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  1. Article ; Online: The sympathetic nervous system in acute kidney injury.

    Grisk, Olaf

    Acta physiologica (Oxford, England)

    2019  Volume 228, Issue 2, Page(s) e13404

    Abstract: Acute kidney injury (AKI) is frequently accompanied by activation of the sympathetic nervous system (SNS). This may result from pre-exisiting chronic diseases associated with sympathetic activation prior to AKI or it may be induced by stressors that ... ...

    Abstract Acute kidney injury (AKI) is frequently accompanied by activation of the sympathetic nervous system (SNS). This may result from pre-exisiting chronic diseases associated with sympathetic activation prior to AKI or it may be induced by stressors that ultimately lead to AKI such as endotoxins and arterial hypotension in circulatory shock. Conversely, sympathetic activation may also result from acute renal injury. Focusing on studies in experimental renal ischaemia and reperfusion (IR), this review summarizes the current knowledge on how the SNS is activated in IR-induced AKI and on the consequences of sympathetic activation for the development of acute renal damage. Experimental studies show beneficial effects of sympathoinhibitory interventions on renal structure and function in response to IR. However, few clinical trials obtained in scenarios that correspond to experimental IR, namely major elective surgery, showed that peri-operative treatment with centrally acting sympatholytics reduced the incidence of AKI. Apparently, discrepant findings on how sympathetic activation influences renal responses to acute IR-induced injury are discussed and future areas of research in this field are identified.
    MeSH term(s) Acute Kidney Injury/drug therapy ; Acute Kidney Injury/physiopathology ; Animals ; Humans ; Reperfusion Injury/physiopathology ; Sympathetic Nervous System/physiopathology ; Sympatholytics/pharmacology
    Chemical Substances Sympatholytics
    Language English
    Publishing date 2019-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13404
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  2. Article ; Online: Caudal medullary and cervical spinal cord neurons in cardiovascular regulation.

    Grisk, Olaf

    Journal of hypertension

    2017  Volume 35, Issue 10, Page(s) 1950–1951

    MeSH term(s) Cervical Cord ; Medulla Oblongata ; Neurons ; Spinal Cord
    Language English
    Publishing date 2017-08-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000001441
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    Zs.A 1885: Show issues Location:
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  3. Book ; Online ; Thesis: Der Beitrag von Kaliumkanälen zur Tonusregulation renaler Widerstandsgefäße und seine Beeinflussung durch sympathische Denervierung

    Mahl, Saskia [Verfasser] / Grisk, Olaf [Akademischer Betreuer] / Grisk, Olaf [Gutachter] / Patzak, Andreas [Gutachter]

    2023  

    Author's details Saskia Mahl ; Gutachter: Olaf Grisk, Andreas Patzak ; Betreuer: Olaf Grisk
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Greifswald
    Publishing place Greifswald
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Renal denervation and hypertension - The need to investigate unintended effects and neural control of the human kidney.

    Grisk, Olaf

    Autonomic neuroscience : basic & clinical

    2017  Volume 204, Page(s) 119–125

    Abstract: Increased renal sympathetic nerve activity (RSNA) is present in human and experimental forms of arterial hypertension. Experimental denervation studies showed that renal nerves contribute to the development of hypertension. Clinical trials provided ... ...

