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  1. Book: A practical atlas of congenital heart disease

    Smith, Audrey / Mckay, Roxane

    2004  

    Author's details Audrey Smith and Roxane McKay
    Keywords Heart Defects, Congenital ; Congenital heart disease ; Herzkrankheit ; Angeborene Krankheit
    Subject Congenitale Krankheit ; Kongenitale Krankheit ; Konnatale Krankheit ; Angeborene Krankheiten ; Herzerkrankung ; Herzkrankheiten
    Subject code 616.12043
    Language English
    Size XIV, 464 S. : überwiegend Ill., 29cm
    Publisher Springer
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013762501
    ISBN 1-85233-729-X ; 978-1-85233-729-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 1465 order for loan Magazin

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  2. Book: Principles of cardiac diagnosis and treatment

    Ross, Donald N. / English, Terence A. / Mckay, Roxane

    a surgeons' guide

    1992  

    Author's details Donald N. Ross ; Terence A. H. English ; Roxane McKay
    Keywords Heart Diseases / diagnosis ; Heart Diseases / surgery ; Herzkrankheit ; Diagnose ; Herzchirurgie
    Subject Herz ; Herz-Thorax-Chirurgie ; Ärztliche Diagnose ; Herzerkrankung ; Herzkrankheiten
    Language English
    Size 269 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003984342
    ISBN 3-540-17494-X ; 0-387-17494-X ; 978-3-540-17494-3 ; 978-0-387-17494-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 1410 order for loan Magazin

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  3. Article ; Online: Aorto-ventricular tunnel.

    McKay, Roxane

    Orphanet journal of rare diseases

    2007  Volume 2, Page(s) 41

    Abstract: Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinutubular junction to the cavity of the left, or (less commonly) right ventricle. The exact incidence is unknown, estimates ranging from 0.5% of ...

    Abstract Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinutubular junction to the cavity of the left, or (less commonly) right ventricle. The exact incidence is unknown, estimates ranging from 0.5% of fetal cardiac malformations to less than 0.1% of congenitally malformed hearts in clinico-pathological series. Approximately 130 cases have been reported in the literature, about twice as many cases in males as in females. Associated defects, usually involving the proximal coronary arteries, or the aortic or pulmonary valves, are present in nearly half the cases. Occasional patients present with an asymptomatic heart murmur and cardiac enlargement, but most suffer heart failure in the first year of life. The etiology of aorto-ventricular tunnel is uncertain. It appears to result from a combination of maldevelopment of the cushions which give rise to the pulmonary and aortic roots, and abnormal separation of these structures. Echocardiography is the diagnostic investigation of choice. Antenatal diagnosis by fetal echocardiography is reliable after 18 weeks gestation. Aorto-ventricular tunnel must be distinguished from other lesions which cause rapid run-off of blood from the aorta and produce cardiac failure. Optimal management of symptomatic aorto-ventricular tunnel consists of diagnosis by echocardiography, complimented with cardiac catheterization as needed to elucidate coronary arterial origins or associated defects, and prompt surgical repair. Observation of the exceedingly rare, asymptomatic patient with a small tunnel may be justified by occasional spontaneous closure. All patients require life-long follow-up for recurrence of the tunnel, aortic valve incompetence, left ventricular function, and aneurysmal enlargement of the ascending aorta.
    MeSH term(s) Aorta/abnormalities ; Echocardiography, Doppler ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/pathology ; Heart Defects, Congenital/surgery ; Heart Failure/etiology ; Heart Murmurs/etiology ; Heart Ventricles/abnormalities ; Humans ; Infant ; Infant, Newborn ; Male ; Prenatal Diagnosis
    Language English
    Publishing date 2007-10-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-1172
    ISSN (online) 1750-1172
    DOI 10.1186/1750-1172-2-41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aorto-ventricular tunnel

    McKay Roxane

    Orphanet Journal of Rare Diseases, Vol 2, Iss 1, p

    2007  Volume 41

    Abstract: Abstract Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinutubular junction to the cavity of the left, or (less commonly) right ventricle. The exact incidence is unknown, estimates ranging ... ...

