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  1. Article ; Online: Evaluation of the functional outcome and mobility of patients after stroke depending on their cognitive state.

    Guzek, Zbigniew / Dziubek, Wioletta / Stefańska, Małgorzata / Kowalska, Joanna

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1515

    Abstract: The study aimed to analyze the functional outcome and mobility in stroke patients depending on their cognitive state. 180 patients after first stroke were divided into four groups: 48 patients without symptoms of cognitive impairment (G1); 38 with mild ... ...

    Abstract The study aimed to analyze the functional outcome and mobility in stroke patients depending on their cognitive state. 180 patients after first stroke were divided into four groups: 48 patients without symptoms of cognitive impairment (G1); 38 with mild cognitive impairment without dementia (G2); 47 with mild dementia (G3); 47 with moderate dementia (G4). The Mini Mental State Examination (MMSE), Barthel Index (BI), Sitting Assessment Scale (SAS), Berg Balance Scale, Trunk Control Test and Test Up & Go were used. The tests were carried out at the time of admission to the ward (T1) and at the time of discharge (T2). A statistically significant improvement was demonstrated in all parameters in almost all groups. No significant difference was observed only in groups G1 and G4 in SAS head. Statistically significant differences in BI results in T2 between groups G1 and G4 were noted. The lowest change in BI was observed in the G4. Regression analysis showed that MMSE and BI at T1 and MMSE score at T2 explained the functional status at T2. Cognitive dysfunction at the time of admission to the ward and discharge may determining the patient's functional status at the time of discharge from the ward.
    MeSH term(s) Humans ; Cognitive Dysfunction/diagnosis ; Stroke/complications ; Stroke/diagnosis ; Dementia/diagnosis ; Cognition
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52236-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Importance of Substituent Position for Antibacterial Activity in the Group of Thiosemicarbazide Derivatives.

    Janowska, Sara / Stefańska, Joanna / Khylyuk, Dmytro / Wujec, Monika

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 6

    Abstract: The search for new antibacterial compounds is still a huge challenge for scientists. Each new chemotherapy drug is not 100% effective when introduced into treatment. Bacteria quickly become resistant to known structures. One promising group of new ... ...

    Abstract The search for new antibacterial compounds is still a huge challenge for scientists. Each new chemotherapy drug is not 100% effective when introduced into treatment. Bacteria quickly become resistant to known structures. One promising group of new compounds is thiosemicarbazides. In the presented work, we looked for the relationship between structure and antibacterial activity within the group of thiosemicarbazide derivatives. This is a continuation of our previous work. Here, we decided to check to what extent the position of the 3-methoxyphenyl substituent affects potency. We obtained new structures that differ in the positions of the substituent in the thiosemicarbazide skeleton. Based on the obtained results of the biological tests, it can be concluded that the substituent in position 1 of thiosemicarbazide derivatives significantly determines their activity. Generally, among the substituents used, trifluoromethylphenyl turned out to be the most promising. The MIC values for compounds with this substituent are 64 µg/mL towards
    MeSH term(s) Structure-Activity Relationship ; Molecular Docking Simulation ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Semicarbazides/pharmacology ; Semicarbazides/chemistry ; Microbial Sensitivity Tests ; Molecular Structure
    Chemical Substances thiosemicarbazide (6056O8W6ET) ; Anti-Bacterial Agents ; Semicarbazides
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061333
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Polymorphism and Red Photoluminescence Emission from 5s

    Rowińska, Magdalena / Stefańska, Dagmara / Bednarchuk, Tamara J / Zaręba, Jan K / Jakubas, Ryszard / Gągor, Anna

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: We explore the crystal structure and luminescent properties of a new 1D organic-inorganic hybrid, ... ...

    Abstract We explore the crystal structure and luminescent properties of a new 1D organic-inorganic hybrid, MHy
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020455
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Effects of root plates, pits and mounds following windthrow events on the biodiversity of plants and lichens in Central European mountain forests.

    Staniaszek-Kik, M / Żarnowiec, J / Chmura, D / Stefańska-Krzaczek, E

    The Science of the total environment

    2023  Volume 898, Page(s) 165428

    Abstract: Windthrows lead to the formation of a characteristic land microtopography and they provide new habitats and substrata for species. The present study is novel, because it concerns different taxonomic groups of organisms and effects of various variables on ...

