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  1. Book ; Online: KE-QI

    Ai, Chunhui / Wang, Derui / Yan, Xu / Xu, Yang / Xie, Wenrui / Cao, Ziqiang

    A Knowledge Enhanced Article Quality Identification Dataset

    2022  

    Abstract: ... entities to Baidu Encyclopedia, then propose Knowledge Enhanced article Quality Identification (KE-QI ... results on KE-QI show that with initialization of our pre-trained Node2Vec model, our model achieves ...

    Abstract With so many articles of varying qualities being produced every moment, it is a very urgent task to screen outstanding articles and commit them to social media. To our best knowledge, there is a lack of datasets and mature research works in identifying high-quality articles. Consequently, we conduct some surveys and finalize 7 objective indicators to annotate the quality of 10k articles. During annotation, we find that many characteristics of high-quality articles (e.g., background) rely more on extensive external knowledge than inner semantic information of articles. In response, we link extracted article entities to Baidu Encyclopedia, then propose Knowledge Enhanced article Quality Identification (KE-QI) dataset. To make better use of external knowledge, we propose a compound model which fuses the text and external knowledge information via a gate unit to classify the quality of an article. Our experimental results on KE-QI show that with initialization of our pre-trained Node2Vec model, our model achieves about 78\% $F_1$, outperforming other baselines.
    Keywords Computer Science - Computation and Language
    Subject code 306
    Publishing date 2022-06-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice.

    Li, Mei / Cheng, Ding / Peng, Chuan / Huang, Yujiao / Geng, Jie / Huang, Guangrui / Wang, Ting / Xu, Anlong

    Chinese medicine

    2023  Volume 18, Issue 1, Page(s) 57

    Abstract: ... therapeutic choice. Xiao-Ke-Yin (XKY) is a medicine and food homology TCM formula consisting of nine "medicine ...

    Abstract Background: In recent decades, the prevalence of metabolic diseases, particularly diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD), has increased dramatically, causing great public health and economic burdens worldwide. Traditional Chinese medicine (TCM) serves as an effective therapeutic choice. Xiao-Ke-Yin (XKY) is a medicine and food homology TCM formula consisting of nine "medicine and food homology" herbs and is used to ameliorate metabolic diseases, such as insulin resistance, diabetes, hyperlipidemia and NAFLD. However, despite its therapeutic potential in metabolic disorders, the underlying mechanisms of this TCM remain unclear. This study aimed to evaluate the therapeutic effectiveness of XKY on glucolipid metabolism dysfunction and explore the potential mechanisms in db/db mice.
    Methods: To verify the effects of XKY, db/db mice were treated with different concentrations of XKY (5.2, 2.6 and 1.3 g/kg/d) and metformin (0.2 g/kg/d, a hypoglycemic positive control) for 6 weeks, respectively. During this study, we detected the body weight (BW) and fasting blood glucose (FBG), oral glucose tolerance test (OGTT), insulin tolerance test (ITT), daily food intake and water intake. At the end of the animal experiment, blood samples, feces, liver and intestinal tissue of mice in all groups were collected. The potential mechanisms were investigated by using hepatic RNA sequencing, 16 S rRNA sequencing of the gut microbiota and metabolomics analysis.
    Results: XKY efficiently mitigated hyperglycemia, IR, hyperlipidemia, inflammation and hepatic pathological injury in a dose dependent manner. Mechanistically, hepatic transcriptomic analysis showed that XKY treatment significantly reversed the upregulated cholesterol biosynthesis which was further confirmed by RT-qPCR. Additionally, XKY administration maintained intestinal epithelial homeostasis, modulated gut microbiota dysbiosis, and regulated its metabolites. In particular, XKY decreased secondary bile acid producing bacteria (Clostridia and Lachnospircaeae) and lowered fecal secondary bile acid (lithocholic acid (LCA) and deoxycholic acid (DCA)) levels to promote hepatic bile acid synthesis by inhibiting the LCA/DCA-FXR-FGF15 signalling pathway. Furthermore, XKY regulated amino acid metabolism including arginine biosynthesis, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and tryptophan metabolism likely by increasing Bacilli, Lactobacillaceae and Lactobacillus, and decreasing Clostridia, Lachnospircaeae, Tannerellaceae and Parabacteroides abundances.
    Conclusion: Taken together, our findings demonstrate that XKY is a promising "medicine food homology" formula for ameliorating glucolipid metabolism and reveal that the therapeutic effects of XKY may due to its downregulation of hepatic cholesterol biosynthesis and modulation of the dysbiosis of the gut microbiota and metabolites.
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-023-00752-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Ting li ke ben

    Xu, Lai

    Ke wen yu can kao da an = Listening Textbook : Scripts and Answers for Reference

    (She ji han yu : 拾级汉语 : / Chen Yu bian zhu : / 陈钰编著 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 8 ji)

    2012  

    Author's details Xu, Lai bian zhu
    Series title She ji han yu : 拾级汉语 : / Chen Yu bian zhu : / 陈钰编著 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 8 ji
    Language Chinese ; English
    Size II, 166 S., 26 cm.
    Publisher Bei jing yu yan da xue chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787561933411 ; 756193341X
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Ting li ke ben

    Xu, Lai

    Lian xi yu huo dong = Listening Textbook : Exercises and Activities

    (She ji han yu : 拾级汉语 : / Chen Yu bian zhu : / 陈钰编著 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 8 ji)

    2012  

    Author's details Xu, Lai bian zhu
    Series title She ji han yu : 拾级汉语 : / Chen Yu bian zhu : / 陈钰编著 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 8 ji
    Language Chinese ; English
    Size 6, III, 127 S., 26 cm.
    Publisher Bei jing yu yan da xue chu ban she
    Publishing place Bei jing
    Document type Book
    Accompanying material 1 CD
    ISBN 9787561933411 ; 756193341X
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: ‘Qiao Ran Bao Ke’: A New Cultivar of Xanthoceras sorbifolium Bunge with Thin Skin

    Xu, Huihui / Wang, Xi / Liu, Xiaojuan / Li, Yingchao / Wang, Libing / Yu, Haiyan / Bi, Quanxin

    HortScience. 2022 June, v. 57, no. 6

    2022  

    Abstract: Yellowhorn (Xanthoceras sorbifolium Bunge) is a deciduous shrub or small tree of the genus Xanthoceras in the family Sapindaceae. It is a unique oil tree species in northern China. Its kernels have a high oil content (>60%) and rich unsaturated fatty ... ...

