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Article: Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis.

Wang, Boyang / Zhang, Dingfan / Zhang, Tingyu / Sutcharitchan, Chayanis / Hua, Jianlin / Hua, Dongfang / Zhang, Bo / Li, Shao

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 88

Abstract: Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill ...

Abstract	Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods: Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results: Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-γ, TNF-α and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion: A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Trial registration Name of the registry: Chinese Clinical Trial Registry: Trial registration number: ChiCTR-TRC-13,003,137: Date of registration: Registered 29 March 2013 - Retrospectively registered: URL of trial registry record: https://www.chictr.org.cn/showproj.html?proj=6422 .
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00781-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrated network pharmacology and gut microbiome analysis to reveal the mechanism of Qu-Zhuo-Tong-Bi decoction against hyperuricemia and gout.

Song, Siyue / Fan, Moqi / Wen, Xianghui / Shi, Xiaowei / Lou, Yu / He, Zhixing / Wen, Chengping / Shao, Tiejuan

Journal of ethnopharmacology

2023 Volume 316, Page(s) 116736

Abstract: Ethnopharmacological relevance: Qu-zhuo-tong-bi decoction (QZTBD) is a classic Chinese ...

Abstract	Ethnopharmacological relevance: Qu-zhuo-tong-bi decoction (QZTBD) is a classic Chinese herbal medicine that has shown therapeutic efficacy in clinical practice against hyperuricemia and gout. However, the potential mechanisms of QZTBD remain poorly investigated. Aim of the study: To assess the therapeutic effects of QZTBD on hyperuricemia and gout and to reveal its mechanisms of action. Materials and methods: A Uox-KO mouse model of hyperuricemia and gout was established, and QZTBD was administered at a dosage of 18.0 g/kg/d. Throughout the experimental period, the effects of QZTBD on gout symptoms were monitored and analyzed. The integrated network pharmacology and gut microbiota analysis strategy was conducted to explore the mechanism of QZTBD in the treatment of hyperuricemia and gout. Targeted metabolomic analysis was performed to investigate the variation of amino acids and Spearman's rank correlation analysis was conducted to reveal the relationship between the discrepant bacterial genera and the altered amino acid. Flow cytometry was utilized to analysis the proportion of Th17 and Treg cells, and the production of pro-inflammatory cytokines was measured by ELISA. qRT-PCR and Western blot assay were applied to detect the expression of mRNA and protein respectively. Autodock vina 1.1.2 was used to evaluate the docking interactions. Results: QZTBD treatment showed remarkable efficacy against hyperuricemia and gout with respect to attenuation of disease activity metrics through gut microbiome recovery and intestinal immune homeostasis. The administration of QZTBD significantly elevated the abundance of Allobaculum and Candidatus sacchairmonas, corrected the aberrant amino acid patterns, repaired the impaired intestinal barrier, restored the balance of Th17/Treg cells via PI3K-AKT-mTOR pathway, and reduced the levels of inflammatory cytokines such as IL-1β, IL-6, TNF-α and IL-17. Fecal microbiota transplantation from QZTBD treated mice demonstrated convincing evidence of efficacy and mechanism of QZTBD. Conclusion: Taken together, our study explores the therapeutic mechanism of an effective herbal formula, QZTBD, for gout treatment through remodeling gut microbiome and regulating the differentiation of CD4
MeSH term(s)	Mice ; Animals ; Hyperuricemia/drug therapy ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Gout/drug therapy ; Cytokines ; TOR Serine-Threonine Kinases
Chemical Substances	Drugs, Chinese Herbal ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cytokines ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-06-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116736
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1494: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Book ; Online: Network pharmacology on the mechanism of Yi Qi Tong Qiao Pill inhibiting allergic rhinitis

Wang, Boyang / Zhang, DingFan / Zhang, Tingyu / Sutcharitchan, Chayanis / Hua, Jianlin / Hua, Dongfang / Zhang, Bo / Li, Shao

2023

Abstract: Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill ...

Abstract	Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods: Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results: Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-{\gamma}, TNF-{\alpha} and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion: A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Comment: 25 pages, 6 figures
Keywords	Quantitative Biology - Quantitative Methods ; None
Subject code	610
Publishing date	2023-05-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice.

Wen, Xianghui / Lou, Yu / Song, Siyue / He, Zhixing / Chen, Juan / Xie, Zhijun / Shi, Xiaowei / Wen, Chengping / Shao, Tiejuan

Frontiers in pharmacology

2021 Volume 11, Page(s) 610556

Abstract: Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat ...

