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  1. Article ; Online: Successful application of airway pressure release ventilation in a child with severe acute respiratory distress syndrome induced by trauma: a case report.

    Su, Jing / Tie, Xin / Chen, Yao / Zou, Tongjuan / Yin, Wanhong

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 79

    Abstract: Background: Trauma has been identified as one of the risk factors for acute respiratory distress syndrome. Respiratory support can be further complicated by comorbidities of trauma such as primary or secondary lung injury. Conventional ventilation ... ...

    Abstract Background: Trauma has been identified as one of the risk factors for acute respiratory distress syndrome. Respiratory support can be further complicated by comorbidities of trauma such as primary or secondary lung injury. Conventional ventilation strategies may not be suitable for all trauma-related acute respiratory distress syndrome. Airway pressure release ventilation has emerged as a potential rescue method for patients with acute respiratory distress syndrome and hypoxemia refractory to conventional mechanical ventilation. However, there is a lack of research on the use of airway pressure release ventilation in children with trauma-related acute respiratory distress syndrome. We report a case of airway pressure release ventilation applied to a child with falling injury, severe acute respiratory distress syndrome, hemorrhagic shock, and bilateral hemopneumothorax. We hope this case report presents a potential option for trauma-related acute respiratory distress syndrome and serves as a basis for future research.
    Case presentation: A 15-year-old female with falling injury who developed severe acute respiratory distress syndrome, hemorrhagic shock, and bilateral hemopneumothorax was admitted to the surgical intensive care unit. She presented refractory hypoxemia despite the treatment of conventional ventilation with deep analgesia, sedation, and muscular relaxation. Lung recruitment was ineffective and prone positioning was contraindicated. Her oxygenation significantly improved after the use of airway pressure release ventilation. She was eventually extubated after 12 days of admission and discharged after 42 days of hospitalization.
    Conclusion: Airway pressure release ventilation may be considered early in the management of trauma patients with severe acute respiratory distress syndrome when prone position ventilation cannot be performed and refractory hypoxemia persists despite conventional ventilation and lung recruitment maneuvers.
    MeSH term(s) Humans ; Child ; Female ; Adolescent ; Continuous Positive Airway Pressure/methods ; Hemopneumothorax/complications ; Shock, Hemorrhagic/complications ; Respiration, Artificial/methods ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Hypoxia/therapy ; Hypoxia/complications
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-024-02894-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study.

    Tie, Xin / Zhao, Yanjie / Su, Jing / Liu, Xing / Zou, Tongjuan / Yin, Wanhong

    Frontiers in medicine

    2024  Volume 11, Page(s) 1331950

    Abstract: Background: Autoimmune diseases exhibit heterogenous dysregulation of pro-inflammatory or anti-inflammatory cytokine expression, akin to the pathophysiology of sepsis. It is speculated that individuals with autoimmune diseases may have an increased ... ...

    Abstract Background: Autoimmune diseases exhibit heterogenous dysregulation of pro-inflammatory or anti-inflammatory cytokine expression, akin to the pathophysiology of sepsis. It is speculated that individuals with autoimmune diseases may have an increased likelihood of developing sepsis and face elevated mortality risks following septic events. However, current observational studies have not yielded consistent conclusions. This study aims to explore the causal relationship between autoimmune diseases and the risks of sepsis and mortality using Mendelian randomization (MR) analysis.
    Methods: We conducted a two-sample MR study involving a European population, with 30 autoimmune diseases as the exposure factors. To assess causal relationships, we employed the inverse variance-weighted (IVW) method and used Cochran's Q test for heterogeneity, as well as the MR pleiotropy residual sum and outlier (MR-PRESSO) global test for potential horizontal pleiotropy.
    Results: Genetically predicted Crohn's disease (
    Conclusion: This MR study identified causal associations between certain autoimmune diseases and risks of sepsis in critical care, and 28-day mortality in the European population. These findings suggest that exploring the mechanisms underlying autoimmune diseases may offer new diagnostic and therapeutic strategies for sepsis prevention and treatment.
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1331950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between minimal decrease in platelet counts and outcomes in septic patients

    Yi Li / Xing Liu / Wanhong Yin / Yiwei Qin / Tongjuan Zou

    BMJ Open, Vol 13, Iss

    a retrospective observational study

    2023  Volume 4

    Abstract: Objectives Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with ... ...

