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  1. Article ; Online: Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction.

    Undi, Ram Babu / Sarvothaman, Shilpa / Narasaiah, Kovuru / Gutti, Usha / Gutti, Ravi Kumar

    Cytokine

    2016  Volume 83, Page(s) 245–249

    Abstract: TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines ... ...

    Abstract TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines participate including interleukins, IL6 and IL12. Interestingly, TLR2 is expressed on megakaryocytes (MKs) and platelets, which is crucial for immune mediated platelet activation. The role of TLR2 on MKs is not completely understood. We observed TLR2 induction leads to MK maturation and is involved in production of ROS which is essential for MK development. In Dami cells, TLR2 up-regulation causes increase in the cytokine production, particularly IL-6, which has been shown to stimulate CFU formation and CD41 expression. Additionally, TLR2 ligand induces wnt β-catenin signalling pathway components suggesting a cross talk between wnt and TLR pathway leading to maturation of MKs. This study shows TLR2 signalling induce cytokine production and regulate wnt signalling thereby cause maturation of MKs.
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2016.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Apoptosis: role in myeloid cell development.

    Sarvothaman, Shilpa / Undi, Ram Babu / Pasupuleti, Satya Ratan / Gutti, Usha / Gutti, Ravi Kumar

    Blood research

    2015  Volume 50, Issue 2, Page(s) 73–79

    Abstract: Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The self-renewing ability ensures that these ... ...

    Abstract Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The self-renewing ability ensures that these pluripotent cells are not depleted from the bone marrow niche. A proper balance between cell death and cell survival is necessary to maintain a homeostatic condition, hence, apoptosis, or programmed cell death, is an essential step in hematopoiesis. Recent studies, however, have introduced a new aspect to this process, citing the significance of the apoptosis mediator, caspase, in cell development and differentiation. Extensive research has been carried out to study the possible role of caspases and other apoptosis related factors in the developmental processes. This review focuses on the various apoptotic factors involved in the development and differentiation of myeloid lineage cells: erythrocytes, megakaryocytes, and macrophages.
    Language English
    Publishing date 2015-06-25
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2015.50.2.73
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: microRNAs: Key Players in Hematopoiesis.

    Raghuwanshi, Sanjeev / Karnati, Hanuma Kumar / Sarvothaman, Shilpa / Gutti, Usha / Saladi, Raja Gopal Venakata / Tummala, Prathibha Reddy / Gutti, Ravi Kumar

    Advances in experimental medicine and biology

    2015  Volume 887, Page(s) 171–211

    Abstract: microRNAs (miRNAs) are small length noncoding RNAs which play a key role in cellular processes such as proliferation, differentiation, and development of lineage hematopoietic cells and matured blood cells. Aberrant expression of miRNAs has been reported ...

    Abstract microRNAs (miRNAs) are small length noncoding RNAs which play a key role in cellular processes such as proliferation, differentiation, and development of lineage hematopoietic cells and matured blood cells. Aberrant expression of miRNAs has been reported in several hematopoietic disorders. The involvement of miRNAs in regulation of various signaling pathways has been shown in hematopoietic disorders. Along with regulatory role, miRNAs are also proven as diagnostic and prognostic markers for these malignancies. Recent studies are evidenced that the miRNA are key regulators of hematopoietic disorders and progression of these disorders shows the importance of targeting the aberrant expression of miRNAs as new therapeutic interventions. The present chapter provides overview of the art related to the importance of miRNAs in developmental hematopoiesis and pathogenesis of hematopoietic disorders including chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myelomas, and B cell lymphomas.
    MeSH term(s) Animals ; Blood Cells/cytology ; Blood Cells/metabolism ; Blood Cells/pathology ; Gene Expression Regulation, Neoplastic ; Hematopoiesis ; Humans ; Leukemia/genetics ; Leukemia/metabolism ; Leukemia/pathology ; Lymphoma/genetics ; Lymphoma/metabolism ; Lymphoma/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-22380-3_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Wnt Signaling: Role in Regulation of Haematopoiesis.

    Undi, Ram Babu / Gutti, Usha / Sahu, Itishri / Sarvothaman, Shilpa / Pasupuleti, Satya Ratan / Kandi, Ravinder / Gutti, Ravi Kumar

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2015  Volume 32, Issue 2, Page(s) 123–134

    Abstract: Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells which are responsible for the generation of various blood cell lineages. One of the significant characteristics of these HSCs is to self-renew, while producing differentiating ... ...

    Abstract Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells which are responsible for the generation of various blood cell lineages. One of the significant characteristics of these HSCs is to self-renew, while producing differentiating cells for normal hematopoiesis. Deregulation of self-renewal and differentiation leads to the hematological malignancies. Several pathways are known to be involved in the maintenance of HSC fate among which Wnt signaling is a crucial pathway which controls development and cell fate determination. Wnt signaling also plays a major role in differentiation, self-renewal and maintenance of HSCs. Wnt ligands activate three major pathways including planar cell polarity, Wnt/β-catenin and Wnt/Ca(2+). It has been shown that Wnt/β-catenin or canonical pathway regulates cell proliferation, survival and differentiation in HSCs, deregulation of this pathway leads to hematological malignancies. Wnt non-canonical pathway regulates calcium signaling and planar cell polarity. In this review, we discuss various signaling pathways induced by Wnt ligands and their potential role in hematopoiesis.
    Language English
    Publishing date 2015-08-28
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-015-0585-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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