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Article ; Online: Evidence over Politics - U.S. Preventive Services Task Force.

Schade, David S / Eaton, R Philip / Wann, Samuel

2023 Volume 388, Issue 14, Page(s) 1343

MeSH term(s)	Humans ; Preventive Health Services ; Advisory Committees ; Politics
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2301322
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Article ; Online: HIV and Addiction Services for People Who Inject Drugs: Healthcare Provider Perceptions on Integrated Care in the U.S. South.

Bradford, Davis / Parman, Mariel / Levy, Sera / Turner, Wesli H / Li, Li / Leisch, Leah / Eaton, Ellen / Crockett, Kaylee B

Journal of primary care & community health

2023 Volume 14, Page(s) 21501319231161208

Abstract: ... S. South. ...

Abstract	This qualitative study evaluates physician training and experience with treatment and prevention services for people who inject drugs (PWID) including medications for opioid use disorder (MOUD) and HIV pre-exposure prophylaxis (PrEP). The Behavioral Model of Healthcare Utilization for Vulnerable Populations was applied as a framework for data analysis and interpretation. Two focus groups were conducted, one with early career physicians (n = 6) and one with mid- to late career physicians (n = 3). Focus group transcripts were coded and analyzed using thematic analysis to identify factors affecting implementation of treatment and prevention services for PWID. Respondents identified that increasing the availability of providers prescribing MOUD was a critical enabling factor for PWID seeking and receiving care. Integrated, interdisciplinary services were identified as an additional resource although these remain fragmented in the current healthcare system. Barriers to care included provider awareness, stigma associated with substance use, and access limitations. Providers identified the interwoven risk factors associated with injection drug use that must be addressed, including the risk of HIV acquisition, notably more at the forefront in the minds of early career physicians. Additional research is needed addressing the medical education curriculum, health system, and healthcare policy to address the addiction and HIV crises in the U.S. South.
MeSH term(s)	Humans ; Substance Abuse, Intravenous/complications ; Drug Users ; HIV Infections/prevention & control ; Health Personnel ; Opioid-Related Disorders/therapy ; Delivery of Health Care, Integrated
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2550221-9
ISSN	2150-1327 ; 2150-1319
ISSN (online)	2150-1327
ISSN	2150-1319
DOI	10.1177/21501319231161208
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Book ; Online: Overseas Basing of U.S. Military Forces

Lostumbo, Michael J / McNerney, Michael J / Peltz, Eric / Eaton, Derek / Frelinger, David R

An Assessment of Relative Costs and Strategic Benefits

2013

Keywords	Economic systems & structures ; Management of real estate, property & plant ; Defence strategy, planning & research ; Military engineering ; Business ; Technology ; History
Language	English
Size	1 Online-Ressource
Publisher	RAND Corporation
Document type	Book ; Online
Note	English
HBZ-ID	HT030611182
ISBN	9780833079145 ; 083307914X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Identification of a poly-cyclopropylglycine-containing peptide via bioinformatic mapping of radical S-adenosylmethionine enzymes.

Kostenko, Anastasiia / Lien, Yi / Mendauletova, Aigera / Ngendahimana, Thacien / Novitskiy, Ivan M / Eaton, Sandra S / Latham, John A

The Journal of biological chemistry

2022 Volume 298, Issue 5, Page(s) 101881

Abstract: Peptide-derived natural products are a large class of bioactive molecules that often contain chemically challenging modifications. In the biosynthesis of ribosomally synthesized and posttranslationally modified peptides (RiPPs), radical-SAM (rSAM) ... ...