    Abstract Increased renal sympathetic nerve activity (RSNA) is present in human and experimental forms of arterial hypertension. Experimental denervation studies showed that renal nerves contribute to the development of hypertension. Clinical trials provided equivocal results on the antihypertensive efficacy of renal denervation in patients spurring discussions on technical aspects of renal denervation and further research on the role of renal nerves for the regulation of kidney function as well as the pathophysiology of hypertension. This review summarizes recent findings on adrenoceptor expression and function in the human kidney, adrenoceptor-dependent regulation of sodium chloride transport in the distal nephron, experimental data on chronic RSNA and the development of high arterial pressure and consequences of renal denervation that may limit its antihypertensive efficacy. Future research needs to reduce the gap between our knowledge on neural control of renal function in animals vs. humans to facilitate translation of experimental animal data to humans. More experimental studies on the temporal relationship between RSNA and arterial pressure in the chronic setting are needed to better define the pathogenetic role of heightened RSNA in different forms of arterial hypertension in order to improve the rational basis for renal denervation in antihypertensive therapy. Finally, research on unintended consequences of renal denervation including but not limited to reinnervation and denervation supersensitivity needs to be intensified to further assess the potential of renal denervation to slow the progression of renal disease and hypertension.
    MeSH term(s) Animals ; Denervation ; Humans ; Hypertension/physiopathology ; Hypertension/surgery ; Kidney/innervation ; Kidney/metabolism ; Kidney/surgery ; Receptors, Adrenergic/metabolism
    Chemical Substances Receptors, Adrenergic
    Language English
    Publishing date 2017-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2016.08.005
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    Zs.A 1533: Show issues Location:
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  5. Book ; Thesis: Bestimmung der Enzymaktivitäten von Ektopeptidasen auf mononukleären Zellen des peripheren Blutes gesunder Probanden und von Patienten mit hochmalignem non-Hodgkin-Lymphom

    Grisk, Olaf

    1992  

    Author's details vorgelegt von Olaf Grisk
    Size 73 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Magdeburg, Med. Akad., Diss., 1993
    HBZ-ID HT004549715
    Database Catalogue ZB MED Medicine, Health

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    93 E 1804 order for loan Magazin

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  6. Article ; Online: Posttranslational regulation of the cation-chloride symporter Na+-K+-2Cl- cotransporter-2 in spontaneously hypertensive rat kidneys.

    Grisk, Olaf

    Journal of hypertension

    2014  Volume 32, Issue 9, Page(s) 1778–1779

    MeSH term(s) Animals ; Blood Pressure/physiology ; Humans ; Hypertension/etiology ; Kidney/metabolism ; Male ; Sodium-Potassium-Chloride Symporters/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Sodium-Potassium-Chloride Symporters ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000000303
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    Zs.MO 614: Show issues

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  7. Article ; Online: Potential benefits of rho-kinase inhibition in arterial hypertension.

    Grisk, Olaf

    Current hypertension reports

    2013  Volume 15, Issue 5, Page(s) 506–513

    Abstract: Arterial hypertension is a major health problem, accounting for 12 % of the global death rate. A large proportion of patients treated for high blood pressure do not reach target blood pressure values. The question arises if new antihypertensive drugs ... ...

    Abstract Arterial hypertension is a major health problem, accounting for 12 % of the global death rate. A large proportion of patients treated for high blood pressure do not reach target blood pressure values. The question arises if new antihypertensive drugs could improve present hypertension treatment. Rho-kinases (ROCKs) are ubiquitously expressed serine/threonine kinases and involved in a variety of cell functions. They contribute to the pathogenesis of human and experimental hypertension. Pharmacological ROCK inhibition has been shown to effectively lower blood pressure in patients and experimental animals. Progress has been made towards the understanding on how non-selective ROCK inhibitors lower arterial pressure and efforts are currently undertaken to develop ROCK inhibitors to improve their specificity and isoenzyme selectivity. If introduction of ROCK inhibitors for the treatment of high blood pressure can significantly advance currently available options of antihypertensive pharmacotherapy awaits further experimental and clinical research.
    MeSH term(s) Animals ; Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/drug effects ; rho-Associated Kinases/antagonists & inhibitors
    Chemical Substances Antihypertensive Agents ; Protein Kinase Inhibitors ; rho-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2013-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-013-0373-0
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  8. Article ; Online: Antihypertensive effects of ACE2 in the paraventricular nucleus: a consequence of reduced neuroinflammation?

    Grisk, Olaf

    Cardiovascular research

    2011  Volume 92, Issue 3, Page(s) 365–366

    MeSH term(s) Angiotensin II ; Animals ; Genetic Therapy ; Humans ; Hypertension/prevention & control ; Male ; Paraventricular Hypothalamic Nucleus/enzymology ; Peptidyl-Dipeptidase A/biosynthesis
    Chemical Substances Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; angiotensin converting enzyme 2 (EC 3.4.17.-)
    Language English
    Publishing date 2011-12-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvr269
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    Zs.A 565: Show issues Location:
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  9. Article ; Online: ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries.