    Abstract Objectives Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.Design A retrospective cohort study.Setting We screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.Participants A total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.Primary and secondary outcome measures Primary and secondary outcomes included 30-day mortality after admission and length of intensive care unit (ICU) stay and hospitalisation, respectively.Results Patients with ≤10% reduction in proportion of platelet counts were associated with significantly lower 30-day mortality (14.1% vs 23.5%, p<0.001, Kaplan-Meier analysis, p<0.0001). Multivariable analysis revealed that decreased platelet-count percentage ≤10% on day 4 after ICU admission was associated with lower probability of 30-day non-survival (OR=0.73, 95% CI 0.64 to 0.82, p<0.001). Patients in the ≤10% group had significantly shorter ICU stays than those in the >10% group (6.8 vs 7.5, p<0.001). Restricted cubic spline curves revealed that mortality rates decreased with increase in proportion of platelet counts.Conclusions A ≤10% decrease in platelet-count percentage among sepsis patients after treatments is independently associated with decreased 30-day mortality, suggesting that changes in proportion of platelet counts after treatments could be an indicator for assessing the therapeutic effects of sepsis.
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study.

    Liu, Xing / Yin, Wanhong / Li, Yi / Qin, Yiwei / Zou, Tongjuan

    BMJ open

    2023  Volume 13, Issue 4, Page(s) e069027

    Abstract: Objectives: Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with ... ...

    Abstract Objectives: Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.
    Design: A retrospective cohort study.
    Setting: We screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.
    Participants: A total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.
    Primary and secondary outcome measures: Primary and secondary outcomes included 30-day mortality after admission and length of intensive care unit (ICU) stay and hospitalisation, respectively.
    Results: Patients with ≤10% reduction in proportion of platelet counts were associated with significantly lower 30-day mortality (14.1% vs 23.5%, p<0.001, Kaplan-Meier analysis, p<0.0001). Multivariable analysis revealed that decreased platelet-count percentage ≤10% on day 4 after ICU admission was associated with lower probability of 30-day non-survival (OR=0.73, 95% CI 0.64 to 0.82, p<0.001). Patients in the ≤10% group had significantly shorter ICU stays than those in the >10% group (6.8 vs 7.5, p<0.001). Restricted cubic spline curves revealed that mortality rates decreased with increase in proportion of platelet counts.
    Conclusions: A ≤10% decrease in platelet-count percentage among sepsis patients after treatments is independently associated with decreased 30-day mortality, suggesting that changes in proportion of platelet counts after treatments could be an indicator for assessing the therapeutic effects of sepsis.
    MeSH term(s) Humans ; Retrospective Studies ; Platelet Count ; Intensive Care Units ; Critical Care ; Sepsis/therapy ; Prognosis
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Global and Regional Lung Ultrasound Score Can Accurately Evaluate the Severity of Lung Disease in Critically Ill Patients.

    Zou, Tongjuan / Yin, Wanhong / Diddams, Maxwell / Kang, Yan

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2020  Volume 39, Issue 9, Page(s) 1879–1880

    MeSH term(s) Critical Illness ; Humans ; Lung/diagnostic imaging ; Lung Diseases/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2020-04-17
    Publishing country England
    Document type Letter
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.15278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Application of Critical Care Ultrasound in Patients With COVID-19: Our Experience and Perspective.

    Zou, Tongjuan / Yin, Wanhong / Kang, Yan

    IEEE transactions on ultrasonics, ferroelectrics, and frequency control

    2020  Volume 67, Issue 11, Page(s) 2197–2206

    Abstract: Up to April 4, 2020, the novel coronavirus disease-2019 COVID-19 has affected more than 1 099000 patients and has become a major global health concern. World Health Organization (WHO) has defined COVID-19 as a global pandemic. Critical care ultrasound ( ... ...

