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Article: Epidemiological and Histopathological Analysis of Head and Neck Cancers in Northern India- A Retrospective Review.

Lakhera, Kamal Kishor / Kumar, Vimal / Singhal, Pranav Mohan / Patel, Pinakin / Chatterjee, Aishwarya / Singh, Suresh / Babu, Agil / Sharma, Raj Govind

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 1, Page(s) 422–427

Abstract: Introduction: Head and neck malignancies are responsible for 30% of all cancers in India with a dramatic increase in numbers due to widespread tobacco consumption. This study aims to assess the epidemiological and histopathological spectrum of these ... ...

Abstract	Introduction: Head and neck malignancies are responsible for 30% of all cancers in India with a dramatic increase in numbers due to widespread tobacco consumption. This study aims to assess the epidemiological and histopathological spectrum of these tumors. Materials and methods: A large retrospective review of 5469 biopsy-proven patients presenting between 2018 and 2022 with head and neck cancers was done. Tumors were analysed for distribution according to sites of presentations, gender, age and histopathological profiles. Results: With a male-to-female ratio of 4.2:1, men constituted 80.80% of the study population. Mean age of presentation in women was 53.5 years, whereas men presented at an earlier age of 47.2 years. Oral cavity was the commonest site involved (59.7% cases) followed by the oropharynx (23.8% cases). Buccal mucosa was the commonest subsite involved with 1112 cases followed by tongue lesions with 1088 cases. Larynx was responsible for 17.04% of cases. All subsites were more commonly affected in men with the highest Male: Female ratio of 8.29:1 seen in larynx. The lowest ratio of 1.02:1 was seen in lesions of the face and scalp. Squamous cell carcinoma (SCC) was the most common histopathological diagnosis encountered in 88.97% of cases followed by basal cell carcinoma which was seen in 2.10% lesions. Conclusion: Oral cavity lesions constitute the bulk of head and neck cancer presentations in India. The disease is more prevalent in men overall and men present at a younger age in comparison to women. SCC is the most prominent histopathology encountered in our study.
Language	English
Publishing date	2023-08-30
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04176-4
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Article: Clinical presentation, diagnosis and management of aerodigestive tract foreign bodies in the paediatric population: Part 2.

Mathew, Rishi P / Liang, Teresa I-Han / Kabeer, Ahamed / Patel, Vimal / Low, Gavin

SA journal of radiology

2021 Volume 25, Issue 1, Page(s) 2027

Abstract: Children, especially toddlers, because of their behaviour, physiology and anatomical characteristics such as oral exploration of their surroundings, have a tendency to place objects in their mouth. Therefore, ingestion or aspiration of foreign bodies ( ... ...

Abstract	Children, especially toddlers, because of their behaviour, physiology and anatomical characteristics such as oral exploration of their surroundings, have a tendency to place objects in their mouth. Therefore, ingestion or aspiration of foreign bodies (FBs) in children is a potentially life-threatening and common problem seen across the world. In this second part of our pictorial review on ingested and aspirated FBs, we focus on the paediatric population, reviewing the current literature and examining the epidemiology, clinical presentation, anatomic considerations, appropriate imaging modalities, key imaging characteristics associated with clinically relevant FBs in the emergency department (ED) and current management protocols.
Language	English
Publishing date	2021-03-23
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	2475950-8
ISSN	2078-6778 ; 1027-202X
ISSN (online)	2078-6778
ISSN	1027-202X
DOI	10.4102/sajr.v25i1.2027
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Article ; Online: The clinical and financial impact of remote clinical oncology pharmacist engagement in community-based practices within The US Oncology Network.

Carroll, Melissa / Koselke, Elizabeth / Howell, Josh / Cho, Judy / Roman, Andrea / Keisler, Meredith / Patel, Toral / Patel, Vimal / Mitchem, Tiffany / Yarbro, Laura / Hough, Shannon

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2023 Volume 30, Issue 1, Page(s) 165–172

Abstract: Introduction: The integration of clinical oncology pharmacists into multidisciplinary healthcare teams is not well-described in the community practice setting. This study aims to analyze the clinical and financial impact of a remote-based clinical ... ...

