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  1. Article ; Online: Nanomaterials as protein mimics or nanologicals.

    Fadeel, Bengt

    Nanomedicine (London, England)

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2024-0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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  2. Book: Handbook of safety assessment of nanomaterials

    Fadeel, Bengt

    from toxicological testing to personalized medicine

    (Pan Stanford series on biomedical nanotechnology ; 5)

    2015  

    Series title Pan Stanford series on biomedical nanotechnology ; 5
    Collection
    Language English
    Size XV, 542 S. : Ill., graph. Darst., Kt.
    Publisher Pan Stanford Publ
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT017812548
    ISBN 978-981-4463-36-2 ; 9789814463379 ; 981-4463-36-1 ; 981446337X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 370 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Nanomaterial characterization: Understanding nano-bio interactions.

    Fadeel, Bengt

    Biochemical and biophysical research communications

    2022  Volume 633, Page(s) 45–51

    Abstract: Nanomaterials are marvelously small, yet they may be harnessed to great effect. Much has been learned with respect to the biological interactions and effects of nanomaterials during the past decade. However, characterization of nanomaterials is typically ...

    Abstract Nanomaterials are marvelously small, yet they may be harnessed to great effect. Much has been learned with respect to the biological interactions and effects of nanomaterials during the past decade. However, characterization of nanomaterials is typically performed on as-synthesized materials. We posit that nanomaterials are dynamic entities and should be studied and regulated as such. Hence, characterization of nanomaterials should take into account their biotransformation. However, in situ characterization of nanomaterials as they undergo dynamic changes (coronation, dissolution, degradation) in a living system remains a formidable challenge in nanosafety. Material scientists and toxicologists need to join forces to address this issue.
    MeSH term(s) Nanostructures/toxicity
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.08.095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  4. Article ; Online: Understanding the immunological interactions of engineered nanomaterials: Role of the bio-corona.

    Fadeel, Bengt

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2022  Volume 14, Issue 6, Page(s) e1798

    Abstract: Engineered nanomaterials are a broad class of materials with the potential for breakthrough applications in many sectors of society not least in medicine. Consequently, safety assessment of nanomaterials and nano-enabled products with respect to human ... ...

    Abstract Engineered nanomaterials are a broad class of materials with the potential for breakthrough applications in many sectors of society not least in medicine. Consequently, safety assessment of nanomaterials and nano-enabled products with respect to human health and the environment is of key importance. To this end, the biological interactions of nanoscale materials must be understood. Here, the dual "identities" of nanomaterials, namely, the material-intrinsic properties or synthetic identity and the acquired, context-dependent properties or biological identity, are discussed in relation to nanomaterial interactions with the immune system, our main defense against foreign intrusion. Specifically, we address whether macrophages and other innate immune cells respond to the synthetic identity or the biological identity of nanomaterials, that is, the surface adsorbed proteins and/or other biomolecules known as the bio-corona, or both? This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.
    MeSH term(s) Humans ; Nanostructures/toxicity ; Nanomedicine/methods ; Macrophages
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HAX-1 expression in human B lymphoma.

    Kwiecinska, A / Ottosson-Wadlund, A / Ceder, R / Grafström, R C / Björck, E / Nordenskjöld, M / Porwit, A / Fadeel, B

    Leukemia

    2011  Volume 25, Issue 5, Page(s) 868–872

    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Immunoenzyme Techniques ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances Adaptor Proteins, Signal Transducing ; HAX1 protein, human ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/leu.2010.321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2295: Show issues Location:
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  6. Article ; Online: Preconcentration and ultrasensitive spectrophotometric estimation of tungsten in soils using polyurethane foam in the presence of rhodamine B

    Hamed M. Al-Saidi / Mohammed A. Abdel-Fadeel / Salman S. Alharthi

    Journal of Saudi Chemical Society, Vol 25, Iss 8, Pp 101301- (2021)

    Kinetic and thermodynamic studies, and designing a simple automated preconcentration system

    2021  

    Abstract: This work describes designing and using a simple automated preconcentration system for estimation of tungsten in soil spectrophotometrically. The preconcentration of tungsten is based upon the retention of ion associate of [RB+.HWO4-] inside a minicolumn ...

