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Article ; Online: À quand la lumière au bout du tunnel ?

Behar-Cohen, Francine

2020 Volume 36, Issue 6-7, Page(s) 592–593

Title translation	Foreword - When we will see the light at the end of the tunnel?
MeSH term(s)	Causality ; Disease Susceptibility/epidemiology ; Genetic Therapy/methods ; Genetic Therapy/trends ; History, 20th Century ; History, 21st Century ; Humans ; Macular Degeneration/complications ; Macular Degeneration/epidemiology ; Macular Degeneration/therapy ; Myopia/epidemiology ; Myopia/etiology ; Ophthalmology/history ; Ophthalmology/methods ; Ophthalmology/trends ; Retina/pathology ; Retina/physiology ; Risk Factors ; Therapies, Investigational/methods ; Therapies, Investigational/trends ; Vision Disorders/epidemiology ; Vision Disorders/etiology ; Vision Disorders/pathology ; Vision Disorders/therapy
Language	French
Publishing date	2020-07-02
Publishing country	France
Document type	Historical Article ; Introductory Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2020093
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Article ; Online: Menura

E. Behar / S. Fatemi / P. Henri / M. Holmström

Annales Geophysicae, Vol 40, Pp 281-

a code for simulating the interaction between a turbulent solar wind and solar system bodies

2022 Volume 297

Abstract: Despite the close relationship between planetary science and plasma physics, few advanced numerical tools allow bridging the two topics. The code Menura proposes a breakthrough towards the self-consistent modelling of these overlapping fields, in a novel ...

Abstract	Despite the close relationship between planetary science and plasma physics, few advanced numerical tools allow bridging the two topics. The code Menura proposes a breakthrough towards the self-consistent modelling of these overlapping fields, in a novel two-step approach allowing for the global simulation of the interaction between a fully turbulent solar wind and various bodies of the solar system. This article introduces the new code and its two-step global algorithm, illustrated by a first example: the interaction between a turbulent solar wind and a comet.
Keywords	Science ; Q ; Physics ; QC1-999 ; Geophysics. Cosmic physics ; QC801-809
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of Structures Labeled by Indocyanine Green in the Rat Choroid and Retina Can Guide Interpretation of Indocyanine Green Angiography.

Mejlachowicz, Dan / Lassiaz, Patricia / Zola, Marta / Leclercq, Bastien / Gélizé, Emmanuelle / Achiedo, Seiki / Zhao, Min / Rousseau, Antoine / Behar-Cohen, Francine

Investigative ophthalmology & visual science

2024 Volume 65, Issue 1, Page(s) 25

Abstract: Purpose: Indocyanine green (ICG) is an albumin and lipoprotein binding dye absorbing in the far red used in angiography to visualize choroidal vessels (ICG angiography [ICGA]). To guide interpretation, ICG transport in the choroid, RPE, and retina of ... ...

