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  1. Article ; Online: APOE targeting strategy in Alzheimer's disease: lessons learned from protective variants.

    Bu, Guojun

    Molecular neurodegeneration

    2022  Volume 17, Issue 1, Page(s) 51

    MeSH term(s) Alzheimer Disease ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Genotype ; Humans
    Chemical Substances Apolipoprotein E4 ; Apolipoproteins E
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-022-00556-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TREMendous microglial effects on neurons.

    Chen, Xiao-Fen / Bu, Guojun

    Immunity

    2024  Volume 57, Issue 1, Page(s) 1–3

    Abstract: TREM2 is exclusively expressed by microglia in the brain and is strongly associated with Alzheimer's disease risk. In this issue of Immunity, Tagliatti et al. shed light on a novel role of TREM2 in shaping neuronal bioenergetics during development. ...

    Abstract TREM2 is exclusively expressed by microglia in the brain and is strongly associated with Alzheimer's disease risk. In this issue of Immunity, Tagliatti et al. shed light on a novel role of TREM2 in shaping neuronal bioenergetics during development.
    MeSH term(s) Microglia ; Neurons ; Brain
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.12.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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  3. Article ; Online: In memoriam of Huaxi Xu, PhD, 1964-2022.

    Bu, Guojun / Zheng, Hui

    Molecular neurodegeneration

    2023  Volume 18, Issue 1, Page(s) 6

    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-022-00587-z
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  4. Article ; Online: A TREM2 antibody energizes microglia.

    Zhao, Na / Bu, Guojun

    Nature neuroscience

    2023  Volume 26, Issue 3, Page(s) 366–368

    MeSH term(s) Humans ; Microglia/metabolism ; Antibodies ; Brain/metabolism ; Extracellular Space/metabolism ; Alzheimer Disease ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/metabolism
    Chemical Substances Antibodies ; TREM2 protein, human ; Membrane Glycoproteins ; Receptors, Immunologic
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01265-z
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    Zs.A 4891: Show issues Location:
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  5. Article ; Online: Counteracting Alzheimer's disease via somatic TERT activation.

    Fu, Yuan / Bu, Guojun / Kanekiyo, Takahisa / Zhao, Jing

    Nature aging

    2023  Volume 1, Issue 12, Page(s) 1081–1082

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Brain ; Telomerase/genetics
    Chemical Substances TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-021-00145-0
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  6. Article ; Online: An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells.

    Raulin, Ana-Caroline / Liu, Chia-Chen / Bu, Guojun

    STAR protocols

    2023  Volume 4, Issue 1, Page(s) 101976

    Abstract: Cholesterol is a structural component of cell membranes. Most cells are incapable of its catabolism, and intracellular cholesterol accumulation is linked to several disorders including cardiovascular and neurodegenerative diseases. Cholesterol efflux, ... ...

    Abstract Cholesterol is a structural component of cell membranes. Most cells are incapable of its catabolism, and intracellular cholesterol accumulation is linked to several disorders including cardiovascular and neurodegenerative diseases. Cholesterol efflux, essential to its metabolism, is dependent on acceptors such as apolipoproteins. Here, we describe an assay to evaluate the capacity of cholesterol acceptors. Cells are treated with an analog of cholesterol tagged with fluorescent BODIPY. Addition of an acceptor leads to BODIPY-cholesterol efflux, measured using a plate reader. For complete details on the use and execution of this protocol, please refer to Liu et al. (2021).
    MeSH term(s) Cholesterol/metabolism ; Apolipoproteins/metabolism ; Boron Compounds ; Biological Transport
    Chemical Substances 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins ; Boron Compounds
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101976
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  7. Article ; Online: Pushing the boundaries of brain organoids to study Alzheimer's disease.

    Cerneckis, Jonas / Bu, Guojun / Shi, Yanhong

    Trends in molecular medicine

    2023  Volume 29, Issue 8, Page(s) 659–672

    Abstract: Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining how complex cell-cell interactions become dysregulated in AD requires ...

    Abstract Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining how complex cell-cell interactions become dysregulated in AD requires novel human cell-based in vitro platforms that could recapitulate the intricate cytoarchitecture and cell diversity of the human brain. Brain organoids (BOs) are 3D self-organizing tissues that partially resemble the human brain architecture and can recapitulate AD-relevant pathology. In this review, we highlight the versatile applications of different types of BOs to model AD pathogenesis, including amyloid-β and tau aggregation, neuroinflammation, myelin breakdown, vascular dysfunction, and other phenotypes, as well as to accelerate therapeutic development for AD.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Phenotype ; Organoids/metabolism
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.05.007
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    Zs.A 4345: Show issues Location:
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  8. Article ; Online: Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.

    Inoue, Yasuteru / Shue, Francis / Bu, Guojun / Kanekiyo, Takahisa

    Molecular neurodegeneration

    2023  Volume 18, Issue 1, Page(s) 46

    Abstract: Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-stroke dementia, subcortical ischemic vascular ... ...

    Abstract Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-stroke dementia, subcortical ischemic vascular dementia, multi-infarct dementia, and mixed dementia. While VCID is acknowledged as the second most common form of dementia after Alzheimer's disease (AD) accounting for 20% of dementia cases, VCID and AD frequently coexist. In VCID, cerebral small vessel disease (cSVD) often affects arterioles, capillaries, and venules, where arteriolosclerosis and cerebral amyloid angiopathy (CAA) are major pathologies. White matter hyperintensities, recent small subcortical infarcts, lacunes of presumed vascular origin, enlarged perivascular space, microbleeds, and brain atrophy are neuroimaging hallmarks of cSVD. The current primary approach to cSVD treatment is to control vascular risk factors such as hypertension, dyslipidemia, diabetes, and smoking. However, causal therapeutic strategies have not been established partly due to the heterogeneous pathogenesis of cSVD. In this review, we summarize the pathophysiology of cSVD and discuss the probable etiological pathways by focusing on hypoperfusion/hypoxia, blood-brain barriers (BBB) dysregulation, brain fluid drainage disturbances, and vascular inflammation to define potential diagnostic and therapeutic targets for cSVD.
    MeSH term(s) Humans ; Dementia, Vascular ; Alzheimer Disease ; Causality ; Risk Factors ; Cerebral Small Vessel Diseases/complications
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-023-00640-5
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  9. Article: Long-Distance Wind Dispersal Drives Population Range Expansion of

    Zhang, Zheng / Wen, Guangyue / Bu, Dexiao / Sun, Guojun / Qiang, Sheng

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 20

    Abstract: Canada goldenrod ( ...

    Abstract Canada goldenrod (
    Language English
    Publishing date 2022-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11202734
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  10. Article ; Online: Lipoproteins in the Central Nervous System: From Biology to Pathobiology.

    Raulin, Ana-Caroline / Martens, Yuka A / Bu, Guojun

    Annual review of biochemistry

    2022  Volume 91, Page(s) 731–759

    Abstract: The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and distribution to maintain homeostasis and neuronal function. Lipid transport mediated by lipoprotein particles, which are complex structures composed of apolipoproteins ...

    Abstract The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and distribution to maintain homeostasis and neuronal function. Lipid transport mediated by lipoprotein particles, which are complex structures composed of apolipoproteins and lipids, has been thoroughly characterized in the periphery. Although lipoproteins in the central nervous system (CNS) were reported over half a century ago, the identification of
    MeSH term(s) Alzheimer Disease/genetics ; Apolipoproteins ; Apolipoproteins E/genetics ; Biology ; Central Nervous System ; Humans
    Chemical Substances Apolipoproteins ; Apolipoproteins E
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-032620-104801
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