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Article ; Online: A bio-inspired silkworm 3D cocoon-like hierarchical self-assembled structure from π-conjugated natural aromatic amino acids.

Mukherjee, Smriti / Reddy, Samala Murali Mohan / Shanmugam, Ganesh

2024 Volume 20, Issue 8, Page(s) 1834–1845

Abstract: The formation of spontaneous 3D self-assembled hierarchical structures from 1D nanofibers is a significant breakthrough in materials science. Overcoming the major challenges associated with developing these 3D structures, such as uncontrolled self- ... ...

Abstract	The formation of spontaneous 3D self-assembled hierarchical structures from 1D nanofibers is a significant breakthrough in materials science. Overcoming the major challenges associated with developing these 3D structures, such as uncontrolled self-assembly, complex procedures, and machinery, has been a formidable task. However, the current discovery reveals that simple π-system (fluorenyl)-functionalized natural aromatic amino acids, phenylalanine (Fmoc-F) and tyrosine (Fmoc-Y), can form bio-inspired 3D cocoon-like structures. These structures are composed of entangled 1D nanofibers created through supramolecular self-assembly using a straightforward one-step process of solvent casting. The self-assembly process relies on π-π stacking of the fluorenyl (π-system) moieties and intermolecular hydrogen bonding between urethane amide groups. The cocoon-like structures are versatile and independent of concentration, temperature, and humidity, making them suitable for various applications. This discovery has profound implications for materials science and the developed advanced biomaterials, such as Fmoc-F and Fmoc-Y, can serve as flexible foundational components for constructing 3D fiber-based structures.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm01746j
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Article ; Online: Development of masked silica tanning system for sustainable leather production.

Srinivasan, Pradeep / Rajagopal, Vedayokesh / Shanmugam, Ganesh / Madhan, Balaraman

Environmental science and pollution research international

2024 Volume 31, Issue 18, Page(s) 26567–26579

Abstract: Amid mounting pressure on the long-term recyclability of chromium in tanned leather and the associated environmental hazards, the quest for an alternative, cleaner tanning system has gained tremendous momentum. In this context, our study explores the ... ...

Abstract	Amid mounting pressure on the long-term recyclability of chromium in tanned leather and the associated environmental hazards, the quest for an alternative, cleaner tanning system has gained tremendous momentum. In this context, our study explores the remarkable potential of silicates as a versatile platform for skin/hide tanning, circumventing the inherent risks and ecological threats posed by chromium exposure and leaching. We present an alternative approach of using a silica-based tanning system, employing a Taguchi model, to optimize a masked silica (MaSil) tanning product/process for achieving effective collagen stabilization. Our results demonstrate the significant advancements made in hydrothermal denaturation temperature, reaching an impressive 79 °C through precise Taguchi parameters-5% SiO
MeSH term(s)	Tanning ; Silicon Dioxide/chemistry
Chemical Substances	Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2024-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32567-9
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Article ; Online: A Novel Surfactant with Short Hydrophobic Head and Long Hydrophilic Tail Generates Vesicles with Unique Structural Feature.

Mukherjee, Smriti / Shanmugam, Ganesh

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 19, Page(s) e2206906

Abstract: Surfactant molecules typically have a long hydrophobic tail and a short hydrophilic head group. It remains unexplored if surfactants can have a short hydrophobic head group and a long hydrophilic tail. Designing such surfactants is a challenge as a ... ...

