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  1. Article ; Online: Deepening the observation of mycosis fungoides through dermoscopy: definition of the dermoscopic profiles of its progression stages and variants.

    Borghi, A

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 36, Issue 7, Page(s) 946

    MeSH term(s) Dermoscopy ; Humans ; Mycosis Fungoides/diagnostic imaging ; Skin Neoplasms/diagnostic imaging
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18191
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    Zs.A 3492: Show issues Location:
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  2. Article ; Online: Extremity and Truncal Soft Tissue Sarcoma: Risk Assessment and Multidisciplinary Management.

    Borghi, Alessandra / Gronchi, Alessandro

    Seminars in radiation oncology

    2024  Volume 34, Issue 2, Page(s) 147–163

    Abstract: Extremity and truncal soft tissue sarcomas are a heterogeneous group of rare cancers that arise from mesenchymal tissues. Hence, the adoption of tailored risk assessment and prognostication tools plays a crucial role in optimizing the decision-making for ...

    Abstract Extremity and truncal soft tissue sarcomas are a heterogeneous group of rare cancers that arise from mesenchymal tissues. Hence, the adoption of tailored risk assessment and prognostication tools plays a crucial role in optimizing the decision-making for which of the many possible treatment strategies to select. Management of these tumors requires a multidisciplinary strategy, which has seen significant development in recent decades. Surgery has emerged as the primary treatment approach, with the main goal of achieving microscopic negative tumor margins. To reduce the likelihood of local recurrence, loco-regional treatments such as radiation therapy and isolated limb perfusion are often added to the treatment regimen in combination with surgery. This approach also enables surgeons to perform limb-sparing surgery, particularly in cases where a positive tumor margin is expected. Chemotherapy may also provide a further benefit in decreasing the probability of local recurrence or reducing distant metastasis in selected patients. Selecting the optimal treatment strategy for these rare tumors is best accomplished by an experienced multi-disciplinary team.
    MeSH term(s) Humans ; Risk Assessment ; Combined Modality Therapy ; Extremities/pathology ; Extremities/surgery ; Sarcoma/pathology ; Sarcoma/surgery ; Radiotherapy, Adjuvant ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/radiotherapy ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2023.12.001
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    Zs.A 3654: Show issues Location:
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  3. Article ; Online: Corrigenda.

    Borghi, Alessandra / Gronchi, Alessandro

    The bone & joint journal

    2023  Volume 105-B, Issue 9, Page(s) 1030

    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.105B9.BJJ-2023-00034
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    Zs.A 6989: Show issues Location:
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  4. Article ; Online: Desmoid tumours (extra-abdominal), a surgeon's nightmare.

    Borghi, Alessandra / Gronchi, Alessandro

    The bone & joint journal

    2023  Volume 105-B, Issue 7, Page(s) 729–734

    Abstract: Desmoid tumours are a rare fibroblastic proliferation of monoclonal origin, arising in deep soft-tissues. Histologically, they are characterized by locally aggressive behaviour and an inability to metastasize, and clinically by a heterogeneous and ... ...

    Abstract Desmoid tumours are a rare fibroblastic proliferation of monoclonal origin, arising in deep soft-tissues. Histologically, they are characterized by locally aggressive behaviour and an inability to metastasize, and clinically by a heterogeneous and unpredictable course. Desmoid tumours can occur in any anatomical site, but commonly arise in the limbs. Despite their benign nature, they can be extremely disabling and sometimes life-threatening, causing severe pain and functional limitations. Their surgical management is complex and challenging, due to uncertainties surrounding the biological and clinical behaviour, rarity, and limited available literature. Resection has been the first-line approach for patients with a desmoid tumour but, during the last few decades, a shift towards a more conservative approach has occurred, with an initial 'wait and see' policy. Many medical and regional forms of treatment are also available for the management of this condition, and others have recently emerged with promising results. However, many areas of controversy remain, and further studies and global collaboration are needed to obtain prospective and randomized data, in order to develop an appropriate shared stepwise approach.
    MeSH term(s) Humans ; Extremities ; Fibromatosis, Aggressive/surgery ; Prospective Studies ; Surgeons
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.105B7.BJJ-2023-0117
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  5. Article ; Online: Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology.

    Borghi, Filipy / Saiardi, Adolfo

    Biochemical Society transactions

    2023  Volume 51, Issue 5, Page(s) 1947–1956

    Abstract: Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP ... ...

    Abstract Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis and functions in various microorganisms and used an evolutionary perspective to theorise key issues of this field and propose solutions. By highlighting the presence of VTC4 in distinct species of very divergent eucaryote clades (Opisthokonta, Viridiplantae, Discoba, and the SAR), we propose that whilst polyP synthesising machinery was present in the ancestral eukaryote, most lineages subsequently lost it during evolution. The analysis of the bacteria-acquired amoeba PPK1 and its unique polyP physiology suggests that eukaryote cells must have developed mechanisms to limit cytosolic polyP accumulation. We reviewed the literature on polyP in the mitochondria from the perspective of its endosymbiotic origin from bacteria, highlighting how mitochondria could possess a polyP physiology reminiscent of their 'bacterial' beginning that is not yet investigated. Finally, we emphasised the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive.
    MeSH term(s) Animals ; Polyphosphates ; Mammals ; Eukaryotic Cells ; Mitochondria ; Biology
    Chemical Substances Polyphosphates
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20230483
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    Zs.A 944: Show issues Location:
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  6. Article: Clinical results and mechanism of action of icosapent ethyl.