    Abstract This work describes designing and using a simple automated preconcentration system for estimation of tungsten in soil spectrophotometrically. The preconcentration of tungsten is based upon the retention of ion associate of [RB+.HWO4-] inside a minicolumn packed with polyurethane foam. The retained ion associate is then automatically and quantitatively eluted by acetone. The tungsten concentration was estimated by measuring the absorbance of elution at 584 nm. The absorbance of elution follows Beer's law in concentration range of 0.5–100 µgL−1 with a detection limit of 0.09 µgL−1. The enhancement factor and relative standard deviation of proposed methodology were 50 and 1.7%, respectively. The system developed in this research is characterized by its low cost and high efficiency, as it uses low-cost PUF as a stationary phase and a few number of pumps and valves. On the other hand, the designed system can be used, in the future, with many detection techniques easily. The composition of the ion association formed between W(VI) ions and RB was calculated by continuous variation method (Job plot) to be 1:1 (W6+:RB). On the other hand, the ion associate in its solid state was synthesized and characterized using elemental analysis and ATR–FTIR technique. The retention of tungsten (VI) ions in the form of [RB+.HWO4-] ion association on the surface of PUFs was confirmed by SEM images and XRF spectra. Moreover, the kinetic and thermodynamic behaviors of the retention of [RB+.HWO4-] on the polyurethane foams were studied in detail. The kinetic models revealed that the retention of [RB+.HWO4-] on PUF surface obeys the pseudo-second-order reaction. The thermodynamic investigations confirmed that the adsorption of [RB+.HWO4-] on PUF surface was spontaneous at 298 K and the interaction between [RB+.HWO4-] and active sites available on PUF surface was physical and electrostatic in nature.
    Keywords Rhodamine B ; Tungsten ; Automated preconcentration ; Untreated polyurethane ; Soil samples ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Nanomedicine: towards innovative solutions in the clinic.

    Fadeel, B

    Journal of internal medicine

    2021  Volume 290, Issue 3, Page(s) 746–748

    MeSH term(s) Humans ; Nanomedicine/trends
    Language English
    Publishing date 2021-02-06
    Publishing country England
    Document type Editorial
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.44: Show issues Location:
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  8. Article ; Online: Proapoptotic effects of the novel proteasome inhibitor b-AP15 on multiple myeloma cells and natural killer cells.

    Feng, Xiaoli / Holmlund, Teresa / Zheng, Chengyun / Fadeel, Bengt

    Experimental hematology

    2014  Volume 42, Issue 3, Page(s) 172–182

    Abstract: The small molecule b-AP15 is a novel inhibitor of proteasome deubiquitination. Recent studies have ... shown that b-AP15 displays antitumor activity in several preclinical, solid tumor models. In this study ... we show that b-AP15 triggers time- and dose-dependent apoptosis of the human multiple myeloma (MM ...

    Abstract The small molecule b-AP15 is a novel inhibitor of proteasome deubiquitination. Recent studies have shown that b-AP15 displays antitumor activity in several preclinical, solid tumor models. In this study, we show that b-AP15 triggers time- and dose-dependent apoptosis of the human multiple myeloma (MM) cell lines RPMI8226 and U266, as determined by phosphatidylserine exposure. Apoptosis was dependent on caspase activation and was partially dependent on cathepsin D. Furthermore, b-AP15 triggered processing of pro-caspase-3 and cleavage of poly (ADP-ribose) polymerase in MM cells. b-AP15 also induced caspase-independent apoptosis in primary human natural killer cells. We also demonstrate that b-AP15 induces activation of the mitochondrial apoptosis pathway in MM cells, with activation of the proapoptotic protein Bax and a pronounced loss of the mitochondrial transmembrane potential. The latter events, however, appeared largely independent of caspase activation. Our data suggest that proteasome deubiquitinase inhibitors may have potential for treatment of multiple myeloma patients.
    MeSH term(s) Adult ; Apoptosis/drug effects ; Blotting, Western ; Caspase 3/metabolism ; Cathepsin D/metabolism ; Cell Line, Tumor ; Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Flow Cytometry ; Humans ; Killer Cells, Natural/cytology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/physiology ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Phosphatidylserines/metabolism ; Piperidones/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Protease Inhibitors/pharmacology ; Time Factors ; bcl-2-Associated X Protein/metabolism
    Chemical Substances 3,5-bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one ; Phosphatidylserines ; Piperidones ; Protease Inhibitors ; bcl-2-Associated X Protein ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspase 3 (EC 3.4.22.-) ; Cathepsin D (EC 3.4.23.5)
    Language English
    Publishing date 2014-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2013.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 922: Show issues Location:
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  9. Article ; Online: Nanosafety: a Perspective on Nano-Bio Interactions.

    Fadeel, Bengt / Keller, Arturo A

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2310540

    Abstract: Engineered nanomaterials offer numerous benefits to society ranging from environmental remediation to biomedical applications such as drug or vaccine delivery as well as clean and cost-effective energy production and storage, and the promise of a more ... ...

    Abstract Engineered nanomaterials offer numerous benefits to society ranging from environmental remediation to biomedical applications such as drug or vaccine delivery as well as clean and cost-effective energy production and storage, and the promise of a more sustainable way of life. However, as nanomaterials of increasing sophistication enter the market, close attention to potential adverse effects on human health and the environment is needed. Here a critical perspective on nanotoxicological research is provided; the authors argue that it is time to leverage the knowledge regarding the biological interactions of nanomaterials to achieve a more comprehensive understanding of the human health and environmental impacts of these materials. Moreover, it is posited that nanomaterials behave like biological entities and that they should be regulated as such.
    Language English
    Publishing date 2024-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202310540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tribute to Jan-Inge Henter, the Paediatrician-Scientist.

    Fadeel, Bengt

    Acta paediatrica (Oslo, Norway : 1992)

    2021  Volume 110, Issue 10, Page(s) 2673–2674

    Language English
    Publishing date 2021-08-11
    Publishing country Norway
    Document type Editorial
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16020
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