Abstract	Introduction: The integration of clinical oncology pharmacists into multidisciplinary healthcare teams is not well-described in the community practice setting. This study aims to analyze the clinical and financial impact of a remote-based clinical oncology pharmacist in four community oncology practices within The US Oncology Network. Methods: Oncology-trained clinical pharmacists electronically reviewed chemotherapy orders for clinical optimization and financial stewardship within four community oncology practices. Each pharmacist was appointed at 0.5 full-time equivalents per practice. Financial, clinical, and workload metrics were tracked to monitor the impact of pharmacist engagement. Results: Over 12 months, 5716 order reviews were completed with an intervention rate of 57%. The most common interventions identified by the pharmacists were interventions with clinical impact on the patient (36%), followed by dose rounding (35%) and therapeutic interchange (30%). Overall, interventions improved the cumulative practice margins by $1,455,033 and reduced total medication costs by $5,962,551. The average program return on investment was 415% (range 100-915%). Conclusion: Community oncology practices seek to provide high-value care in a lean, resource-constrained model. An oncology clinical pharmacist is a cost-effective and clinically invaluable care team member in community oncology practice. Pharmacists in this setting identified opportunities to improve medication safety and regimen optimization and demonstrated a significant tremendous financial impact on small-scale budgets in community oncology.
MeSH term(s)	Humans ; Community Health Services ; Medical Oncology ; Pharmacists ; Telemedicine
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552231173860
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Article ; Online: Inosine induces stemness features in CAR-T cells and enhances potency.

Klysz, Dorota D / Fowler, Carley / Malipatlolla, Meena / Stuani, Lucille / Freitas, Katherine A / Chen, Yiyun / Meier, Stefanie / Daniel, Bence / Sandor, Katalin / Xu, Peng / Huang, Jing / Labanieh, Louai / Keerthi, Vimal / Leruste, Amaury / Bashti, Malek / Mata-Alcazar, Janette / Gkitsas, Nikolaos / Guerrero, Justin A / Fisher, Chris /

Patel, Sunny / Asano, Kyle / Patel, Shabnum / Davis, Kara L / Satpathy, Ansuman T / Feldman, Steven A / Sotillo, Elena / Mackall, Crystal L

Cancer cell

2024 Volume 42, Issue 2, Page(s) 266–282.e8

Abstract: Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted ... ...

Abstract	Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8
MeSH term(s)	Humans ; T-Lymphocytes/metabolism ; Inosine
Chemical Substances	Inosine (5A614L51CT)
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2024.01.002
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Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Universal posttransplant cyclophosphamide after allogeneic transplant, a retrospective single institution study.

Cooper, Dennis L / Manago, Jacqueline / Patel, Vimal / Schaar, Dale / Tyno, Anne / Lin, Yong / Strair, Roger

Leukemia research

2022 Volume 122, Page(s) 106934

Abstract: Background: The excellent results of posttransplant cyclophosphamide in decreasing graft-versus-host disease (GVHD) after haploidentical (HI) allogeneic transplant have challenged current donor selection algorithms.: Patients and methods: We compared ...

Abstract	Background: The excellent results of posttransplant cyclophosphamide in decreasing graft-versus-host disease (GVHD) after haploidentical (HI) allogeneic transplant have challenged current donor selection algorithms. Patients and methods: We compared outcomes after matched sibling (MSD) versus alternative donor transplant using identical graft-versus-host disease (GVHD) prophylaxis including posttransplant cyclophosphamide (PTCy. Endpoints included engraftment, time outside of the hospital in the first 100 days after transplant, overall survival (OS), non-relapse mortality (NRM) and percentage of patients disease-free and off immunosuppression (DFOI) at one year and at the last follow-up. Results: There were significant differences at baseline between matched donor versus HI donor transplants with higher disease-risk index (DRI), more female-to-male donor recipient pairs and a higher percentage of Black patients in the HI group. Engraftment and time out of the hospital favored MSD and matched unrelated donor transplants. Multivariate analysis showed that high DRI and Black race were associated with decreased survival and Black race was associated with a higher NRM. Conclusions: With the use of PTCy, our results support current donor selection algorithms. The finding of decreased survival and increased NRM in Black patients requires confirmation in a larger number of patients as well as the development of mitigation strategies.
MeSH term(s)	Humans ; Male ; Female ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Transplantation Conditioning/methods ; Hematopoietic Stem Cell Transplantation/methods ; Retrospective Studies ; Cyclophosphamide/therapeutic use ; Recurrence ; Allografts
Chemical Substances	Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2022.106934
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Zs.A 1321: Show issues

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Article ; Online: Diagnostic performance of S100B as a rule-out test for intracranial pathology in head-injured patients presenting to the emergency department who meet NICE Head Injury Guideline criteria for CT-head scan.

