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  1. Article ; Online: 'Big History', history and citations in nutritional science.

    Trayhurn, Paul

    Journal of nutritional science

    2022  Volume 11, Page(s) e18

    MeSH term(s) Nutritional Sciences
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2656288-1
    ISSN 2048-6790 ; 2048-6790
    ISSN (online) 2048-6790
    ISSN 2048-6790
    DOI 10.1017/jns.2022.16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carpe Diem

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    an update on the Journal of Nutritional Science

    2023  Volume 12

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Adipokines: inflammation and the pleiotropic role of white adipose tissue.

    Trayhurn, Paul

    The British journal of nutrition

    2022  Volume 127, Issue 2, Page(s) 161–164

    Abstract: I had been working on the endocrine and signalling role of white adipose tissue (WAT) since 1994 following the identification of the ob (Lep) gene(1), this after some 15 years investigating the physiological role of brown adipose tissue. The ob gene, a ... ...

    Abstract I had been working on the endocrine and signalling role of white adipose tissue (WAT) since 1994 following the identification of the ob (Lep) gene(1), this after some 15 years investigating the physiological role of brown adipose tissue. The ob gene, a mutation in which it is responsible for the profound obesity of ob/ob (Lepob/Lepob) mice, is expressed primarily in white adipocytes and encodes the pleiotropic hormone leptin. The discovery of this adipocyte hormone had wide-ranging implications, including that white fat has multiple functions that far transcend the traditional picture of a simple lipid storage organ.
    MeSH term(s) Adipocytes ; Adipokines ; Adipose Tissue, Brown/physiology ; Adipose Tissue, White/physiology ; Animals ; Inflammation ; Leptin/genetics ; Mice
    Chemical Substances Adipokines ; Leptin
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521003962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Brown Adipose Tissue: A Short Historical Perspective.

    Trayhurn, Paul

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2448, Page(s) 1–18

    Abstract: Brown adipose tissue (BAT) was first identified by Conrad Gessner in 1551, but it was only in 1961 that it was firmly identified as a thermogenic organ. Key developments in the subsequent two decades demonstrated that: (1) BAT is quantitatively important ...

    Abstract Brown adipose tissue (BAT) was first identified by Conrad Gessner in 1551, but it was only in 1961 that it was firmly identified as a thermogenic organ. Key developments in the subsequent two decades demonstrated that: (1) BAT is quantitatively important to non-shivering thermogenesis in rodents, (2) uncoupling of oxidative phosphorylation through a mitochondrial proton conductance pathway is the central mechanism by which heat is generated, (3) uncoupling protein-1 is the critical factor regulating proton leakage in BAT mitochondria. Following pivotal studies on cafeteria-fed rats and obese ob/ob mice, BAT was then shown to have a central role in the regulation of energy balance and the etiology of obesity. The application of fluorodeoxyglucose positron emission tomography in the late 2000s confirmed that BAT is present and active in adults, resulting in renewed interest in the tissue in human energetics and obesity. Subsequent studies have demonstrated a broad metabolic role for BAT, the tissue being an important site of glucose disposal and triglyceride clearance, as well as of insulin action. BAT continues to be a potential target for the treatment of obesity and related metabolic disorders.
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Animals ; Energy Metabolism ; Mice ; Obesity/metabolism ; Rats ; Thermogenesis ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
    Chemical Substances Uncoupling Protein 1
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2087-8_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ‘Big History’, history and citations in nutritional science

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    2022  Volume 11

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: JNS

    Trayhurn, Paul

    Journal of nutritional science

    2020  Volume 9, Page(s) e32

    MeSH term(s) Bibliometrics ; Humans ; Nutritional Sciences ; Periodicals as Topic
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2656288-1
    ISSN 2048-6790 ; 2048-6790
    ISSN (online) 2048-6790
    ISSN 2048-6790
    DOI 10.1017/jns.2020.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Adipokines: inflammation and the pleiotropic role of white adipose tissue

    Trayhurn, Paul

    British journal of nutrition. 2022 Jan. 28, v. 127, no. 2

    2022  

    Abstract: I had been working on the endocrine and signalling role of white adipose tissue (WAT) since 1994 following the identification of the ob (Lep) gene⁽¹⁾, this after some 15 years investigating the physiological role of brown adipose tissue. The ob gene, a ... ...

