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Article: Lutetium Lu 177 vipivotide tetraxetan for prostate cancer.

Liu, Xing / Fang, Gao-Chuan / Lu, Hao / Shi, Zhen-Duo / Chen, Zhe-Sheng / Han, Cong-Hui

Drugs of today (Barcelona, Spain : 1998)

2023 Volume 59, Issue 1, Page(s) 37–49

Abstract: On March 23, 2022, the U.S. Food and Drug Administration (FDA) approved Pluvicto (lutetium Lu 177 ... therapy for eligible men with PSMA-positive mCRPC. Lutetium Lu 177 vipivotide tetraxetan is a radioligand ... and clinical studies of the novel drug lutetium Lu 177 vipivotide tetraxetan for the treatment ...

Abstract	On March 23, 2022, the U.S. Food and Drug Administration (FDA) approved Pluvicto (lutetium Lu 177 vipivotide tetraxetan), also known as 177Lu-PSMA-617, for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) who have highly expressed prostate-specific membrane antigen (PSMA) and have at least one metastatic lesion. It is the first FDA-approved targeted radioligand therapy for eligible men with PSMA-positive mCRPC. Lutetium Lu 177 vipivotide tetraxetan is a radioligand that strongly binds to PSMA, making it ideal for treating cancers of the prostate by targeted radiation, resulting in DNA damage and cell death. PSMA is overexpressed in cancer cells while being lowly expressed in normal tissues, which makes it an ideal theranostic target. As precision medicine advances, this is a thrilling turning point for highly individualized treatments. This review aims to summarize the pharmacology and clinical studies of the novel drug lutetium Lu 177 vipivotide tetraxetan for the treatment of mCRPC, emphasizing its mechanism of action, pharmacokinetics and safety.
MeSH term(s)	Male ; Humans ; Lutetium/adverse effects ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostate-Specific Antigen/therapeutic use ; Treatment Outcome
Chemical Substances	177Lu-PSMA-617 ; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Lutetium (5H0DOZ21UJ) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-02-22
Publishing country	Spain
Document type	Review ; Journal Article
ISSN	1699-3993
ISSN	1699-3993
DOI	10.1358/dot.2023.59.1.3476574
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Article ; Online: Isolation and Crystallographic Characterization of Lu

Shen, Wang-Qiang / Bao, Li-Piao / Hu, Shuai-Feng / Gao, Xue-Jiao / Xie, Yun-Peng / Gao, Xing-Fa / Huang, Wen-Huan / Lu, Xing

Chemistry (Weinheim an der Bergstrasse, Germany)

2018 Volume 24, Issue 62, Page(s) 16692–16698

Abstract: The small ... ...

Abstract	The small Sc
Language	English
Publishing date	2018-10-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-x
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201804651
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Article ; Online: Reply to "In regard to the article by Lu K et al.: removing a suprapatellar intramedullary nail via a suprapatellar approach: a retrospective cohort study".

Lu, Ke / Gao, Yi-Jun

International orthopaedics

2022 Volume 46, Issue 12, Page(s) 2983–2984

MeSH term(s)	Humans ; Bone Nails
Language	English
Publishing date	2022-09-07
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-022-05576-x
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Zs.A 1324: Show issues

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Article ; Online: Εfficacy and safety of vortioxetine (Lu AA21004) in the treatment of adult patients with major depressive disorder: A systematic review and a meta‑analysis of randomized controlled trials.

Gao, Shan / Xie, Xingxing / Fan, Ling / Zhang, Deming

Experimental and therapeutic medicine

2023 Volume 26, Issue 5, Page(s) 515

Abstract: Vortioxetine is a novel drug for the treatment of major depressive disorder (MDD). It has been reported that vortioxetine exhibits positive effect on the acute stage of MDD, while it can effectively prevent the recurrence of MDD during the maintenance ... ...

