Article ; Online: Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.
Environmental toxicology and pharmacology
2024 , Page(s) 104452
Abstract: Individuals working in diverse fields are consistently exposed to work-related pollutants that can impact their overall health. The current study investigated the presence of pollutants in seven different occupational groups and their impact on human ... ...
Abstract | Individuals working in diverse fields are consistently exposed to work-related pollutants that can impact their overall health. The current study investigated the presence of pollutants in seven different occupational groups and their impact on human health. Biochemical and genetic approaches were employed. Heavy metals were determined by ICP-MS technique. Oxidative stress biochemical markers and molecular analysis of the glutathione transferases gene SNPs (GSTT1, GSTM1, GSTP1), catalase (CAT, rs7943316), and superoxide dismutase (SOD, rs17880487) was carried out. The results revealed a significantly higher quantity of Cd among five occupational groups. Catalase, malonaldehyde, and glutathione was significantly dysregulated. Molecular analysis of the gene SNPs suggests a probable relationship between the antioxidants and the phenotypic expression of the CAT, GSTP1, GSTT1, and GSTM1 SNPs. It is concluded that chronic exposure to occupational contaminants like Cd affects human health through oxidative stress in association with some of their gene SNPs. |
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Language | English |
Publishing date | 2024-04-23 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 1318302-3 |
ISSN | 1872-7077 ; 1382-6689 |
ISSN (online) | 1872-7077 |
ISSN | 1382-6689 |
DOI | 10.1016/j.etap.2024.104452 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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