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  1. Book: Smith & Aitkenhead's textbook of anaesthesia

    Smith, Graham / Thompson, Jonathan P. / Moppett, Iain / Wiles, Matthew D.

    edited by Jonanthan Thompson, Iain Moppett, Matthew Wiles

    2019  

    Title variant Textbook of anaesthesia
    Keywords Anesthesia ; Anesthetics
    Subject code 617.96
    Language English
    Size xii, 948 Seiten, Illustrationen, 24 cm
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Edinburgh
    Publishing country Great Britain
    Document type Book
    Accompanying material Zugang zu enhanced digital version über Code
    HBZ-ID HT020993771
    ISBN 978-0-7020-7500-1 ; 9780702075346 ; 0-7020-7500-0 ; 0702075345
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 1013 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Artificial Sweeteners: A New Dietary Environmental Risk Factor for Atrial Fibrillation?

    Koeth, Robert A / Smith, Jonathan D / Chung, Mina K

    Circulation. Arrhythmia and electrophysiology

    2024  Volume 17, Issue 3, Page(s) e012761

    MeSH term(s) Humans ; Sweetening Agents/adverse effects ; Sugar-Sweetened Beverages ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Prospective Studies ; Risk Factors ; Genetic Predisposition to Disease
    Chemical Substances Sweetening Agents
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.124.012761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6667: Show issues Location:
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  3. Article ; Online: JACR Health Policy Expert Panel: Generative Artificial Intelligence.

    Lee, Christoph I / Chen, Jonathan H / Kohli, Marc D / Smith, Andrew D / Liao, Joshua M

    Journal of the American College of Radiology : JACR

    2024  

    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2024.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6636: Show issues Location:
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  4. Article ; Online: SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome.

    Stamenkovic, Vera / Lautz, Jonathan D / Harsh, Felicia M / Smith, Stephen E P

    Molecular psychiatry

    2024  

    Abstract: Glutamatergic synapses encode information from extracellular inputs using dynamic protein interaction networks (PINs) that undergo widespread reorganization following synaptic activity, allowing cells to distinguish between signaling inputs and generate ... ...

    Abstract Glutamatergic synapses encode information from extracellular inputs using dynamic protein interaction networks (PINs) that undergo widespread reorganization following synaptic activity, allowing cells to distinguish between signaling inputs and generate coordinated cellular responses. Here, we investigate how Fragile X Messenger Ribonucleoprotein (FMRP) deficiency disrupts signal transduction through a glutamatergic synapse PIN downstream of NMDA receptor or metabotropic glutamate receptor (mGluR) stimulation. In cultured cortical neurons or acute cortical slices from P7, P17 and P60 FMR1
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02418-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Bridging the 13-Year Evidence Gap: A Time for Age-Inclusive Research.

    Oni, Louise / Smith, Rona / Salama, Alan D / Barratt, Jonathan / Trachtman, Howard / Saleem, Moin

    Journal of the American Society of Nephrology : JASN

    2024  Volume 35, Issue 4, Page(s) 502–504

    MeSH term(s) Evidence Gaps
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
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  6. Article ; Online: Connecting the Dots From GWAS to Function in Atrial Fibrillation for

    Wass, Sojin Y / Smith, Jonathan D / Chung, Mina K

    Circulation research

    2023  Volume 133, Issue 4, Page(s) 330–332

    MeSH term(s) Humans ; Atrial Fibrillation/genetics ; Genome-Wide Association Study ; Dilatation ; Genetic Predisposition to Disease ; Homeodomain Proteins/genetics
    Chemical Substances ZFHX3 protein, human (143258-00-8) ; Homeodomain Proteins
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.323281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: HDL Is Not Dead Yet.

    Lorkowski, Shuhui Wang / Smith, Jonathan D

    Biomedicines

    2022  Volume 10, Issue 1

    Abstract: High-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with coronary heart disease (CHD) in multiple epidemiological studies, but whether HDL is causal or merely associated with CHD is unclear. Recent trials for HDL-raising drugs ... ...

