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  1. Book: Apoptosis

    Reed, John C. / Green, Douglas R.

    physiology and pathology

    2011  

    Author's details ed. by John C. Reed ; Douglas R. Green
    Keywords Apoptosis ; Apoptosis / physiology ; Cell Death
    Language English
    Size XIII, 421 S., [16] Bl. : zahlr. Ill., graph. Darst., 28 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT017042792
    ISBN 978-0-521-88656-7 ; 0-521-88656-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 4915 order for loan Magazin

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  2. Article ; Online: Bcl-2 on the brink of breakthroughs in cancer treatment.

    Reed, John C

    Cell death and differentiation

    2017  Volume 25, Issue 1, Page(s) 3–6

    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism
    Chemical Substances Antineoplastic Agents ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2017-12-14
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: John Francis Delong, a Frontier Physician.

    Reed, C I

    Annals of medical history

    2021  Volume 3, Issue 3, Page(s) 296–299

    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 418598-5
    ISSN 0743-3131
    ISSN 0743-3131
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  4. Article ; Online: K63 ubiquitination in immune signaling.

    Madiraju, Charitha / Novack, Jeffrey P / Reed, John C / Matsuzawa, Shu-Ichi

    Trends in immunology

    2022  Volume 43, Issue 2, Page(s) 148–162

    Abstract: Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, ...

    Abstract Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, is altered by K63 ubiquitination. In this review, we detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network. Many pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can target K63 ubiquitination to inhibit pathogen immune responses; we describe novel details of the pathways involved and summarize recent clinically relevant SARS-CoV-2-specific responses. We also discuss recent evidence that regulatory T cell (Treg) versus T helper (T
    MeSH term(s) COVID-19 ; Humans ; Lysine/metabolism ; SARS-CoV-2 ; Signal Transduction ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.12.005
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  5. Article ; Online: White sclera is present in chimpanzees and other mammals.

    Clark, Isabelle R / Lee, Kevin C / Poux, Tucker / Langergraber, Kevin E / Mitani, John C / Watts, David / Reed, James / Sandel, Aaron A

    Journal of human evolution

    2023  Volume 176, Page(s) 103322

    MeSH term(s) Animals ; Pan troglodytes ; Sclera ; Mammals
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120141-4
    ISSN 1095-8606 ; 0047-2484
    ISSN (online) 1095-8606
    ISSN 0047-2484
    DOI 10.1016/j.jhevol.2022.103322
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  6. Article ; Online: Spatiotemporal Dynamics of Neuroinflammation Relate to Behavioral Recovery in Rats with Spinal Cord Injury.

    Mu, Chaoqi / Reed, Jamie L / Wang, Feng / Tantawy, M Noor / Gore, John C / Chen, Li Min

    Molecular imaging and biology

    2023  Volume 26, Issue 2, Page(s) 240–252

    Abstract: Purpose: The degree and dynamic progression of neuroinflammation after traumatic spinal cord injuries (SCI) are crucial determinants of the severity of injury and potential for recovery. We used Positron Emission Tomography (PET) to monitor ... ...

    Abstract Purpose: The degree and dynamic progression of neuroinflammation after traumatic spinal cord injuries (SCI) are crucial determinants of the severity of injury and potential for recovery. We used Positron Emission Tomography (PET) to monitor neuroinflammation longitudinally, correlating it with Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) and behavior in contusion-injured rats. These studies help validate CEST metrics and confirm how imaging may be used to evaluate the efficacy of therapies and understand their mechanisms of action.
    Procedures: 12 SCI and 4 sham surgery rats were subjected to CEST MRI and PET-Translocator Protein (TSPO) scans for 8 weeks following injury. Z-spectra from the SCI were analyzed using a 5-Lorentzian pool model for fitting. Weekly motor and somatosensory behavior were correlated with imaging metrics, which were validated through post-mortem histological and immuo-staining using ionized calcium-binding adaptor protein-1 (iba-1, microglia) and glial fibrillary acidic protein (GFAP, astrocytes).
    Results: PET-TSPO showed widespread inflammation and post-mortem histology confirmed the presence of activated microglia. Changes in CEST and nuclear Overhauser Effect (NOE) peaks at 3.5 ppm and -1.6 ppm respectively were largest within the first week after injury and more pronounced in rostral versus caudal segments. These temporal indices of neuroinflammation corresponded to the recovery of locomotor behaviors and somatic sensation in rats with moderate contusion injury. The results confirm that CEST MRI metrics are sensitive indices of states of neuroinflammation within injured spinal cords.
    Conclusions: The detection of dynamic spatiotemporal features of neuroinflammation progression underscores the importance of considering their timings and locations for neuroprotective and anti-inflammatory therapies. The availability of noninvasive MRI indices of neuroinflammation may facilitate clinical trials aimed at treatments that promote recovery after SCI.
    MeSH term(s) Rats ; Animals ; Neuroinflammatory Diseases ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology ; Spinal Cord/pathology ; Inflammation/metabolism ; Carrier Proteins/metabolism ; Contusions
    Chemical Substances Carrier Proteins
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01875-w
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  7. Article ; Online: Ketamine Use for Palliative Care in the Austere Environment: Is Ketamine the Path Forward for Palliative Care.

