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  1. Article ; Conference proceedings: Remarks of AMI President J. Patrick Boyle before the Agriculture Outlook Conference, February 22, 1995

    Boyle, J.P

    Agricultural Outlook Forum. Proceedings / 1995.

    1995  

    Keywords agricultural economics
    Language English
    Size p. 30-34.
    Document type Article ; Conference proceedings
    Note Meeting held February 22-23, 1995 in Arlington, Virginia.
    Database NAL-Catalogue (AGRICOLA)

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  2. Book: 101 consejos para mantenerse sano con diabetes

    Boyle, Patrick J.

    [evite las complicaciones del corazón, los riñones, los ojos, los pies y la piel; mantenga los niveles de azúcar en sangre saludables; aprenda a mantenerse sano de por vida ¡y mucho, mucho más!]

    2001  

    Title variant Ciento uno consejos para mantenerse sano con diabetes
    Author's details American Diabetes Association. [Por el] Equipo para el Cuicado de la Diabetes de la Universidad de Nuevo México. [Patrick J. Boyle ...]
    Language Spanish
    Size 127 S. : Ill.
    Publisher Ed. Albatros
    Publishing place Buenos Aires
    Publishing country Argentina
    Document type Book
    HBZ-ID HT013325644
    ISBN 950-24-0977-9 ; 978-950-24-0977-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 1850 order for loan Magazin

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  3. Article: Benign Tumors Associated With Heterozygous NTHL1 Variant.

    Anderson, Danyon J / Boyle, Andrew / Reinicke, Trenton / Woods, Bison / Hsieh, Patrick

    Cureus

    2021  Volume 13, Issue 7, Page(s) e16220

    Abstract: ... ...

    Abstract NTHL1
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.16220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Computational Modeling and Simulation of the Fibrotic Human Atria.

    Bifulco, Savannah F / Boyle, Patrick M

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2735, Page(s) 105–115

    Abstract: Patient-specific modeling of atrial electrical activity enables the execution of simulations that can provide mechanistic insights and provide novel solutions to vexing clinical problems. The geometry and fibrotic remodeling of the heart can be ... ...

    Abstract Patient-specific modeling of atrial electrical activity enables the execution of simulations that can provide mechanistic insights and provide novel solutions to vexing clinical problems. The geometry and fibrotic remodeling of the heart can be reconstructed from clinical-grade medical scans and used to inform personalized models with detail incorporated at the cell- and tissue-scale to represent changes in image-identified diseased regions. Here, we provide a rubric for the reconstruction of realistic atrial models from pre-segmented 3D renderings of the left atrium with fibrotic tissue regions delineated, which are the output from clinical-grade systems for quantifying fibrosis. We then provide a roadmap for using those models to carry out patient-specific characterization of the fibrotic substrate in terms of its potential to harbor reentrant drivers via cardiac electrophysiology simulations.
    MeSH term(s) Humans ; Atrial Fibrillation/pathology ; Atrial Remodeling ; Models, Cardiovascular ; Action Potentials ; Heart Atria/surgery ; Computer Simulation ; Fibrosis
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3527-8_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prediction of Shock-Refractory Ventricular Fibrillation During Resuscitation of Out-of-Hospital Cardiac Arrest.

    Coult, Jason / Yang, Betty Y / Kwok, Heemun / Kutz, J Nathan / Boyle, Patrick M / Blackwood, Jennifer / Rea, Thomas D / Kudenchuk, Peter J

    Circulation

    2023  Volume 148, Issue 4, Page(s) 327–335

    Abstract: Background: Out-of-hospital cardiac arrest due to shock-refractory ventricular fibrillation (VF) is associated with relatively poor survival. The ability to predict refractory VF (requiring ≥3 shocks) in advance of repeated shock failure could enable ... ...