    Abstract Windthrows lead to the formation of a characteristic land microtopography and they provide new habitats and substrata for species. The present study is novel, because it concerns different taxonomic groups of organisms and effects of various variables on species composition, richness and abundance within root plate-pit-mound (RPM) complexes. For the first time we studied lichens, liverworts, mosses and vascular plants on RPM complexes across major vegetation types, from deciduous to coniferous forests. We analyzed 164 RPM complexes which included in total 268 components: 115 root plates, 80 pits and 73 mounds. Besides the vegetation types and component types the following variables were also considered: dimensions (area, size), age (decomposition degree), species of the uprooted tree, shade, and elevation. The research revealed that root plates, pits and mounds had their own indicator species, but the key factors for the species composition were the species of uprooted trees and the vegetation type. Furthermore, the type of component and the vegetation type were also the most main variables determining the richness and abundance of the studied taxonomic groups of species. Analyses revealed the greatest species richness and abundance of lichens on root plates, and the highest richness of liverworts and vascular plants in pits. The type of component had no effect on the species richness of mosses. However, they were most abundant on mounds. The response of individual groups to the vegetation types and other variables varied. Findings from the study indicated that the presence of uprooted trees with different features (size and age, species of uprooted tree) is important for the biodiversity of mountain forests. We recommend leaving uprooted trees in forest communities for natural colonization, preferably large objects. Moreover, in managed forests a mosaic of forest communities that mimic the structure of natural unmanaged forests should be supported.
    MeSH term(s) Lichens ; Forests ; Biodiversity ; Ecosystem ; Trees ; Plants ; Bryophyta ; Tracheophyta
    Language English
    Publishing date 2023-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  5. Article ; Online: The relevance of blood gases levels in newborns: the sampling matters.

    Jassem-Bobowicz, Joanna / Stefanska, Katarzyna

    Ginekologia polska

    2023  

    Language English
    Publishing date 2023-03-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/GP.a2023.0015
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 118: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: A Comparative Analysis of Functional Status and Mobility in Stroke Patients with and without Aphasia.

    Guzek, Zbigniew / Dziubek, Wioletta / Stefańska, Małgorzata / Kowalska, Joanna

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: All researchers agree that aphasia is a serious consequence of a stroke, but they also report contradictory data regarding the functional outcome. The aim of this study was, therefore, to assess the functional outcomes of stroke patients with and without ...

    Abstract All researchers agree that aphasia is a serious consequence of a stroke, but they also report contradictory data regarding the functional outcome. The aim of this study was, therefore, to assess the functional outcomes of stroke patients with and without aphasia, who were undertaking a regular rehabilitation programme.
    Materials and methods: The study group consisted of 116 post-stroke patients, including 54 patients without aphasia (G1) and 62 patients with aphasia (G2). The following tests were used before (T1) and after (T2) rehabilitation measurement points: Barthel Index (BI), Sitting Assessment Scale (SAS), Berg Balance Scale (BBS), Trunk Control Test (TCT), Test Up & Go (TUG) and the Timed Walk Test (TWT).
    Results: The group of post-stroke patients with aphasia had a significantly longer time since a stroke on admission, a significantly longer length of stay in the ward and significantly worse SAS and TCT scores at T2, compared to patients without aphasia. Both groups achieved significant improvement in all studied parameters (SAS, TCT, BI, BBS, TUG and TWT). Aphasia was a predictor of functional status in the stroke patients group, but only at the time of admission to the ward.
    Conclusions: Patients with and without aphasia have an equal likelihood of improving their functional status and returning to independence. Aphasia should not be an absolute factor that excludes stroke patients from research studies on their functional status.
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123478
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  7. Article ; Online: Broadband near-infrared luminescence properties of Sc

    Stefańska, D / Kabański, A / Adaszyński, M / Ptak, M / Lisiecki, R / Starościk, N / Hanuza, J

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 296, Page(s) 122699

    Abstract: The structural and spectroscopic properties of ... ...