Abstract	Surfactant molecules typically have a long hydrophobic tail and a short hydrophilic head group. It remains unexplored if surfactants can have a short hydrophobic head group and a long hydrophilic tail. Designing such surfactants is a challenge as a lengthy hydrophilic tail would completely solubilize the molecules. In this context, herein, the Fmoc-functionalized Gly-Pro-Hyp (GPO) tripeptide repeat-based molecule (Fm-GPO) with fluorenyl moiety as a short hydrophobic head and peptide as a long hydrophilic tail is demonstrated as a reverse surfactant at physiological pH, for the first time. π-π stacking of the fluorenyl moieties and intermolecular hydrogen bonding between the peptide chains with extended polyproline-II structure promoted the self-assembly into spherical vesicles with a unique feature of a large hydrophilic area in the interior and exterior of the bilayer. The current Fm-GPO system offers a new class of surfactants with unique features that can aid in the design of drug-loaded vehicles, which can be target-specific as the peptide chain can be manipulated with different functional ultra-short peptide sequences.
MeSH term(s)	Surface-Active Agents/chemistry ; Peptides/chemistry ; Hydrophobic and Hydrophilic Interactions ; Amino Acid Sequence
Chemical Substances	Surface-Active Agents ; Peptides
Language	English
Publishing date	2023-02-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202206906
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Article ; Online: Collagen Mimicry with a Short Collagen Model Peptide.

Mukherjee, Smriti / Sundarapandian, Ashokraj / Ayyadurai, Niraikulam / Shanmugam, Ganesh

Macromolecular rapid communications

2023 Volume 45, Issue 4, Page(s) e2300573

Abstract: Mimicking triple helix and fibrillar network of collagen through collagen model peptide(CMP) with short GPO tripeptide repeats is a great challenge. Herein, a minimalistic CMP comprising only five GPO repeats [(GPO) ...

Abstract	Mimicking triple helix and fibrillar network of collagen through collagen model peptide(CMP) with short GPO tripeptide repeats is a great challenge. Herein, a minimalistic CMP comprising only five GPO repeats [(GPO)
MeSH term(s)	Peptides/chemistry ; Collagen/chemistry
Chemical Substances	Peptides ; Collagen (9007-34-5)
Language	English
Publishing date	2023-11-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.202300573
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Article ; Online: Isotope-edited vibrational circular dichroism study reveals a flexible N-terminal structure of islet amyloid peptide (NFGAIL) in amyloid fibril form: A site-specific local structural analysis.

Unnikrishnan, Anagha C / Shanmugam, Ganesh

Journal of structural biology

2022 Volume 214, Issue 4, Page(s) 107910

Abstract: The short peptide fragment NFGAIL (IAPf) is a well-known amyloidogenic peptide (22-27), derived from human islet amyloid polypeptide(hIAPP), whose fibrillar structure is often used to better understand the wild-type hIAPP amyloid fibrils, associated with ...

Abstract	The short peptide fragment NFGAIL (IAPf) is a well-known amyloidogenic peptide (22-27), derived from human islet amyloid polypeptide(hIAPP), whose fibrillar structure is often used to better understand the wild-type hIAPP amyloid fibrils, associated with type II diabetes. Despite an extensive study, the fibrillar structure of IAPf at the amino acid residue level is still unclear. Herein, the vibrational circular dichroism(VCD) spectroscopic technique coupled with isotope labelling strategy has been used to study the site-specific local structure of IAPf amyloid fibrils. Two
MeSH term(s)	Humans ; Amyloid ; Diabetes Mellitus, Type 2 ; Peptides ; Phenylalanine ; Glycine ; Isotopes
Chemical Substances	Amyloid ; Peptides ; Phenylalanine (47E5O17Y3R) ; Glycine (TE7660XO1C) ; Isotopes
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032718-6
ISSN	1095-8657 ; 1047-8477
ISSN (online)	1095-8657
ISSN	1047-8477
DOI	10.1016/j.jsb.2022.107910
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Article ; Online: Structural Insights into the Amyloid Fibril Polymorphism Using an Isotope-Edited Vibrational Circular Dichroism Study at the Amino Acid Residue Level.

Unnikrishnan, Anagha C / Balamurugan, Kanagasabai / Shanmugam, Ganesh

The journal of physical chemistry. B

2023 Volume 127, Issue 36, Page(s) 7674–7684

Abstract: Polymorphism is common in both in vitro and in vivo amyloid fibrils formed by the same peptide/protein. However, the differences in their self-assembled structures at the amino acid level remain poorly understood. In this study, we utilized isotope- ... ...

