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Article ; Online: Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth.

Sameshima, Tomohiro / Ashina, Mariko / Fukuda, Takuya / Kido, Takumi / Abe, Shinya / Watanabe, Yuko / Sato, Itsuko / Yano, Yoshihiko / Tanimura, Kenji / Nagase, Hiroaki / Nozu, Kandai / Fujioka, Kazumichi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 921

Abstract: Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency ...

Abstract	Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age are unclear. We retrospectively analyzed infants admitted to our institution between June 1, 2018, and March 31, 2022, whose clinical and PIVKA-II data were available, and classified them into preterm and term infant groups. Overall incidence of PIVKA-II-positive cases (≥ 50 mAU/mL) was 42.8%, including 0.6% apparent VK deficiency (≥ 5000 mAU/mL), 3.1% experimental VK deficiency (1000-4999 mAU/mL), and 10.7% latent VK deficiency (200-999 mAU/mL) cases. Incidence of PIVKA-II-positive cases was significantly higher in the term group than in the preterm group (49.4% vs. 29.7%, p < 0.001). Gestational age correlated with PIVKA-II levels (r
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Vitamin K ; Infant, Premature ; Retrospective Studies ; Gestational Age ; Health Facilities
Chemical Substances	Vitamin K (12001-79-5)
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51674-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Review of Toyoda K,

Lo, Benjamin W Y / Miyawaki, Satoru / Fukuda, Hitoshi / Koyanagi, Masaomi

Surgical neurology international

2020 Volume 11, Page(s) 53

Abstract: Background: Prior meta-analyses showed that treatment with cilostazol, with or without aspirin, significantly reduced the incidence of recurrent ischemic stroke, occurrence of hemorrhagic stroke, and frequency of other serious vascular adverse events.!## ...

Abstract	Background: Prior meta-analyses showed that treatment with cilostazol, with or without aspirin, significantly reduced the incidence of recurrent ischemic stroke, occurrence of hemorrhagic stroke, and frequency of other serious vascular adverse events. Methods: This review highlights the value of the randomized controlled trial (RCT) by Toyoda Results: Patients on dual therapy consisting of cilostazol/aspirin or cilostazol/clopidogrel had significantly lower frequencies of recurrent stroke. However, there were significant differences in the incidence of attendant hemorrhagic complications utilizing mono or dual therapy. Conclusion: This RCT demonstrated the safety of dual therapy, consisting of cilostazol/aspirin or cilostazol/ clopidogrel, in preventing secondary ischemic stroke in a high-risk Japanese population. Further studies are required to generalize these findings to other patient populations worldwide.
Language	English
Publishing date	2020-03-28
Publishing country	United States
Document type	Editorial
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_83_2020
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Article: WNK3 kinase maintains neuronal excitability by reducing inwardly rectifying K

Sinha, Adya Saran / Wang, Tianying / Watanabe, Miho / Hosoi, Yasushi / Sohara, Eisei / Akita, Tenpei / Uchida, Shinichi / Fukuda, Atsuo

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 856262

Abstract: The with-no-lysine (WNK) family of serine-threonine kinases and its downstream kinases of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase-1 (OSR1) may regulate intracellular ... ...

Abstract	The with-no-lysine (WNK) family of serine-threonine kinases and its downstream kinases of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress-responsive kinase-1 (OSR1) may regulate intracellular Cl
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.856262
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Article ; Online: Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth

Tomohiro Sameshima / Mariko Ashina / Takuya Fukuda / Takumi Kido / Shinya Abe / Yuko Watanabe / Itsuko Sato / Yoshihiko Yano / Kenji Tanimura / Hiroaki Nagase / Kandai Nozu / Kazumichi Fujioka

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 6

Abstract: Abstract Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK ...

Abstract	Abstract Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age are unclear. We retrospectively analyzed infants admitted to our institution between June 1, 2018, and March 31, 2022, whose clinical and PIVKA-II data were available, and classified them into preterm and term infant groups. Overall incidence of PIVKA-II-positive cases (≥ 50 mAU/mL) was 42.8%, including 0.6% apparent VK deficiency (≥ 5000 mAU/mL), 3.1% experimental VK deficiency (1000–4999 mAU/mL), and 10.7% latent VK deficiency (200–999 mAU/mL) cases. Incidence of PIVKA-II-positive cases was significantly higher in the term group than in the preterm group (49.4% vs. 29.7%, p < 0.001). Gestational age correlated with PIVKA-II levels (r2 = 0.117, p < 0.0001). Median serum PIVKA-II levels and incidence of PIVKA-II-positive cases (≥ 50 mAU/mL, 16.4%) were lower at 5 days after birth than at birth, possibly reflecting the postnatal VK prophylaxis impact. Only one infant was diagnosed with VK deficiency bleeding (PIVKA-II levels, at birth: 10,567 mAU/mL; at day 5: 2418 mAU/mL). Thus, serum PIVKA-II levels after birth weakly correlated with gestational age. VK deficiency was more common in term infants than in preterm infants.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Distribution of proteinase K-resistant anti-α-synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall.