Abstract	Peptide-derived natural products are a large class of bioactive molecules that often contain chemically challenging modifications. In the biosynthesis of ribosomally synthesized and posttranslationally modified peptides (RiPPs), radical-SAM (rSAM) enzymes have been shown to catalyze the formation of ether, thioether, and carbon-carbon bonds on the precursor peptide. The installation of these bonds typically establishes the skeleton of the mature RiPP. To facilitate the search for unexplored rSAM-dependent RiPPs for the community, we employed a bioinformatic strategy to screen a subfamily of peptide-modifying rSAM enzymes which are known to bind up to three [4Fe-4S] clusters. A sequence similarity network was used to partition related families of rSAM enzymes into >250 clusters. Using representative sequences, genome neighborhood diagrams were generated using the Genome Neighborhood Tool. Manual inspection of bacterial genomes yielded numerous putative rSAM-dependent RiPP pathways with unique features. From this analysis, we identified and experimentally characterized the rSAM enzyme, TvgB, from the tvg gene cluster from Halomonas anticariensis. In the tvg gene cluster, the precursor peptide, TvgA, is comprised of a repeating TVGG motif. Structural characterization of the TvgB product revealed the repeated formation of cyclopropylglycine, where a new bond is formed between the γ-carbons on the precursor valine. This novel RiPP modification broadens the functional potential of rSAM enzymes and validates the proposed bioinformatic approach as a practical broad search tool for the discovery of new RiPP topologies.
MeSH term(s)	Amino Acid Sequence ; Carbon/metabolism ; Computational Biology ; Peptides/chemistry ; Protein Processing, Post-Translational ; S-Adenosylmethionine/metabolism
Chemical Substances	Peptides ; Carbon (7440-44-0) ; S-Adenosylmethionine (7LP2MPO46S)
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2022.101881
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Article ; Online: Characteristics of Post-ICU and Post-COVID Recovery Clinics in 29 U.S. Health Systems.

Danesh, Valerie / Boehm, Leanne M / Eaton, Tammy L / Arroliga, Alejandro C / Mayer, Kirby P / Kesler, Shelli R / Bakhru, Rita N / Baram, Michael / Bellinghausen, Amy L / Biehl, Michelle / Dangayach, Neha S / Goldstein, Nir M / Hoehn, K Sarah / Islam, Marjan / Jagpal, Sugeet / Johnson, Annie B / Jolley, Sarah E / Kloos, Janet A / Mahoney, Eric J /

Maley, Jason H / Martin, Sara F / McSparron, Jakob I / Mery, Marissa / Saft, Howard / Santhosh, Lekshmi / Schwab, Kristin / Villalba, Dario / Sevin, Carla M / Montgomery, Ashley A

Critical care explorations

2022 Volume 4, Issue 3, Page(s) e0658

Abstract: The multifaceted long-term impairments resulting from critical illness and COVID-19 require interdisciplinary management approaches in the recovery phase of illness. Operational insights into the structure and process of recovery clinics (RCs) from ... ...

Abstract	The multifaceted long-term impairments resulting from critical illness and COVID-19 require interdisciplinary management approaches in the recovery phase of illness. Operational insights into the structure and process of recovery clinics (RCs) from heterogeneous health systems are needed. This study describes the structure and process characteristics of existing and newly implemented ICU-RCs and COVID-RCs in a subset of large health systems in the United States. Design: Cross-sectional survey. Setting: Thirty-nine RCs, representing a combined 156 hospitals within 29 health systems participated. Patients: None. Interventions: None. Measurement and main results: RC demographics, referral criteria, and operating characteristics were collected, including measures used to assess physical, psychologic, and cognitive recoveries. Thirty-nine RC surveys were completed (94% response rate). ICU-RC teams included physicians, pharmacists, social workers, physical therapists, and advanced practice providers. Funding sources for ICU-RCs included clinical billing ( Conclusions: Operating structures of RCs vary, though almost all describe modest capacity and reliance on volunteerism and discretionary institutional support. ICU- and COVID-RCs in the United States employ varied funding sources and endorse different assessment measures during visits to guide care coordination. Common features include integration of ICU clinicians, interdisciplinary approach, and focus on severe critical illness. The heterogeneity in RC structures and processes contributes to future research on the optimal structure and process to achieve the best postintensive care syndrome and postacute sequelae of COVID outcomes.
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000658
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Article ; Online: Context Matters for Nurses Leading Pain Improvement in U.S. Hospitals.

Tavernier, Susan S / Guo, Jia-Wen / Eaton, Jacqueline / Brant, Jeannine M / Berry, Patricia / Beck, Susan L

Pain management nursing : official journal of the American Society of Pain Management Nurses

2018 Volume 19, Issue 5, Page(s) 474–486

Abstract: Background: Pain continues to be a problem in hospitalized patients. Contextual factors contribute to the success of pain quality improvement efforts.: Aims: This paper describes nurse team leaders' perceptions of organizational context and factors ... ...