    Reed, John R / Parks, Stephanie K / Kaniaru, Antony / Hefley, Justin / Yauger, Young / Edwards, Jeremy V / Glymph, Derrick C

    The American journal of hospice & palliative care

    2024  , Page(s) 10499091241246520

    Abstract: The goal of palliative care is to focus on the holistic needs of the patient and their family versus the pathology of the patient's diagnosis to reduce the stress of illness. U.S. servicemembers deployed to austere environments worldwide have ... ...

    Abstract The goal of palliative care is to focus on the holistic needs of the patient and their family versus the pathology of the patient's diagnosis to reduce the stress of illness. U.S. servicemembers deployed to austere environments worldwide have significantly less access to palliative care than in military treatment facilities in the U.S. Preparation for future conflicts introduces the concept of prolonged medical management for an environment where urgent casualty evacuation is impossible. Ketamine is currently widely used for analgesia and anesthesia in the care of military service members and its use has increased in combat zones of Iraq and Afghanistan due to the favorable preservation of respiratory function, minimal changes in hemodynamics, and lower pain scores compared to opioids. Ketamine acts as a non-competitive antagonist on N-methyl-D aspartate (NMDA) receptors. Its anesthesia and analgesic effects are complex and include both presynaptic and postsynaptic neurons in brain and spinal cord. The use of palliative care to minimize suffering should not be withheld due to the logistical boundaries of austere military environments or lack of guidelines for recommended use. The use of ketamine for palliative care is a new clinical management strategy to provide both sedation and pain management for an acute pain crisis or comfort measures for the terminally ill. This makes ketamine an attractive consideration for palliative care when managing critically wounded patients for an extended time.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074344-3
    ISSN 1938-2715 ; 1049-9091
    ISSN (online) 1938-2715
    ISSN 1049-9091
    DOI 10.1177/10499091241246520
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  8. Article ; Online: Detection and characterization of resting state functional networks in squirrel monkey brain.

    Sengupta, Anirban / Wang, Feng / Mishra, Arabinda / Reed, Jamie L / Chen, Li Min / Gore, John C

    Cerebral cortex communications

    2023  Volume 4, Issue 3, Page(s) tgad018

    Abstract: Resting-state fMRI based on analyzing BOLD signals is widely used to derive functional networks in the brain and how they alter during disease or injury conditions. Resting-state networks can also be used to study brain functional connectomes across ... ...

    Abstract Resting-state fMRI based on analyzing BOLD signals is widely used to derive functional networks in the brain and how they alter during disease or injury conditions. Resting-state networks can also be used to study brain functional connectomes across species, which provides insights into brain evolution. The squirrel monkey (SM) is a non-human primate (NHP) that is widely used as a preclinical model for experimental manipulations to understand the organization and functioning of the brain. We derived resting-state networks from the whole brain of anesthetized SMs using Independent Component Analysis of BOLD acquisitions. We detected 15 anatomically constrained resting-state networks localized in the cortical and subcortical regions as well as in the white-matter. Networks encompassing visual, somatosensory, executive control, sensorimotor, salience and default mode regions, and subcortical networks including the Hippocampus-Amygdala, thalamus, basal-ganglia and brainstem region correspond well with previously detected networks in humans and NHPs. The connectivity pattern between the networks also agrees well with previously reported seed-based resting-state connectivity of SM brain. This study demonstrates that SMs share remarkable homologous network organization with humans and other NHPs, thereby providing strong support for their suitability as a translational animal model for research and additional insight into brain evolution across species.
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7376
    ISSN (online) 2632-7376
    DOI 10.1093/texcom/tgad018
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  9. Article ; Online: Elevated Southern Hemisphere moisture availability during glacial periods.

    Weij, Rieneke / Sniderman, J M Kale / Woodhead, Jon D / Hellstrom, John C / Brown, Josephine R / Drysdale, Russell N / Reed, Elizabeth / Bourne, Steven / Gordon, Jay

    Nature

    2024  Volume 626, Issue 7998, Page(s) 319–326

    Abstract: Late Pleistocene ice-age climates are routinely characterized as having imposed moisture stress on low- to mid-latitude ... ...

    Abstract Late Pleistocene ice-age climates are routinely characterized as having imposed moisture stress on low- to mid-latitude ecosystems
    MeSH term(s) Animals ; Humans ; Animal Migration ; Australia ; Cold Temperature ; Desert Climate ; Ecosystem ; History, Ancient ; Humidity ; Ice Cover ; Plants ; Pollen ; Volatilization
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06989-3
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  10. Article ; Online: Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex.

    Chapman, Christopher L / Holt, Sadie M / O'Connell, Cameron T / Brazelton, Shaun C / Medved, Hannah N / Howells, William A B / Reed, Emma L / Needham, Karen Wiedenfeld / Halliwill, John R / Minson, Christopher T

    Journal of applied physiology (Bethesda, Md. : 1985)

    2024  Volume 136, Issue 3, Page(s) 492–508

    Abstract: Insufficient hydration is prevalent among free living adults. This study investigated whether hypohydration ... ...

    Abstract Insufficient hydration is prevalent among free living adults. This study investigated whether hypohydration alters
    MeSH term(s) Female ; Male ; Young Adult ; Humans ; Creatinine ; Hand Strength ; Reflex ; Hemodynamics ; Water
    Chemical Substances Creatinine (AYI8EX34EU) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00728.2023
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