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Article ; Online: [No title information]

Madsen, Morten Brok Molbech / Ivarsen, Anders / Hjortdal, Jesper

2023 Volume 185, Issue 48

Abstract: Corneal grafting is performed approximately 650 times a year in Denmark. A summary of these procedures is given in this review. Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy are frequent indications for transplantation. Previously, ... ...

Title translation	Corneal grafting.
Abstract	Corneal grafting is performed approximately 650 times a year in Denmark. A summary of these procedures is given in this review. Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy are frequent indications for transplantation. Previously, penetrating keratoplasty was the technique of choice but is nowadays mainly used for combined stromal and endothelial pathology. Instead, techniques specifically replacing diseased layers are more common. The Danish Cornea Bank is the only center in Denmark which undertakes preparation and distribution of tissue. The operative procedures are performed at Aarhus University Hospital or Rigshospitalet Glostrup.
MeSH term(s)	Humans ; Corneal Diseases/surgery ; Corneal Diseases/pathology ; Corneal Transplantation ; Cornea ; Fuchs' Endothelial Dystrophy/pathology ; Fuchs' Endothelial Dystrophy/surgery ; Keratoplasty, Penetrating
Language	Danish
Publishing date	2023-11-27
Publishing country	Denmark
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: Visual function after ultrathin Descemet's stripping automated endothelial keratoplasty or Descemet's membrane endothelial keratoplasty combined with cataract surgery: a randomised controlled clinical trial.

Madsen, Morten Brok Molbech / Ivarsen, Anders / Hjortdal, Jesper

The British journal of ophthalmology

2023

Abstract: Aims: To compare best-corrected visual acuity (BCVA), contrast sensitivity and endothelial cell density (ECD) after ultrathin Descemet's stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK).: ... ...

Abstract	Aims: To compare best-corrected visual acuity (BCVA), contrast sensitivity and endothelial cell density (ECD) after ultrathin Descemet's stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Methods: A randomised, single-blinded, single-centre design was used. 72 patients with Fuchs' endothelial dystrophy and cataract were randomised to UT-DSAEK or DMEK combined with phacoemulsification and lens implantation. 27 patients with cataract were included in a control group and treated with phacoemulsification and lens implantation. The primary outcome was BCVA at 12 months. Results: Compared with UT-DSAEK, DMEK resulted in better BCVA with mean differences of 6.1 early treatment diabetic retinopathy study (ETDRS) (p=0.001) after 3 months, 7.4 ETDRS (p<0.001) after 6 months and 5.7 ETDRS (p<0.001) after 12 months. The control group obtained significantly better BCVA with a mean difference of 5.2 ETDRS (p<0.001) compared with DMEK 12 months postoperatively. Compared with UT-DSAEK, contrast sensitivity was significantly better 3 months after DMEK with a mean difference of 0.10 LogCS (p=0.03). However, our study found no effect after 12 months (p=0.08). ECD was significantly lower after UT-DSAEK compared with DMEK with mean differences of 332 cells/mm Conclusions: Compared with UT-DSAEK, DMEK resulted in better BCVA 3, 6 and 12 months postoperatively. Twelve months postoperatively, DMEK had a higher ECD than UT-DSAEK; however, no difference in contrast sensitivity was found. Trial registration number: NCT04417959.
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjo-2023-323304
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Article ; Online: Macular Thickness After Ultrathin Descemet Stripping Automated Endothelial Keratoplasty and Descemet Membrane Endothelial Keratoplasty Combined With Cataract Surgery: A Randomized Controlled Clinical Trial.

Molbech Madsen, Morten Brok / Ivarsen, Anders / Hjortdal, Jesper

Cornea

2023 Volume 42, Issue 12, Page(s) 1536–1543

Abstract: Purpose: The aim was to investigate alterations in central retinal thickness (CRT) and their implications for visual acuity after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty ( ... ...

