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  1. Article: Uncovering the Structural Diversity of Y(III) Naphthalene-2,6-Dicarboxylate MOFs Through Coordination Modulation.

    Griffin, Sarah L / Wilson, Claire / Forgan, Ross S

    Frontiers in chemistry

    2019  Volume 7, Page(s) 36

    Abstract: Metal-organic frameworks (MOFs)-network structures built from metal ions or clusters and connecting organic ligands-are typically synthesized by solvothermal self-assembly. For transition metal based MOFs, structural predictability is facilitated by ... ...

    Abstract Metal-organic frameworks (MOFs)-network structures built from metal ions or clusters and connecting organic ligands-are typically synthesized by solvothermal self-assembly. For transition metal based MOFs, structural predictability is facilitated by control over coordination geometries and linker connectivity under the principles of isoreticular synthesis. For rare earth (RE) MOFs, coordination behavior is dominated by steric and electronic factors, leading to unpredictable structures, and poor control over self-assembly. Herein we show that coordination modulation-the addition of competing ligands into MOF syntheses-offers programmable access to six different Y(III) MOFs all connected by the same naphthalene-2,6-dicarboxylate ligand, despite controlled synthesis of multiple phases from the same metal-ligand combination often being challenging for rare earth MOFs. Four of the materials are isolable in bulk phase purity, three are amenable to rapid microwave synthesis, and the fluorescence sensing ability of one example toward metal cations is reported. The results show that a huge variety of structurally versatile MOFs can potentially be prepared from simple systems, and that coordination modulation is a powerful tool for systematic control of phase behavior in rare earth MOFs.
    Language English
    Publishing date 2019-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2019.00036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative Profiles of SARS-CoV-2 Spike-Specific Human Milk Antibodies Elicited by mRNA- and Adenovirus-Based COVID-19 Vaccines.

    Yang, Xiaoqi / Fox, Alisa / DeCarlo, Claire / Norris, Caroline / Griffin, Samantha / Wedekind, Sophie / Flanagan, James M / Shenker, Natalie / Powell, Rebecca L

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2022  Volume 17, Issue 8, Page(s) 638–646

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adenoviridae/genetics ; Antibodies, Viral ; Breast Feeding ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Female ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Lactation ; Milk, Human ; RNA, Messenger ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2022.0019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Uncovering the Structural Diversity of Y(III) Naphthalene-2,6-Dicarboxylate MOFs Through Coordination Modulation

    Sarah L. Griffin / Claire Wilson / Ross S. Forgan

    Frontiers in Chemistry, Vol

    2019  Volume 7

    Abstract: Metal-organic frameworks (MOFs)—network structures built from metal ions or clusters and connecting organic ligands—are typically synthesized by solvothermal self-assembly. For transition metal based MOFs, structural predictability is facilitated by ... ...

    Abstract Metal-organic frameworks (MOFs)—network structures built from metal ions or clusters and connecting organic ligands—are typically synthesized by solvothermal self-assembly. For transition metal based MOFs, structural predictability is facilitated by control over coordination geometries and linker connectivity under the principles of isoreticular synthesis. For rare earth (RE) MOFs, coordination behavior is dominated by steric and electronic factors, leading to unpredictable structures, and poor control over self-assembly. Herein we show that coordination modulation—the addition of competing ligands into MOF syntheses—offers programmable access to six different Y(III) MOFs all connected by the same naphthalene-2,6-dicarboxylate ligand, despite controlled synthesis of multiple phases from the same metal-ligand combination often being challenging for rare earth MOFs. Four of the materials are isolable in bulk phase purity, three are amenable to rapid microwave synthesis, and the fluorescence sensing ability of one example toward metal cations is reported. The results show that a huge variety of structurally versatile MOFs can potentially be prepared from simple systems, and that coordination modulation is a powerful tool for systematic control of phase behavior in rare earth MOFs.
    Keywords metal-organic frameworks ; yttrium ; coordination modulation ; microwave synthesis ; fluorescent sensing ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: "Post-GDM support would be really good for mothers": A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes.

    Dennison, Rebecca A / Griffin, Simon J / Usher-Smith, Juliet A / Fox, Rachel A / Aiken, Catherine E / Meek, Claire L

    PloS one

    2022  Volume 17, Issue 1, Page(s) e0262852

    Abstract: Background: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. ... ...