    Abstract Abstract Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinutubular junction to the cavity of the left, or (less commonly) right ventricle. The exact incidence is unknown, estimates ranging from 0.5% of fetal cardiac malformations to less than 0.1% of congenitally malformed hearts in clinico-pathological series. Approximately 130 cases have been reported in the literature, about twice as many cases in males as in females. Associated defects, usually involving the proximal coronary arteries, or the aortic or pulmonary valves, are present in nearly half the cases. Occasional patients present with an asymptomatic heart murmur and cardiac enlargement, but most suffer heart failure in the first year of life. The etiology of aorto-ventricular tunnel is uncertain. It appears to result from a combination of maldevelopment of the cushions which give rise to the pulmonary and aortic roots, and abnormal separation of these structures. Echocardiography is the diagnostic investigation of choice. Antenatal diagnosis by fetal echocardiography is reliable after 18 weeks gestation. Aorto-ventricular tunnel must be distinguished from other lesions which cause rapid run-off of blood from the aorta and produce cardiac failure. Optimal management of symptomatic aorto-ventricular tunnel consists of diagnosis by echocardiography, complimented with cardiac catheterization as needed to elucidate coronary arterial origins or associated defects, and prompt surgical repair. Observation of the exceedingly rare, asymptomatic patient with a small tunnel may be justified by occasional spontaneous closure. All patients require life-long follow-up for recurrence of the tunnel, aortic valve incompetence, left ventricular function, and aneurysmal enlargement of the ascending aorta.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2007-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease: Adenine-Diet and 5/6th Nephrectomy.

    Makhloufi, Camélia / Crescence, Lydie / Darbousset, Roxane / McKay, Nathalie / Massy, Ziad A / Dubois, Christophe / Panicot-Dubois, Laurence / Burtey, Stéphane / Poitevin, Stéphane

    TH open : companion journal to thrombosis and haemostasis

    2020  Volume 4, Issue 2, Page(s) e66–e76

    Abstract: The coexistence of bleeding and thrombosis in patients with chronic kidney disease (CKD) is frequent and poorly understood. Mouse models are essential to understand complications of CKD and to develop new therapeutic approaches improving the health of ... ...

    Abstract The coexistence of bleeding and thrombosis in patients with chronic kidney disease (CKD) is frequent and poorly understood. Mouse models are essential to understand complications of CKD and to develop new therapeutic approaches improving the health of patients. We evaluated the hemostasis in two models of renal insufficiency: adenine-diet and 5/6th nephrectomy (5/6Nx). Compared with 5/6Nx mice, mice fed with 0.25% adenine had more severe renal insufficiency and so higher levels of prothrombotic uremic toxins like indoxyl sulfate. More severe renal inflammation and fibrosis were observed in the adenine group, as demonstrated by histological and reverse transcription quantitative polymerase chain reaction experiments. Liver fibrinogen γ chain expression and level of plasma fibrinogen were increased only in adenine mice. In both CKD mouse models, tissue factor (TF) expression was increased in kidney and aorta extracts. Immunochemistry analysis of kidney sections showed that TF is localized in the vascular walls. Thrombin-antithrombin complexes were significantly increased in plasma from both adenine and 5/6Nx mice. Tail bleeding time increased significantly only in adenine mice, whereas platelet count was not significant altered. Finally, results obtained by intravital microscopy after laser-induced endothelial injury showed impaired platelet function in adenine mice and an increase in fibrin generation in 5/6Nx mice. To summarize, adenine diet causes a more severe renal insufficiency compared with 5/6Nx. The TF upregulation and the hypercoagulable state were observed in both CKD models. Bleeding tendency was observed only in the adenine model of CKD that recapitulates the whole spectrum of hemostasis abnormalities observed in advanced human CKD.
    Language English
    Publishing date 2020-04-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0040-1705138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7138: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Book: A practical atlas of congenital heart disease

    Smith, Audrey / McKay, Roxane

    2004  

    Author's details Audrey Smith and Roxane McKay ; with forewords by John W. Kirklin and James K. Kirklin, Hajar A. Hajar Al Binali
    MeSH term(s) Heart Defects, Congenital
    Language English
    Size xiv, 464 p. :, ill.
    Publisher Springer
    Publishing place London ; New York
    Document type Book
    ISBN 9781852337292 ; 185233729X
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: Extracardiac Fontan with direct cavopulmonary connections.

    McKay, Roxane / Dearani, Joseph A

    The Annals of thoracic surgery

    2008  Volume 85, Issue 2, Page(s) 669–671

    Abstract: In order to optimize the Fontan circulation, a technique for direct superior and inferior cavopulmonary connections was devised. Such pathways retain growth potential, obviate suture lines within the right atrium, and avoid prosthetic implants. They thus ...