Abstract	Background: Pain continues to be a problem in hospitalized patients. Contextual factors contribute to the success of pain quality improvement efforts. Aims: This paper describes nurse team leaders' perceptions of organizational context and factors perceived to help and hinder the process of leading a unit-based improvement effort focused on pain. Design: Qualitative descriptive design. Setting: Interviews took place over the telephone. Participants: Nurses from 106 hospitals across the United States. Methods: Investigators interviewed 125 nurses leading a unit-based pain quality improvement project in partnership with the National Database of Nursing Quality Indicators. Lewin's Field Theory guided a thematic analysis. Results: Key contextual factors related to the amount of change in the health care environment and characteristics of the organization and providers. Helping forces included characteristics of nurses, teamwork, a culture of quality, opportunities for learning, pain management resources, and accountability for pain management. Hindering forces included: barriers to involvement, attitudes and relationships, lack of knowledge, and types of patients. Conclusions: Overcoming the pervasive barriers of constant change and lack of staff involvement while also capitalizing on the culture of quality and characteristics of the health care team may further enhance and sustain improvement efforts related to pain management of hospitalized patients. New models for influencing quality improvement could be strengthened with involving frontline staff in both planning and implementation of improvement efforts. Clinical implications: Because of the diverse responses, it is recommended that each unit conduct a force-field analysis to guide successful implementation of improvement efforts.
MeSH term(s)	Adult ; Delivery of Health Care/methods ; Delivery of Health Care/standards ; Female ; Hospitalization/statistics & numerical data ; Hospitals/statistics & numerical data ; Humans ; Interviews as Topic/methods ; Male ; Middle Aged ; Nurses/psychology ; Nurses/statistics & numerical data ; Pain Management/methods ; Pain Management/standards ; Qualitative Research ; Quality Improvement ; United States
Language	English
Publishing date	2018-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2213260-0
ISSN	1532-8635 ; 1524-9042
ISSN (online)	1532-8635
ISSN	1524-9042
DOI	10.1016/j.pmn.2018.05.003
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Article ; Online: Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.

Henry, Eric R / Cellmer, Troy / Dunkelberger, Emily B / Metaferia, Belhu / Hofrichter, James / Li, Quan / Ostrowski, David / Ghirlando, Rodolfo / Louis, John M / Moutereau, Stéphane / Galactéros, Frédéric / Thein, Swee Lay / Bartolucci, Pablo / Eaton, William A

Proceedings of the National Academy of Sciences of the United States of America

2020 Volume 117, Issue 26, Page(s) 15018–15027

Abstract: The pathology of sickle cell disease is caused by polymerization of the abnormal hemoglobin S ... hemoglobin S at about 1 y after birth. Calculations of sickling times, based on a recently discovered ... of hemoglobin S with pancellular hereditary persistence of fetal hemoglobin are both relatively benign ...

Abstract	The pathology of sickle cell disease is caused by polymerization of the abnormal hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to deform and occlude the circulation. Drugs that allosterically shift the quaternary equilibrium from the polymerizing T quaternary structure to the nonpolymerizing R quaternary structure are now being developed. Here we update our understanding on the allosteric control of fiber formation at equilibrium by showing how the simplest extension of the classic quaternary two-state allosteric model of Monod, Wyman, and Changeux to include tertiary conformational changes provides a better quantitative description. We also show that if fiber formation is at equilibrium in vivo, the vast majority of cells in most tissues would contain fibers, indicating that it is unlikely that the disease would be survivable once the nonpolymerizing fetal hemoglobin has been replaced by adult hemoglobin S at about 1 y after birth. Calculations of sickling times, based on a recently discovered universal relation between the delay time prior to fiber formation and supersaturation, show that in vivo fiber formation is very far from equilibrium. Our analysis indicates that patients survive because the delay period allows the majority of cells to escape the small vessels of the tissues before fibers form. The enormous sensitivity of the duration of the delay period to intracellular hemoglobin composition also explains why sickle trait, the heterozygous condition, and the compound heterozygous condition of hemoglobin S with pancellular hereditary persistence of fetal hemoglobin are both relatively benign conditions.
MeSH term(s)	Allosteric Regulation ; Anemia, Sickle Cell/metabolism ; Erythrocytes/chemistry ; Erythrocytes/metabolism ; Fetal Hemoglobin/chemistry ; Fetal Hemoglobin/metabolism ; Hemoglobin, Sickle/chemistry ; Hemoglobin, Sickle/metabolism ; Humans ; Kinetics ; Oxygen/chemistry ; Oxygen/metabolism
Chemical Substances	Hemoglobin, Sickle ; Fetal Hemoglobin (9034-63-3) ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1922004117
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Article: An Inventory and Assessment of Sample Sources for Survey Research with Agricultural Producers in the U.S