    Abstract Background: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, achieving and maintaining these behaviours in the postpartum period is challenging. This study sought to explore women's views on suggested practical approaches to achieve and maintain a healthy diet and physical activity to reduce T2DM risk.
    Methods: Semi-structured interviews with 20 participants in Cambridgeshire, UK were conducted at three to 48 months after GDM. The participants' current diet and physical activity, intentions for any changes, and views on potential interventions to help manage T2DM risk through these behaviours were discussed. Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions, and thematic framework were based on a recent systematic review.
    Results: Most of the participants wanted to eat more healthily and be more active. A third of the participants considered that postpartum support for these behaviours would be transformative, a third thought it would be beneficial, and a third did not want additional support. The majority agreed that more information about the impact of diet and physical activity on diabetes risk, support to exercise with others, and advice about eating healthily, exercising with a busy schedule, monitoring progress and sustaining changes would facilitate a healthy diet and physical activity. Four other suggested interventions received mixed responses. It would be acceptable for this support to be delivered throughout pregnancy and postpartum through a range of formats. Clinicians were seen to have important roles in giving or signposting to support.
    Conclusions: Many women would appreciate more support to reduce their T2DM risk after GDM and believe that a variety of interventions to integrate changes into their daily lives would help them to sustain healthier lifestyles.
    MeSH term(s) Adult ; Diabetes Mellitus, Type 2 ; Diabetes, Gestational ; Diet, Healthy ; Exercise ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Postpartum Period ; Pregnancy ; Pregnancy in Diabetics
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0262852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: “Post-GDM support would be really good for mothers”

    Rebecca A. Dennison / Simon J. Griffin / Juliet A. Usher-Smith / Rachel A. Fox / Catherine E. Aiken / Claire L. Meek

    PLoS ONE, Vol 17, Iss

    A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes

    2022  Volume 1

    Abstract: Background Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, ...

    Abstract Background Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, achieving and maintaining these behaviours in the postpartum period is challenging. This study sought to explore women’s views on suggested practical approaches to achieve and maintain a healthy diet and physical activity to reduce T2DM risk. Methods Semi-structured interviews with 20 participants in Cambridgeshire, UK were conducted at three to 48 months after GDM. The participants’ current diet and physical activity, intentions for any changes, and views on potential interventions to help manage T2DM risk through these behaviours were discussed. Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions, and thematic framework were based on a recent systematic review. Results Most of the participants wanted to eat more healthily and be more active. A third of the participants considered that postpartum support for these behaviours would be transformative, a third thought it would be beneficial, and a third did not want additional support. The majority agreed that more information about the impact of diet and physical activity on diabetes risk, support to exercise with others, and advice about eating healthily, exercising with a busy schedule, monitoring progress and sustaining changes would facilitate a healthy diet and physical activity. Four other suggested interventions received mixed responses. It would be acceptable for this support to be delivered throughout pregnancy and postpartum through a range of formats. Clinicians were seen to have important roles in giving or signposting to support. Conclusions Many women would appreciate more support to reduce their T2DM risk after GDM and believe that a variety of interventions to integrate changes into their daily lives would help them to sustain healthier ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: "Post-GDM support would be really good for mothers"

    Rebecca A Dennison / Simon J Griffin / Juliet A Usher-Smith / Rachel A Fox / Catherine E Aiken / Claire L Meek

    PLoS ONE, Vol 17, Iss 1, p e

    A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes.

    2022  Volume 0262852

    Abstract: Background Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, ...