Abstract	Purpose: Indocyanine green (ICG) is an albumin and lipoprotein binding dye absorbing in the far red used in angiography to visualize choroidal vessels (ICG angiography [ICGA]). To guide interpretation, ICG transport in the choroid, RPE, and retina of rats was studied. Methods: Two conditions were used: RPE/choroid organoculture, incubated for 45 minutes in DMEM medium, 1% fetal bovine serum containing 0.25 mg/mL ICG and RPE/choroid and neural retina flat-mounts at 1 and 6 hours after intravenous ICG injection. Early and late sequences of ICGA were recorded until 6 hours. Ultra-deep red confocal microscope was used to localize ICG in flat-mounts and immunohistochemistry was performed for caveolin-1, tryptase (mast cell marker), and tubulin β3 (a nerve marker). Results: In the organoculture, ICG penetrated homogeneously in the cytoplasm and stained the membranes of the RPE. At 1 hour after intravenous injection, ICG appeared in fine granules in RPE, partly labeled with caveolin-1 and decreasing at 6 hours. At 1 hour and 6 hours, ICG was found in the retinal vessels, faintly in the inner retina, and in the photoreceptor outer segments at 6 hours. In the choroid, ICG colocalized with mast cells, immunostained with tryptase, and accumulated along the large tubulin β3-labeled nerve bundles. The hypothesis was raised on the interpretation of late ICGA infrared photography in case of transthyretin amyloidosis with neuropathy. Conclusions: Beside being a vascular dye, ICG is transported from the vessels to the RPE toward the outer retina. It stains mast cells and large choroidal nerves. These observations could help the analysis of ICGA images.
MeSH term(s)	Animals ; Rats ; Indocyanine Green ; Caveolin 1 ; Tryptases ; Tubulin ; Angiography ; Retina/diagnostic imaging ; Choroid ; Amyloid Neuropathies, Familial
Chemical Substances	Indocyanine Green (IX6J1063HV) ; Caveolin 1 ; Tryptases (EC 3.4.21.59) ; Tubulin
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.65.1.25
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Article ; Online: Tris(1,3-dichloro-2-propyl) phosphate disrupts cellular metabolism within human embryonic kidney (HEK293) cells.

Avila-Barnard, Sarah / Ha, Megan / Nemarugommula, Charvita / Wiegand, Jenna L / Ke, Haiyan / De Souza, Amancio / Behar, Rachel / Volz, David C

Journal of hazardous materials

2024 Volume 466, Page(s) 133660

Abstract: Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used, additive flame retardant that migrates from end-use products, leading to ubiquitous exposure of humans around the world. However, little is known about whether TDCIPP disrupts the ... ...

Abstract	Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used, additive flame retardant that migrates from end-use products, leading to ubiquitous exposure of humans around the world. However, little is known about whether TDCIPP disrupts the physiology of human embryonic cells. Therefore, the objective of this study was to determine whether TDCIPP alters cell viability, cellular metabolism, cytosine methylation, and reactive oxygen species (ROS) levels within human embryonic kidney (HEK293) cells. Relative to vehicle controls, TDCIPP (0.015-0.1225 µM) resulted in a concentration-dependent increase in cell viability, a finding that was driven by an increase in relative ATP abundance. Interestingly, TDCIPP (0.061-0.98 µM) increased the rate of glycolysis - an adaptive mechanism consistent with the Warburg effect exhibited by tumorigenic cells. Moreover, relative to vehicle-treated cells, TDCIPP (0.245-15.63 µM) exposure for 48 h (but not 24 h) resulted in a significant, concentration-dependent decrease in ROS in situ, and TDCIPP (0.245 µM) exposure significantly increased carnosine within the histidine metabolism pathway. However, TDCIPP did not affect global 5-methylcytosine (5-mC) methylation (0.015-15.63 µM), cell membrane integrity (0.061-0.98 µM), nor the abundance of mitochondria (0.061-1.95 µM). Overall, our findings with TDCIPP point to a novel mechanism of action that may be relevant to human embryonic stem cells.
MeSH term(s)	Humans ; Phosphates ; Organophosphorus Compounds ; HEK293 Cells ; Reactive Oxygen Species/metabolism ; Organophosphates ; Flame Retardants ; Kidney/metabolism
Chemical Substances	tris(1,3-dichloroisopropyl) phosphate ; Phosphates ; Organophosphorus Compounds ; Reactive Oxygen Species ; Organophosphates ; Flame Retardants
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133660
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Article: Leadless Pacing: Therapy, Challenges and Novelties.

Wijesuriya, Nadeev / De Vere, Felicity / Mehta, Vishal / Niederer, Steven / Rinaldi, Christopher A / Behar, Jonathan M

Arrhythmia & electrophysiology review

2023 Volume 12, Page(s) e09

Abstract: Leadless pacing is a rapidly growing field. Initially designed to provide right ventricular pacing for those who were contraindicated for conventional devices, the technology is growing to explore the potential benefit of avoiding long-term transvenous ... ...