Abstract	Vortioxetine is a novel drug for the treatment of major depressive disorder (MDD). It has been reported that vortioxetine exhibits positive effect on the acute stage of MDD, while it can effectively prevent the recurrence of MDD during the maintenance period. Currently, the results of systematic reviews on vortioxetine are insufficient since several efficacy measures, such as the 24-Items Hamilton Rating Scale for Depression (HADRS-24) total score and other safety factors have not been evaluated. Therefore, the present study aimed to evaluate the efficacy and safety of different doses of vortioxetine on the treatment of adult patients with MDD via assessing more efficacy and safety indicators. The clinical, double-blind, parallel and randomized controlled trials (RCTs) on the effect of vortioxetine on MDD were retrieved from PubMed\Medline, EBSCO, Embase, Cochrane Library, OVID, Web of Science and clinical trial registration websites from database inception to November 2022. A total of two investigators independently screened the included references and independently evaluated their quality. The meta-analysis was performed using Revman 5.0 software. The present systematic review was registered in PROSPERO (registration no. CRD42018106343). In the present study 11 RCTs were included, with a total of 4,908 adult patients with MDD. More specifically, 1,158 patients were included in the 5-mg vortioxetine group, 736 in the 10-mg group, 298 in the 15-mg group, 864 in the 20-mg group and 1,852 in the placebo group. All 11 studies were randomized, double-blinded and parallel control trials, and all publications were evaluated as high quality. The meta-analysis results showed that patients in the 5-, 10- and 20-mg vortioxetine groups exhibited significantly higher Montgomery-Asberg Depression Rating Scale (MADRS) response (≥50%) and remission (≤10%) rates compared with the placebo group (P<0.05). The pooled analysis also revealed a statistically significant change in the total score of HADRS-24, MADRS, Sheehan Disability Scale (SDS), Clinical Global Impression Scale-Improvement (CGI-I) and HADRS-24 response rate in the 10- and 20-mg vortioxetine groups compared with the placebo group (P<0.05). However, no statistically significant changes in the total score of HADRS-24, MADRS, SDS, CGI-I and HADRS-24 response rate were obtained in the 5-mg group compared with the placebo group (P>0.05). Furthermore, the most common adverse events were nausea, hyperhidrosis, insomnia and vomiting, the incidence of which was increased with higher doses of vortioxetine. Overall, the results suggested that vortioxetine administration at doses of 5-20 mg was significantly effective and safe compared with placebo in the treatment of MDD. However, 5 mg vortioxetine displayed no difference in the HADRS-24, MADRS, SDS and CGI-I total scores, and HADRS-24 response rate. Furthermore, patient treatment with increasing vortioxetine doses was associated with good tolerance and high safety. Nevertheless, more multi-center, high-quality and long-term RCTs are still needed to support the aforementioned findings.
Language	English
Publishing date	2023-09-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2023.12214
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Article ; Online: Triple-Helix Molecular Switch Electrochemiluminescence Nanoamplifier Based on a S-Doped Lu

Gao, Huan / Zhang, Junfang / Liu, Ying / Tu, Wenwen / Wei, Tianxiang / Dai, Zhihui

Analytical chemistry

2019 Volume 91, Issue 18, Page(s) 12038–12045

Abstract: ... an electrochemiluminescence (ECL) biosensor for microRNA determination. The newly synthesized S-doped Lu ...

Abstract	Development of sensitive detection methods for microRNAs has realistic application value for early clinical analysis and accurate diagnosis. In this study, a triple-helix molecular switch electrochemiluminescence resonance energy transfer (ECL-RET) nanoamplifier was designed to construct an electrochemiluminescence (ECL) biosensor for microRNA determination. The newly synthesized S-doped Lu
MeSH term(s)	Biosensing Techniques ; Electrochemical Techniques ; Fluorescence Resonance Energy Transfer ; Humans ; Lutetium/chemistry ; MicroRNAs/analysis ; Oxides/chemistry ; Silver Compounds/chemistry
Chemical Substances	MicroRNAs ; Oxides ; Silver Compounds ; Lutetium (5H0DOZ21UJ) ; silver sulfide (9ZB10YHC1C)
Language	English
Publishing date	2019-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.9b03071
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Zs.A 4033: Show issues

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Article: [Study on HPLC specific chromatograms of Lu Dangshen].

