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  1. Book ; Thesis: Extrazelluläre Adeninnukleotide

    Haunstetter, Armin

    Untersuchungen zum Katabolismus und zur Effektorfunktion an Peritonealmakrophagen und leukämischen Zellen

    1994  

    Author's details vorgelegt von Armin Haunstetter
    Language German
    Size 63 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1994
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT006357095
    Database Catalogue ZB MED Medicine, Health

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    1994 MB 841 order for loan Magazin

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  2. Article ; Online: Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice.

    Schmid, Anna Marlene / Razim, Agnieszka / Wysmołek, Magdalena / Kerekes, Daniela / Haunstetter, Melissa / Kohl, Paul / Brazhnikov, Georgii / Geissler, Nora / Thaler, Michael / Krčmářová, Eliška / Šindelář, Martin / Weinmayer, Tamara / Hrdý, Jiří / Schmidt, Katy / Nejsum, Peter / Whitehead, Bradley / Palmfeldt, Johan / Schild, Stefan / Inić-Kanada, Aleksandra /
    Wiedermann, Ursula / Schabussova, Irma

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 349

    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01405-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice.

    Schmid, Anna Marlene / Razim, Agnieszka / Wysmołek, Magdalena / Kerekes, Daniela / Haunstetter, Melissa / Kohl, Paul / Brazhnikov, Georgii / Geissler, Nora / Thaler, Michael / Krčmářová, Eliška / Šindelář, Martin / Weinmayer, Tamara / Hrdý, Jiří / Schmidt, Katy / Nejsum, Peter / Whitehead, Bradley / Palmfeldt, Johan / Schild, Stefan / Inić-Kanada, Aleksandra /
    Wiedermann, Ursula / Schabussova, Irma

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 297

    Abstract: Background: E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offers a non-invasive and ... ...

    Abstract Background: E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offers a non-invasive and convenient delivery method. This route bypasses the gastrointestinal tract and provides direct access to the airways, which are the target of asthma prevention. G- bacteria such as E. coli O83 release outer membrane vesicles (OMVs) to communicate with the environment. Here we investigate whether intranasally administered E. coli O83 OMVs (EcO83-OMVs) can reduce allergic airway inflammation in mice.
    Methods: EcO83-OMVs were isolated by ultracentrifugation and characterised their number, morphology (shape and size), composition (proteins and lipopolysaccharide; LPS), recognition by innate receptors (using transfected HEK293 cells) and immunomodulatory potential (in naïve splenocytes and bone marrow-derived dendritic cells; BMDCs). Their allergy-preventive effect was investigated in a mouse model of ovalbumin-induced allergic airway inflammation.
    Results: EcO83-OMVs are spherical nanoparticles with a size of about 110 nm. They contain LPS and protein cargo. We identified a total of 1120 proteins, 136 of which were enriched in OMVs compared to parent bacteria. Proteins from the flagellum dominated. OMVs activated the pattern recognition receptors TLR2/4/5 as well as NOD1 and NOD2. EcO83-OMVs induced the production of pro- and anti-inflammatory cytokines in splenocytes and BMDCs. Intranasal administration of EcO83-OMVs inhibited airway hyperresponsiveness, and decreased airway eosinophilia, Th2 cytokine production and mucus secretion.
    Conclusions: We demonstrate for the first time that intranasally administered OMVs from probiotic G- bacteria have an anti-allergic effect. Our study highlights the advantages of OMVs as a safe platform for the prophylactic treatment of allergy. Video Abstract.
    MeSH term(s) Humans ; Animals ; Mice ; Escherichia coli ; Lipopolysaccharides ; HEK293 Cells ; Hypersensitivity/prevention & control ; Hypersensitivity/metabolism ; Immunity, Innate ; Asthma/metabolism ; Inflammation/metabolism ; Extracellular Vesicles/metabolism ; Probiotics/pharmacology
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01329-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Extrazelluläre Adeninnukleotide

    Haunstetter, Armin

    Untersuchungen zum Katabolismus und zur Effektorfunktion an Peritonealmakrophagen und leukämischen Zellen

    1994  

    Author's details Armin Haunstetter
    Language Undetermined
    Size 63 Bl, graph. Darst
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Erlangen, Nürnberg, Univ., Diss. : 1994
    Note Mikrofiche-Ausg.: 1994. 1 Mikrofiche : 24x
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Toward antiapoptosis as a new treatment modality.