    Abstract Up to April 4, 2020, the novel coronavirus disease-2019 COVID-19 has affected more than 1 099000 patients and has become a major global health concern. World Health Organization (WHO) has defined COVID-19 as a global pandemic. Critical care ultrasound (CCUS) can rapidly acquire the image of lung and other organs and demonstrate the pathophysiological changes to guide precise therapy in COVID-19 pneumonia without radiation or interfering with personal protective equipment. In addition, the application of CCUS can cover the whole courses from the fever clinic to the intensive care unit to improve the treatment. We would like to present the CCUS features about COVID-19 pneumonia and share the application experience of CCUS in Wuhan, China, and hope it works for physicians worldwide to solve the problem and improve the outcome.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections/diagnostic imaging ; Critical Care/methods ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Patient Positioning ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Ultrasonography/methods
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1525-8955
    ISSN (online) 1525-8955
    DOI 10.1109/TUFFC.2020.3020628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Different definitions of feeding intolerance and their associations with outcomes of critically ill adults receiving enteral nutrition: a systematic review and meta-analysis.

    Li, Jianbo / Wang, Lijie / Zhang, Huan / Zou, Tongjuan / Kang, Yan / He, Wei / Xu, Yuan / Yin, Wanhong

    Journal of intensive care

    2023  Volume 11, Issue 1, Page(s) 29

    Abstract: Background: A unified clinical definition of feeding intolerance (FI) is urged for better management of enteral nutrition (EN) in critically ill patients. We aimed to identify optimum clinical FI definitions based on reported evidence.: Methods: We ... ...

    Abstract Background: A unified clinical definition of feeding intolerance (FI) is urged for better management of enteral nutrition (EN) in critically ill patients. We aimed to identify optimum clinical FI definitions based on reported evidence.
    Methods: We searched clinical studies comparing FI with non-FI with a clear definition, summarized the evidence by random-effect meta-analyses, and rated the certainty of evidence by the Grading of Recommendations Assessment, Development and Evaluation frameworks.
    Results: Five thousand five hundred twenty-five records were identified, of which 26 eligible studies enrolled 25,189 adult patients. Most patient-centered outcomes were associated with FI overall. Low to very low certainty evidence established FI defined as large gastric residual volume (GRV) ≥ 250 ± 50 mL combined with any other gastrointestinal symptoms (GIS) had a significant association with high mortalities in particular all-cause hospital mortality (odds ratio [OR] 1.90, 95% confidence interval [CI] 1.40-2.57), the incidence of pneumonia (OR 1.54, 95% CI 1.13-2.09) and prolonged length of hospital stay (mean difference 4.20, 95% CI 2.08-6.32), with a moderate hospital prevalence (41.49%, 95% CI 31.61-51.38%). 3-day enteral feeding (EF) delivered percentage < 80% had a moderate hospital prevalence (38.23%, 95% CI 24.88-51.58) but a marginally significant association with all-cause hospital mortality (OR 1.90, 95% CI 1.03-3.50).
    Conclusions: In critically ill adult patients receiving EN, the large-GRV-centered GIS to define FI seemed to be superior to 3-day EF-insufficiency in terms of both close associations with all-cause hospital mortality and acceptable hospital prevalence (Registered PROSPERO: CRD42022326273).
    Trial registration: The protocol for this review and meta-analysis was registered with PROSPERO: CRD42022326273. Registered 10 May 2022.
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-023-00674-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Functional mitral regurgitation combined with increased early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio is associated with a poor prognosis in patients with shock.

