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Book ; Online: Plumer's principles & practice of intravenous therapy

Weinstein, Sharon / Plumer, Ada Lawrence

2007

Title variant	Plumer's principles and practice of intravenous therapy ; Principles & practice of intravenous therapy ; Principles and practice of intravenous therapy
Author's details	Sharon M. Weinstein
Keywords	Infusions, intravenous - methods ; Infusions, intravenous - nursing ; Fluid therapy - methods ; Parenteral nutrition - methods ; Nurse's role ; Evidence-based medicine
Language	English
Size	1 Online-Ressource (xvii, 753 Seiten), Illustrationen
Edition	8th ed.
Publisher	Lippincott Williams & Wilkins
Publishing place	Philadelphia
Document type	Book ; Online
Note	Includes bibliographical references and index
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	978-0-7817-5944-1 ; 0-7817-5944-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: High dietary K

Wang, Tong / Liu, Tommy / Xu, Shuhua / Frindt, Gustavo / Weinstein, Alan M / Palmer, Lawrence G

American journal of physiology. Renal physiology

2023 Volume 325, Issue 2, Page(s) F224–F234

Abstract: The impact of chronic dietary ... ...

Abstract	The impact of chronic dietary K
MeSH term(s)	Rats ; Animals ; Sodium-Hydrogen Exchanger 3/metabolism ; Kidney Tubules, Proximal/metabolism ; Nephrons/metabolism ; Kidney/metabolism ; Sodium/metabolism ; Glomerular Filtration Rate
Chemical Substances	Sodium-Hydrogen Exchanger 3 ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00013.2023
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Article ; Online: Considerations for prenatal and postpartum management of a female patient with ornithine transcarbamylase deficiency

Annette Feigenbaum / Leah Lamale-Smith / Lawrence Weinstein

Molecular Genetics and Metabolism Reports, Vol 33, Iss , Pp 100894- (2022)

2022

Abstract: We report on pregnancy management and outcomes in a 27-year-old female patient with ornithine transcarbamylase (OTC) deficiency, the most common inherited enzyme deficiency in the urea cycle. Our patient was diagnosed during childhood after ... ...

Abstract	We report on pregnancy management and outcomes in a 27-year-old female patient with ornithine transcarbamylase (OTC) deficiency, the most common inherited enzyme deficiency in the urea cycle. Our patient was diagnosed during childhood after hyperammonemia associated with surgery and steroid treatment and was well-controlled with nitrogen scavenger treatment, low-protein diet, and L-citrulline supplementation. OTC gene sequencing identified a variant of unknown significance that has more recently been classified as likely pathogenic. Women with OTC deficiency are at increased risk of hyperammonemia during pregnancy and the postpartum period, therefore monthly follow up and laboratory assessments are critical in management decision making. Our patient was maintained on glycerol phenylbutyrate, L-citrulline and essential amino acid supplements, along with restricted protein intake during pregnancy. A multidisciplinary approach with the obstetrics, prenatal genetics, high risk obstetric, and anesthesia teams was also necessary for optimal management during pregnancy, throughout labor and delivery, and during the postpartum period. After successful childbirth and discharge, our patient experienced a hyperammonemic crisis related to poor enteral nutrition, and acute management protocols were implemented to stabilize her. For her newborn son, acute hyperammonemia protocols were on standby, and newborn screening and laboratory testing were expedited to assess his risk. He was healthy and did not experience symptoms of concern. In this case report, we emphasize the importance of close collaboration with maternal-fetal medicine team members during and immediately after pregnancy to ensure successful management of a female patient with OTC deficiency and her newborn.
Keywords	Urea cycle disorder ; Ornithine transcarbamylase deficiency ; X-linked ; hyperammonemia ; Peripartum management ; Pregnancy ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.

Lawrence, Wayne R / Lim, Jung-Eun / Huang, Jiaqi / Sampson, Joshua N / Weinstein, Stephanie J / Albanes, Demetrius

European journal of clinical nutrition

2022 Volume 76, Issue 9, Page(s) 1254–1265

Abstract: Background/objectives: The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its influence on health ... ...

Abstract	Background/objectives: The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its influence on health outcomes. Identifying vitamin-E-associated metabolites through agnostic metabolomics analyses can contribute to elucidating the specific associations and disease etiology. This study aims to investigate the association between circulating metabolites and serum α-tocopherol concentration in an un-supplemented state. Subjects/methods: Metabolomic analysis of 4,294 male participants was conducted based on pre-supplementation fasting serum in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. The associations between 1,791 known metabolites measured by ultra-high-performance LC-MS/GC-MS and HPLC-determined α-tocopherol concentration were estimated using multivariable linear regression. Differences in metabolite levels per unit difference in α-tocopherol concentration were calculated as standardized β-coefficients and standard errors. Results: A total of 252 metabolites were associated with serum α-tocopherol at the Bonferroni-corrected p value (p < 2.79 × 10 Conclusions: The large number of metabolites, particularly lipid and amino acid compounds associated with serum α-tocopherol provide leads regarding potential mechanisms through which vitamin E influences human health, including its role in cardiovascular disease and cancer.
MeSH term(s)	Amino Acids ; Humans ; Lipids ; Male ; Neoplasms/prevention & control ; Vitamin E ; alpha-Tocopherol ; beta Carotene
Chemical Substances	Amino Acids ; Lipids ; beta Carotene (01YAE03M7J) ; Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-022-01112-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A 28-year prospective analysis of serum vitamin E, vitamin E-related genetic variation and risk of prostate cancer.