Abstract	Purpose: The aim was to investigate alterations in central retinal thickness (CRT) and their implications for visual acuity after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) combined with cataract surgery. Methods: A total of 72 eyes of 72 patients with Fuchs endothelial dystrophy and cataract were included and equally randomized to either UT-DSAEK or DMEK. A control group of 40 eyes of 40 patients with cataract were included for cataract surgery. All participants were examined preoperatively as well as 3 and 6 months postoperatively. Results: There was no significant difference in CRT between the study groups after surgery ( P = 0.896). A significant difference in best-corrected visual acuity (BCVA) progression over time was found between the study groups ( P < 0.0001). Average improvements of 8.03 EDTRS after UT-DSAEK ( P < 0.001) and 16.77 EDTRS after DMEK ( P < 0.001) were found 6 months postoperatively. No significant correlation was found between the change in BCVA and CRT from baseline to 3 months postoperatively (r 2 < 0.0001, P = 0.96) and from baseline to 6 months postoperatively (r 2 = 0.0053, P = 0.46). Conclusions: CRT was not altered by UT-DSAEK, DMEK, or cataract surgery 3 and 6 months postoperatively. BCVA significantly improved 3 and 6 months after UT-DSAEK and DMEK, respectively. No significant correlations were found between the change in BCVA and CRT postoperatively. As such CRT alterations were comparable after UT-DSAEK, DMEK, and cataract surgery.
MeSH term(s)	Humans ; Descemet Membrane/surgery ; Descemet Stripping Endothelial Keratoplasty ; Fuchs' Endothelial Dystrophy/surgery ; Visual Acuity ; Cataract ; Retrospective Studies ; Endothelium, Corneal
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003256
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Article ; Online: Follow-up surveillance of Wilm's tumour - Authors' reply.

Brok, Jesper / Pritchard-Jones, Kathy / Spreafico, Filippo

The Lancet. Oncology

2018 Volume 19, Issue 10, Page(s) e503

MeSH term(s)	Child ; Follow-Up Studies ; Humans ; Kidney Neoplasms ; Neoplasm Recurrence, Local ; Retrospective Studies ; Wilms Tumor
Language	English
Publishing date	2018-10-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(18)30691-0
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Maternal versus paternal inheritance of a 132 bp 11p15.5 microdeletion affecting

Stoltze, Ulrik Kristoffer / Hansen, Thomas Van Overeem / Brok, Jesper Sune / Grønskov, Karen / Tumer, Zeynep / Ahlborn, Lise Barlebo / Schmiegelow, Kjeld / Wadt, Karin A W

Journal of medical genetics

2022 Volume 60, Issue 2, Page(s) 128–130

MeSH term(s)	Humans ; Beckwith-Wiedemann Syndrome/genetics ; DNA Methylation ; Genomic Imprinting ; Paternal Inheritance/genetics ; Phenotype ; Maternal Inheritance ; Male ; Female ; RNA, Long Noncoding/genetics
Chemical Substances	KCNQ1OT1 long non-coding RNA, human ; RNA, Long Noncoding
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmedgenet-2021-108335
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Article ; Online: Risk factors for neonatal sepsis in Sub-Saharan Africa: a systematic review with meta-analysis.

Bech, Christine Manich / Stensgaard, Christina Nadia / Lund, Stine / Holm-Hansen, Charlotte / Brok, Jesper Sune / Nygaard, Ulrikka / Poulsen, Anja

BMJ open

2022 Volume 12, Issue 9, Page(s) e054491

Abstract: Objectives: To identify the risk factors for neonatal sepsis in Sub-Saharan Africa.: Design: Systematic review and meta-analysis.: Data sources: PubMed, Embase, Web of Science, African Index Medicus and ClinicalTrials.gov were searched for ... ...