    Abstract The structural and spectroscopic properties of Sc
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.122699
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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
    Z 1611 a: Show issues
    924/340: Show issues

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  8. Article ; Online: An Er

    Vu, T H Q / Bondzior, B / Stefańska, D / Dereń, P J

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 20, Page(s) 8056–8065

    Abstract: A bifunctional luminescent material is one of the most intriguing topics in recent years with significant growth in the number of investigations. Herein, we report the potential of ... ...

    Abstract A bifunctional luminescent material is one of the most intriguing topics in recent years with significant growth in the number of investigations. Herein, we report the potential of Ba
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt00554a
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  9. Article ; Online: Organization of Carotenoid Aggregates in Membranes Studied Selectively using Resonance Raman Optical Activity.

    Hachlica, Natalia / Stefańska, Marta / Mach, Marzena / Kowalska, Magdalena / Wydro, Pawel / Domagała, Agnieszka / Kessler, Jiři / Zając, Grzegorz / Kaczor, Agnieszka

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2306707

    Abstract: ... carotene molecules is an important feature of J-aggregates that show increased orientational freedom and ...

    Abstract In living organisms, carotenoids are incorporated in biomembranes, remarkably modulating their mechanical characteristics, fluidity, and permeability. Significant resonance enhancement of Raman optical activity (ROA) signals of carotenoid chiral aggregates makes resonance ROA (RROA), a highly selective tool to study exclusively carotenoid assemblies in model membranes. Hence, RROA is combined with electronic circular dichroism (ECD), dynamic light scattering (DLS), molecular dynamics, and quantum-chemical calculations to shed new light on the carotenoid aggregation in dipalmitoylphosphatidylcholine (DPPC) liposomes. Using representative members of the carotenoid family: apolar α-carotene and more polar fucoxanthin and zeaxanthin, the authors demonstrate that the stability of carotenoid aggregates is directly linked with their orientation in membranes and the monomer structures inside the assemblies. In particular, polyene chain distortion of α-carotene molecules is an important feature of J-aggregates that show increased orientational freedom and stability inside liposomes compared to H-assemblies of more polar xanthophylls. In light of these results, RROA emerges as a new tool to study active compounds and drugs embedded in membranes.
    Language English
    Publishing date 2024-01-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202306707
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  10. Article ; Online: Activity of singly and doubly modified derivatives of C20-epi-salinomycin against Staphylococcus strains.

    Czerwonka, Dominika / Podsiad, Małgorzata / Stefańska, Joanna / Antoszczak, Michał / Huczyński, Adam

    The Journal of antibiotics

    2022  Volume 75, Issue 8, Page(s) 445–453

    Abstract: Natural polyether ionophore salinomycin (Sal) has been widely used in veterinary medicine as an antibiotic effective in the treatment of coccidian protozoa and Gram-positive bacteria. Moreover, chemical modification of the Sal structure has been found to ...

    Abstract Natural polyether ionophore salinomycin (Sal) has been widely used in veterinary medicine as an antibiotic effective in the treatment of coccidian protozoa and Gram-positive bacteria. Moreover, chemical modification of the Sal structure has been found to be a promising strategy to generate semisynthetic analogs with biological activity profiles improved relative to those of the native compound. In this context, we synthesized and thoroughly evaluated the antibacterial potential of a library of C1/C20 singly and doubly modified derivatives of C20-epi-salinomycin, that is, analogs of Sal with inversed stereochemistry at the C20 position. Among the synthesized analog structures, the most promising antibacterial active agents were those obtained via regioselective O-acylation of C20-epi-hydroxyl, particularly esters 7, 9, and 11. Such C20 singly modified compounds showed excellent inhibitory activity against planktonic staphylococci, both standard and clinical strains, and revealed potential in preventing the formation of bacterial biofilms. In combination with their non-genotoxic properties, these Sal derivatives represent attractive candidates for further antimicrobial drug development.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cell Line, Tumor ; Pyrans/chemistry ; Pyrans/pharmacology ; Staphylococcus
    Chemical Substances Anti-Bacterial Agents ; Pyrans ; salinomycin (62UXS86T64)
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-022-00536-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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