Abstract	Leadless pacing is a rapidly growing field. Initially designed to provide right ventricular pacing for those who were contraindicated for conventional devices, the technology is growing to explore the potential benefit of avoiding long-term transvenous leads in any patient who requires pacing. In this review, we first examine the safety and performance of leadless pacing devices. We then review the evidence for their use in special populations, such as patients with high risk of device infection, patients on haemodialysis, and patients with vasovagal syncope who represent a younger population who may wish to avoid transvenous pacing. We also summarise the evidence for leadless cardiac resynchronisation therapy and conduction system pacing and discuss the challenges of managing issues, such as system revisions, end of battery life and extractions. Finally, we discuss future directions in the field, such as completely leadless cardiac resynchronisation therapy-defibrillator devices and whether leadless pacing has the potential to become a first-line therapy in the near future.
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2813970-7
ISSN	2050-3377 ; 2050-3369
ISSN (online)	2050-3377
ISSN	2050-3369
DOI	10.15420/aer.2022.41
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Article ; Online: First use of a rotating mechanical dilator sheath to extract an epicardial defibrillator lead from the pericardial space.

Mehta, Vishal S / Elliott, Mark K / Regan, William / Behar, Jonathan M / Rosenthal, Eric / Rinaldi, Christopher A

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2022 Volume 24, Issue 11, Page(s) 1833

MeSH term(s)	Humans ; Pacemaker, Artificial ; Defibrillators, Implantable ; Pericardium
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euac060
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Article ; Online: Assessing collaboration among team scientists within a triadic research center partnership.

Behar-Horenstein, Linda S / Richey, Joyce M / Smith, Ukamaka Diké

Qualitative research in medicine & healthcare

2021 Volume 5, Issue 2, Page(s) 9724

Abstract: Few studies have utilized qualitative methods to assess the perceived effectiveness of collaboration among research center interdisciplinary team scientists. Stages of team development served as the theoretical framework to characterize minority serving ... ...

Abstract	Few studies have utilized qualitative methods to assess the perceived effectiveness of collaboration among research center interdisciplinary team scientists. Stages of team development served as the theoretical framework to characterize minority serving institution (MSI) and predominantly White institutions (PWI) participants' challenges and successes during a National Institutes of Health (NIH) sponsored cancer health disparities training and research program. We present the finding of an inductive analysis of four open-ended survey questions across two years. Fostering an awareness of the inherently taxing, yet centrality of group (team) development may advance an understanding of team dynamics and lead to increased team cohesion and productivity. In conclusion, we provide recommendations to assist multiple principal investigators who embark on team development.
Language	English
Publishing date	2021-10-05
Publishing country	Italy
Document type	Journal Article
ISSN	2532-2044
ISSN (online)	2532-2044
DOI	10.4081/qrmh.2021.9724
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Article ; Online: Affect variability and emotional reactivity in generalized anxiety disorder.

Ranney, Rachel M / Behar, Evelyn / Yamasaki, Alissa S

Journal of behavior therapy and experimental psychiatry

2019 Volume 68, Page(s) 101542

Abstract: Background and objectives: Research indicates that greater variability in affect and emotion over time is associated with depression and anxiety. However, it remains unclear whether individuals with generalized anxiety disorder (GAD) experience greater ... ...