Abstract	Polymorphism is common in both in vitro and in vivo amyloid fibrils formed by the same peptide/protein. However, the differences in their self-assembled structures at the amino acid level remain poorly understood. In this study, we utilized isotope-edited vibrational circular dichroism (VCD) on a well-known amyloidogenic peptide fragment (N
MeSH term(s)	Humans ; Amino Acids ; Amyloid ; Circular Dichroism ; Glycine/genetics ; Phenylalanine ; Amyloidogenic Proteins ; Islet Amyloid Polypeptide
Chemical Substances	Amino Acids ; Amyloid ; Glycine (TE7660XO1C) ; Phenylalanine (47E5O17Y3R) ; Amyloidogenic Proteins ; Islet Amyloid Polypeptide
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c03437
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Article ; Online: Corrigendum to "Genetically encoded dihydroxyphenylalanine coupled with tyrosinase for strain promoted labelling" [Bioorg. Med. Chem. 50 (2021) 116460].

George, Augustine / Indhu, Mohan / Ashokraj, Sundarapandian / Shanmugam, Ganesh / Ganesan, Ponesakki / Kamini, Numbi Ramudu / Ayyadurai, Niraikulam

Bioorganic & medicinal chemistry

2024 Volume 103, Page(s) 117664

Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2024.117664
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Zs.A 3815: Show issues

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Article ; Online: A Unique Temperature-Induced Reverse Supramolecular Chirality-Assisted Gel-to-Gel Transition.

Duraisamy, Dinesh Kumar / Reddy, Samala Murali Mohan / Saveri, Puchalapalli / Deshpande, Abhijit P / Shanmugam, Ganesh

Macromolecular rapid communications

2024 , Page(s) e2400018

Abstract: Supramolecular hydrogels typically undergo a gel-to-sol transition with heat, as intermolecular interactions within the gel weaken. Although gel-to-gel transitions during heating are rare, they may occur due to minor rearrangements caused by thermal ... ...

Abstract	Supramolecular hydrogels typically undergo a gel-to-sol transition with heat, as intermolecular interactions within the gel weaken. Although gel-to-gel transitions during heating are rare, they may occur due to minor rearrangements caused by thermal forces in the supramolecular self-assembled structure. Here, an unprecedented temperature-induced gel-to-gel transition assisted by supramolecular chiral inversion in a hydrogel system is presented. The transition results from a left-handed M-type helix to a right-handed P-type helix, attributed to the π-system-conjugated amino acid, l-Tyrosine (Fm- l-Tyr). Upon solvent dilution, Fm-l-Tyr induces translucent hydrogel formed by entangled fibers with a kinetically stable left-handed M-type supramolecular helix. At 70 °C, hydrogel transforms into an opaque gel with a reverse supramolecular chirality yielding a thermodynamically stable right-handed P-type helix. Supramolecular chiral inversion is substantiated by two chiroptical methods. This unique gel-to-gel transition, accompanied by chiral inversion, is anticipated to attract attention, especially for applications sensitive to chirality.
Language	English
Publishing date	2024-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.202400018
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Article ; Online: Biomimetic design of fibril-forming non-immunogenic collagen like proteins for tissue engineering.

Aarthy, Mayilvahanan / Hemalatha, Thiagarajan / Suryalakshmi, Pandurangan / Vinoth, Vetrivel / Mercyjayapriya, Jebakumar / Shanmugam, Ganesh / Ayyadurai, Niraikulam

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 130999

Abstract: Collagen, a key component of extracellular matrix serves as a linchpin for maintaining structural integrity and functional resilience. Concerns over purity and immunogenicity of animal-derived collagens have spurred efforts to develop synthetic collagen- ... ...

