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  1. Article ; Online: Extended q-Range X-Ray Scattering Reveals High-Resolution Structural Details of Biomacromolecules in Aqueous Solutions.

    Chen, Jiahui / Borkiewicz, Olaf J / Grishaev, Alexander V / Zhang, Fan / Bera, Mrinal K / Ruett, Uta / Levin, Igor

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 31, Page(s) e202203551

    Abstract: ... of biomacromolecules in aqueous solution from X-ray scattering experiments measured over a range of scattering vectors ... q) that is approximately two orders of magnitude wider than used previously for such systems ... Scattering data with such an extended q-range enables the recovery of the underlying real-space atomic pair ...

    Abstract We communicate a feasibility study for high-resolution structural characterization of biomacromolecules in aqueous solution from X-ray scattering experiments measured over a range of scattering vectors (q) that is approximately two orders of magnitude wider than used previously for such systems. Scattering data with such an extended q-range enables the recovery of the underlying real-space atomic pair distribution function, which facilitates structure determination. We demonstrate the potential of this method for biomacromolecules using several types of cyclodextrins (CD) as model systems. We successfully identified deviations of the tilting angles for the glycosidic units in CDs in aqueous solutions relative to their values in the crystalline forms of these molecules. Such level of structural detail is inaccessible from standard small angle scattering measurements. Our results call for further exploration of ultra-wide-angle X-ray scattering measurements for biomacromolecules.
    Language English
    Publishing date 2023-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comprehensive Identification of Short and Medium-Sized Peptides from Pixian Broad Bean Paste Protein Hydrolysates Using UPLC-Q-TOF-MS and UHPLC-Q Exactive HF-X.

    Li, Mingyang / Fan, Wenlai / Xu, Yan

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 27, Page(s) 8288–8299

    Abstract: Pixian broad bean paste (PBBP) is an indispensable food widely used in many East Asian countries, yet the knowledge about bioactive peptides released from parent proteins by enzymatic hydrolysis is limited. A total of 5867 low-molecular weight peptides ... ...

    Abstract Pixian broad bean paste (PBBP) is an indispensable food widely used in many East Asian countries, yet the knowledge about bioactive peptides released from parent proteins by enzymatic hydrolysis is limited. A total of 5867 low-molecular weight peptides were identified in the highly bioactive subfractions of the PBBP alcalase hydrolysates using traditional and peptidomics approaches. 19 short peptides (3-5 amino acids) were identified by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry, including 5 tripeptides, 8 tetrapeptides, and 6 pentapeptides. 5848 medium-sized peptides (6-10 amino acids) were characterized using the peptidomics approach, including 1484 hexapeptides, 1217 heptapeptides, 1634 octapeptides, 927 nonapeptides, and 586 decapeptides. The comprehensive method can be used for the investigation of bioactive peptides in complex food matrices.
    MeSH term(s) Amino Acids/chemistry ; Chromatography, High Pressure Liquid/methods ; Mass Spectrometry ; Peptides/chemistry ; Protein Hydrolysates
    Chemical Substances Amino Acids ; Peptides ; Protein Hydrolysates
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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  3. Article ; Online: Characterization of Metabolite Landscape Distinguishes Medicinal Fungus Cordyceps sinensis and other Cordyceps by UHPLC-Q Exactive HF-X Untargeted Metabolomics

    Chuyu Tang / Xiuzhang Li / Tao Wang / Jie Wang / Mengjun Xiao / Min He / Xiyun Chang / Yuejun Fan / Yuling Li

    Molecules, Vol 28, Iss 23, p

    2023  Volume 7745

    Abstract: Cordyceps represent a valuable class of medicinal fungi with potential utilization. The overexploitation and resource scarcity of Cordyceps sinensis (CS) have led to the emergence of Cordyceps such as Cordyceps militaris (CM) and Cordyceps cicadae (CC) ... ...