Guan, Lin-jing / Lian, Yun-lan / Li, Jian-kuan / Zhen, Xian / Shi, Xian-hai / Gao, Jian-ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Volume 40, Issue 14, Page(s) 2854–2861

Abstract: ... specific chromatograms between the Lu Dangshen and other different base sources and different producing ... chromatograms of Lu Dangshen was established and the relative retention times of seven peaks was determined, and ... identified; The HPLC specific chromatograms of Lu Dangshen provided a method for scientific evaluation and ...

Abstract	In this paper, the RP-HPLC specific chromatography was adopted, with DIKMA-C18 (4.6 mm x 250 mm, 5 µm) as the chromatographic column, with a gradient elution compose of acetonitrile and 0.1% phosphoric acid at flow rate of 0.8 mL · min(-1), the detection wavelength was 220 nm. The difference of the HPLC specific chromatograms between the Lu Dangshen and other different base sources and different producing area of Codonopsis Radix was compared, involved in the similarities and differences of the number and the relative peak area of characteristic peaks in the HPLC specific chromatograms. The HPLC specific chromatograms of Lu Dangshen was established and the relative retention times of seven peaks was determined, and the peaks of codonopyrrolidium B, syringin, lobetyolin, tangshenoside I and atractylenoide III were identified; The HPLC specific chromatograms of Lu Dangshen provided a method for scientific evaluation and effective control the quality of Lu Dangshen from Shanxi famous-region.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Codonopsis/chemistry ; Drugs, Chinese Herbal/analysis ; Glucosides/analysis ; Phenylpropionates/analysis ; Plant Roots/chemistry ; Quality Control
Chemical Substances	Drugs, Chinese Herbal ; Glucosides ; Phenylpropionates ; syringin (I6F5B11C96)
Language	Chinese
Publishing date	2015-07
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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Zs.A 3056: Show issues

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Article: Electroprecipitation of Nanometer-Thick Films of Ln(OH)₃ [Ln = La, Ce, and Lu] at Pt Microelectrodes and Their Effect on Electron-Transfer Reactions

Majumdar, Pavel / Gao, Rui / White, Henry S.

Langmuir. 2022 June 17, v. 38, no. 26

2022

Abstract: We report investigations of the deposition of nanometer-thick Ln(OH)₃ films (Ln = La, Ce, and Lu ...

Abstract	We report investigations of the deposition of nanometer-thick Ln(OH)₃ films (Ln = La, Ce, and Lu) and their effect on outer-sphere and inner-sphere electron-transfer reactions. Insoluble Ln(OH)₃ films are deposited from aqueous solutions of LaCl₃ onto the surface of 12.5 μm radius Pt microdisk electrodes during water or oxygen reduction. Both reactions produce interfacial OH–, which complexes with Ln³⁺, resulting in the precipitation of Ln(OH)₃. Surface analyses by scanning electron microscopy (SEM), SEM–energy-dispersive X-ray spectroscopy, and atomic force microscopy indicate the formation of a 1–2 nm thick uniform film. Outer-sphere electron-transfer reactions (Ru(NH₃)₆³⁺ reduction, FcMeOH oxidation, and Fe(CN)₆⁴–/³– oxidation/reduction) were investigated at Ln(OH)₃-modified electrodes of different film thicknesses. The results demonstrate that the steady-state transport-limited current for these reactions decreases with an increase in the film thickness. Moreover, the degree of blockage depends upon the redox species, suggesting that the Ln(OH)₃ films are free from pinholes greater than the size of the redox molecules. This suggests that the films are either ionically conducting or that electron tunneling occurs across these thin layers. A similar blocking effect was observed for the inner-sphere reductions of H₂O and O₂. We further demonstrate that the thickness of La(OH)₃ films can be controlled by anodic dissolution. Additionally, we show that La³⁺ lowers the supersaturation of dissolved H₂ required to nucleate a stable nanobubble.
Keywords	X-radiation ; atomic force microscopy ; electron transfer ; microelectrodes ; nanobubbles ; oxidation ; oxygen ; spectroscopy
Language	English
Dates of publication	2022-0617
Size	p. 8125-8134.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c01008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Data of temperature, thermal conductivity, heat production and heat flow of the southern Tan-Lu Fault Zone, East-Central China.

