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  1. Article ; Online: Amphiphilic multi-targeting copolymer micelles efficiently deliver pZNF580 to promote endothelial cell proliferation and migration.

    Li, Chen / Xu, Qirong / Meng, Xiangyan / Duo, Xinghong / Feng, Yakai

    Journal of materials chemistry. B

    2024  Volume 12, Issue 11, Page(s) 2843–2854

    Abstract: Cationic copolymers are widely used in gene delivery as a non-viral gene vector, but their applications are limited by low transfection efficiency and high cytotoxicity. In order to enhance the transfection efficiency of copolymer micelles to endothelial ...

    Abstract Cationic copolymers are widely used in gene delivery as a non-viral gene vector, but their applications are limited by low transfection efficiency and high cytotoxicity. In order to enhance the transfection efficiency of copolymer micelles to endothelial cells (HUVECs) and reduce their cytotoxicity, this study synthesized an amphipathic multi-targeted copolymer micelle delivery system PCLMD-PPEGMA-NLS-TAT-REDV (TCMs). Gel test results showed that TCMs showed good pZNF580 binding ability and could effectively load the pZNF580 plasmid. The CCK-8 results show that when the concentration of TCMs is greater than 60 μg mL
    MeSH term(s) Humans ; Micelles ; Endothelial Cells ; Polymers ; Transfection ; Neovascularization, Pathologic ; Cell Proliferation
    Chemical Substances Micelles ; Polymers
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02849f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Associations of Lifestyle Patterns With Overweight and Depressive Symptoms Among United States Emerging Adults With Different Employment Statuses.

    Xie, Qian-Wen / Fan, Xu Li / Luo, Xiangyan / Chen, Jieling

    International journal of public health

    2023  Volume 68, Page(s) 1606451

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Overweight/epidemiology ; Depression/epidemiology ; Nutrition Surveys ; Life Style ; Employment
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2023.1606451
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Associations Between Parental Employment and Children's Screen Time: A Longitudinal Study of China Health and Nutrition Survey.

    Xie, Qian-Wen / Luo, Xiangyan / Chen, Roujia / Zhou, Xudong

    International journal of public health

    2023  Volume 67, Page(s) 1605372

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Child ; Humans ; Longitudinal Studies ; Screen Time ; Parents ; Employment ; Nutrition Surveys
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2022.1605372
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation.

    Xu, Qirong / Li, Chen / Meng, Xiangyan / Duo, Xinghong / Feng, Yakai

    Regenerative biomaterials

    2024  Volume 11, Page(s) rbae013

    Abstract: Endothelial cell proliferation plays an important role in angiogenesis and treatment of related diseases. The aim of this study was to evaluate the effect of polyethylenimine (PEI)-modified graphene quantum dots (GQDs) gene vectors on endothelial cell ... ...

    Abstract Endothelial cell proliferation plays an important role in angiogenesis and treatment of related diseases. The aim of this study was to evaluate the effect of polyethylenimine (PEI)-modified graphene quantum dots (GQDs) gene vectors on endothelial cell proliferation. The GQDs-cationic polymer gene vectors were synthesized by amidation reaction, and used to deliver pZNF580 gene to Human umbilical vein endothelial cells (HUVECs) for promoting their proliferation. The chemical modification of GQDs can adjust gene vectors' surface properties and charge distribution, thereby enhancing their interaction with gene molecules, which could effectively compress the pZNF580 gene. The CCK-8 assay showed that the cell viability was higher than 80% at higher vector concentration (40 μg/mL), demonstrating that the GQDs-cationic polymer gene vectors and their gene complex nanoparticles (NPs) having low cytotoxicity. The results of the live/dead cell double staining assay were consistent with those of the CCK-8 assay, in which the cell viability of the A-GQDs/pZNF580 (94.38 ± 6.39%), C-GQDs-PEI- polylactic acid-co-polyacetic acid (PLGA)/pZNF580 (98.65 ± 6.60%) and N-GQDs-PEI-PLGA/pZNF580 (90.08 ± 1.60%) groups was significantly higher than that of the Lipofectamine 2000/pZNF580 (71.98 ± 3.53%) positive treatment group. The results of transfection and western blot experiments showed that the vector significantly enhanced the delivery of plasmid to HUVECs and increased the expression of pZNF580 in HUVECs. In addition, the gene NPs better promote endothelial cell migration and proliferation. The cell migration rate and proliferation ability of C-GQDs-PEI-PLGA/pZNF580 and N-GQDs-PEI-PLGA/pZNF580 treatment groups were higher than those of Lipofectamine 2000/pDNA treatment group. Modified GQDs possess the potential to serve as efficient gene carriers. They tightly bind gene molecules through charge and other non-covalent interactions, significantly improving the efficiency of gene delivery and ensuring the smooth release of genes within the cell. This innovative strategy provides a powerful means to promote endothelial cell proliferation.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2799042-4
    ISSN 2056-3426 ; 2056-3418
    ISSN (online) 2056-3426
    ISSN 2056-3418
    DOI 10.1093/rb/rbae013
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  5. Article ; Online: Intracranial artery calcification as an independent predictor of ischemic stroke: a systematic review and a meta-analysis.