    Abstract High-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with coronary heart disease (CHD) in multiple epidemiological studies, but whether HDL is causal or merely associated with CHD is unclear. Recent trials for HDL-raising drugs were either not effective in reducing CHD events or, if beneficial in reducing CHD events, were not conclusive as the findings could be attributed to the drugs' LDL-reducing activity. Furthermore, the first large Mendelian randomization study did not causally relate HDL-C levels to decreased CHD. Thus, the hypothesis that HDL is protective against CHD has been rightfully challenged. However, subsequent Mendelian randomization studies found HDL characteristics that are causally related to decreased CHD. Many aspects of HDL structure and function, especially in reverse cholesterol transport, may be better indicators of HDL's protective activity than simply measuring HDL-C. Cholesterol efflux capacity is associated with lower levels of prevalent and incident CHD, even after adjustment for HDL-C and apolipoprotein A-1 levels. Also, subjects with very high levels of HDL-C, including those with rare mutations that disrupt hepatic HDL uptake and reverse cholesterol transport, may be at higher risk for CHD than those with moderate levels. We describe here several cell-based and cell-free in vitro assays of HDL structure and function that may be used in clinical studies to determine which of HDL's functions are best associated with protection against CHD. We conclude that the HDL hypothesis may need revision based on studies of HDL structure and function, but that the HDL hypothesis is not dead yet.
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10010128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era.

    Hai, Qimin / Smith, Jonathan D

    Metabolites

    2021  Volume 11, Issue 8

    Abstract: The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase ( ...

    Abstract The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase (
    Language English
    Publishing date 2021-08-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11080543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: "Neuroanatomical integration of homeostatic and hedonic brain regions to regulate consummatory behavior".

    Smith, Ashley E / Hommel, Jonathan D

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2021  Volume 47, Issue 1, Page(s) 417

    MeSH term(s) Animals ; Brain/physiology ; Consummatory Behavior ; Feeding Behavior/physiology ; Homeostasis
    Language English
    Publishing date 2021-08-24
    Publishing country England
    Document type News ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-021-01165-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
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  10. Article ; Online: Reciprocated competition between two forest carnivores drives dietary specialization.

    Smith, Matthew M / Erb, John D / Pauli, Jonathan N

    The Journal of animal ecology

    2023  Volume 92, Issue 9, Page(s) 1695–1706

    Abstract: Competition shapes animal communities, but the strength of the interaction varies spatially depending on the availability and aggregation of resources and competitors. Among carnivores, competition is particularly pronounced with the strongest ... ...

    Abstract Competition shapes animal communities, but the strength of the interaction varies spatially depending on the availability and aggregation of resources and competitors. Among carnivores, competition is particularly pronounced with the strongest interactions between similar species with intermediate differences in body size. While ecologists have emphasized interference competition among carnivores based on dominance hierarchies from body size (smaller = subordinate; larger = dominant), the reciprocity of exploitative competition from subordinate species has been overlooked even though efficient exploitation can limit resource availability and influence foraging. Across North America, fishers Pekania pennanti and martens (Martes spp.) are two phylogenetically related forest carnivores that exhibit a high degree of overlap in habitat use and diet and differ in body size by a factor of 2-5×, eliciting particularly strong interspecific competition. In the Great Lakes region, fishers and martens occur both allopatrically and sympatrically; where they co-occur, the numerically dominant species varies spatially. This natural variation in competitors and environmental conditions enables comparisons to understand how interference and exploitative competition alter dietary niche overlap and foraging strategies. We analysed stable isotopes (δ
    MeSH term(s) Animals ; Ecosystem ; Carnivora ; Forests ; Mustelidae/physiology ; Diet
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.13962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 72/708: Show issues
    Z 2600: Show issues

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