    Zhou, Ran / Zou, Tongjuan / Yin, Wanhong / Wang, Xiaoting / Kang, Yan

    Chinese medical journal

    2021  Volume 134, Issue 19, Page(s) 2299–2305

    Abstract: Background: Functional mitral regurgitation (FMR) is common in critically ill patients and may cause left atrial (LA) pressure elevation. This study aims to explore the prognostic impact of synergistic LA pressure elevation and FMR in patients with ... ...

    Abstract Background: Functional mitral regurgitation (FMR) is common in critically ill patients and may cause left atrial (LA) pressure elevation. This study aims to explore the prognostic impact of synergistic LA pressure elevation and FMR in patients with shock.
    Methods: We retrospectively screened 130 consecutive patients of 175 patients with shock from April 2016 to June 2017. The incidence and impact of FMR and early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio (E/e') ≥ 4 within 6 h of shock on the prognosis of patients were evaluated. Finally, the synergistic effect of FMR and E/e' were assessed by combination, grouping, and trend analyses.
    Results: Forty-four patients (33.8%) had FMR, and 15 patients (11.5%) had E/e' elevation. A multivariate analysis revealed FMR and E/e' as independent correlated factors for 28-day mortality (P = 0.043 and 0.028, respectively). The Kaplan-Meier survival analysis revealed a significant difference in survival between patients with and without FMR (χ2 = 7.672, P = 0.006) and between the E/e' ≥ 14 and E/e' < 14 groups (χ2 = 19.351, P < 0.010). Twenty-eight-day mortality was significantly different among the four groups (χ2 = 30.141, P < 0.010). The risk of 28-day mortality was significantly higher in group 4 (E/e' ≥ 14 with FMR) compared with groups 1 (E/e' < 14 without FMR) and 2 (E/e' < 14 with FMR) (P = 0.001 and 0.046, respectively).
    Conclusions: Patients with shock can be identified by the presence of FMR. FMR and E/e' are independent risk factors for a poor prognosis in these patients, and prognosis is worst when FMR and E/e' ≥ 14 are present. It may be possible to improve prognosis by reducing LA pressure and E/e'.
    Trial registration: ClinicalTrials.gov, NCT03082326.
    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve Insufficiency/diagnostic imaging ; Prognosis ; Retrospective Studies ; Shock
    Language English
    Publishing date 2021-09-15
    Publishing country China
    Document type Journal Article ; Observational Study
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Application of Critical Care Ultrasound in patients with COVID-19

    Zou, Tongjuan / Yin, Wanhong / Kang, Yan

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    Our experience and perspective

    2020  , Page(s) 1–1

    Keywords Acoustics and Ultrasonics ; Instrumentation ; Electrical and Electronic Engineering ; covid19
    Publisher Institute of Electrical and Electronics Engineers (IEEE)
    Publishing country us
    Document type Article ; Online
    ISSN 0885-3010
    DOI 10.1109/tuffc.2020.3020628
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Application of Critical Care Ultrasound in Patients With COVID-19: Our Experience and Perspective

    Zou, Tongjuan / Yin, Wanhong / Kang, Yan

    IEEE Trans Ultrason Ferroelectr Freq Control

    Abstract: Up to April 4, 2020, the novel coronavirus disease-2019 COVID-19 has affected more than 1 099000 patients and has become a major global health concern. World Health Organization (WHO) has defined COVID-19 as a global pandemic. Critical care ultrasound ( ... ...

    Abstract Up to April 4, 2020, the novel coronavirus disease-2019 COVID-19 has affected more than 1 099000 patients and has become a major global health concern. World Health Organization (WHO) has defined COVID-19 as a global pandemic. Critical care ultrasound (CCUS) can rapidly acquire the image of lung and other organs and demonstrate the pathophysiological changes to guide precise therapy in COVID-19 pneumonia without radiation or interfering with personal protective equipment. In addition, the application of CCUS can cover the whole courses from the fever clinic to the intensive care unit to improve the treatment. We would like to present the CCUS features about COVID-19 pneumonia and share the application experience of CCUS in Wuhan, China, and hope it works for physicians worldwide to solve the problem and improve the outcome.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #739253
    Database COVID19

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