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  1. Article ; Online: Interferon regulatory factor 4 a master regulator of hypertensive kidney fibrosis and inflammation?

    Kyaw, Tin / Drummond, Grant / Bobik, Alex

    Journal of hypertension

    2023  Volume 41, Issue 6, Page(s) 906–908

    MeSH term(s) Humans ; Animals ; Mice ; Inflammation ; Hypertension/complications ; Hypertension/pathology ; Kidney Diseases/pathology ; Kidney/pathology ; Interferon Regulatory Factors ; Fibrosis ; Mice, Inbred C57BL
    Chemical Substances Interferon Regulatory Factors
    Language English
    Publishing date 2023-05-03
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 614: Show issues

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  2. Article ; Online: Is angiogenic CD4+ T-cell mediated inflammation responsible for endothelial dysfunction in essential hypertension?

    Kyaw, Tin / Bobik, Alex

    Journal of hypertension

    2021  Volume 39, Issue 5, Page(s) 867–868

    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 614: Show issues

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  3. Article ; Online: Myocarditis: causes, mechanisms, and evolving therapies.

    Kyaw, Tin / Drummond, Grant / Bobik, Alex / Peter, Karlheinz

    Expert opinion on therapeutic targets

    2023  Volume 27, Issue 3, Page(s) 225–238

    Abstract: Introduction: Myocarditis is a severe lymphocyte-mediated inflammatory disorder of the heart, mostly caused by viruses and immune checkpoint inhibitors (ICIs). Recently, myocarditis as a rare adverse event of mRNA vaccines for SARS-CoV-2 has caused ... ...

    Abstract Introduction: Myocarditis is a severe lymphocyte-mediated inflammatory disorder of the heart, mostly caused by viruses and immune checkpoint inhibitors (ICIs). Recently, myocarditis as a rare adverse event of mRNA vaccines for SARS-CoV-2 has caused global attention. The clinical consequences of myocarditis can be very severe, but specific treatment options are lacking or not yet clinically proven.
    Areas covered: This paper offers a brief overview of the biology of viruses that frequently cause myocarditis, focusing on mechanisms important for viral entry and replication following host infection. Current and new potential therapeutic targets/strategies especially for viral myocarditis are reviewed systematically. In particular, the immune system in myocarditis is dissected with respect to infective viral and non-infective, ICI-induced myocarditis.
    Expert opinion: Vaccination is an excellent emerging preventative strategy for viral myocarditis, but most vaccines still require further development. Anti-viral treatments that inhibit viral replication need to be considered following viral infection in host myocardium, as lower viral load reduces inflammation severity. Understanding how the immune system continues to damage the heart even after viral clearance will define novel therapeutic targets/strategies. We propose that viral myocarditis can be best treated using a combination of antiviral agents and immunotherapies that control cytotoxic T cell activity.
    MeSH term(s) Humans ; Myocarditis/therapy ; Myocarditis/drug therapy ; COVID-19 Vaccines/adverse effects ; COVID-19/therapy ; COVID-19/complications ; SARS-CoV-2 ; Myocardium ; Antiviral Agents/therapeutic use
    Chemical Substances COVID-19 Vaccines ; Antiviral Agents
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2193330
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Conference proceedings: Cardiovascular structure and reactivity in hypertension

    Bobik, Alex

    proceedings of a satellite symposium to the 15th meeting of the International Society of Hypertension

    (Blood pressure ; 4, Suppl. 2)

    1995  

    Institution Symposium Cardiovascular Structure and Reactivity in Hypertension: Mechanisms and Implications for Patient Management
    International Society of Hypertension
    Author's details [Symposium Cardiovascular Structure and Reactivity in Hypertension: Mechanisms and Implications for Patient Management ... in Melbourne, Australia, in March 1994]. Ed. by Alex Bobik
    Series title Blood pressure ; 4, Suppl. 2
    Collection
    Keywords Hypertrophy / therapy / congresses ; Cardiovascular System / pathology / congresses ; Hypertension / complications / congresses ; Hypertrophy / complications / congresses
    Language English
    Size 125 S. : Ill., graph. Darst.
    Publisher Scandinavian Univ. Press
    Publishing place Oslo u.a.
    Publishing country Norway
    Document type Book ; Conference proceedings
    HBZ-ID HT006793940
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3843 -4,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Early adaptive CD4+ T-cell immunity in atherosclerosis goes local.

    Kyaw, Tin / Bobik, Alex

    Cardiovascular research

    2019  Volume 116, Issue 2, Page(s) 253–255

    MeSH term(s) Adaptive Immunity ; Aorta ; Atherosclerosis ; CD4-Positive T-Lymphocytes ; Humans
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz269
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Mapping human pluripotent stem cell-endothelial cell differentiation using scRNA-seq: a step towards therapeutic angiogenesis.