    Abstract Background Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, achieving and maintaining these behaviours in the postpartum period is challenging. This study sought to explore women's views on suggested practical approaches to achieve and maintain a healthy diet and physical activity to reduce T2DM risk. Methods Semi-structured interviews with 20 participants in Cambridgeshire, UK were conducted at three to 48 months after GDM. The participants' current diet and physical activity, intentions for any changes, and views on potential interventions to help manage T2DM risk through these behaviours were discussed. Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions, and thematic framework were based on a recent systematic review. Results Most of the participants wanted to eat more healthily and be more active. A third of the participants considered that postpartum support for these behaviours would be transformative, a third thought it would be beneficial, and a third did not want additional support. The majority agreed that more information about the impact of diet and physical activity on diabetes risk, support to exercise with others, and advice about eating healthily, exercising with a busy schedule, monitoring progress and sustaining changes would facilitate a healthy diet and physical activity. Four other suggested interventions received mixed responses. It would be acceptable for this support to be delivered throughout pregnancy and postpartum through a range of formats. Clinicians were seen to have important roles in giving or signposting to support. Conclusions Many women would appreciate more support to reduce their T2DM risk after GDM and believe that a variety of interventions to integrate changes into their daily lives would help them to sustain healthier ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Familial Associations of Prevalence and Cause-Specific Mortality for Thoracic Aortic Disease and Bicuspid Aortic Valve in a Large-Population Database.

    Glotzbach, Jason P / Hanson, Heidi A / Tonna, Joseph E / Horns, Joshua J / McCarty Allen, Chelsea / Presson, Angela P / Griffin, Claire L / Zak, Megan / Sharma, Vikas / Tristani-Firouzi, Martin / Selzman, Craig H

    Circulation

    2023  Volume 148, Issue 8, Page(s) 637–647

    Abstract: Background: Thoracic aortic disease and bicuspid aortic valve (BAV) likely have a heritable component, but large population-based studies are lacking. This study characterizes familial associations of thoracic aortic disease and BAV, as well as ... ...

    Abstract Background: Thoracic aortic disease and bicuspid aortic valve (BAV) likely have a heritable component, but large population-based studies are lacking. This study characterizes familial associations of thoracic aortic disease and BAV, as well as cardiovascular and aortic-specific mortality, among relatives of these individuals in a large-population database.
    Methods: In this observational case-control study of the Utah Population Database, we identified probands with a diagnosis of BAV, thoracic aortic aneurysm, or thoracic aortic dissection. Age- and sex-matched controls (10:1 ratio) were identified for each proband. First-degree relatives, second-degree relatives, and first cousins of probands and controls were identified through linked genealogical information. Cox proportional hazard models were used to quantify the familial associations for each diagnosis. We used a competing-risk model to determine the risk of cardiovascular-specific and aortic-specific mortality for relatives of probands.
    Results: The study population included 3 812 588 unique individuals. Familial hazard risk of a concordant diagnosis was elevated in the following populations compared with controls: first-degree relatives of patients with BAV (hazard ratio [HR], 6.88 [95% CI, 5.62-8.43]); first-degree relatives of patients with thoracic aortic aneurysm (HR, 5.09 [95% CI, 3.80-6.82]); and first-degree relatives of patients with thoracic aortic dissection (HR, 4.15 [95% CI, 3.25-5.31]). In addition, the risk of aortic dissection was higher in first-degree relatives of patients with BAV (HR, 3.63 [95% CI, 2.68-4.91]) and in first-degree relatives of patients with thoracic aneurysm (HR, 3.89 [95% CI, 2.93-5.18]) compared with controls. Dissection risk was highest in first-degree relatives of patients who carried a diagnosis of both BAV and aneurysm (HR, 6.13 [95% CI, 2.82-13.33]). First-degree relatives of patients with BAV, thoracic aneurysm, or aortic dissection had a higher risk of aortic-specific mortality (HR, 2.83 [95% CI, 2.44-3.29]) compared with controls.
    Conclusions: Our results indicate that BAV and thoracic aortic disease carry a significant familial association for concordant disease and aortic dissection. The pattern of familiality is consistent with a genetic cause of disease. Furthermore, we observed higher risk of aortic-specific mortality in relatives of individuals with these diagnoses. This study provides supportive evidence for screening in relatives of patients with BAV, thoracic aneurysm, or dissection.
    MeSH term(s) Humans ; Bicuspid Aortic Valve Disease ; Aortic Valve ; Heart Valve Diseases/diagnosis ; Case-Control Studies ; Prevalence ; Cause of Death ; Aortic Diseases ; Aortic Aneurysm, Thoracic/genetics ; Aortic Dissection/genetics
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.060439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

    Andreia L. Pinto / Ranjit K. Rai / Jonathan C. Brown / Paul Griffin / James R. Edgar / Anand Shah / Aran Singanayagam / Claire Hogg / Wendy S. Barclay / Clare E. Futter / Thomas Burgoyne

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolution ... ...

