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Article ; Online: Development of Yin-Yang ligand for cannabinoid receptors.

Qiu, Yanli / Zhao, Yitian / Hu, Tao / Yang, Meifang / Li, Fei / Li, Cuixia / Gu, Weiliang / Yang, Xiaodi / Zhao, Suwen / Tao, Houchao

Bioorganic chemistry

2023 Volume 133, Page(s) 106377

Abstract: ... effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer ... unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions ... activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality ...

Abstract	Cannabinoid receptors (CBs), including CB1 and CB2, are the key components of a lipid signaling endocannabinoid system (ECS). Development of synthetic cannabinoids has been attractive to modulate ECS functions. CB1 and CB2 are structurally closely related subtypes but with distinct functions. While most efforts focus on the development of selective ligands for single subtype to circumvent the undesired off-target effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions as an antagonist for CB1 and concurrently an agonist for CB2. We found that in the pyrazole-cored scaffold, the arm of N1-phenyl group could be a switch, modification of which yielded various ligands with distinct activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality which, based on the docking study and molecular dynamic simulation, was proposed to be resulted from the hydrogen bonding with S173 and S285 in CB1 and CB2, respectively. Our results demonstrated the feasibility of structure guided ligand evolution for challenging Yin-Yang ligand.
MeSH term(s)	Cannabinoids/pharmacology ; Cannabinoids/chemistry ; Endocannabinoids ; Ligands ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/chemistry ; Receptors, Cannabinoid/metabolism ; Yin-Yang
Chemical Substances	Cannabinoids ; Endocannabinoids ; Ligands ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106377
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Article ; Online: The Yin Yang 1 of Penaeus vannamei regulates transcription of the small subunit hemocyanin gene during Vibrio parahaemolyticus infection.

Yang, Peikui / Zhao, Xianliang / Aweya, Jude Juventus / Zhang, Yueling

Developmental and comparative immunology

2023 Volume 151, Page(s) 105087

Abstract: ... the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates ...

Abstract	Hemocyanin is a respiratory protein, it is also a multifunctional immune molecule that plays a vital role against pathogen invasion in shrimp. However, the regulation of hemocyanin gene expression in shrimp hemocytes and the mechanisms involved during pathogen infection remains unclear. Here, we used DNA pull-down followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates transcription of the small subunit hemocyanin gene of P. vannamei (PvHMCs) in hemocytes during Vibrio parahaemolyticus AHPND (VP
MeSH term(s)	Animals ; Hemocyanins ; Arthropod Proteins/genetics ; Penaeidae ; Vibrio parahaemolyticus ; Chromatography, Liquid ; Yin-Yang ; Tandem Mass Spectrometry ; Immunity, Innate/genetics
Chemical Substances	Hemocyanins (9013-72-3) ; Arthropod Proteins
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2023.105087
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Zs.A 1327: Show issues

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Article ; Online: Restricted Phase Space Thermodynamics of Einstein-Power-Yang-Mills AdS Black Hole.

Du, Yun-Zhi / Li, Huai-Fan / Zhang, Yang / Zhou, Xiang-Nan / Zhao, Jun-Xin

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 4

Abstract: We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context ... of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated. ...

Abstract	We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context of the gauge-gravity duality. Under this framework, Newton's gravitational constant and the cosmological constant are varied in the system. We rewrite the thermodynamic first law in a more extended form containing both the pressure and the central charge of the dual conformal field theory, i.e., the restricted phase transition formula. A novel phenomena arises: the dual quantity of pressure is the effective volume, not the geometric one. That leads to a new behavior of the Van de Waals-like phase transition for this system with the fixed central charge: the supercritical phase transition. From the Ehrenfest's scheme perspective, we check out the second-order phase transition of the EPYM AdS black hole. Furthermore the effect of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated.
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25040687
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Article: Yang-xin-xue keli exerts therapeutic effects

Long, Kunlan / Zhao, Ziyi / Chen, Jun / Zhi, Lijia / Wang, Chunxia / Liao, Dan / Wang, Meng / Gao, Peiyang

Frontiers in pharmacology

2022 Volume 13, Page(s) 931453

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.931453
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Article: Mechanism of action of vinegared Cornu Cervi Degelatinatum in suppressing spleen kidney yang deficient ulcerative colitis through NCK2-JNK pathway.