Abstract	Objectives: To identify the risk factors for neonatal sepsis in Sub-Saharan Africa. Design: Systematic review and meta-analysis. Data sources: PubMed, Embase, Web of Science, African Index Medicus and ClinicalTrials.gov were searched for observational studies from January 2010 to August 2020. Setting: Sub-Saharan Africa, at all levels of healthcare facilities. Participants: 'Neonates' (<28 days of age) at risk of developing either clinical and/or laboratory-dependent diagnosis of sepsis. Outcome measures: Identification of any risk factors for neonatal sepsis. Results: A total of 36 studies with 23 605 patients from secondary or tertiary level of care facilities in 10 countries were included. Six studies were rated as good quality, 8 as fair and 22 as poor. Four studies were omitted in the meta-analysis due to insufficient data. The significant risk factors were resuscitation (OR 2.70, 95% CI 1.36 to 5.35), low birth weight <1.5 kg (OR 3.37, 95% CI 1.59 to 7.13) and 1.5-2.5 kg (OR 1.36, 95% CI 1.01 to 1.83), low Apgar score at the first minute (OR 3.69, 95% CI 2.34 to 5.81) and fifth minute (OR 2.55, 95% CI 1.46 to 4.45), prematurity <37 weeks (OR 1.91, 95% CI 1.27 to 2.86), no crying at birth (OR 3.49, 95% CI 1.42 to 8.55), male sex (OR 1.30, 95% CI 1.01 to 1.67), prolonged labour (OR 1.57, 95% CI 1.08 to 2.27), premature rupture of membranes (OR 2.15, 95% CI 1.34 to 3.47), multiple digital vaginal examinations (OR 2.22, 95% CI 1.27 to 3.89), meconium-stained amniotic fluid (OR 2.72, 95% CI 1.58 to 4.69), intrapartum maternal fever (OR 2.28, 95% CI 1.18 to 4.39), foul-smelling vaginal discharge (OR 3.31, 95% CI 2.16 to 5.09) and low socioeconomic status (OR 1.93, 95% CI 1.11 to 3.35). We found considerable heterogeneity in the meta-analysis of 11 out of 15 identified risk factors. Conclusion: Multiple risk factors for neonatal sepsis in Sub-Saharan Africa were identified. We revealed risk factors not listed by the WHO guidelines. The included studies overall had high risk of bias and high heterogeneity and thus, additional research of high quality is needed. Prospero registration number: CRD42020191067.
MeSH term(s)	Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Newborn, Diseases ; Male ; Neonatal Sepsis/complications ; Neonatal Sepsis/epidemiology ; Risk Factors ; Sepsis/epidemiology ; Sepsis/etiology
Language	English
Publishing date	2022-09-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-054491
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Article ; Online: Germline (epi)genetics reveals high predisposition in females: a 5-year, nationwide, prospective Wilms tumour cohort.

Stoltze, Ulrik Kristoffer / Hildonen, Mathis / Hansen, Thomas Van Overeem / Foss-Skiftesvik, Jon / Byrjalsen, Anna / Lundsgaard, Malene / Pignata, Laura / Grønskov, Karen / Tumer, Zeynep / Schmiegelow, Kjeld / Brok, Jesper Sune / Wadt, Karin A W

Journal of medical genetics

2023 Volume 60, Issue 9, Page(s) 842–849

Abstract: Background: Studies suggest that Wilms tumours (WT) are caused by underlying genetic (5%-10%) and epigenetic (2%-29%) mechanisms, yet studies covering both aspects are sparse.: Methods: We performed prospective whole-genome sequencing of germline DNA ...

Abstract	Background: Studies suggest that Wilms tumours (WT) are caused by underlying genetic (5%-10%) and epigenetic (2%-29%) mechanisms, yet studies covering both aspects are sparse. Methods: We performed prospective whole-genome sequencing of germline DNA in Danish children diagnosed with WT from 2016 to 2021, and linked genotypes to deep phenotypes. Results: Of 24 patients (58% female), 3 (13%, all female) harboured pathogenic germline variants in WT risk genes ( Conclusion: We find that most females (57%) and 33% of all patients with WT had either a genetic or another indicator of WT predisposition. This emphasises the need for scrutiny when diagnosing patients with WT, as early detection of underlying predisposition may impact treatment, follow-up and genetic counselling.
MeSH term(s)	Male ; Female ; Humans ; F-Box-WD Repeat-Containing Protein 7/genetics ; Fetal Macrosomia/genetics ; Genomic Imprinting ; Wilms Tumor/genetics ; Genotype ; Beckwith-Wiedemann Syndrome/pathology ; DNA Methylation/genetics ; Disease Susceptibility ; Kidney Neoplasms/genetics ; Germ Cells/pathology
Chemical Substances	F-Box-WD Repeat-Containing Protein 7
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmg-2022-108982
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Article ; Online: Advances in the clinical management of high-risk Wilms tumors.