Rogan, Alice / Sik, Annabelle / Dickinson, Emily / Patel, Vimal / Peckler, Brad / McQuade, David / Larsen, Peter D

Emergency medicine journal : EMJ

2022 Volume 40, Issue 3, Page(s) 159–166

Abstract: Background: Traumatic brain injury is a common ED presentation. CT-head utilisation is escalating, exacerbating resource pressure in the ED. The biomarker S100B could assist clinicians with CT-head decisions by excluding intracranial pathology. ... ...

Abstract	Background: Traumatic brain injury is a common ED presentation. CT-head utilisation is escalating, exacerbating resource pressure in the ED. The biomarker S100B could assist clinicians with CT-head decisions by excluding intracranial pathology. Diagnostic performance of S100B was assessed in patients meeting National Institute of Health and Clinical Excellence Head Injury Guideline (NICE HIG) criteria for CT-head within 6 and 24 hours of injury. Methods: This multicentre prospective observational study included adult patients presenting to the ED with head injuries between May 2020 and June 2021. Informed consent was obtained from patients meeting NICE HIG CT-head criteria. A venous blood sample was collected and serum was tested for S100B using a Cobas Elecsys-S100 module; >0.1 µg/mL was the threshold used to indicate a positive test. Intracranial pathology reported on CT-head scan by the duty radiologist was used as the reference standard to review diagnostic performance. Results: This study included 265 patients of whom 35 (13.2%) had positive CT-head findings. Within 6 hours of injury, sensitivity of S100B was 93.8% (95% CI 69.8% to 99.8%) and specificity was 30.8% (22.6% to 40.0%). Negative predictive value (NPV) was 97.3% (95% CI 84.2% to 99.6%) and area under the curve (AUC) was 0.73 (95% CI 0.61 to 0.85; p=0.003). Within 24 hours of injury, sensitivity was 82.9% (95% CI 66.4% to 93.44%) and specificity was 43.0% (95% CI 36.6% to 49.7%). NPV was 94.29% (95% CI 88.7% to 97.2%) and AUC was 0.65 (95% CI 0.56 to 0.74; p=0.046). Theoretically, use of S100B as a rule-out test would have reduced CT-head scans by 27.1% (95% CI 18.9% to 36.8%) within 6 hours and 37.4% (95% CI 32.0% to 47.2%) within 24 hours. The risk of missing a significant injury with this approach would have been 0.75% (95% CI 0.0% to 2.2%) within 6 hours and 2.3% (95% CI 0.5% to 4.1%) within 24 hours. Conclusion: Within 6 hours of injury, S100B performed well as a diagnostic test to exclude significant intracranial pathology in low-risk patients presenting with head injury. In theory, if used in addition to NICE HIGs, CT-head rates could reduce by one-quarter with a potential miss rate of <1%.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; S100 Calcium Binding Protein beta Subunit ; Craniocerebral Trauma/etiology ; Tomography, X-Ray Computed ; Emergency Service, Hospital ; Biomarkers
Chemical Substances	S100 Calcium Binding Protein beta Subunit ; Biomarkers ; S100B protein, human
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2022-212549
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Article: Inosine Induces Stemness Features in CAR T cells and Enhances Potency.

Klysz, Dorota D / Fowler, Carley / Malipatlolla, Meena / Stuani, Lucille / Freitas, Katherine A / Meier, Stefanie / Daniel, Bence / Sandor, Katalin / Xu, Peng / Huang, Jing / Labanieh, Louai / Leruste, Amaury / Bashti, Malek / Keerthi, Vimal / Mata-Alcazar, Janette / Gkitsas, Nikolaos / Guerrero, Justin A / Fisher, Chris / Patel, Sunny /

Asano, Kyle / Patel, Shabnum / Davis, Kara L / Satpathy, Ansuman T / Feldman, Steven A / Sotillo, Elena / Mackall, Crystal L

bioRxiv : the preprint server for biology

2023

Abstract: Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted ... ...

Abstract	Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.21.537859
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Article ; Online: Pharmacokinetics and Pharmacodynamics of Apixaban in Nephrotic Syndrome: Findings From a Phase 1a Trial.