Li, Tianshi / Shi, Mengqi / Zhao, Yan / He, Zhongmei / Zong, Ying / Chen, Weijia / Du, Rui

Heliyon

2024 Volume 10, Issue 2, Page(s) e24782

Abstract: ... the kidney to support yang, astringing, and stopping bleeding, and is used for spleen kidney yang deficient ...

Abstract	As a traditional Chinese herbal medicine, Cornu Cervi Degelatinatum (CCD) has the effect of warming the kidney to support yang, astringing, and stopping bleeding, and is used for spleen kidney yang deficient (SKYD). This experiment was to investigate the therapeutic effects of different processes of CCD on SKYD type ulcerative colitis (UC) rats and to explore its impact on the intestinal flora of rats. Methods: ELISA was used to study the anti-inflammatory activity of Cornu Cervi Degelatinatum processed with water (WCCD) and Cornu Cervi Degelatinatum processed with vinegar (VCCD). 16SrRNA and transcriptome sequencing were used to detect the composition of rat intestinal flora and gene expression; RT-PCR and Western blot were used to verify the role of WCCD and VCCD in treating UC. Results: WCCD and VCCD have therapeutic effects on UC, could reduce tissue damage. VCCD performed better in improving Bacteroidetes/Firmicutes ratios and species evenness and abundance; performed better in increasing the quantity of lactobacillus. VCCD simultaneously inhibit the intestinal inflammatory response through NCK2, PAK4, and JNK signaling pathways. Conclusions: WCCD and VCCD play a therapeutic role in UC by regulating the proportion of different flora in the intestinal flora. VCCD regulates the intestinal flora and inflammatory response by interfering with the NCK2, PAK4 and JNK signaling pathways.
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24782
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Article ; Online: Microstructural white matter changes in chronic migraine patients with liver-yang hyperactivity and qi-blood deficiency syndrome: a diffusion tensor imaging study.

Shi, Min / Yang, Jie / Yang, Dongdong / Yang, Xuhong / Zhao, Huan

Neuroreport

2022 Volume 33, Issue 10, Page(s) 422–428

Abstract: ... Sixteen CM patients diagnosed with liver-yang hyperactivity (LH) syndrome and 16 CM patients with qi-blood ...

Abstract	White matter alterations in patients with chronic migraine (CM) have been reported. Traditional Chinese medicine (TCM) syndromes are clinical syndromes proposed by TCM doctors based on long-term clinical observation and classification of the clinical symptoms and signs of CM patients. This study aimed to analyze the whole-brain diffusion tensor imaging (DTI) data of CM patients with different types of TCM syndromes. Sixteen CM patients diagnosed with liver-yang hyperactivity (LH) syndrome and 16 CM patients with qi-blood deficiency (QD) syndrome were recruited in this study. Thirty-one healthy controls (HCs) were also enrolled. All subjects underwent DTI and T1-weighted MRI acquisition. Thirty HCs and 30 CM patients (LH group: n = 15; QD group: n = 15) were included in the final analysis. No significant difference was observed in the DTI indexes between CM patients and HCs, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). The mean FAs of the left tapetum and the mean MD values for the right medial lemniscus and the right inferior cerebellar peduncle were significantly different in the LH and HC groups. The mean AD values for the right cingulate gyrus and the left uncinate fasciculus, as well as the mean RD for the right inferior cerebellar peduncle and the left tapetum, were also significantly different between these two groups. CM patients with LH and QD syndrome showed altered FA and diffusivity in comparison to healthy controls, suggesting that there may be significant white matter microstructural alterations in these patients.
MeSH term(s)	Anisotropy ; Brain/diagnostic imaging ; Diffusion Tensor Imaging/methods ; Humans ; Liver ; Migraine Disorders/diagnostic imaging ; Qi ; Syndrome ; White Matter/diagnostic imaging
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000001800
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Zs.A 3118: Show issues

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Article ; Online: Two new species of the genus Eophileurus Arrow, 1908 (Coleoptera: Scarabaeidae: Dynastinae) from the Philippines and Vietnam, with first description of E. quadratifovealis Yang & Pathomwattananurak, 2022 female.

