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  1. Book: Male and sperm factors that maximize IVF success

    Aitken, John / Mortimer, David / Kovacs, Gabor

    2020  

    Author's details edited by John Aitken, David Mortimer, Gabor Kovacs
    Keywords Infertility, Male / etiology ; Infertility, Male / therapy ; Fertilization in Vitro ; Spermatozoa / physiology
    Language English
    Size ix, 235 Seiten, Illustrationen
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT020528021
    ISBN 978-1-108-70831-9 ; 9781108762571 ; 1-108-70831-5 ; 1108762573
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1001 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Male reproductive ageing: a radical road to ruin.

    Aitken, R John

    Human reproduction (Oxford, England)

    2023  Volume 38, Issue 10, Page(s) 1861–1871

    Abstract: In modern post-transition societies, we are reproducing later and living longer. While the impact of age on female reproductive function has been well studied, much less is known about the intersection of age and male reproduction. Our current ... ...

    Abstract In modern post-transition societies, we are reproducing later and living longer. While the impact of age on female reproductive function has been well studied, much less is known about the intersection of age and male reproduction. Our current understanding is that advancing age brings forth a progressive decline in male fertility accompanied by a reduction in circulating testosterone levels and the appearance of age-dependent reproductive pathologies including benign prostatic hypertrophy and erectile dysfunction. Paternal ageing is also associated with a profound increase in sperm DNA damage, the appearance of multiple epigenetic changes in the germ line and an elevated mutational load in the offspring. The net result of such changes is an increase in the disease burden carried by the progeny of ageing males, including dominant genetic diseases such as Apert syndrome and achondroplasia, as well as neuropsychiatric conditions including autism and spontaneous schizophrenia. The genetic basis of these age-related effects appears to involve two fundamental mechanisms. The first is a positive selection mechanism whereby stem cells containing mutations in a mitogen-activated protein kinase pathway gain a selective advantage over their non-mutant counterparts and exhibit significant clonal expansion with the passage of time. The second is dependent on an age-dependent increase in oxidative stress which impairs the steroidogenic capacity of the Leydig cells, disrupts the ability of Sertoli cells to support the normal differentiation of germ cells, and disrupts the functional and genetic integrity of spermatozoa. Given the central importance of oxidative stress in defining the impact of chronological age on male reproduction, there may be a role for antioxidants in the clinical management of this process. While animal studies are supportive of this strategy, carefully designed clinical trials are now needed if we are to realize the therapeutic potential of this approach in a clinical context.
    MeSH term(s) Animals ; Male ; Female ; Semen ; Reproduction ; Aging/genetics ; Spermatozoa/physiology ; Mutation
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dead157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The changing tide of human fertility.

    Aitken, R John

    Human reproduction (Oxford, England)

    2022  Volume 37, Issue 4, Page(s) 629–638

    Abstract: Abstract: Over the past half-century, the world has witnessed a steep decline in fertility rates in virtually every country on Earth. This universal decline in fertility is being driven by increasing prosperity largely through the mediation of social ... ...

    Abstract Abstract: Over the past half-century, the world has witnessed a steep decline in fertility rates in virtually every country on Earth. This universal decline in fertility is being driven by increasing prosperity largely through the mediation of social factors, the most powerful of which are the education of women and an accompanying shift in life's purpose away from procreation. In addition, it is clear that environmental and lifestyle factors are also having a profound impact on our reproductive competence particularly in the male where increasing prosperity is associated with a significant rise in the incidence of testicular cancer and a secular decline in semen quality and testosterone levels. On a different timescale, we should also recognize that the increased prosperity associated with the demographic transition greatly reduces the selection pressure on high fertility genes by lowering the rates of infant and childhood mortality. The retention of poor fertility genes within the human population is also being exacerbated by the increased uptake of ART. It is arguable that all of these elements are colluding to drive our species into an infertility trap. If we are to avoid the latter, it will be important to recognize the factors contributing to this phenomenon and adopt the social, political, environmental and lifestyle changes needed to bring this situation under control.
    MeSH term(s) Birth Rate ; Child ; Female ; Fertility ; Humans ; Infertility ; Male ; Population Dynamics ; Semen Analysis ; Testicular Neoplasms
    Language English
    Publishing date 2022-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deac011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: So near yet so far away.