Fukasawa, Nei / Maeda, Miku / Sugiyama, Yoshifumi / Fukuda, Takahiro / Shimoda, Masayuki

Pathology international

2023 Volume 74, Issue 1, Page(s) 1–12

Abstract: ... from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically ...

Abstract	Lewy body disease (LBD) is characterized by the appearance of Lewy neurites and Lewy bodies, which are predominantly composed of α-synuclein. Notably, the cardiac plexus (CP) is one of the main targets of LBD research. Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any part of the CP. Thus, we aimed to clarify the emergence and/or propagation of LBP in the CP. In this study, 263 consecutive autopsy cases of patients aged ≥50 years were included, with one region per case selected from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically stained with anti-α-synuclein antibodies to assess LBP. We stained all three MPAs in 17 cases with low-density LBP and observed the actual distribution of LBP. LBP were identified in the CP in 20.2% (53/263) of patients. Moreover, we found that LBP may appear in only one region of MPAs, mainly in the young-old group (35.3% (6/17) of patients). These findings suggest that it is possible to underestimate LBP in the CP, especially in the young-old group, by restricting the search to only one of the three MPAs.
MeSH term(s)	Humans ; alpha-Synuclein ; Endopeptidase K ; Lewy Body Disease/pathology ; Axons/pathology ; Lewy Bodies/pathology
Chemical Substances	alpha-Synuclein ; Endopeptidase K (EC 3.4.21.64)
Language	English
Publishing date	2023-12-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13389
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Ud II Zs.200: Show issues

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Article ; Online: Inconsistent Dosing of Non-Vitamin K Oral Anticoagulants: Differences Between the United States and Japan.

Ono, Tomohiko / Kohsaka, Shun / Takatsuki, Seiji / Fukuda, Keiichi / Suzuki, Masahiro

Journal of the American College of Cardiology

2017 Volume 70, Issue 1, Page(s) 118

MeSH term(s)	Anticoagulants ; Atrial Fibrillation ; Humans ; Japan ; Off-Label Use ; Registries ; United States
Chemical Substances	Anticoagulants
Language	English
Publishing date	2017-08-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2017.03.609
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation.

Fukuda, Yasunori / Kaishima, Misato / Ohnishi, Toshiyuki / Tohyama, Kimio / Chisaki, Ikumi / Nakayama, Yusuke / Ogasawara-Shimizu, Mari / Kawamata, Yuji

Biochemical and biophysical research communications

2017 Volume 484, Issue 2, Page(s) 358–364

Abstract: ... revealed upregulation of MATE2-K and activation of Nrf2 signaling in response to fluid shear stress ... Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 ...

Abstract	Accurate prediction of drug-induced renal toxicity is necessary for development of safer drugs for patients. Cellular assay systems that recapitulate physiologically relevant microenvironments have been proposed for correct estimation of drug responses in the human body. However, establishment of such assay systems for accurate prediction of renal toxicity is challenging because of the lack of readily available in vitro assay systems. In this study, we investigated the cellular response to fluid shear stress, which is a characteristic of the environment in the kidney proximal tubules, using microfluidic devices. The global gene expression profiles of human primary proximal tubule cells under the fluidic conditions revealed upregulation of MATE2-K and activation of Nrf2 signaling in response to fluid shear stress. Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling. These results strongly suggest that fluid shear stress is involved in the expression and maintenance of function of tissue-specific drug transporters in the proximal tubule, where the cells are exposed to continuous shear stress by primary urine. Furthermore, the microfluidic culture of human proximal tubules was demonstrated to be a useful system to analyze the regulatory mechanisms of gene expression in physiologically relevant cell conditions.
MeSH term(s)	Cells, Cultured ; Gene Expression Profiling ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/metabolism ; NF-E2-Related Factor 2/metabolism ; Organic Cation Transport Proteins/genetics ; Stress, Mechanical
Chemical Substances	NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Organic Cation Transport Proteins ; SLC47A2 protein, human
Language	English
Publishing date	2017-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.01.124
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Zs.A 116: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Contemporary trend of reduced-dose non-vitamin K anticoagulants in Japanese patients with atrial fibrillation: A cross-sectional analysis of a multicenter outpatient registry.