Lawrence, Wayne R / Lim, Jung-Eun / Huang, Jiaqi / Weinstein, Stephanie J / Mӓnnistӧ, Satu / Albanes, Demetrius

Prostate cancer and prostatic diseases

2022 Volume 25, Issue 3, Page(s) 553–560

Abstract: Objective: Investigate the relationship between serum α-tocopherol concentration and long-term risk of prostate cancer, and evaluate the interaction with vitamin E-related genetic variants and their polygenic risk score (PRS).: Methods: We conducted ... ...

Abstract	Objective: Investigate the relationship between serum α-tocopherol concentration and long-term risk of prostate cancer, and evaluate the interaction with vitamin E-related genetic variants and their polygenic risk score (PRS). Methods: We conducted a biochemical analysis of 29,102 male Finnish smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Serum α-tocopherol was measured at baseline using high-performance liquid chromatography, and 2724 prostate cancer cases were identified during 28 years of follow-up. Cox proportional hazards models examined whether serum α-tocopherol concentrations were associated with prostate cancer risk. Among 8383 participants, three SNPs related to vitamin E status (rs964184, rs2108622, and rs11057830) were examined to determine whether they modified the relationship between serum α-tocopherol concentrations and prostate cancer risk, both individually and as a PRS using logistic regression models. Results: No association was observed between serum α-tocopherol and prostate cancer risk (fifth quintile (Q5) vs. Q1 hazard ratio (HR) = 0.87, 95% confidence interval (95% CI) 0.75, 1.02; P-trend = 0.57). Though no interactions were seen by population characteristics, high α-tocopherol concentration was associated with reduced prostate cancer risk among the trial α-tocopherol supplementation group (Q5 quintile vs. Q1 HR = 0.79, 95% CI 0.64, 0.99). Finally, no associated interaction between the three SNPs or their PRS and prostate cancer risk was observed. Conclusion: Although there was a weak inverse association between α-tocopherol concentration and prostate cancer risk over nearly three decades, our findings suggest that men receiving the trial α-tocopherol supplementation who had higher baseline serum α-tocopherol concentration experienced reduced prostate cancer risk. Vitamin E-related genotypes did not modify the serum α-tocopherol-prostate cancer risk association.
MeSH term(s)	Humans ; Male ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/etiology ; Prostatic Neoplasms/genetics ; Risk Factors ; Vitamin E ; alpha-Tocopherol ; beta Carotene
Chemical Substances	beta Carotene (01YAE03M7J) ; Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-022-00511-y
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Article ; Online: In search of opportunity and community: Internal migration of refugees in the United States.

Mossaad, Nadwa / Ferwerda, Jeremy / Lawrence, Duncan / Weinstein, Jeremy / Hainmueller, Jens

Science advances

2020 Volume 6, Issue 32, Page(s) eabb0295

Abstract: At a time of heightened anxiety surrounding immigration, state governments have increasingly sought to manage immigrant and refugee flows. Yet the factors that influence where immigrants choose to settle after arrival remain unclear. We bring evidence to ...

Abstract	At a time of heightened anxiety surrounding immigration, state governments have increasingly sought to manage immigrant and refugee flows. Yet the factors that influence where immigrants choose to settle after arrival remain unclear. We bring evidence to this question by analyzing population-level data for refugees resettled within the United States. Unlike other immigrants, refugees are assigned to initial locations across the country but are free to relocate and select another residence after arrival. Drawing on individual-level administrative data for adult refugees resettled between 2000 and 2014 (
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abb0295
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Book: Plumer's principles & practice of intravenous therapy

Weinstein, Sharon M. / Plumer, Ada Lawrence

1997

Author's details	Sharon M. Weinstein
Keywords	Infusions, Intravenous
Language	English
Size	XX, 663 S. : Ill., graph. Darst.
Edition	6. ed.
Publisher	Lippincott
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007570581
ISBN	0-397-55311-0 ; 978-0-397-55311-2
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
1997 A 5094	order for loan	Magazin

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Article ; Online: The Crohn's Disease-Health Index: Development and Evaluation of a Novel Outcome Measure.