Ortiz, Michael V / Koenig, Christa / Armstrong, Amy E / Brok, Jesper / de Camargo, Beatriz / Mavinkurve-Groothuis, Annelies M C / Herrera, Thelma B Velasquez / Venkatramani, Rajkumar / Woods, Andrew D / Dome, Jeffrey S / Spreafico, Filippo

Pediatric blood & cancer

2023 Volume 70, Issue 3, Page(s) e30153

Abstract: Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time ... ...

Abstract	Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time reflecting improvements in therapy, we introduce the authors' view of the historical and current approach to the classification and treatment of high-risk WT. For this review, we consider high-risk WT to include patients with newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low- or low middle-income settings, socio-economic factors expand the definition of what constitutes a high-risk WT. As conventional therapies are inadequate to cure the majority of high-risk WT patients, advancement of laboratory and early-phase clinical investigations to identify active agents is urgently needed.
MeSH term(s)	Humans ; Kidney Neoplasms/pathology ; Neoplasm Staging ; Wilms Tumor/pathology ; Prognosis ; Recurrence
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30153
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Zs.A 1131: Show issues

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Article ; Online: Advances in the clinical management of high-risk Wilms tumors.

Pediatric blood & cancer

2023 Volume 70 Suppl 2, Page(s) e30342

Abstract	Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time reflecting improvements in therapy, we introduce the authors' view of the historical and current approach to the classification and treatment of high-risk WT. For this review, we consider high-risk WT to include patients with newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low- or low middle-income settings, socio-economic factors expand the definition of what constitutes a high-risk WT. As conventional therapies are inadequate to cure the majority of high-risk WT patients, advancement of laboratory and early-phase clinical investigations to identify active agents is urgently needed.
MeSH term(s)	Humans ; Kidney Neoplasms/pathology ; Neoplasm Staging ; Wilms Tumor/pathology ; Prognosis ; Recurrence
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30342
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Article ; Online: Home-Based Specialized Pediatric Palliative Care: A Systematic Review and Meta-Analysis.

Hammer, Nanna Maria / Bidstrup, Pernille Envold / Brok, Jesper / Devantier, Minna / Sjøgren, Per / Schmiegelow, Kjeld / Larsen, Anders / Kurita, Geana Paula / Olsen, Marianne / Larsen, Hanne Bækgaard

Journal of pain and symptom management

2023 Volume 65, Issue 4, Page(s) e353–e368

Abstract: Context: Although specialized pediatric palliative care (SPPC) teams increasingly provide home-based care, the evidence of its impact has not yet been systematically evaluated.: Objectives: To examine the impact of home-based SPPC in children and ... ...

Abstract	Context: Although specialized pediatric palliative care (SPPC) teams increasingly provide home-based care, the evidence of its impact has not yet been systematically evaluated. Objectives: To examine the impact of home-based SPPC in children and adolescents with life-limiting conditions, regarding place of death, quality of life and symptom burden. Methods: We searched Medline, EMBASE, CINAHL, PsycINFO, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus for studies comparing children and adolescents with life-limiting conditions receiving home-based SPPC with children and adolescents not receiving home-based SPPC, or studies reporting before-and-after measurements. We included studies that reported on place of death, quality of life and/or symptoms. Two authors independently screened the articles, extracted data, and assessed quality. Results were synthesized as a systematic narrative synthesis and meta-analysis, using a random-effects model. Results: We included five studies, which reported on 392 children and adolescents. Meta-analysis showed that receiving home-based SPPC was associated with a more than fourfold increased likelihood of home death (risk ratio 4.64, 95% confidence interval 3.06-7.04; 3 studies; n=296). Most studies reported improved quality of life and reduced symptom burden. The included studies were of low to moderate quality with a high risk of bias. Conclusion: This systematic review suggests that home-based SPPC is associated with increased likelihood of home death, and might be associated with improved quality of life and reduced symptom burden. The small number of studies and an overall high risk of bias, however, makes the overall strength of evidence low.
MeSH term(s)	Adolescent ; Child ; Humans ; Palliative Care ; Quality of Life ; Hospice and Palliative Care Nursing ; Home Care Services
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2022.12.139
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