    Abstract Background: Out-of-hospital cardiac arrest due to shock-refractory ventricular fibrillation (VF) is associated with relatively poor survival. The ability to predict refractory VF (requiring ≥3 shocks) in advance of repeated shock failure could enable preemptive targeted interventions aimed at improving outcome, such as earlier administration of antiarrhythmics, reconsideration of epinephrine use or dosage, changes in shock delivery strategy, or expedited invasive treatments.
    Methods: We conducted a cohort study of VF out-of-hospital cardiac arrest to develop an ECG-based algorithm to predict patients with refractory VF. Patients with available defibrillator recordings were randomized 80%/20% into training/test groups. A random forest classifier applied to 3-s ECG segments immediately before and 1 minute after the initial shock during cardiopulmonary resuscitation was used to predict the need for ≥3 shocks based on singular value decompositions of ECG wavelet transforms. Performance was quantified by area under the receiver operating characteristic curve.
    Results: Of 1376 patients with VF out-of-hospital cardiac arrest, 311 (23%) were female, 864 (63%) experienced refractory VF, and 591 (43%) achieved functional neurological survival. Total shock count was associated with decreasing likelihood of functional neurological survival, with a relative risk of 0.95 (95% CI, 0.93-0.97) for each successive shock (
    Conclusions: A machine learning algorithm using ECGs surrounding the initial shock predicts patients likely to experience refractory VF, and could enable rescuers to preemptively target interventions to potentially improve resuscitation outcome.
    MeSH term(s) Humans ; Female ; Male ; Out-of-Hospital Cardiac Arrest/diagnosis ; Out-of-Hospital Cardiac Arrest/therapy ; Out-of-Hospital Cardiac Arrest/complications ; Electric Countershock/adverse effects ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/therapy ; Ventricular Fibrillation/complications ; Cohort Studies ; Cardiopulmonary Resuscitation/adverse effects
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.063651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  6. Article: Machine Learning and the Conundrum of Stroke Risk Prediction.

    Chahine, Yaacoub / Magoon, Matthew J / Maidu, Bahetihazi / Del Álamo, Juan C / Boyle, Patrick M / Akoum, Nazem

    Arrhythmia & electrophysiology review

    2023  Volume 12, Page(s) e07

    Abstract: Stroke is a leading cause of death worldwide. With escalating healthcare costs, early non-invasive stroke risk stratification is vital. The current paradigm of stroke risk assessment and mitigation is focused on clinical risk factors and comorbidities. ... ...

    Abstract Stroke is a leading cause of death worldwide. With escalating healthcare costs, early non-invasive stroke risk stratification is vital. The current paradigm of stroke risk assessment and mitigation is focused on clinical risk factors and comorbidities. Standard algorithms predict risk using regression-based statistical associations, which, while useful and easy to use, have moderate predictive accuracy. This review summarises recent efforts to deploy machine learning (ML) to predict stroke risk and enrich the understanding of the mechanisms underlying stroke. The surveyed body of literature includes studies comparing ML algorithms with conventional statistical models for predicting cardiovascular disease and, in particular, different stroke subtypes. Another avenue of research explored is ML as a means of enriching multiscale computational modelling, which holds great promise for revealing thrombogenesis mechanisms. Overall, ML offers a new approach to stroke risk stratification that accounts for subtle physiologic variants between patients, potentially leading to more reliable and personalised predictions than standard regression-based statistical associations.
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2813970-7
    ISSN 2050-3377 ; 2050-3369
    ISSN (online) 2050-3377
    ISSN 2050-3369
    DOI 10.15420/aer.2022.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Retraction notice to "Neuroanatomical predictors of L-DOPA response in older adults with psychomotor slowing and depression: A pilot study" [J. Affect. Disord. 265 (2020) 439-444].

    Rutherford, Bret R / Choi, Jongwoo / Slifstein, Mark / O'Boyle, Kaleigh / Abi-Dargham, Anissa / Brown, Patrick J / Wall, Melanie W / Vanegas-Arroyave, Nora / Sakhardande, Jayant / Stern, Yaakov / Roose, Steven P

    Journal of affective disorders

    2023  Volume 330, Page(s) 369

    Language English
    Publishing date 2023-03-23
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases.

    Howard, Thomas P / Boyle, Patrick J / Marcus, Karen J / Haas-Kogan, Daphne A / Liu, Kevin X

    Pediatric blood & cancer

    2021  Volume 68, Issue 12, Page(s) e29331

    Abstract: Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole-brain radiotherapy (WBRT) versus focal ... ...