Ono, Tomohiko / Ikemura, Nobuhiro / Kimura, Takehiro / Ueda, Ikuko / Tanaka, Hiroaki / Tokuda, Hanako / Yajima, Noriyuki / Matsumura, Keisuke / Suzuki, Masahiro / Fukuda, Keiichi / Kohsaka, Shun / Takatsuki, Seiji

Journal of cardiology

2018 Volume 73, Issue 1, Page(s) 14–21

Abstract: Background: Non-vitamin K antagonist oral anticoagulants (NOACs) have been widely used to prevent ...

Abstract	Background: Non-vitamin K antagonist oral anticoagulants (NOACs) have been widely used to prevent stroke in non-valvular atrial fibrillation (NVAF) patients. Stringent monitoring is not required for NOACs, albeit dose adjustments are needed based on specific patient factors, such as renal function, body weight and age, or concomitant medications. We investigated the NOAC dosing patterns and evaluated the predictors of the non-standardized dose reduction (NSDR). Methods: A total of 2452 newly diagnosed NVAF patients were consecutively recruited from secondary- and tertiary-care hospitals between 2012 and 2017. The NOAC doses were classified as one of three: (1) full dose; (2) standardized dose reduction (SDR); or (3) NSDR, consistent with Japanese package inserts. Results: Overall, 66.8% (N=1637) of the NVAF patients (median age: 69 years, interquartile range [IQR]: 60-76; 70% male; median CHA Conclusions: Nearly half of the NOAC dose reductions in our registry were deemed "non-standardized," which were seen mostly in patients at significant risk for ischemic stroke. The physician's apprehension regarding excessive bleeding under NOAC use should be appropriately balanced with concern for an increased risk of embolic events.
MeSH term(s)	Administration, Oral ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Cross-Sectional Studies ; Female ; Hemorrhage/chemically induced ; Humans ; Japan ; Male ; Middle Aged ; Outpatients/statistics & numerical data ; Registries ; Stroke/etiology ; Stroke/prevention & control ; Time Factors
Chemical Substances	Anticoagulants
Language	English
Publishing date	2018-10-25
Publishing country	Netherlands
Document type	Evaluation Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2018.09.003
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Zs.A 1794: Show issues

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Article ; Online: Nitrogen K-edge x-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution.

Shimada, Hiroyuki / Minami, Hirotake / Okuizumi, Naoto / Sakuma, Ichiro / Ukai, Masatoshi / Fujii, Kentaro / Yokoya, Akinari / Fukuda, Yoshihiro / Saitoh, Yuji

The Journal of chemical physics

2015 Volume 142, Issue 17, Page(s) 175102

Abstract: X-ray absorption near edge structure (XANES) was measured at energies around the N K-edge ... conditions. The features of resonant excitations below the N K-edge in the XANES spectra for CMP, dTMP, and ...

Abstract	X-ray absorption near edge structure (XANES) was measured at energies around the N K-edge of the pyrimidine-containing nucleotides, cytidine 5'-monophosphate (CMP), 2'-deoxythymidine 5'-monophosphate (dTMP), and uridine 5'-monophosphate (UMP), in aqueous solutions and in dried films under various pH conditions. The features of resonant excitations below the N K-edge in the XANES spectra for CMP, dTMP, and UMP changed depending on the pH of the solutions. The spectral change thus observed is systematically explained by the chemical shift of the core-levels of N atoms in the nucleobase moieties caused by structural changes due to protonation or deprotonation at different proton concentrations. This interpretation is supported by the results of theoretical calculations using density functional theory for the corresponding nucleobases in the neutral and protonated or deprotonated forms.
MeSH term(s)	Electrons ; Hydrogen-Ion Concentration ; Hydroxyl Radical/chemistry ; Models, Chemical ; Molecular Structure ; Nitrogen ; Protons ; Pyrimidine Nucleotides/chemistry ; Solutions ; Water/chemistry ; X-Ray Absorption Spectroscopy
Chemical Substances	Protons ; Pyrimidine Nucleotides ; Solutions ; Water (059QF0KO0R) ; Hydroxyl Radical (3352-57-6) ; Nitrogen (N762921K75)
Language	English
Publishing date	2015-05-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4919744
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Z 4' 49/16: Show issues

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Book ; Thesis: Regulation of Na +, K +-ATPase in rat renal proximal tubule

Fukuda, Yutaka

oncogenic, pathophysiological and pharmacological aspects

1991

Author's details	Yutaka Fukuda
Size	Getr. Zählung : graph. Darst.
Publishing country	Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Stockholm, Karolinska Institutet, Diss., 1991
HBZ-ID	HT003954057
ISBN	91-628-0174-0 ; 978-91-628-0174-8
Database	Catalogue ZB MED Medicine, Health

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