Ulrich-Schad, Jessica D. / Li, Shuang / Arbuckle, J. G. / Avemegah, Edem / Brasier, Kathryn J. / Burnham, Morey / Kumar Chaudhary, Anil / Eaton, Weston M. / Gu, Wei / Haigh, Tonya / Jackson-Smith, Douglas / Metcalf, Alexander L. / Pradhananga, Amit / Prokopy, Linda S. / Sanderson, Matthew / Wade, Emma / Wilke, Adam

Society & natural resources. 2022 July 3, v. 35, no. 7

2022

Abstract: ... in the U.S., finding that government program participant lists are used most often, while private vendor ...

Abstract	Researchers need probability samples to collect representative survey data about the behaviors and attitudes of agricultural producers they study in relation to the natural resources that they manage, yet obtaining accurate and complete sampling frames is challenging. We extract data from a publication database to identify the most commonly used sampling frame sources in survey research of agricultural producers in the U.S., finding that government program participant lists are used most often, while private vendor samples are increasingly being purchased. Based on our research experience, we find that for many projects, private vendors can provide the most rigorous samples. Given that survey methods remain a useful and popular method for studying the behaviors and attitudes of producers on a variety of topics, such an assessment and guide is needed for researchers and practitioners.
Keywords	databases ; inventories ; probability ; surveys
Language	English
Dates of publication	2022-0703
Size	p. 804-812.
Publishing place	Routledge
Document type	Article
ZDB-ID	2018099-8
ISSN	1521-0723 ; 0894-1920
ISSN (online)	1521-0723
ISSN	0894-1920
DOI	10.1080/08941920.2022.2081392
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC.

Khaliullin, Bulat / Aggarwal, Priyanka / Bubas, Michael / Eaton, Gareth R / Eaton, Sandra S / Latham, John A

FEBS letters

2016 Volume 590, Issue 16, Page(s) 2538–2548

Abstract: ... and mftC that encode for the peptide substrate, peptide chaperone, and a radical S-adenosylmethionine ... a radical S-adenosylmethionine (SAM) enzyme. Finally, we show that MftC catalyzes the oxidative ...

Abstract	Mycofactocin is a putative, peptide derived, cofactor that is associated primarily with the Mycobacterium genera including the pathogen M. tuberculosis. The pathway consists of the three genes mftA, mftB, and mftC that encode for the peptide substrate, peptide chaperone, and a radical S-adenosylmethionine protein (RS), respectively. Here, we show that the MftB acts as a peptide chaperone, binding MftA with a submicromolar KD (~ 100 nm) and MftC with a low micromolar KD (~ 2 μm). Moreover, we demonstrate that MftC is a radical S-adenosylmethionine (SAM) enzyme. Finally, we show that MftC catalyzes the oxidative decarboxylation of the peptide MftA.
MeSH term(s)	Catalysis ; Humans ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/genetics ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/pathogenicity ; Mycobacterium ulcerans/chemistry ; Mycobacterium ulcerans/enzymology ; Mycobacterium ulcerans/genetics ; Peptides/chemistry ; Peptides/genetics ; Protein Binding ; Protein O-Methyltransferase/chemistry ; Protein O-Methyltransferase/genetics ; S-Adenosylmethionine/chemistry ; S-Adenosylmethionine/metabolism ; Substrate Specificity
Chemical Substances	Iron-Sulfur Proteins ; Molecular Chaperones ; Peptides ; S-Adenosylmethionine (7LP2MPO46S) ; Protein O-Methyltransferase (EC 2.1.1.-)
Language	English
Publishing date	2016-06-29
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.12249
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Article ; Online: Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper.

Eaton, William A

American journal of hematology

2019 Volume 95, Issue 2, Page(s) 205–211

Abstract: 70 years ago, Linus Pauling, the legendary genius of ... ...

Abstract	70 years ago, Linus Pauling, the legendary genius of 20
MeSH term(s)	Anemia, Sickle Cell/history ; Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/pathology ; Hemoglobin, Sickle/history ; Hemoglobin, Sickle/metabolism ; History, 20th Century ; Humans ; Periodicals as Topic/history ; Polymerization
Chemical Substances	Hemoglobin, Sickle
Language	English
Publishing date	2019-12-31
Publishing country	United States
Document type	Historical Article ; Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.25687
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