Article ; Online: Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword.
2022 Volume 53, Issue 5, Page(s) 1788–1801
Abstract: Besides damaging the brain, stroke causes systemic changes, including to the gastrointestinal system. A growing body of evidence supports the role of the gut and its microbiota in stroke, stroke prognosis, and recovery. The gut microbiota can increase ... ...
Abstract | Besides damaging the brain, stroke causes systemic changes, including to the gastrointestinal system. A growing body of evidence supports the role of the gut and its microbiota in stroke, stroke prognosis, and recovery. The gut microbiota can increase the risk of a cerebrovascular event, playing a role in the onset of stroke. Conversely, stroke can induce dysbiosis of the gut microbiota and epithelial barrier integrity. This has been proposed as a contributor to systemic infections. In this review, we describe the role of the gut microbiota, microbiome and microbiota-derived metabolites in experimental and clinical stroke, and their potential use as therapeutic targets. Fourteen clinical studies have identified 62 upregulated (eg, |
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MeSH term(s) | Animals ; Brain ; Dysbiosis ; Fatty Acids, Volatile ; Gastrointestinal Microbiome ; Humans ; Mice ; Stroke/microbiology |
Chemical Substances | Fatty Acids, Volatile |
Language | English |
Publishing date | 2022-02-09 |
Publishing country | United States |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 80381-9 |
ISSN | 1524-4628 ; 0039-2499 ; 0749-7954 |
ISSN (online) | 1524-4628 |
ISSN | 0039-2499 ; 0749-7954 |
DOI | 10.1161/STROKEAHA.121.036800 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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