    Abstract Cordyceps represent a valuable class of medicinal fungi with potential utilization. The overexploitation and resource scarcity of Cordyceps sinensis (CS) have led to the emergence of Cordyceps such as Cordyceps militaris (CM) and Cordyceps cicadae (CC) as substitutes. The medicinal value of CS is often considered superior to other Cordyceps , potentially owing to differences in active ingredients. This study aimed to evaluate the differences in the composition and abundance of the primary and secondary metabolites of CS and its substitutes by untargeted metabolomics. A total of 4671 metabolites from 18 superclasses were detected. CS and its substitutes were rich in amino acids, lipids, organic acids, and their derivatives. We statistically analyzed the metabolites and found a total of 285 differential metabolites (3′-Adenylic acid, O-Adipoylcarnitine, L-Dopachrome, etc.) between CS and CC, CS and CM, and CM and CC, which are potential biomarkers. L-glutamate and glycerophospholipids were differential metabolites. A KEGG enrichment analysis indicated that the tyrosine metabolic pathway and tryptophan metabolism pathway are the most differentially expressed pathways among the three Cordyceps . In contrast, CS was enriched in a higher abundance of most lipid metabolites when compared to CM and CC, which may be an indispensable foundation for the pharmacological functions of CS. In conclusion, systematic, untargeted metabolomics analyses for CS and other Cordyceps have delivered a precious resource for insights into metabolite landscapes and predicted potential components of disease therapeutics.
    Keywords Cordyceps sinensis ; Cordyceps militaris ; Cordyceps cicadae ; untargeted metabolomics ; differential metabolites ; Organic chemistry ; QD241-441
    Subject code 500
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Comprehensive Identification of Short and Medium-Sized Peptides from Pixian Broad Bean Paste Protein Hydrolysates Using UPLC-Q–TOF–MS and UHPLC-Q Exactive HF-X

    Li, Mingyang / Fan, Wenlai / Xu, Yan

    Journal of agricultural and food chemistry. 2022 July 02, v. 70, no. 27

    2022  

    Abstract: Pixian broad bean paste (PBBP) is an indispensable food widely used in many East Asian countries, yet the knowledge about bioactive peptides released from parent proteins by enzymatic hydrolysis is limited. A total of 5867 low-molecular weight peptides ... ...

    Abstract Pixian broad bean paste (PBBP) is an indispensable food widely used in many East Asian countries, yet the knowledge about bioactive peptides released from parent proteins by enzymatic hydrolysis is limited. A total of 5867 low-molecular weight peptides were identified in the highly bioactive subfractions of the PBBP alcalase hydrolysates using traditional and peptidomics approaches. 19 short peptides (3–5 amino acids) were identified by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry, including 5 tripeptides, 8 tetrapeptides, and 6 pentapeptides. 5848 medium-sized peptides (6–10 amino acids) were characterized using the peptidomics approach, including 1484 hexapeptides, 1217 heptapeptides, 1634 octapeptides, 927 nonapeptides, and 586 decapeptides. The comprehensive method can be used for the investigation of bioactive peptides in complex food matrices.
    Keywords enzymatic hydrolysis ; faba beans ; food chemistry ; mass spectrometry ; peptidomics ; subtilisin ; tripeptides ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2022-0702
    Size p. 8288-8299.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02487
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1185: Show issues

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  5. Article: GC x GC-TOF/MS and UPLC-Q-TOF/MS based untargeted metabolomics coupled with physicochemical properties to reveal the characteristics of different type daqus for making soy sauce aroma and flavor type baijiu

    Yang, L. / Fan, W. / Xu, Y.

    LWT - food science and technology

    2021  Volume 146, Issue -, Page(s) 111416

    Language English
    Document type Article
    ZDB-ID 2169058-3
    ISSN 0023-6438
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 2634: Show issues

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  6. Article ; Online: Continuous wave and passively Q-switched Nd:Lu xY1-x VO4 laser at 1.34 μm with V3+:YAG as the saturable absorber.

    Zhang, Shuaiyi / Huang, Haitao / Xu, Lin / Wang, Mingjian / Chen, Fan / Xu, Jianqiu / He, Jingliang / Zhao, Bin

    Optics express

    2011  Volume 19, Issue 3, Page(s) 1830–1835

    Abstract: We demonstrated a diode-pumped continuous wave and passively Q-switched Nd:Lu(x)Y(1-x)VO4 laser ... at 1.34 μm with V3+:YAG as the saturable absorber. The crystal Nd:Lu(x)Y(1-x)VO4 with equal ionic ratio ... x = 0.5) shows better laser performance. The maximum continuous wave output power of 1.45 W was ...

    Abstract We demonstrated a diode-pumped continuous wave and passively Q-switched Nd:Lu(x)Y(1-x)VO4 laser at 1.34 μm with V3+:YAG as the saturable absorber. The crystal Nd:Lu(x)Y(1-x)VO4 with equal ionic ratio (x = 0.5) shows better laser performance. The maximum continuous wave output power of 1.45 W was obtained with the optical efficiency of 20.1% and the slope efficiency of 24.5%. For the pulsed operation, the minimum pulse width achieved was 42 ns with the pulse repetition frequency of 142 kHz, and the single pulse energy and the peak power were estimated to be 6.62 μJ and 157.6 W, respectively.
    MeSH term(s) Computer-Aided Design ; Equipment Design ; Equipment Failure Analysis ; Lasers, Solid-State ; Refractometry/instrumentation ; Signal Processing, Computer-Assisted/instrumentation
    Language English
    Publishing date 2011-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.19.001830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Comparison of the exposure characteristics of soft-x-ray film SIOFM-5FW with Kodak 101-05 and Ilford Q-plates.