    Abstract In order to optimize the Fontan circulation, a technique for direct superior and inferior cavopulmonary connections was devised. Such pathways retain growth potential, obviate suture lines within the right atrium, and avoid prosthetic implants. They thus enable definitive, single-stage ventricular unloading, regardless of patient size or great artery position.
    MeSH term(s) Adolescent ; Angiography ; Child ; Child, Preschool ; Cohort Studies ; Combined Modality Therapy ; Echocardiography, Doppler ; Female ; Follow-Up Studies ; Fontan Procedure/methods ; Heart Bypass, Right/methods ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Male ; Pulmonary Circulation/physiology ; Retrospective Studies ; Risk Assessment ; Treatment Outcome
    Language English
    Publishing date 2008-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2007.04.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Assessment of Thrombotic and Bleeding Tendency in Two Mouse Models of Chronic Kidney Disease: Adenine-Diet and 5/6th Nephrectomy

    Makhloufi, Camélia / Crescence, Lydie / Darbousset, Roxane / McKay, Nathalie / Massy, Ziad A. / Dubois, Christophe / Panicot-Dubois, Laurence / Burtey, Stéphane / Poitevin, Stéphane

    TH Open

    2020  Volume 04, Issue 02, Page(s) e66–e76

    Abstract: The coexistence of bleeding and thrombosis in patients with chronic kidney disease (CKD) is frequent and poorly understood. Mouse models are essential to understand complications of CKD and to develop new therapeutic approaches improving the health of ... ...

    Abstract The coexistence of bleeding and thrombosis in patients with chronic kidney disease (CKD) is frequent and poorly understood. Mouse models are essential to understand complications of CKD and to develop new therapeutic approaches improving the health of patients. We evaluated the hemostasis in two models of renal insufficiency: adenine-diet and 5/6th nephrectomy (5/6Nx). Compared with 5/6Nx mice, mice fed with 0.25% adenine had more severe renal insufficiency and so higher levels of prothrombotic uremic toxins like indoxyl sulfate. More severe renal inflammation and fibrosis were observed in the adenine group, as demonstrated by histological and reverse transcription quantitative polymerase chain reaction experiments. Liver fibrinogen γ chain expression and level of plasma fibrinogen were increased only in adenine mice. In both CKD mouse models, tissue factor (TF) expression was increased in kidney and aorta extracts. Immunochemistry analysis of kidney sections showed that TF is localized in the vascular walls. Thrombin–antithrombin complexes were significantly increased in plasma from both adenine and 5/6Nx mice. Tail bleeding time increased significantly only in adenine mice, whereas platelet count was not significant altered. Finally, results obtained by intravital microscopy after laser-induced endothelial injury showed impaired platelet function in adenine mice and an increase in fibrin generation in 5/6Nx mice. To summarize, adenine diet causes a more severe renal insufficiency compared with 5/6Nx. The TF upregulation and the hypercoagulable state were observed in both CKD models. Bleeding tendency was observed only in the adenine model of CKD that recapitulates the whole spectrum of hemostasis abnormalities observed in advanced human CKD.
    Keywords tissue factor ; platelets ; hemostasis
    Language English
    Publishing date 2020-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0040-1705138
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  9. Article: The aorto-ventricular tunnels.

    McKay, Roxane / Anderson, Robert H / Cook, Andrew C

    Cardiology in the young

    2003  Volume 12, Issue 6, Page(s) 563–580

    MeSH term(s) Aorta/pathology ; Aorta/surgery ; Aortic Diseases/diagnosis ; Aortic Diseases/surgery ; Cardiac Surgical Procedures/methods ; Education, Medical, Continuing ; Heart Ventricles/pathology ; Heart Ventricles/surgery ; Humans
    Language English
    Publishing date 2003-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/s1047951102001038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
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  10. Article: Fibromuscular dysplasia of the aorta presenting as multiple recurrent thoracic aneurysms

    Radhi, Jasim M. / McKay, Roxane / Tyrrell, Michael J.

    International Journal of Angiology

    1998  Volume 7, Issue 03, Page(s) 215–218

    Abstract: A 17-year-old boy, who had undergone resection of aortic coarctation with a large saccular aneurysm 10 years previously, developed recurrent aneurysms above and below the site of a Gore-Tex interposition graft. These were resected using femoral-femoral ... ...

    Abstract A 17-year-old boy, who had undergone resection of aortic coarctation with a large saccular aneurysm 10 years previously, developed recurrent aneurysms above and below the site of a Gore-Tex interposition graft. These were resected using femoral-femoral bypass, and the upper thoracic aorta was replaced with a Hemashield Dacron tube. Histology of the aorta showed fibromuscular dysplasia. In addition to aortic dissection and aortic rupture, such patients may be at risk of forming further aneurysms.
    Language English
    Publishing date 1998-06-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1144390-x
    ISSN 1615-5939 ; 1061-1711
    ISSN (online) 1615-5939
    ISSN 1061-1711
    DOI 10.1007/BF01617396
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3635: Show issues Location:
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