    Abstract Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolution electron microscopy and tomography provide new insight into the infection process.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium.

    Pinto, Andreia L / Rai, Ranjit K / Brown, Jonathan C / Griffin, Paul / Edgar, James R / Shah, Anand / Singanayagam, Aran / Hogg, Claire / Barclay, Wendy S / Futter, Clare E / Burgoyne, Thomas

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1609

    Abstract: Ultrastructural studies of SARS-CoV-2 infected cells are crucial to better understand the mechanisms of viral entry and budding within host cells. Here, we examined human airway epithelium infected with three different isolates of SARS-CoV-2 including ... ...

    Abstract Ultrastructural studies of SARS-CoV-2 infected cells are crucial to better understand the mechanisms of viral entry and budding within host cells. Here, we examined human airway epithelium infected with three different isolates of SARS-CoV-2 including the B.1.1.7 variant by transmission electron microscopy and tomography. For all isolates, the virus infected ciliated but not goblet epithelial cells. Key SARS-CoV-2 entry molecules, ACE2 and TMPRSS2, were found to be localised to the plasma membrane including microvilli but excluded from cilia. Consistently, extracellular virions were seen associated with microvilli and the apical plasma membrane but rarely with ciliary membranes. Profiles indicative of viral fusion where tomography showed that the viral membrane was continuous with the apical plasma membrane and the nucleocapsids diluted, compared with unfused virus, demonstrate that the plasma membrane is one site of entry where direct fusion releasing the nucleoprotein-encapsidated genome occurs. Intact intracellular virions were found within ciliated cells in compartments with a single membrane bearing S glycoprotein. Tomography showed concentration of nucleocapsids round the periphery of profiles strongly suggestive of viral budding into these compartments and this may explain how virions gain their S glycoprotein containing envelope.
    MeSH term(s) COVID-19 ; Epithelium/metabolism ; Humans ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29255-y
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  10. Article ; Online: Signet ring gastric and esophageal adenocarcinomas: characteristics and prognostic implications.

    Khan, Niall / Donohoe, Claire L / Phillips, Alexander W / Griffin, S Michael / Reynolds, John V

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2020  Volume 33, Issue 11

    Abstract: Controversy exists as to the relevance of the signet ring carcinoma (SRC) histological subtype of esophagogastric adenocarcinoma to long-term prognosis, with some studies reporting a worsened oncological outcome and others no clinically relevant impact. ... ...

    Abstract Controversy exists as to the relevance of the signet ring carcinoma (SRC) histological subtype of esophagogastric adenocarcinoma to long-term prognosis, with some studies reporting a worsened oncological outcome and others no clinically relevant impact. A retrospective analysis of outcomes of patients who underwent surgery with curative intent in two high-volume centers (2000-2015) was undertaken. Tumors were analyzed according to location (esophageal, junctional or gastric). Propensity score matching (PSM) analysis was used to match patients with signet ring histology to those without (195 SRC vs. 573 non-SRC), based on age, tumor location, use of neoadjuvant and adjuvant chemotherapy and pathological stage. A total of 2,500 patients with esophagogastric adenocarcinomas were treated, of whom 198 (7.9%) had signet ring histology. Signet ring tumors were more likely to have positive lymph nodes at pathological analysis (59% vs. 50%, P = 0.009). The 5-year survival rate for patients with early signet ring tumors (Stage 0/I/IIa) was 65% versus 85% for other early cancers (P < 0.003). Patients with esophageal signet ring tumors had a particularly poor prognosis with 23% 2-year survival and none alive at 5 years. With PSM, overall survival (OS) was significantly poorer in the signet ring group (44.3 ± 8.6 vs. 59.8 ± 8.5 months, 5-year OS 41% vs. 50%, P = 0.027). Signet ring cells within esophagogastric adenocarcinoma are associated with a poorer prognosis. Genomic studies to identify the composition of such tumors as well as identify strategies to improve treatment for this subtype are warranted.
    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Carcinoma, Signet Ring Cell/surgery ; Esophageal Neoplasms/pathology ; Humans ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doaa016
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