    Abstract Yellowhorn (Xanthoceras sorbifolium Bunge) is a deciduous shrub or small tree of the genus Xanthoceras in the family Sapindaceae. It is a unique oil tree species in northern China. Its kernels have a high oil content (>60%) and rich unsaturated fatty acids—such as oleic acid, linoleic acid, and neuronal acid—that have high edible and medicinal values. Unsaturated fatty acids scavenge free radicals and have antioxidant functions. Oleic acid and linoleic acid prevent and treat cardiovascular diseases and have significant effects on lowering blood pressure. Neurotic acid could repair and regenerate the damaged nervous system and enhance memory (Yu et al., 2017). The yellowhorn oil also has properties similar to those of ordinary diesel oil, and it is a good biomass energy tree species (Ma et al., 2020; Wang et al., 2012). Additionally, it is an ecological tree for landscaping and forestation that has high ornamental value, with colorful flowers and strong resistance to stress.
    Keywords Xanthoceras sorbifolium ; antioxidants ; bioenergy ; blood pressure ; cultivars ; diesel fuel ; linoleic acid ; lipid content ; memory ; neurons ; oils ; oleic acid ; ornamental value ; shrubs ; trees ; China
    Language English
    Dates of publication 2022-06
    Size p. 731-732.
    Publishing place American Society for Horticultural Science
    Document type Article
    ISSN 2327-9834
    DOI 10.21273/HORTSCI16589-22
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: A group-buying mechanism for considering strategic consumer behaviorChenxu Ke, Bo Yan, Ruofan Xu

    Ke, Chenxu / Xu, Ruofan / Yan, Bo

    Electronic commerce research Vol. 17, No. 4 , p. 721-752

    2017  Volume 17, Issue 4, Page(s) 721–752

    Keywords Strategic consumer ; Group buying ; E-commerce ; Equilibrium theory
    Language English
    Publisher Springer Science + Business Media Inc
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 2106016-2 ; 2038488-9
    ISSN 1572-9362 ; 1389-5753
    ISSN (online) 1572-9362
    ISSN 1389-5753
    Database ECONomics Information System

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  7. Book: Jing du ke ben

    Xu, Guoping / Gao, Shunquan / He, Jin

    Intensive reading textbook

    (She ji han yu : 拾级汉语 : / bian zhu Xu Guoping, Gao Shunquan, He jin : / 编著许国萍, 高顺全, 何瑾 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 10 ji)

    2012  

    Author's details bian zhu Xu Guoping, Gao Shunquan, He jin
    Series title She ji han yu : 拾级汉语 : / bian zhu Xu Guoping, Gao Shunquan, He jin : / 编著许国萍, 高顺全, 何瑾 ; = 10 level Chinese / zhu bian Gao Shunquan, Wu Zhongwei, Tao Lian ; Di 10 ji
    Language Chinese ; English
    Size 6, III, 243 S., 26 cm.
    Publisher Bei jing yu yan da xue chu ban she
    Publishing place Bei jing
    Document type Book
    Accompanying material 1 CD
    ISBN 9787561932759 ; 7561932758
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice.

    Li, Xiaoqing / Li, Xinxin / Wang, Genbei / Xu, Yan / Wang, Yuanyuan / Hao, Ruijia / Ma, Xiaohui

    Frontiers of medicine

    2018  Volume 12, Issue 6, Page(s) 688–696

    Abstract: Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 ...

    Abstract Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms against hyperglycemia remain poorly understood. This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy mice model. Our results indicate that XKQ can significantly reduce food and water intake. XKQ treatment also remarkably decreases both the fasting blood glucose and blood glucose in the oral glucose tolerance test. Additionally, XKQ can significantly decrease the serum alanine aminotransferase level and liver index and can alleviate the fat degeneration in liver tissues. Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-Akt, and GLUT4 in the skeletal muscle of KKAy mice. XKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway in the skeletal muscle.
    MeSH term(s) Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Female ; Glucose Tolerance Test ; Glucose Transporter Type 4/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin/blood ; Insulin Resistance ; Liver/drug effects ; Liver/pathology ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects
    Chemical Substances Blood Glucose ; Drugs, Chinese Herbal ; Glucose Transporter Type 4 ; Hypoglycemic Agents ; Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2018-11-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-018-0662-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Cell Death and Disease

    Xu, Ke

    (Biochemistry ; 39)

    2023  

    Series title Biochemistry ; 39
    Keywords Cellular biology (cytology) ; Biology, life sciences
    Language English
    Size 1 electronic resource (138 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030379059
    ISBN 9781837682461 ; 1837682461
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Book ; Online: Tumor Angiogenesis and Modulators

    Xu, Ke

    2022  

    Keywords Oncology ; Clinical & internal medicine
    Language English
    Size 1 electronic resource (164 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030378891
    ISBN 9781803558363 ; 1803558369
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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