    Lubomirov, Lubomir T / Mantke, René / Enzmann, Thomas / Metzler, Doris / Korotkova, Tatiana / Hescheler, Jürgen / Pfitzer, Gabriele / Grisk, Olaf

    Journal of hypertension

    2023  Volume 41, Issue 7, Page(s) 1201–1214

    Abstract: Objective: Small arteries from different organs vary with regard to the mechanisms that regulate vasoconstriction. This study investigated the impact of advanced age on the regulation of vasoconstriction in isolated human small arteries from kidney ... ...

    Abstract Objective: Small arteries from different organs vary with regard to the mechanisms that regulate vasoconstriction. This study investigated the impact of advanced age on the regulation of vasoconstriction in isolated human small arteries from kidney cortex and periintestinal mesenteric tissue.
    Methods: Renal and mesenteric tissues were obtained from patients (mean age 71 ± 9 years) undergoing elective surgery. Furthermore, intrarenal and mesenteric arteries from young and aged mice were studied. Arteries were investigated by small vessel myography and western blot.
    Results: Human intrarenal arteries (h-RA) showed higher stretch-induced tone and higher reactivity to α 1 adrenergic receptor stimulation than human mesenteric arteries (h-MA). Rho-kinase (ROK) inhibition resulted in a greater decrease in Ca 2+ and depolarization-induced tone in h-RA than in h-MA. Basal and α 1 adrenergic receptor stimulation-induced phosphorylation of the regulatory light chain of myosin (MLC 20 ) was higher in h-RA than in h-MA. This was associated with higher ROK-dependent phosphorylation of the regulatory subunit of myosin light-chain-phosphatase (MLCP), MYPT1-T853. In h-RA phosphorylation of ribosomal S6-kinase II (RSK2-S227) was significantly higher than in h-MA. Stretch-induced tone and RSK2 phosphorylation was also higher in interlobar arteries (m-IAs) from aged mice than in respective vessels from young mice and in murine mesenteric arteries (m-MA) from both age groups.
    Conclusion: Vasoconstriction in human intrarenal arteries shows a greater ROK-dependence than in mesenteric arteries. Activation of RSK2 may contribute to intrarenal artery tone dysregulation associated with aging. Compared with h-RA, h-MA undergo age-related remodeling leading to a reduction of the contractile response to α 1 adrenergic stimulation.
    MeSH term(s) Humans ; Mice ; Animals ; Middle Aged ; Aged ; Aged, 80 and over ; rho-Associated Kinases/metabolism ; Receptors, Adrenergic, alpha-1/metabolism ; Mesenteric Arteries/metabolism ; Signal Transduction ; Vasoconstriction ; Myosins/metabolism ; Phosphorylation ; Myosin-Light-Chain Phosphatase/metabolism
    Chemical Substances rho-Associated Kinases (EC 2.7.11.1) ; Receptors, Adrenergic, alpha-1 ; Myosins (EC 3.6.4.1) ; Myosin-Light-Chain Phosphatase (EC 3.1.3.53)
    Language English
    Publishing date 2023-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003450
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  10. Article: Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery.

    Lubomirov, Lubomir T / Schroeter, Mechthild M / Hasse, Veronika / Frohn, Marina / Metzler, Doris / Bust, Maria / Pryymachuk, Galyna / Hescheler, Jürgen / Grisk, Olaf / Chalovich, Joseph M / Smyth, Neil R / Pfitzer, Gabriele / Papadopoulos, Symeon

    Frontiers in physiology

    2023  Volume 14, Page(s) 1099278

    Abstract: Stretch-induced vascular tone is an important element of autoregulatory adaptation of cerebral vasculature to maintain cerebral flow constant despite changes in perfusion pressure. Little is known as to the regulation of tone in senescent basilar ... ...

    Abstract Stretch-induced vascular tone is an important element of autoregulatory adaptation of cerebral vasculature to maintain cerebral flow constant despite changes in perfusion pressure. Little is known as to the regulation of tone in senescent basilar arteries. We tested the hypothesis, that thin filament mechanisms in addition to smooth muscle myosin-II regulatory-light-chain-(MLC
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1099278
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