Abstract	Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat hyperuricemia and gout with no obvious adverse effects. However, the mechanism by which QZTBD treats gout has not been fully explored. Here, we investigated the effects of QZTBD on gouty arthritis and its therapeutic mechanism from the perspective of the gut microbiome. Our results demonstrated that QZTBD was effective for reducing serum uric acid level and attenuating paw edema and mechanical allodynia. QZTBD promoted the abundance of butyrate-producing bacteria and the production of SCFAs. Further study revealed that QZTBD restored the intestinal barrier function, modulated the expression of GPR43 and ABCG2, suppressed the activity of key glycolysis-related enzymes, and inhibited the generation of intestinal inflammatory factors. These findings suggested that QZTBD is an effective therapeutic drug for gouty arthritis. Butyrate-producing bacteria and its metabolites SCFAs might act as a potential target of QZTBD.
Language	English
Publishing date	2021-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.610556
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment of effect of Zhu-tan Tong-luo decoction on CYP450 isoforms activity of rats.

Jin, Yongxi / Shao, Lingjiu / Li, Gaowen / Shao, Mengmeng / Zhi, Yinghao / Zhu, Wenzong

International journal of clinical and experimental medicine

2015 Volume 8, Issue 9, Page(s) 15940–15948

Abstract: In order to investigate the effects of Zhu-tan Tong-luo decoction on the metabolic capacity ... CYP1A2, CYP3A4, CYP2C9, CYP2D6. The rats were randomly divided into acute Zhu-Tan Tong-Luo decoction ... group (Low, High), chronic Zhu-Tan Tong-Luo decoction group (Low, High) and control group. The acute ...

Abstract	In order to investigate the effects of Zhu-tan Tong-luo decoction on the metabolic capacity of cytochrome P450 (CYP) enzymes, a cocktail method was employed to evaluate the activities of CYP2B6, CYP2C19, CYP1A2, CYP3A4, CYP2C9, CYP2D6. The rats were randomly divided into acute Zhu-Tan Tong-Luo decoction group (Low, High), chronic Zhu-Tan Tong-Luo decoction group (Low, High) and control group. The acute group rats were given 0.6, 1.2 g/kg (Low, High) Zhu-tan Tong-luo decoction by intragastric administration for 1 day, and the chronic group for 14 days. Six probe drugs bupropion, omeprazole, phenacetin, testosterone, tolbutamide, and metroprolol were given to rats through intragastric administration, and the plasma concentrations were determined by UPLC-MS/MS. There statistical pharmacokinetics differences for omeprazole, phenacetin, testosterone, tolbutamide, and metroprolol in rats were observed by comparing acute Zhu-tan Tong-luo decoction group with control group; and statistical pharmacokinetics differences for bupropion, omeprazole, phenacetin, testosterone, tolbutamide, and metroprolol were observed by comparing chronic Zhu-Tan Tong-Luo decoction group with control group. After intragastric administration of Zhu-Tan Tong-Luo decoction may slightly induce the activities of CYP2B6, CYP2C19, CYP1A2, CYP3A4, CYP2C9, CYP2D6 of rats. Induction of drug metabolizing enzyme by Zhu-Tan Tong-Luo decoction would reduce the efficacy of other drug. Additional, there no statistical difference for biochemical results after 1 or 14 intragastric administration of Zhu-Tan Tong-Luo decoction.
Language	English
Publishing date	2015-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418305-2
ISSN	1940-5901
ISSN	1940-5901
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Article ; Online: The combination of herbal medicine Weng-li-tong with Tolterodine may be better than Tolterodine alone in the treatment of overactive bladder in women: a randomized placebo-controlled prospective trial.

Xiao, Dong-Dong / Lv, Jian-Wei / Xie, Xin / Jin, Xing-Wei / Lu, Mu-Jun / Shao, Yuan

BMC urology

2016 Volume 16, Issue 1, Page(s) 49

Abstract: Background: To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT ...