    Pinto, Alexander R / Bobik, Alex

    European heart journal

    2019  Volume 41, Issue 9, Page(s) 1037–1039

    MeSH term(s) Cell Differentiation ; Humans ; Pluripotent Stem Cells ; Sequence Analysis, RNA ; Single-Cell Analysis
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz464
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  7. Article ; Online: Low Tregs: A targetable risk factor for life-threatening cardiovascular complications after major noncardiac surgery.

    Kyaw, Tin / Bobik, Alex

    Journal of leukocyte biology

    2019  Volume 107, Issue 5, Page(s) 713–715

    Abstract: Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery. ...

    Abstract Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery.
    MeSH term(s) Atherosclerosis ; Humans ; Postoperative Complications/etiology ; Risk Factors ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2019-10-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.3CE0919-318R
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  8. Article ; Online: The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture.

    Noonan, Jonathan / Bobik, Alex / Peter, Karlheinz

    British journal of pharmacology

    2021  Volume 179, Issue 5, Page(s) 979–997

    Abstract: The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant limitations in our understanding and ability to identify unstable plaque pathology and prevent plaque rupture, most ... ...

    Abstract The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular mortality and morbidity. Despite significant limitations in our understanding and ability to identify unstable plaque pathology and prevent plaque rupture, most atherosclerosis research utilises preclinical animal models exhibiting stable atherosclerosis. Here, we introduce the tandem stenosis (TS) mouse model that reflects plaque instability and rupture, as seen in patients. The TS model involves dual ligation of the right carotid artery, leading to locally predefined unstable atherosclerosis in hypercholesterolaemic mice. It exhibits key characteristics of human unstable plaques, including plaque rupture, luminal thrombosis, intraplaque haemorrhage, large necrotic cores, thin or ruptured fibrous caps and extensive immune cell accumulation. Altogether, the TS model represents an ideal preclinical tool for improving our understanding of human plaque instability and rupture, for the development of imaging technologies to identify unstable plaques, and for the development and testing of plaque-stabilising treatments for the prevention of atherosclerotic plaque rupture. LINKED ARTICLES: This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.
    MeSH term(s) Animals ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/pathology ; Constriction, Pathologic ; Disease Models, Animal ; Humans ; Mice ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/pathology
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15356
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  9. Article ; Online: Evolving BAFF targeted therapies for preventing acute myocardial infarctions and ischemic strokes.

    Kyaw, Tin / Toh, Ban-Hock / Bobik, Alex

    Expert opinion on therapeutic targets

    2020  Volume 24, Issue 1, Page(s) 7–12

    MeSH term(s) Animals ; Atherosclerosis/complications ; Atherosclerosis/physiopathology ; Atherosclerosis/therapy ; B-Cell Activating Factor/metabolism ; Humans ; Ischemic Stroke/etiology ; Ischemic Stroke/prevention & control ; Molecular Targeted Therapy ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control
    Chemical Substances B-Cell Activating Factor ; TNFSF13B protein, human
    Language English
    Publishing date 2020-01-15
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2020.1708325
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  10. Article ; Online: Banco Interamericano de Desenvolvimento (BID) no espaço-tempo

    José Alex Rego Soares / Márcio Bobik Braga

    Geosul, Vol 36, Iss

    uma análise crítica sobre seu papel no financiamento da integração regional

    2021  Volume 79

    Abstract: O objetivo do artigo consiste em analisar a desempenho do BID enquanto banco de integração regional e o tratamento dispensado ao circulo vicioso crédito-renda no período de sua criação até o começo do século XX. Dadas as circunstâncias comumente ... ...

    Abstract O objetivo do artigo consiste em analisar a desempenho do BID enquanto banco de integração regional e o tratamento dispensado ao circulo vicioso crédito-renda no período de sua criação até o começo do século XX. Dadas as circunstâncias comumente apresentadas em regiões com alta desigualdade de renda, a promoção do crédito fica presa nesse circuito vicioso, pois só há acesso ao crédito quem possui renda. Assim sendo, problematizamos como o Banco Interamericano não foi capaz de se consolidar como uma instituição financeira internacional de primeira linha no Sistema Financeiro Mundial (SFM). O BID tampouco ocupa o espaço de agente facilitador da integração regional na acepção da compactação entre espaço e tempo como dinamizador do crédito, uma vez que o desenho institucional do BID impossibilita o crédito no processo de integração regional.
    Keywords Exclusão Financeira ; BID ; Integração Regional ; Crédito ; Renda ; Human ecology. Anthropogeography ; GF1-900 ; Physical geography ; GB3-5030 ; Geography (General) ; G1-922
    Language Portuguese
    Publishing date 2021-09-01T00:00:00Z
    Publisher Universidade Federal de Santa Catarina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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