    Borghi, Claudio / Bragagni, Alessio

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl B, Page(s) B37–B40

    Abstract: Serum triglyceride concentration is considered as an additional component that often contributes to residual cardiovascular risk in patients already at high risk; these considerations have led to several clinical studies aimed at evaluating the efficacy ... ...

    Abstract Serum triglyceride concentration is considered as an additional component that often contributes to residual cardiovascular risk in patients already at high risk; these considerations have led to several clinical studies aimed at evaluating the efficacy of supplements based on omega-3 fatty acids in reducing serum triglyceride levels and consequently cardiovascular risk. Although partially inconclusive and contradictory, these clinical trials laid the foundations for the implementation of the REDUCE-IT and EVAPORATE studies, in which the use of a purified derivative of eicosapentaenoic acid, icosapent ethyl, resulted in a significant reduction both of the composite for cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke and of the reduction in the volumetric progression up to the induction of a real regression of the coronary atheromatous plaques detected by computerized coronary angiography tomography. Surprisingly, these brilliant results seem to be, at least in part, not related to the reduction of triglyceride concentration. The purpose of this article is to examine the latest evidence regarding icosapent ethyl therapy, describing the results of the main clinical trials performed to date and formulating hypotheses on the potential mechanisms of action of this fascinating molecule.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad088
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  7. Article ; Online: Laparoscopic ovarian sentinel lymph node mapping using indocyanine green for ovarian restaging purpose.

    Mauro, Jessica / Borghi, Chiara / Surace, Alessandro / Buda, Alessandro

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004908
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    Zs.A 3198: Show issues Location:
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  8. Article ; Online: Evidence for improving the therapeutic response to ixekizumab: more than just a statistic.

    Borghi, A

    The British journal of dermatology

    2018  Volume 178, Issue 6, Page(s) 1237–1238

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Psoriasis
    Chemical Substances Antibodies, Monoclonal, Humanized ; ixekizumab (BTY153760O)
    Language English
    Publishing date 2018-06-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.16653
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  9. Article: 'Use of lipid-lowering therapy: the guidelines, the drugs or the patient?'

    Borghi, Claudio / Bragagni, Alessio

    European heart journal supplements : journal of the European Society of Cardiology

    2022  Volume 24, Issue Suppl I, Page(s) I29–I33

    Abstract: The current step up approach in the therapy of dyslipidemias aims to reduce the amount of LDL cholesterol below a threshold that varies according to the patient's risk category, with a pharmacological approach that sees statins as a fundamental ... ...

    Abstract The current step up approach in the therapy of dyslipidemias aims to reduce the amount of LDL cholesterol below a threshold that varies according to the patient's risk category, with a pharmacological approach that sees statins as a fundamental cornerstone. Although absolutely functional in reducing cardiovascular events, this therapeutic algorithm does not yet take into consideration the innumerable phenotypic variables that we can find in dyslipidemic subjects. The ever finer understanding of the pathophysiological mechanisms underlying dyslipidemias in combination with the novelties obtained through DNA genotyping will allow, in the near future, the development of a 'tailor-made' therapy for each category of patients. This article will summarize the most recent evidence regarding the therapy of dyslipidemias, with particular attention to the concept of cumulative exposure and some hypotheses on possible initial therapeutic proposals in patients with diabetes, vasculopathy, with hypertriglyceridaemia and with high levels of Lp (a).
    Language English
    Publishing date 2022-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suac069
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  10. Article ; Online: Caffè, ipertensione e malattie cardiovascolari: nuove acquisizioni.

    Borghi, Claudio / Bragagni, Alessio

    Giornale italiano di cardiologia (2006)

    2022  Volume 23, Issue 5, Page(s) 323–327

    Abstract: Coffee is the most widespread drink in the world, immediately after water. In the United States, coffee consumption amounts to 400 million cups per day and is, globally, the main source of caffeine. In view of such a high worldwide use, it is of great ... ...

    Title translation New evidence on coffee consumption, hypertension and cardiovascular diseases.
    Abstract Coffee is the most widespread drink in the world, immediately after water. In the United States, coffee consumption amounts to 400 million cups per day and is, globally, the main source of caffeine. In view of such a high worldwide use, it is of great interest for the scientific community to understand whether or not this drink has an impact on health. In the first clinical studies aimed at investigating the effects of coffee, a possible deleterious effect on systemic blood pressure and on the incidence of cardiovascular diseases was hypothesized. These data have been interpreted on the basis of the mild increase in blood pressure that can occur immediately following the consumption of caffeine. Coffee, however, contains more than 1000 chemical components, among which are polyphenols such as chlorogenic acid and lignans, with antioxidant and anti-inflammatory properties, and substances with a vasodilating action such as vitamin E, niacin, potassium and magnesium. It is therefore likely that if, on the one hand, caffeine causes a mild increase in blood pressure, on the other hand, the countless substances contained in coffee are able to counteract this effect, actually resulting in a health benefit. The latest evidence available in the literature shows indeed how the consumption of 3-5 cups of coffee a day is not only harmless, but is even able to significantly reduce the incidence of and mortality from cardiovascular diseases, as well as mortality from all causes.
    MeSH term(s) Caffeine/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Chlorogenic Acid ; Coffee/chemistry ; Humans ; Hypertension/complications ; Hypertension/epidemiology
    Chemical Substances Coffee ; Chlorogenic Acid (318ADP12RI) ; Caffeine (3G6A5W338E)
    Language Italian
    Publishing date 2022-04-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3796.37814
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