    Abstract Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole-brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery or stereotactic radiotherapy, for these indications are limited. We report a single institution experience of 26 pediatric patients treated with radiotherapy for solid tumor CNS metastases without leptomeningeal disease. Focal radiotherapy (n = 10) was well tolerated and survival outcomes did not differ between patients treated with WBRT (n = 16) versus focal radiation, suggesting that focal radiotherapy may be considered for patients with limited CNS metastases.
    MeSH term(s) Brain Neoplasms/pathology ; Central Nervous System/pathology ; Child ; Cranial Irradiation/adverse effects ; Humans ; Meningeal Neoplasms ; Neoplasms, Second Primary/etiology ; Radiosurgery/adverse effects
    Language English
    Publishing date 2021-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29331
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1131: Show issues Location:
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  9. Article: Far-red and sensitive sensor for monitoring real time H

    Lee, Justin Daho / Nguyen, Amanda / Jin, Zheyu Ruby / Moghadasi, Aida / Gibbs, Chelsea E / Wait, Sarah J / Evitts, Kira M / Asencio, Anthony / Bremner, Samantha B / Zuniga, Shani / Chavan, Vedant / Williams, Andy / Smith, Netta / Regnier, Michael / Young, Jessica E / Mack, David / Nance, Elizabeth / Boyle, Patrick M / Berndt, Andre

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract H
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.06.579232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

    Mehta, Puja / Samanta, Romit J / Wick, Katherine / Coll, Rebecca C / Mawhinney, Thea / McAleavey, Patrick G / Boyle, Andrew J / Conlon, John / Shankar-Hari, Manu / Rogers, Angela / Calfee, Carolyn S / Matthay, Michael A / Summers, Charlotte / Chambers, Rachel Clare / McAuley, Daniel Francis / O'Kane, Cecilia M

    Thorax

    2024  Volume 79, Issue 3, Page(s) 227–235

    Abstract: Background: Inflammatory subphenotypes have been identified in acute respiratory distress syndrome (ARDS). Hyperferritinaemia in sepsis is associated with hyperinflammation, worse clinical outcomes, and may predict benefit with immunomodulation. Our aim ...

    Abstract Background: Inflammatory subphenotypes have been identified in acute respiratory distress syndrome (ARDS). Hyperferritinaemia in sepsis is associated with hyperinflammation, worse clinical outcomes, and may predict benefit with immunomodulation. Our aim was to determine if raised ferritin identified a subphenotype in patients with ARDS.
    Methods: Baseline plasma ferritin concentrations were measured in patients with ARDS from two randomised controlled trials of simvastatin (Hydroxymethylglutaryl-CoA Reductase Inhibition with Simvastatin in Acute Lung Injury to Reduce Pulmonary Dysfunction-2 (HARP-2); discovery cohort, UK) and neuromuscular blockade (ROSE; validation cohort, USA). Results were analysed using a logistic regression model with restricted cubic splines, to determine the ferritin threshold associated with 28-day mortality.
    Results: Ferritin was measured in 511 patients from HARP-2 (95% of patients enrolled) and 847 patients (84% of patients enrolled) from ROSE. Ferritin was consistently associated with 28-day mortality in both studies and following a meta-analysis, a log-fold increase in ferritin was associated with an OR 1.71 (95% CI 1.01 to 2.90) for 28-day mortality. Patients with ferritin >1380 ng/mL (HARP-2 28%, ROSE 24%) had a significantly higher 28-day mortality and fewer ventilator-free days in both studies. Mediation analysis, including confounders (acute physiology and chronic health evaluation-II score and ARDS aetiology) demonstrated a statistically significant contribution of interleukin (IL)-18 as an intermediate pathway between ferritin and mortality.
    Conclusions: Ferritin is a clinically useful biomarker in ARDS and is associated with worse patient outcomes. These results provide support for prospective interventional trials of immunomodulatory agents targeting IL-18 in this hyperferritinaemic subgroup of patients with ARDS.
    MeSH term(s) Humans ; Prospective Studies ; Interleukin-18 ; Simvastatin ; Respiratory Distress Syndrome/etiology ; Inflammation
    Chemical Substances Interleukin-18 ; Simvastatin (AGG2FN16EV)
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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