Qiao-Zhi Yang Georgi Geshev / Pathomwattananurak, Wuttipon / Zhao, Ming-Zhi

Zootaxa

2023 Volume 5249, Issue 2, Page(s) 290–300

Abstract: Two new species, Eophileurus varipunctatus Yang, Pathomwattananurak & Zhao, new species ... from Mindoro and Palawan, the Philippines and Eophileurus vietnamensis Yang, Pathomwattananurak & Zhao ... quadratifovealis Yang & Pathomwattananurak, 2022 is described for the first time. ...

Abstract	Two new species, Eophileurus varipunctatus Yang, Pathomwattananurak & Zhao, new species from Mindoro and Palawan, the Philippines and Eophileurus vietnamensis Yang, Pathomwattananurak & Zhao, new species from Vietnam are described and illustrated. Eophileurus iwasei Muramoto, 1995 and E. chinensis (Faldermann, 1935) are illustrated and compared to each new species, respectively. The female of E. quadratifovealis Yang & Pathomwattananurak, 2022 is described for the first time.
MeSH term(s)	Female ; Animals ; Coleoptera ; Philippines ; Vietnam
Language	English
Publishing date	2023-03-01
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5249.2.6
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Article ; Online: The miR-17-92 cluster: Yin and Yang in human cancers.

Zhao, Wenyuan / Gupta, Ananya / Krawczyk, Janusz / Gupta, Sanjeev

Cancer treatment and research communications

2022 Volume 33, Page(s) 100647

Abstract: MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis. ...

Abstract	MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis. Dysregulation of miRNA expression has been implicated in human cancers, and they may also serve as biomarkers of disease progression and prognosis. The miR-17-92 cluster is one of the most widely studied miRNA clusters, which was initially reported as an oncogene, but was later reported to exhibit tumour suppressive effects in some human cancers. This review summarizes the recent progress and context-dependant role of this cluster in various cancers. We summarize the known mechanisms which regulate miR-17-92 expression and molecular pathways that are in turn controlled by it. We discuss examples where it acts as an oncogene or a tumour suppressor along with key targets affecting hallmarks of cancer. We discuss how cellular contexts regulate the biological effects of miR-17-92. The plausible mechanisms of its paradoxical roles are explained, and mechanisms are described that may contribute to cell fate regulation by miR-17-92. Further, we discuss recently developed strategies to target miR-17-92 cluster in human cancers. MiR-17-92 may serve as a potential biomarker for prognosis and response to therapy as well as a target for cancer prevention and therapeutics.
Language	English
Publishing date	2022-10-14
Publishing country	England
Document type	Journal Article ; Review
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2022.100647
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Article ; Online: The yin and yang of intracellular delivery of amphipathic optical probes using

Agarwal, Hitesh K / Janicek, Radoslav / Zhao, Jun / Sambath, Karthik / Egger, Marcel / Niggli, Ernst / Ellis-Davies, Graham C R

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 17, Page(s) 2826–2829

Abstract: Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must ... ...

Abstract	Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must be smuggled through the plasma membrane in a transiently neutral form, with intracellular esterases used to deprotect the masked anions. Here we explore the ability of the synthetically easily accessible
MeSH term(s)	Calcium/chemistry ; Calcium/metabolism ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cytosol/chemistry ; Cytosol/metabolism ; Esterases/chemistry ; Esterases/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Humans ; Molecular Structure ; Myocytes, Cardiac/chemistry ; Myocytes, Cardiac/metabolism ; Particle Size
Chemical Substances	Fluorescent Dyes ; Esterases (EC 3.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc06792c
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Article: Nanotoxicology and Nanomedicine: The Yin and Yang of Nano-Bio Interactions for the New Decade.

Bondarenko, Olesja / Mortimer, Monika / Kahru, Anne / Feliu, Neus / Javed, Ibrahim / Kakinen, Aleksandr / Lin, Sijie / Xia, Tian / Song, Yang / Davis, Thomas P / Lynch, Iseult / Parak, Wolfgang J / Leong, David Tai / Ke, Pu Chun / Chen, Chunying / Zhao, Yuliang

Nano today

2021 Volume 39

Abstract: ... for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two ...

Abstract	Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials - the main subjects of nanotoxicology - have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2224882-1
ISSN	1878-044X ; 1748-0132
ISSN (online)	1878-044X
ISSN	1748-0132
DOI	10.1016/j.nantod.2021.101184
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