    Aitken, R John

    F&S reports

    2020  Volume 1, Issue 3, Page(s) 176

    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Editorial
    ISSN 2666-3341
    ISSN (online) 2666-3341
    DOI 10.1016/j.xfre.2020.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of oxidative stress on male and female germ cells: implications for fertility.

    Aitken, R John

    Reproduction (Cambridge, England)

    2019  Volume 159, Issue 4, Page(s) R189–R201

    Abstract: Male and female germ lines are vulnerable to oxidative stress. In spermatozoa, such stress triggers a lipid peroxidation cascade that culminates in the generation of electrophilic lipid aldehydes that bind to DNA and a raft of proteins involved in the ... ...

    Abstract Male and female germ lines are vulnerable to oxidative stress. In spermatozoa, such stress triggers a lipid peroxidation cascade that culminates in the generation of electrophilic lipid aldehydes that bind to DNA and a raft of proteins involved in the delivery of functionally competent cells. One set of targets for these aldehydes are the proteins of the mitochondrial electron transport chain. When this interaction occurs, mitochondrial ROS generation is enhanced leading to the sustained generation of oxidative damage in a self-perpetuating cycle. Such damage affects all aspects of sperm function including motility, sperm-egg recognition, acrosomal exocytosis and sperm-oocyte fusion. Oxidative stress in the male germ line also attacks the integrity of sperm DNA with potential impacts on the developmental capacity of embryos and the health and wellbeing of the offspring. Potential pathways of reactive oxygen species (ROS) generation in male germ cells could involve enhanced lipoxygenase activity, activation of NADPH oxidase and/or electron leakage from mitochondria. Similarly, in the female germ line, both the induction of oocyte senescence following ovulation and the deterioration of oocyte quality with maternal age appear to involve the generation of oxidative damage. In this case, the mitochondria appear to be a particularly important source of ROS compromising the viability and fertilizability of the oocyte and interfering with the normal segregation of chromosomes during meiosis. In light of these considerations, antioxidants should have some role to play in the preservation of reproductive function in both men and women; however, we still await appropriate trials to test this hypothesis.
    MeSH term(s) Antioxidants/therapeutic use ; Female ; Humans ; Infertility/drug therapy ; Infertility/etiology ; Male ; Oocytes/metabolism ; Oxidative Stress ; Spermatozoa/metabolism
    Chemical Substances Antioxidants
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-19-0452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Studies on men's health and fertility

    Agarwal, Ashok / Aitken, R. John / Alvarez, Juan G.

    (Oxidative stress in applied basic research and clinical practice)

    2012  

    Author's details Ashok Agarwal ; R. John Aitken ; Juan G. Alvarez, ed
    Series title Oxidative stress in applied basic research and clinical practice
    Language English
    Size XVI, 671 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017204148
    ISBN 978-1-61779-775-0 ; 9781617797767 ; 1-61779-775-8 ; 1617797766
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2012 A 1746 order for loan Magazin

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  7. Article ; Online: Should we be measuring DNA damage in human spermatozoa? New light on an old question.

    Aitken, R John / Bakos, Hassan W

    Human reproduction (Oxford, England)

    2021  Volume 36, Issue 5, Page(s) 1175–1185

    Abstract: Assessments of sperm DNA damage are controversial because of perceived uncertainties over the relationship with pregnancy and the limited range of therapies available should positive results be returned. In this article, we highlight recent data ... ...

    Abstract Assessments of sperm DNA damage are controversial because of perceived uncertainties over the relationship with pregnancy and the limited range of therapies available should positive results be returned. In this article, we highlight recent data supporting a chain of associations between oxidative stress in the male germ line, DNA damage in spermatozoa, defective DNA repair in the oocyte, the mutational load carried by the resulting embryo and the long-term health trajectory of the offspring. Any condition capable of generating oxidative damage in spermatozoa (age, obesity, smoking, prolonged abstinence, varicocele, chemical exposures, radiation etc.) is capable of influencing offspring health in this manner, creating a range of pathologies in the progeny including neuropsychiatric disorders and cancer. If sperm DNA damage is detected, there are several therapeutic interventions that can be introduced to improve DNA quality prior to the use of these cells in ART. We therefore argue that infertility specialists should be engaged in the diagnosis and remediation of sperm DNA damage as a matter of best practice, in order to minimize the risk of adverse health outcomes in children conceived using ART.
    MeSH term(s) Child ; DNA Damage ; Female ; Humans ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Male ; Oocytes ; Oxidative Stress ; Pregnancy ; Spermatozoa/metabolism
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deab004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2892: Show issues Location:
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  8. Book ; Conference proceedings: Male contraception, a choice on the horizon