Abstract	Background: To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB). Methods: A prospective, randomized, single-blind multi-center trial was performed which included 182 OAB patients treated with either placebo (n = 26), WLT (n = 52), tolterodine (n = 52) or WLT plus tolterodine (n = 52). The overactive bladder symptom score (OABSS) and micturition behavior were measured to evaluate treatment efficacy. Results: In total, 146 patients [placebo (n = 23), WLT (n = 39), tolterodine (n = 41) and WLT plus tolterodine (n = 43)] completed 8 weeks of treatment. Compared to those treated with placebo, patients in three intervention groups showed significant improvements in the OABSS, voiding frequency, average voided volume and urgency incontinence. WLT had a slower onset than tolterodine or combination therapy in reducing urgency incontinence. Compared with tolterodine, WLT had a weaker effect in improving OABSS (P = 0.022) and daily voiding frequency (P = 0.034). The combination therapy had better efficacy than WLT or tolterodine alone in improving the OABSS, voiding frequency and voided volume. No significant differences in the changes in quality of life scores were observed among the three intervention groups. Residual urine increased significantly in tolterodine group (P = 0.004), but not in combination group. WLT resulted in fewer adverse effects than tolterodine such as dry mouth (P = 0.002), weak stream (P = 0.002) and less residual urine (P < 0.001). Conclusions: WLT could improve OAB symptoms in women, while it had slower onset and weaker efficacy but fewer adverse effects than tolterodine. The combination of WLT and tolterodine was more efficacious than tolterodine alone in improving OAB symptoms. Trial registration: Chinese Clinical Trial Registry [ ChiCTR-IPR-14005626 ]. Date of registration: 7 December 2014.
MeSH term(s)	Adult ; Drug Therapy, Combination ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Middle Aged ; Muscarinic Antagonists/therapeutic use ; Phytotherapy ; Prospective Studies ; Single-Blind Method ; Tolterodine Tartrate/therapeutic use ; Urinary Bladder, Overactive/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Muscarinic Antagonists ; Tolterodine Tartrate (5T619TQR3R)
Language	English
Publishing date	2016-08-08
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-016-0167-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Studies of the Synergistic Actions of Three Herbs in Tong-Mai Formula

Zhai, Xue-Jia / Qu, Hai-Bin / Shao, Qing

Chromatographia. 2009 June, v. 69, no. 11-12

2009

Abstract: Tong-Mai oral liquid, containing three herbs (Pueraria radix, radix Salviae miltiorrhizae and ... to invigorate the 'blood' and dispel 'blood stasis', which arises from poor blood circulation. In Tong-Mai ... as index components. In the Tong-Mai oral liquid group, puerarin and daidzein showed the maximum plasma ...

Abstract	Tong-Mai oral liquid, containing three herbs (Pueraria radix, radix Salviae miltiorrhizae and rhizoma Chuanxiong), is a formula created under the theory of traditional Chinese medicine (TCM) to invigorate the 'blood' and dispel 'blood stasis', which arises from poor blood circulation. In Tong-Mai formula, Pueraria radix is used for improved blood circulation and to treat cardiovascular diseases and arrhythmia. Radix Salviae miltiorrhizae was widely used in TCMs for treatment of coronary heart disease, blood circulation diseases, and other cardiovascular diseases; rhizoma Chuanxiong is used to treat thrombosis and platelet aggregation. Clinically, combining the use of these herbs was therapeutically valuable, which suggests that they might synergistically prevent thrombosis. In this study, the pharmacokinetic behaviors of puerarin and daidzein in rat plasma were studied after orally administrated to four kinds of extracts. Puerarin and daidzein were set as index components. In the Tong-Mai oral liquid group, puerarin and daidzein showed the maximum plasma concentration and the lowest clearance rate of plasma. The results indicated that the herbal constituents in Tong-Mai formula showed synergism, and it may be helpful to certificate the rationality of the matching in Tong-Mai formula.
Language	English
Dates of publication	2009-06
Size	p. 1267-1273.
Publisher	Vieweg Verlag
Publishing place	Wiesbaden
Document type	Article
ZDB-ID	80097-1
ISSN	0009-5893
ISSN	0009-5893
DOI	10.1365/s10337-009-1064-5
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 4557: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Book: Shi jie chuan tong yi xue hu li xue

Cheng, Shao'en

(Shi jie chuan tong yi xue da xi)

1998

Title variant	Nursing in world traditional medicine
Author's details	Cheng Shaoen, Zhang Shaoling zhu bian = [Nursing in world traditional medicine / responsible chief editor, Cheng Shaoen, Zhang Shaoling]
Series title	Shi jie chuan tong yi xue da xi
MeSH term(s)	Nursing Care/methods ; Medicine, Traditional
Language	Chinese
Size	xviii, 445 p.
Edition	Di 1 ban.
Publisher	Ke xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787030062826 ; 7030062825
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Xin jiao tong zong he zheng

Shao, Lizheng

1982

Title translation	Anginal syndrome.
Author's details	Shao Lizheng, Hua Zuqing bian zhu
MeSH term(s)	Angina Pectoris
Language	Chinese
Size	3, 198 p. :, ill.
Edition	Di 1 ban.
Publisher	Shanghai ke xue ji shu chu ban she
Publishing place	Shanghai
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Feng su tong yi jiao zhu

Wang, Liqi / Ying, Shao

1981

Author's details	Ying shao zhuan; wang li qi jiao zhu
Keywords	China
Language	Chinese
Size	2 v. (2, 8, 17, 652 p.), 21 cm
Edition	Di 1 ban
Publisher	zhong hua shu ju
Publishing place	Bei jing
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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