Wang, Yibo / Hu, Shengbiao / Wang, Zhuting / Jiang, Guangzheng / Hu, Di / Zhang, Kesong / Gao, Peng / Hu, Jie / Zhang, Tao

Data in brief

2019 Volume 26, Page(s) 104459

Abstract: In this article we report 5 terrestrial heat flow points along the southern Tan-Lu Fault Zone based ... Heat flow, heat production, thermal structure and its tectonic implication of the southern Tan-Lu Fault Zone ...

Abstract	In this article we report 5 terrestrial heat flow points along the southern Tan-Lu Fault Zone based on the first systematic deep borehole temperature measurements and thermal conductivities of 128 rock samples. All the temperature logs after 1 m spacing is plotted. The thermal properties test data of all samples have been collated separately, and the thermal conductivity correction data for different depths is presented. In combination with steady state temperature and thermal properties testing, the vertical variation of heat flow is calculated. Detailed interpretation of this data can be found in a research article titled "Heat flow, heat production, thermal structure and its tectonic implication of the southern Tan-Lu Fault Zone, East-Central China" (Wang et al., 2019) [1].
Language	English
Publishing date	2019-08-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2019.104459
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Article ; Online: Na2RE2TeO4(BO3)2 (RE = Y, Dy-Lu): luminescent and structural studies on a series of mixed metal borotellurates.

Feng, Jiang-He / Hu, Chun-Li / Xu, Xiang / Kong, Fang / Mao, Jiang-Gao

Inorganic chemistry

2015 Volume 54, Issue 5, Page(s) 2447–2454

Abstract: The first examples of metal borotellurates, namely, Na2RE2TeO4(BO3)2 (RE = Y, Dy-Lu) have been ...

Abstract	The first examples of metal borotellurates, namely, Na2RE2TeO4(BO3)2 (RE = Y, Dy-Lu) have been prepared by using solid-state reactions. They possess similar structures and crystallize in space group P21/c (No. 14). These compounds feature a novel [RE2TeO4(BO3)2](2-) 3D network structure composed of linear [TeO4(BO3)2](8-) anions interconnected by RE(3+) ions with the voids of the network filled by the Na(+) ions. They exhibit high thermal stability (higher than 800 °C). Results of magnetic measurements on Dy, Ho, and Er compounds indicate that they display weak antiferromagnetic interaction between RE(III) centers. Luminescent studies show that Na2Er2TeO4(BO3)2 has a strong emission at 1.562 μm with a wide fwhm (70 nm) and moderate lifetime (0.18 ms), whereas Na2Yb2TeO4(BO3)2 has a strong NIR region emission around 1.02 μm. Furthermore, UV-vis-NIR absorption spectra, infrared spectra, and DFT calculations for the Y compound as a representative were also accomplished.
Language	English
Publishing date	2015-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic503068s
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Book ; Online: Covalent Organic Frameworks

Gao, Yanan / Lu, Fei / Lu, Fei

2023

Keywords	Organic chemistry ; Chemistry
Language	English
Size	1 electronic resource (122 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030377695
ISBN	9781803569611 ; 1803569611
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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