    Haunstetter, A / Izumo, S

    Circulation research

    2000  Volume 86, Issue 4, Page(s) 371–376

    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Cardiomyopathies/drug therapy ; Cardiomyopathies/physiopathology ; Humans ; Signal Transduction/physiology
    Language English
    Publishing date 2000-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/01.res.86.4.371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Future perspectives and potential implications of cardiac myocyte apoptosis.

    Haunstetter, A / Izumo, S

    Cardiovascular research

    2000  Volume 45, Issue 3, Page(s) 795–801

    Abstract: Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been detected in different cardiac disease states such as ischemic heart ... ...

    Abstract Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been detected in different cardiac disease states such as ischemic heart disease and congestive heart failure. In addition, some evidence for the molecular mechanisms in cardiac myocyte apoptosis has been evolving, although at present the implications thereof for clinical cardiac disease are not known in most of the cases. Based on these new insights, it is the intention of this article to highlight some topics in apoptosis research that might be of particular interest to define the future role and potentials of new therapeutic approaches aimed at preventing myocyte apoptosis.
    MeSH term(s) Animals ; Apoptosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cell Cycle ; Heart/physiology ; Heart/physiopathology ; Humans ; Mitochondria, Heart/metabolism ; Receptors, Tumor Necrosis Factor/metabolism ; Research
    Chemical Substances Receptors, Tumor Necrosis Factor
    Language English
    Publishing date 2000-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1016/s0008-6363(99)00264-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  7. Article: Apoptosis: basic mechanisms and implications for cardiovascular disease.

    Haunstetter, A / Izumo, S

    Circulation research

    1998  Volume 82, Issue 11, Page(s) 1111–1129

    MeSH term(s) Animals ; Apoptosis/physiology ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/physiopathology ; Humans ; Muscle Fibers, Skeletal/chemistry ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/enzymology ; Myocardium/chemistry ; Myocardium/cytology ; Myocardium/enzymology
    Language English
    Publishing date 1998-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/01.res.82.11.1111
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  8. Article ; Online: Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion.

    Kristen, Arnt V / Ackermann, Katrin / Buss, Sebastian / Lehmann, Lorenz / Schnabel, Philipp A / Haunstetter, Armin / Katus, Hugo A / Hardt, Stefan E

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2013  Volume 22, Issue 4, Page(s) 280–286

    Abstract: Summary: The detailed molecular mechanisms following activation of apoptosis in ischemia-reperfusion injury are unknown. This study using different transgenic mouse models provided first evidence that apoptosis in myocardial ischemia-reperfusion injury ... ...