Abstract	Collagen, a key component of extracellular matrix serves as a linchpin for maintaining structural integrity and functional resilience. Concerns over purity and immunogenicity of animal-derived collagens have spurred efforts to develop synthetic collagen-based biomaterials. Despite several collagen mimics, there remains limited exploration of non-immunogenic biomaterials with the capacity for effective self-assembly. To combat the lacuna, collagen like protein (CLP) variants were rationally designed and recombinantly expressed, incorporating human telopeptide sequences (CLP-N and CLP-NC) and bioactive binding sites (CLP-NB). Circular dichroism analyses of the variants confirmed the triple helical conformation, with variations in thermal stability and conformation attributed to the presence of telopeptides at one or both ends of CLP. The variants had propensity to form oligomers, setting the stage for fibrillogenesis. The CLP variants were biocompatible, hemocompatible and supported cell proliferation and migration, particularly CLP-NB with integrin-binding sites. Gene expression indicated a lack of significant upregulation of inflammatory markers, highlighting the non-immunogenic nature of these variants. Lyophilized CLP scaffolds maintained their triple-helical structure and offered favorable biomaterial characteristics. These results accentuate the potential of designed CLP variants in tissue engineering, regenerative medicine and industrial sectors, supporting the development of biocompatible scaffolds and implants for therapeutic and cosmetic purposes.
MeSH term(s)	Tissue Engineering/methods ; Humans ; Collagen/chemistry ; Biocompatible Materials/chemistry ; Cell Proliferation/drug effects ; Tissue Scaffolds/chemistry ; Biomimetics/methods ; Animals ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Cell Movement/drug effects
Chemical Substances	Collagen (9007-34-5) ; Biocompatible Materials
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130999
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Article ; Online: Statistical Analysis on Impact of Image Preprocessing of CT Texture Patterns and Its CT Radiomic Feature Stability: A Phantom Study.

Palani, Dharmendran / Ganesh, Kadirampatti M / Karunagaran, Lavanya / Govindaraj, Kesavan / Shanmugam, Senthilkumar

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 6, Page(s) 2061–2072

Abstract: Aim: To examine computed tomography (CT) radiomic feature stability on various texture patterns during pre-processing utilizing the Credence Cartridge Radiomics (CCR) phantom textures.: Materials and methods: Imaging Biomarker Explorer (IBEX) ... ...

Abstract	Aim: To examine computed tomography (CT) radiomic feature stability on various texture patterns during pre-processing utilizing the Credence Cartridge Radiomics (CCR) phantom textures. Materials and methods: Imaging Biomarker Explorer (IBEX) expansion for the abbreviation IBEX extracted 51 radiomic features of 4 categories from 11 textures image regions of interest (ROI) of the phantom. 19 software pre-processing algorithms processed each CCR phantom ROI. All ROI texture processed image features were retrieved. Pre-processed CT image radiomic features were compared to non-processed features to measure its textural influence. Wilcoxon T-tests measured the pre-processing relevance of CT radiomic features on various textures. Hierarchical cluster analysis (HCA) was performed to cluster processer potency and texture impression likeness. Results: The pre-processing filter, CT texture Cartridge, and feature category affect the CCR phantom CT image's radiomic properties. Pre-processing is statistically unaltered by Gray Level Run Length Matrix (GLRLM ) expansion for the abbreviation GLRLM and Neighborhood Intensity Difference matrix (NID) expansion for the abbreviation NID feature categories. The 30%, 40%, and 50% honeycomb are regular directional textures and smooth 3D-printed plaster resin, most of the image pre-processing feature alterations exhibited significant p-values in the histogram feature category. The Laplacian Filter, Log Filter, Resample, and Bit Depth Rescale Range pre-processing algorithms hugely influenced histogram and Gray Level Co-occurrence Matrix (GLCM) image features. Conclusion: We found that homogenous intensity phantom inserts, CT radiomic feature, are less sensitive to feature swaps during pre-processing than normal directed honeycomb and regular projected smooth 3D-printed plaster resin CT image textures. Because they lose fewer information during image enhancement, This feature concentration empowerment of the images also enhances texture pattern recognition.
MeSH term(s)	Humans ; Tomography, X-Ray Computed/methods ; Tomography Scanners, X-Ray Computed ; Phantoms, Imaging ; Image Processing, Computer-Assisted/methods ; Algorithms
Language	English
Publishing date	2023-06-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.6.2061
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