    Fan, P Z / Zhou, J Z / Li, Y L

    Applied optics

    2007  Volume 36, Issue 13, Page(s) 2843–2847

    Abstract: ... ray film, SIOFM-5FW, with Kodak101-05 and Ilford Q-plates in the soft-x-ray and extreme UV region ... In identical exposure and processing conditions, we compare the exposure characteristics of soft-x ... greater than 10 nm, the response of SIOFM-5FW lies between the Kodak101-05 and the Ilford Q-plates but is ...

    Abstract In identical exposure and processing conditions, we compare the exposure characteristics of soft-x-ray film, SIOFM-5FW, with Kodak101-05 and Ilford Q-plates in the soft-x-ray and extreme UV region below 100 nm, using D-19 and Phenisol developers. The experimental results show that for radiation greater than 10 nm, the response of SIOFM-5FW lies between the Kodak101-05 and the Ilford Q-plates but is closer to the former. For radiation of less than 10 nm, the SIOFM-5FW is more sensitive than the Kodak101-05 plate, with a higher saturated optical density, a higher dynamic range, and an obvious carbon K absorption edge structure in the spectra obtained. The effects of the two developers used on the exposure characteristics are discussed.
    Language English
    Publishing date 2007-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 1559-128X
    ISSN 1559-128X
    DOI 10.1364/ao.36.002843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Small-cell lung carcinoma with long-term survival: a case report and review of the literature].

    Lü, C / Zhu, T / Fan, S / Wu, X / Xia, Q

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2024  Volume 43, Issue 12, Page(s) 2152–2157

    Abstract: We report a rare case of small-cell lung carcinoma with long-term survival treated in the Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. The pathological-clinical features and diagnosis-treatment progress were ... ...

    Abstract We report a rare case of small-cell lung carcinoma with long-term survival treated in the Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. The pathological-clinical features and diagnosis-treatment progress were analyzed, and the comprehensive treatment strategies, tumor heterogeneity and prognosis of this tumor type were discussed by comparing with other previous studies. The 62-year-old patient was diagnosed with small-cell lung carcinoma and received surgery, radiotherapy and multi-line treatment, and had survived for 13 years after the surgery. The heterogeneity of small cell lung carcinoma should be carefully evaluated to improve the prognosis of the patients.
    MeSH term(s) Humans ; Middle Aged ; China ; Lung ; Lung Neoplasms ; Small Cell Lung Carcinoma
    Language Chinese
    Publishing date 2024-01-08
    Publishing country China
    Document type Review ; Case Reports ; English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.12.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: [Inflammatory rhabdomyoblastic tumor: a clinicopathological analysis of 3 cases].

    Gong, C X / Shao, X / Fan, Q H

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2023  Volume 52, Issue 2, Page(s) 169–171

    MeSH term(s) Humans ; Neoplasms ; Rhabdomyosarcoma
    Language Chinese
    Publishing date 2023-02-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20220507-00380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2958: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 360: Show issues

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  10. Article: [An interpretation of the British Association for the Study of the Liver practice guideline for the evaluation and treatment of hepatolenticular degeneration].

    Xiao, Q Q / Xu, X / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 30, Issue 11, Page(s) 1154–1157

    Abstract: Hepatolenticular degeneration is common among rare diseases. China has a higher incidence rate than Western countries, and it is increasing year by year. The disease is easy to overlook and misdiagnose due to its complexity and non-specific clinical ... ...

    Abstract Hepatolenticular degeneration is common among rare diseases. China has a higher incidence rate than Western countries, and it is increasing year by year. The disease is easy to overlook and misdiagnose due to its complexity and non-specific clinical manifestations. Therefore, the British Association for the Study of the Liver has recently issued practice guidelines for the evaluation and treatment of hepatolenticular degeneration in order to aid clinicians in improving the clinical decision-making process regarding diagnosis, treatment, and long-term follow-up management. Herein is a brief introduction and interpretation of the content of the guideline, with aim of facilitating its application in clinical practice.
    MeSH term(s) Humans ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/therapy ; China ; Incidence
    Language Chinese
    Publishing date 2023-02-27
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20220511-00257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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