    Abstract Summary: The detailed molecular mechanisms following activation of apoptosis in ischemia-reperfusion injury are unknown. This study using different transgenic mouse models provided first evidence that apoptosis in myocardial ischemia-reperfusion injury is rather linked to the mitochondrial pathway than to death receptor pathway.
    Introduction: There is a wealth of evidence for activation of apoptosis in ischemia-reperfusion injury. However, the understanding of detailed molecular mechanism is lacking.
    Methods: The extent of myocardial infarction after ligation of the left anterior descending artery in mice carrying different transgenes for inhibition of either the intrinsic or the extrinsic or a combination of both apoptotic cascades was evaluated. The extent of myocardial damage was assessed by echocardiographic determination of left ventricular (LV) ejection fraction, LV hemodynamics, troponin T, and histology. The rate of apoptosis was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 staining.
    Results: Highest perioperative rate of death was observed in the dominant-negative form of a truncated Fas-associated death domain (FADD-DN) group. Infarction size by 2,3,5-triphenyltetrazolium chloride (TTC) staining was smaller in the Bcl-2, but not in the other groups as compared to wild-type mice. This was accompanied by lower troponin T values in Bcl-2 transgenic mice as compared to the all other groups. Troponin T correlated well with macroscopic extent of myocardial infarction by TTC staining. A lower decline of LV ejection fraction was seen in the Bcl-2 as compared to wild-type or FADD-DN mice. A smaller number of TUNEL- and caspase-3-positive myocyte nuclei were observed in the Bcl-2 and FADD-DN group as compared to wild-type mice.
    Conclusions: We provide first evidence for protective effects on the myocardium in a transgenic mouse model of myocardial ischemia-reperfusion due to inhibition of the Bcl-2, but not the FADD pathway despite that reduced apoptotic cells were observed in both groups as compared to wild-type mice.
    MeSH term(s) Animals ; Apoptosis/genetics ; Caspase 3/metabolism ; Disease Models, Animal ; Fas-Associated Death Domain Protein/genetics ; Fas-Associated Death Domain Protein/metabolism ; Hemodynamics ; Mice ; Mice, Transgenic ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Myocardial Infarction/genetics ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardium/metabolism ; Myocardium/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Stroke Volume ; Troponin T/metabolism ; Ventricular Function, Left
    Chemical Substances Fas-Associated Death Domain Protein ; Proto-Oncogene Proteins c-bcl-2 ; Troponin T ; Casp3 protein, mouse (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2013.01.004
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    Zs.A 3572: Show issues Location:
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  9. Article: How do obstetric providers discuss referrals for prenatal genetic counseling?

    Bernhardt, Barbara A / Haunstetter, Carrie Mastromarino / Roter, Debra / Geller, Gail

    Journal of genetic counseling

    2005  Volume 14, Issue 2, Page(s) 109–117

    Abstract: To investigate referrals of pregnant women to genetic counseling, we analysed transcripts from audiotaped first prenatal visits of 104 patients (72 actual patient visits and 32 simulated patient visits) with 32 providers (obstetricians and nurse-midwives) ...

    Abstract To investigate referrals of pregnant women to genetic counseling, we analysed transcripts from audiotaped first prenatal visits of 104 patients (72 actual patient visits and 32 simulated patient visits) with 32 providers (obstetricians and nurse-midwives). All patients had at least one indication for referral. Only 10% of visits with actual patients included a genetic counseling referral. When genetic counseling was discussed, it was only briefly described, primarily as an information session. This study shows that the majority of pregnant women with an indication for referral for genetic counseling are not referred. In addition, obstetric providers' inadequate descriptions of prenatal genetic counseling may result in women being poorly prepared for genetic counseling sessions.
    MeSH term(s) Adult ; Communication ; Female ; Genetic Counseling ; Humans ; Middle Aged ; Obstetrics ; Physician-Patient Relations ; Pregnancy ; Prenatal Care ; Prenatal Diagnosis ; Referral and Consultation
    Language English
    Publishing date 2005-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1117799-8
    ISSN 1059-7700
    ISSN 1059-7700
    DOI 10.1007/s10897-005-4064-0
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    Zs.A 4263: Show issues Location:
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  10. Article: Images in cardiology. Cardiac sarcoidosis.

    Zimmermann, R / Haunstetter, A / Kübler, W

    Heart (British Cardiac Society)

    1997  Volume 78, Issue 1, Page(s) 6

    MeSH term(s) Adult ; Cardiomyopathies/diagnostic imaging ; Fatal Outcome ; Humans ; Male ; Sarcoidosis/diagnostic imaging ; Thallium Radioisotopes ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Thallium Radioisotopes
    Language English
    Publishing date 1997-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/hrt.78.1.6
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