    Abstract I had been working on the endocrine and signalling role of white adipose tissue (WAT) since 1994 following the identification of the ob (Lep) gene⁽¹⁾, this after some 15 years investigating the physiological role of brown adipose tissue. The ob gene, a mutation in which it is responsible for the profound obesity of ob/ob (Lepᵒᵇ/Lepᵒᵇ) mice, is expressed primarily in white adipocytes and encodes the pleiotropic hormone leptin. The discovery of this adipocyte hormone had wide-ranging implications, including that white fat has multiple functions that far transcend the traditional picture of a simple lipid storage organ.
    Keywords brown adipose tissue ; genes ; inflammation ; leptin ; lipids ; mutation ; nutrition ; obesity ; white adipocytes ; white adipose tissue
    Language English
    Dates of publication 2022-0128
    Size p. 161-164.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521003962
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 916: Show issues

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  8. Article ; Online: Through fat and thin - a journey with the adipose tissues.

    Trayhurn, Paul

    The Proceedings of the Nutrition Society

    2020  Volume 80, Issue 1, Page(s) 92–104

    Abstract: The paper is based on the lecture that I gave on receiving the Nutrition Society's inaugural Gowland Hopkins Award for contributions to Cellular and Molecular Nutrition. It reviews studies on the adipose tissues, brown and white, conducted by the groups ... ...

    Abstract The paper is based on the lecture that I gave on receiving the Nutrition Society's inaugural Gowland Hopkins Award for contributions to Cellular and Molecular Nutrition. It reviews studies on the adipose tissues, brown and white, conducted by the groups that I have led since entering nutrition research in 1975. The initial focus was on exploring metabolic factors that underpin the development of obesity using animal models. This resulted in an interest in non-shivering thermogenesis with brown adipose tissue being identified as the key effector of facultative heat production. Brown fat is less thermogenically active in various obese rodents, and major changes in activity are exhibited under physiological conditions such as lactation and fasting consistent with a general role for the tissue in nutritional energetics. My interests moved to white adipose tissue following the cloning of the Ob gene. Our initial contributions in this area included demonstrating nutritional regulation of Ob gene expression and circulating leptin levels, as well as a regulatory role for the sympathetic nervous system operating through β3-adrenoceptors. My interests subsequently evolved to a wider concern with the endocrine/signalling role of adipose tissue. Inflammation is a characteristic of white fat in obesity with the release of inflammation-related adipokines, and we proposed that hypoxia underlies this inflammatory state. O2-deprivation was shown to have substantial effects on gene expression and cellular function in white adipocytes. The hypoxia studies led to the proposition that O2 should be considered as a critical macronutrient.
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Humans ; Nutritional Physiological Phenomena ; Obesity/metabolism ; Thermogenesis
    Language English
    Publishing date 2020-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S002966512000004X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.179: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Oxygen-A Critical, but Overlooked, Nutrient.

    Trayhurn, Paul

    Frontiers in nutrition

    2019  Volume 6, Page(s) 10

    Abstract: Gaseous oxygen is essential for all aerobic animals, without which mitochondrial respiration and oxidative phosphorylation cannot take place. It is not, however, regarded as a "nutrient" by nutritionists and does not feature as such within the discipline ...

    Abstract Gaseous oxygen is essential for all aerobic animals, without which mitochondrial respiration and oxidative phosphorylation cannot take place. It is not, however, regarded as a "nutrient" by nutritionists and does not feature as such within the discipline of nutritional science. This is primarily a consequence of the route by which O
    Language English
    Publishing date 2019-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2019.00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: JNS

    Paul Trayhurn

    Journal of Nutritional Science, Vol

    an update on citation ‘impact’ and remit

    2020  Volume 9

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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