Derebail, Vimal K / Zhu, Jing / Crawford, Matthew L / Garnier, Julia R / Martin, Karlyn A / Skinner, Sarah / Patel, Tejendra / Froment, Anne / Sketch, Margaret R / Szeto, Andy H / Patel, Sheel M / Torrice, Chad D / Tiefenbacher, Stefan / Adcock, Dorothy M / Grant, Russell P / Key, Nigel S / Crona, Daniel J

American journal of kidney diseases : the official journal of the National Kidney Foundation

2022 Volume 81, Issue 3, Page(s) 373–376

MeSH term(s)	Humans ; Nephrotic Syndrome ; Pyrazoles ; Pyridones ; Factor Xa Inhibitors
Chemical Substances	apixaban (3Z9Y7UWC1J) ; Pyrazoles ; Pyridones ; Factor Xa Inhibitors
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Clinical Trial, Phase I ; Letter
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2022.09.011
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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Article ; Online: Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing.

Balke-Want, Hyatt / Keerthi, Vimal / Gkitsas, Nikolaos / Mancini, Andrew G / Kurgan, Gavin L / Fowler, Carley / Xu, Peng / Liu, Xikun / Asano, Kyle / Patel, Sunny / Fisher, Christopher J / Brown, Annie K / Tunuguntla, Ramya H / Patel, Shabnum / Sotillo, Elena / Mackall, Crystal L / Feldman, Steven A

Molecular cancer

2023 Volume 22, Issue 1, Page(s) 100

Abstract: Background: Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors. However, access to CAR-T cells is not adequate to ... ...

Abstract	Background: Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors. However, access to CAR-T cells is not adequate to meet clinical needs, in part due to high cost and long lead times for manufacturing clinical grade virus. Non-viral site directed CAR integration can be accomplished using CRISPR/Cas9 and double-stranded DNA (dsDNA) or single-stranded DNA (ssDNA) via homology-directed repair (HDR), however yields with this approach have been limiting for clinical application (dsDNA) or access to large yields sufficient to meet the manufacturing demands outside early phase clinical trials is limited (ssDNA). Methods: We applied homology-independent targeted insertion (HITI) or HDR using CRISPR/Cas9 and nanoplasmid DNA to insert an anti-GD2 CAR into the T cell receptor alpha constant (TRAC) locus and compared both targeted insertion strategies in our system. Next, we optimized post-HITI CRISPR EnrichMENT (CEMENT) to seamlessly integrate it into a 14-day process and compared our knock-in with viral transduced anti-GD2 CAR-T cells. Finally, we explored the off-target genomic toxicity of our genomic engineering approach. Results: Here, we show that site directed CAR integration utilizing nanoplasmid DNA delivered via HITI provides high cell yields and highly functional cells. CEMENT enriched CAR T cells to approximately 80% purity, resulting in therapeutically relevant dose ranges of 5.5 × 10 Conclusions: Our work provides a novel platform to perform guided CAR insertion into primary human T-cells using nanoplasmid DNA and holds the potential to increase access to CAR-T cell therapies.
MeSH term(s)	Humans ; T-Lymphocytes ; DNA ; Recombinational DNA Repair ; Immunotherapy, Adoptive
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-023-01799-7
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Article: Clinical presentation, diagnosis and management of aerodigestive tract foreign bodies in the adult population: Part 1.

Mathew, Rishi P / Sarasamma, Sreekutty / Jose, Merin / Toms, Ajith / Jayaram, Vinayak / Patel, Vimal / Low, Gavin

SA journal of radiology

2021 Volume 25, Issue 1, Page(s) 2022

Abstract: In the adult population, foreign bodies may be accidentally or intentionally ingested or even inserted into a body cavity. The majority of accidentally ingested foreign bodies pass through the alimentary tract without any complications and rarely require ...

Abstract	In the adult population, foreign bodies may be accidentally or intentionally ingested or even inserted into a body cavity. The majority of accidentally ingested foreign bodies pass through the alimentary tract without any complications and rarely require intervention. Accidentally ingested foreign bodies are usually fish bones, bones of other animals, and dentures. Oesophageal food impaction is the commonest cause of oesophageal foreign bodies in the Western hemisphere. Intentionally ingested foreign bodies may be organic or inorganic, and often require intervention; these patients have either underlying psychological or mental disease or are involved in illegal activities such as body packing, which involves trafficking narcotics. Imaging plays a crucial role in not only identifying the type, number and location of the foreign body but also in excluding any complications. In this comprehensive pictorial review, we provide an overview of the spectrum of foreign bodies ingested in adults, emphasising the role of various imaging modalities, their limitations and common foreign body mimickers on imaging.
Language	English
Publishing date	2021-03-23
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	2475950-8
ISSN	2078-6778 ; 1027-202X
ISSN (online)	2078-6778
ISSN	1027-202X
DOI	10.4102/sajr.v25i1.2022
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