallero, S / van der Kolk, N / van Doremalen, L V R / van Leeuwen, M / Vande Vyvre, P / Varga, D / Varga, Z / Varga-Kofarago, M / Vargas, A / Vasileiou, M / Vasiliev, A / Vázquez Doce, O / Vechernin, V / Vercellin, E / Vergara Limón, S / Vermunt, L / Vértesi, R / Verweij, M / Vickovic, L / Vilakazi, Z / Villalobos Baillie, O / Vino, G / Vinogradov, A / Virgili, T / Vislavicius, V / Vodopyanov, A / Volkel, B / Völkl, M A / Voloshin, K / Voloshin, S A / Volpe, G / von Haller, B / Vorobyev, I / Voscek, D / Vozniuk, N / Vrláková, J / Wagner, B / Wang, C / Wang, D / Weber, M / Weelden, R J G V / Wegrzynek, A / Wenzel, S C / Wessels, J P / Wiechula, J / Wikne, J / Wilk, G / Wilkinson, J / Willems, G A / Windelband, B / Winn, M / Witt, W E / Wright, J R / Wu, W / Wu, Y / Xu, R / Yalcin, S / Yamaguchi, Y / Yamakawa, K / Yang, S / Yano, S / Yin, Z / Yokoyama, H / Yoo, I-K / Yoon, J H / Yuan, S / Yuncu, A / Zaccolo, V / Zaman, A / Zampolli, C / Zanoli, H J C / Zardoshti, N / Zarochentsev, A / Závada, P / Zaviyalov, N / Zbroszczyk, H / Zhalov, M / Zhang, S / Zhang, X / Zhang, Y / Zherebchevskii, V / Zhi, Y / Zhigareva, N / Zhou, D / Zhou, Y / Zhu, J / Zhu, Y / Zichichi, A / Zinovjev, G / Zurlo, N

Physical review letters

2022 Volume 128, Issue 1, Page(s) 12001

Abstract: The p_{T}-differential production cross sections of prompt D^{0}, Λ_{c}^{+}, and Σ_{c}^{0,++}(2455 ... for the three Σ_{c}^{0,+,++} isospin states, the baryon-to-meson cross section ratios Σ_{c}^{0,+,++}/D^{0} and Λ ... _{c}^{+}/D^{0} are calculated in the transverse momentum (p_{T}) intervals 2

Abstract	The p_{T}-differential production cross sections of prompt D^{0}, Λ_{c}^{+}, and Σ_{c}^{0,++}(2455) charmed hadrons are measured at midrapidity (\|y\|<0.5) in pp collisions at sqrt[s]=13 TeV. This is the first measurement of Σ_{c}^{0,++} production in hadronic collisions. Assuming the same production yield for the three Σ_{c}^{0,+,++} isospin states, the baryon-to-meson cross section ratios Σ_{c}^{0,+,++}/D^{0} and Λ_{c}^{+}/D^{0} are calculated in the transverse momentum (p_{T}) intervals 2<p_{T}<12 and 1<p_{T}<24 GeV/c. Values significantly larger than in e^{+}e^{-} collisions are observed, indicating for the first time that baryon enhancement in hadronic collisions also extends to the Σ_{c}. The feed-down contribution to Λ_{c}^{+} production from Σ_{c}^{0,+,++} is also reported and is found to be larger than in e^{+}e^{-} collisions. The data are compared with predictions from event generators and other phenomenological models, providing a sensitive test of the different charm-hadronization mechanisms implemented in the models.<br />
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.128.012001
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Article ; Online: Generation of plasmonic hot carriers from d-bands in metallic nanoparticles.

Román Castellanos, Lara / Kahk, Juhan Matthias / Hess, Ortwin / Lischner, Johannes

The Journal of chemical physics

2020 Volume 152, Issue 10, Page(s) 104111

Abstract: We present an approach to master the well-known challenge of calculating the contribution of d ... spherical well model for the nanoparticle wavefunctions to flat d-bands using the envelope function ... of the plasmon due to transitions either from a d-band state to an sp-band state or from an sp-band state ...

Abstract	We present an approach to master the well-known challenge of calculating the contribution of d-bands to plasmon-induced hot carrier rates in metallic nanoparticles. We generalize the widely used spherical well model for the nanoparticle wavefunctions to flat d-bands using the envelope function technique. Using Fermi's golden rule, we calculate the generation rates of hot carriers after the decay of the plasmon due to transitions either from a d-band state to an sp-band state or from an sp-band state to another sp-band state. We apply this formalism to spherical silver nanoparticles with radii up to 20 nm and also study the dependence of hot carrier rates on the energy of the d-bands. We find that for nanoparticles with a radius less than 2.5 nm, sp-band state to sp-band state transitions dominate hot carrier production, while d-band state to sp-band state transitions give the largest contribution for larger nanoparticles.
Language	English
Publishing date	2020-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0003123
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Article ; Online: zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D.

Castillo-Castellanos, Francisco / Ramírez, Laura / Lomelí, Hilda

Life sciences

2021 Volume 284, Page(s) 119900

Abstract: ... as a latitude-dependent autoimmune disease (LDAD) risk gene, as it is responsive to vitamin D and has been ... of the embryos to respond to vitamin D, indicating additional participation of Zmiz1a as a mediator of vitamin D ...

Abstract	ZMIZ1 is a transcriptional coactivator that is related to members of the protein inhibitor of activated STAT (PIAS) family. ZMIZ1 regulates the activity of various transcription factors including the androgen receptor, p53, and Smad3. ZMIZ1 also interacts with Notch1 and selectively regulates Notch1 target genes relevant for T cell development and leukemogenesis in mammals. Human ZMIZ1 is additionally characterized as a latitude-dependent autoimmune disease (LDAD) risk gene, as it is responsive to vitamin D and has been associated with at least eleven blood cell traits. To address the function of ZMIZ1 in fish, we introduced CRISPR/Cas9 mutations in the zmiz1a gene in zebrafish. We observed that inactivation of zmiz1a in developing zebrafish larvae results in lethality at 15 days post fertilization (dpf) and delayed erythroid maturation. Differential gene expression analysis indicated that 15 dpf zmiz1a-null larvae had altered expression of autophagy genes, and erythrocytes that lacked Zmiz1a function exhibited an accumulation of mitochondrial DNA. Furthermore, we observed that autophagy gene expression was dysregulated at earlier stages of development, which suggests the involvement of Zmiz1a in the regulation of autophagy genes beyond the process of red blood cell differentiation. Finally, we showed that the loss of Zmiz1a decreased the capacity of the embryos to respond to vitamin D, indicating additional participation of Zmiz1a as a mediator of vitamin D activity.
MeSH term(s)	Animals ; Autophagy/drug effects ; Autophagy/genetics ; Base Sequence ; Cell Differentiation/drug effects ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Embryo, Nonmammalian/pathology ; Erythrocytes/drug effects ; Erythrocytes/pathology ; Erythropoiesis/drug effects ; Erythropoiesis/genetics ; Gene Dosage ; Gene Expression Regulation/drug effects ; Hemoglobins/metabolism ; Inflammation/genetics ; Mutation/genetics ; Transcriptome/genetics ; Vitamin D/pharmacology ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Hemoglobins ; Zebrafish Proteins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-08-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119900
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