Abstract	Background and objectives: Research indicates that greater variability in affect and emotion over time is associated with depression and anxiety. However, it remains unclear whether individuals with generalized anxiety disorder (GAD) experience greater affect variability due to individual differences or differences in the stimuli they encounter. The current study investigated whether individuals with analogue GAD demonstrate greater affect variability in response to a standardized set of stimuli. Methods: Participants were 134 (95 female) undergraduate participants with analogue GAD (endorsing DSM-IV criteria A, B, C, and E on the GAD-Q-IV; n = 66) or with no symptoms of GAD (n = 68). Participants reported affective reactions (positive affect, negative affect, affective arousal, and affective dominance) to each of nine sets of standardized images varying in valence (positive, neutral, or negative) and arousal (low, medium, or high). Results: In a logistic regression model controlling for baseline measurements, higher variability of affective arousal across the nine sets of images uniquely predicted analogue GAD status, whereas variability in positive affect, negative affect, and affective dominance did not. Additional analyses revealed that lower mean affective arousal also uniquely predicted analogue GAD. Limitations: Limitations include using self-report measures to determine analogue GAD status; using a short laboratory session for the assessment of affect variability; and potential repeated testing effects. Conclusions: These findings suggest that individuals with GAD symptoms experience higher levels of affective arousal variability, even when the stimuli presented are held constant. Assessing variability in affective arousal may be helpful in both conceptualizing and treating individuals with GAD symptoms.
MeSH term(s)	Affect ; Anxiety Disorders/psychology ; Arousal ; Diagnostic and Statistical Manual of Mental Disorders ; Emotions ; Female ; Humans ; Individuality ; Male ; Self Report ; Young Adult
Language	English
Publishing date	2019-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	280250-8
ISSN	1873-7943 ; 0005-7916
ISSN (online)	1873-7943
ISSN	0005-7916
DOI	10.1016/j.jbtep.2019.101542
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Article ; Conference proceedings: Evaluation of the Feasibility of a Cardiorespiratory Screening Protocol in the Thoroughbred Racehorse

Batten, C. / Maas, L. T. / Lehman, M. / Dupois-Dowd, F. / Buecken, W. / Gentille, S. / Scott, F. / Webb, R. / Behar, J. / Hopkins, S. / de Solis, C. Navas / Morgan, J. M.

VCOT Open

2024 Volume 07, Issue S 01

Event/congress	2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions, Arthrex Campus, Naples, Florida, United States, 2024-04-11
Language	English
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2934191-7
ISSN	2625-2325 ; 2625-2325
ISSN (online)	2625-2325
ISSN	2625-2325
DOI	10.1055/s-0044-1786223
Database	Thieme publisher's database

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Article ; Online: Takotsubo syndrome and complete heart block, which came first? A case report.

Nadeem, Mohammad Khurram / Walsh, Jason Leo / Davies, Simon / Behar, Jonathan M

European heart journal. Case reports

2021 Volume 6, Issue 1, Page(s) ytab500

Abstract: Background: In 2018, the European Society of Cardiology published two consensus documents on takotsubo syndrome (TTS), which include the current consensus on nomenclature, diagnosis, management, and complications. However, little is mentioned on the ... ...

Abstract	Background: In 2018, the European Society of Cardiology published two consensus documents on takotsubo syndrome (TTS), which include the current consensus on nomenclature, diagnosis, management, and complications. However, little is mentioned on the association with complete heart block (CHB), except that 'AV block [occurs in] 2.9% of cases'. Complete heart block is a recognized rare association of TTS, but causation is often unclear. Does CHB trigger TTS or vice-versa? Here, we present a case of TTS associated with CHB. Case summary: An 89-year-old woman presented with a transient loss of consciousness, acute chest pain, and dyspnoea. A few days prior to this her daughter died suddenly of a myocardial infarction. On presentation, troponin levels were elevated, the electrocardiogram showed CHB with a broad QRS and an echo showed apical akinesis and ballooning. Angiographic investigation excluded significant coronary artery disease. A dual-chamber pacemaker was implanted after a brief period of temporary pacing. Ventricular function normalized during follow-up and her underlying rhythm remained CHB. Discussion: Takotsubo syndrome may be triggered by both emotional and physical stressors. Complete heart block is recognized association, but causation is often unclear. In our case, a clear emotional trigger was identified suggesting the TTS may have precipitated CHB not vice versa.
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytab500
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