Varma, Anika / Weinstein, Jennifer / Seabury, Jamison / Rosero, Spencer / Wagner, Ellen / Zizzi, Christine / Kaat, Aaron / Luebbe, Elizabeth / Dilek, Nuran / Heatwole, John / Saubermann, Lawrence / Temple, Larissa / Rogoff, Scott / Heatwole, Chad

Journal of clinical gastroenterology

2024

Abstract: Objective: We sought to develop and validate the Crohn's Disease-Health Index (CD-HI), a disease-specific, patient-reported outcome measure that serially measures Crohn's disease (CD) symptomatic burden in adults with CD.: Background: As therapeutic ... ...

Abstract	Objective: We sought to develop and validate the Crohn's Disease-Health Index (CD-HI), a disease-specific, patient-reported outcome measure that serially measures Crohn's disease (CD) symptomatic burden in adults with CD. Background: As therapeutic interventions are tested among patients with CD, responsive outcome measures are needed to track disease progression and therapeutic gain during clinical trials. Patients and methods: We conducted a national cross-sectional study of individuals with CD to identify the most prevalent and impactful symptoms of CD. The most relevant symptoms were included in the CD-HI. We used factor analysis, qualitative patient interviews, test-retest reliability evaluation, and known group validity testing to evaluate and optimize the CD-HI. Results: The CD-HI contains 12 subscales that comprehensively measure CD burden using the patient's perspective. Fifteen adults with CD beta tested the CD-HI and found the instrument to be clear, easy to use, and relevant to them. Twenty-three adults with CD participated in an assessment of test-retest reliability, which indicated high reliability of individual questions, subscales, and the full instrument (intraclass correlation coefficient = 0.84 for the full instrument). The CD-HI and its subscales demonstrated a high internal consistency (Cronbach α = 0.98 for the full instrument). The CD-HI distinguished between groups of individuals with CD known to differ in disease severity. Conclusions: This research supports the use of the CD-HI as a valid, sensitive, reliable, and relevant patient-reported outcome to determine the multifactorial disease burden of those with CD, assess the relevance and merit of future CD therapies, and support drug labeling claims.
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001976
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Book: Guesstimation 2.0

Weinstein, Lawrence

solving today's problems on the back of a napkin

2012

Title variant	Gue??timation 2.0
Author's details	Lawrence Weinstein
Keywords	Estimation theory ; Problem solving
Language	English
Size	XV, 359 S., zahlr. Ill.
Publisher	Princeton Univ. Press
Publishing place	Princeton, NJ u.a.
Document type	Book
Note	Literaturverz. S. 351 - 353 ; Titelschreibweise in der Vorlage: "Gue??timation 2.0". - Sequel to "Guesstimation"
ISBN	9780691150802 ; 069115080X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion.

Yang, Lei / Xu, Yuanyuan / Gravotta, Diego / Frindt, Gustavo / Weinstein, Alan M / Palmer, Lawrence G

The Journal of general physiology

2021 Volume 153, Issue 8

Abstract: We measured the activities of epithelial Na channels (ENaC) and ROMK channels in the distal nephron of the mouse kidney and assessed their role in the process of K+ secretion under different physiological conditions. Under basal dietary conditions (0.5% ... ...

Abstract	We measured the activities of epithelial Na channels (ENaC) and ROMK channels in the distal nephron of the mouse kidney and assessed their role in the process of K+ secretion under different physiological conditions. Under basal dietary conditions (0.5% K), ENaC activity, measured as amiloride-sensitive currents, was high in cells at the distal end of the distal convoluted tubule (DCT) and proximal end of the connecting tubule (CNT), a region we call the early CNT (CNTe). In more distal parts of the CNT (aldosterone-sensitive portion [CNTas]), these currents were minimal. This functional difference correlated with alterations in the intracellular location of ENaC, which was at or near the apical membrane in CNTe and more cytoplasmic in the CNTas. ROMK activity, measured as TPNQ-sensitive currents, was substantial in both segments. A mathematical model of the rat nephron suggested that K+ secretion by the CNTe predicted from these currents provides much of the urinary K+ required for K balance on this diet. In animals fed a K-deficient diet (0.1% K), both ENaC and ROMK currents in the CNTe decreased by ∼50%, predicting a 50% decline in K+ secretion. Enhanced reabsorption by a separate mechanism is required to avoid excessive urinary K+ losses. In animals fed a diet supplemented with 3% K, ENaC currents increased modestly in the CNTe but strongly in the CNTas, while ROMK currents tripled in both segments. The enhanced secretion of K+ by the CNTe and the recruitment of secretion by the CNTas account for the additional transport required for K balance. Therefore, adaptation to increased K+ intake involves the extension of robust K+ secretion to more distal parts of the nephron.
MeSH term(s)	Animals ; Epithelial Sodium Channels ; Kidney Tubules, Distal/metabolism ; Mice ; Nephrons/metabolism ; Potassium Channels, Inwardly Rectifying ; Rats ; Sodium/metabolism
Chemical Substances	Epithelial Sodium Channels ; Potassium Channels, Inwardly Rectifying ; Sodium (9NEZ333N27)
Language	English
Publishing date	2021-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202112902
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