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  1. Article ; Online: Futility in Clinical Trials.

    Wendelberger, Barbara / Lewis, Roger J

    JAMA

    2023  

    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.14111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revisiting the Analogy Between Clinical Trials and Diagnostic Tests by Interpreting a Negative Trial as a Negative Test for Efficacy.

    Lewis, Roger J / Viele, Kert

    JAMA

    2023  Volume 329, Issue 23, Page(s) 2023–2025

    MeSH term(s) Diagnostic Tests, Routine ; Clinical Trials as Topic ; Diagnostic Techniques and Procedures ; Treatment Outcome
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.8972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Reporting Guideline for Mediation Analyses.

    Yadav, Kabir / Lewis, Roger J

    JAMA

    2021  Volume 326, Issue 11, Page(s) 1011–1012

    MeSH term(s) Consensus ; Mediation Analysis ; Research Design
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.15462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Estimands, Estimators, and Estimates.

    Little, Roderick J / Lewis, Roger J

    JAMA

    2021  Volume 326, Issue 10, Page(s) 967–968

    MeSH term(s) Data Interpretation, Statistical ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptides/administration & dosage ; Humans ; Hypoglycemic Agents/administration & dosage ; Models, Statistical ; Randomized Controlled Trials as Topic ; Sitagliptin Phosphate/administration & dosage
    Chemical Substances Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8) ; Sitagliptin Phosphate (TS63EW8X6F)
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.2886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immortal Time Bias in Observational Studies.

    Yadav, Kabir / Lewis, Roger J

    JAMA

    2021  Volume 325, Issue 7, Page(s) 686–687

    MeSH term(s) Adult ; Bias ; Cardiovascular Diseases/etiology ; Data Interpretation, Statistical ; Female ; Heart Disease Risk Factors ; Humans ; Menopause, Premature ; Middle Aged ; Observational Studies as Topic ; Time Factors
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.9151
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  6. Article ; Online: Introducing the JAMA Summit.

    Bibbins-Domingo, Kirsten / Angus, Derek C / Park, Hannah / Lewis, Roger J / Khera, Rohan / Zeis, Jennifer / Flanagin, Annette / Curfman, Gregory

    JAMA

    2024  

    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.5570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Treatment Effects in Multicenter Randomized Clinical Trials.

    Senn, Stephen J / Lewis, Roger J

    JAMA

    2019  Volume 321, Issue 12, Page(s) 1211–1212

    MeSH term(s) Antibodies, Monoclonal ; Humans ; Migraine Disorders ; Randomized Controlled Trials as Topic ; Research Design
    Chemical Substances Antibodies, Monoclonal ; fremanezumab
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.1480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Number Needed to Treat: Conveying the Likelihood of a Therapeutic Effect.

    Saver, Jeffrey L / Lewis, Roger J

    JAMA

    2019  Volume 321, Issue 8, Page(s) 798–799

    MeSH term(s) Aspirin ; Coronary Artery Bypass ; Probability ; Saphenous Vein ; Ticagrelor
    Chemical Substances Ticagrelor (GLH0314RVC) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.21971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The tension between clinical and microbiological relevance in applying clinical trial results for Gram negative bacterial infections.

    Tong, Steven Y C / Lewis, Roger J / Morpeth, Susan C

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 12, Page(s) 1733–1735

    MeSH term(s) Cephalosporins ; Gram-Negative Bacterial Infections/drug therapy ; Humans
    Chemical Substances Cephalosporins
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.09.011
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    Zs.A 4541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 284: Show issues

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  10. Article ; Online: The pragmatic clinical trial in a learning health care system.

    Lewis, Roger J

    Clinical trials (London, England)

    2016  Volume 13, Issue 5, Page(s) 484–492

    Abstract: Background/aims: A learning health care system ideally incorporates the ability to adapt to the pace of change, the incorporation of new clinical research paradigms, and leverages electronic health record systems and clinical decision support systems to ...

    Abstract Background/aims: A learning health care system ideally incorporates the ability to adapt to the pace of change, the incorporation of new clinical research paradigms, and leverages electronic health record systems and clinical decision support systems to narrow the divide between research and clinical practice.
    Methods: An adaptive clinical trial can be embedded into the sites and practice of clinical care in a highly pragmatic way to simultaneously generate high-quality data on treatment efficacy and improve the care of patients. This approach can be expanded into a pragmatic platform trial, meaning a trial that is intended to evaluate multiple treatments for a disease or diseases, possibly in combination, and with the available treatments potentially changing over time. This strategy is illustrated using a trial currently being implemented in Europe and funded by the European Union, evaluating three different "domains" of treatments for patients with severe community-acquired pneumonia requiring intensive care.
    Results: Simulation studies demonstrate that this approach has the potential to save lives while identifying the best treatment strategies for this critically ill population.
    Conclusion: Patients are likely to benefit if we can merge clinical trials and decision support into a single continuous learning process.
    MeSH term(s) Academic Medical Centers/organization & administration ; Biomedical Research/methods ; Clinical Trials as Topic/methods ; Humans ; Research Design ; United States
    Language English
    Publishing date 2016-06-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138796-5
    ISSN 1740-7753 ; 1740-7745
    ISSN (online) 1740-7753
    ISSN 1740-7745
    DOI 10.1177/1740774516655097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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