    Aitken, R. John

    proceedings of the final meeting of the joint Rockefeller / Ernst Schering network on epididymal research (AMPPA: applied molecular pharmacology of posttesticular activity) ; Bellagio, Italy, October, 2002

    (Molecular and cellular endocrinology ; 216, 1/2 = Special issue)

    2004  

    Institution Schering-Forschungsgesellschaft
    Author's details [sponsored by the Ernst Schering Research Foundation ...]. Guest ed.: R. John Aitken
    Series title Molecular and cellular endocrinology ; 216, 1/2 = Special issue
    Collection
    Language English
    Size IX S., S. 1 - S. 94 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    Note Auch als Monographie ersch.
    HBZ-ID HT014022956
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1127 -216- not available for loan Zeitschriften-Lesesaal

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  9. Book ; Conference proceedings: Male contraception, a choice on the horizon

    Aitken, R. John

    [proceedings of the Final Meeting of the Joint Rockefeller / Ernst Schering Network on Epididymal Research (AMPPA: Applied Molecular Pharmacology of Posttesticular Activity) ; Bellagio, Italy, October, 2002]

    2004  

    Institution The Rockefeller Foundation
    Event/congress Final Meeting on Epididymal Research, AMPPA: Applied Molecular Pharmacology of Posttesticular Activity (2002, Bellagio)
    Author's details ed. by R. John Aitken
    Keywords Empfängnisverhütung ; Mann
    Subject Antikonzeption ; Kontrazeption ; Verhütung ; Interzeption ; Konzeptionsverhütung ; Schwangerschaftsverhütung ; Erwachsener Mann ; Männlicher Erwachsener ; Männer
    Language English
    Size 94 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT014121157
    ISBN 0-444-51684-0 ; 978-0-444-51684-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2004 A 3539 order for loan Magazin

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  10. Article ; Online: OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: The impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization.

    Aitken, R John / Bromfield, Elizabeth G / Gibb, Zamira

    Reproduction (Cambridge, England)

    2022  Volume 164, Issue 6, Page(s) F79–F94

    Abstract: In brief: Many aspects of the reproductive process are impacted by oxidative stress. This article summarizes the chemical nature of reactive oxygen species and their role in both the physiological regulation of reproductive processes and the ... ...

    Abstract In brief: Many aspects of the reproductive process are impacted by oxidative stress. This article summarizes the chemical nature of reactive oxygen species and their role in both the physiological regulation of reproductive processes and the pathophysiology of infertility.
    Abstract: This article lays out the fundamental principles of oxidative stress. It describes the nature of reactive oxygen species (ROS), the way in which these potentially toxic metabolites interact with cells and how they impact both cellular function and genetic integrity. The mechanisms by which ROS generation is enhanced to the point that the cells' antioxidant defence mechanisms are overwhelmed are also reviewed taking examples from both the male and female reproductive system, with a focus on gametogenesis and fertilization. The important role of external factors in exacerbating oxidative stress and impairing reproductive competence is also examined in terms of their ability to disrupt the physiological redox regulation of reproductive processes. Developing diagnostic and therapeutic strategies to cope with oxidative stress within the reproductive system will depend on the development of a deeper understanding of the nature, source, magnitude, and location of such stress in order to fashion personalized treatments that meet a given patient's clinical needs.
    MeSH term(s) Male ; Female ; Humans ; Reactive Oxygen Species/metabolism ; Antioxidants/metabolism ; Oxidative Stress/physiology ; Reproduction ; Gametogenesis ; Fertilization
    Chemical Substances Reactive Oxygen Species ; Antioxidants
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-22-0126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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