    Li, Xuelong / Du, Heng / Li, Jia / Chen, Xiangyan

    BMC neurology

    2023  Volume 23, Issue 1, Page(s) 21

    Abstract: Background and purpose: The association between intracranial artery calcification (IAC) and the risk of ischemic stroke occurrence or poor prognosis had not yet been fully understood. In this study, we conducted a meta-analysis of existing studies aimed ...

    Abstract Background and purpose: The association between intracranial artery calcification (IAC) and the risk of ischemic stroke occurrence or poor prognosis had not yet been fully understood. In this study, we conducted a meta-analysis of existing studies aimed to assess whether IAC can be used to predict future ischemic stroke and post-stroke mortality.
    Methods: Medline, Cochrane, Web of Science and Google Scholar databases were searched up to June 30, 2022. Studies were included if they reported risk ratio (RR) or odds ratios (OR) and corresponding 95% confidence intervals (CI) of stroke concerning the presence of IAC. Random or fixed effects model meta-analyses were performed. Meta-analysis was conducted by using Stata version 16.0.
    Results: Twelve studies involving 9346 participants were included. Compared with those without IAC, patients with IAC had a higher risk of stroke occurrence (adjusted OR 1.62, 95% CI 1.18-2.23, P = 0.001) and stroke recurrence (adjusted OR 1.77, 95% CI 1.25-2.51, P = 0.003). However, we did not find a significant correlation between IAC and post-stroke mortality (pooled OR 1.12, 95% CI 0.80-1.56, P = 0.504).
    Conclusions: Our meta-analysis demonstrated that the presence of IAC was identified as an independent risk factor for ischemic stroke occurrence and recurrence but is not a predictor of post-stroke mortality.
    MeSH term(s) Humans ; Brain Ischemia/etiology ; Ischemic Stroke/complications ; Stroke/etiology ; Risk Factors ; Arteries
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-023-03069-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Physiological responses and transcriptomic analysis of

    Zhou, Xiangyan / Ma, Yanming / Miao, Rong / Li, Caijuan / Liu, Ziliang / Zhang, Dan / Chen, Sijin / Luo, Jiaqi / Tang, Wenhui

    Frontiers in plant science

    2024  Volume 15, Page(s) 1297812

    Abstract: Introduction: The potato (: Methods: In this study, we used : Results: Results showed the accumulation of 2,4-epibrassionolide (EBL) in T potatoes. We found that under high salt situations, the changed Na: Discussion: These findings suggested ... ...

    Abstract Introduction: The potato (
    Methods: In this study, we used
    Results: Results showed the accumulation of 2,4-epibrassionolide (EBL) in T potatoes. We found that under high salt situations, the changed Na
    Discussion: These findings suggested that
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1297812
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  7. Article ; Online: Risk assessment scales to predict risk of lower extremity deep vein thrombosis among multiple trauma patients: a prospective cohort study.

    Chen, Huijuan / Sun, Libing / Kong, Xiangyan

    BMC emergency medicine

    2023  Volume 23, Issue 1, Page(s) 144

    Abstract: Background: Deep vein thrombosis (DVT) is a common complication in orthopedic patients. Previous studies have focused on major orthopedic surgery.There are few studies with multiple trauma. We aimed to describe the prevalence of DVT and compare the ... ...

    Abstract Background: Deep vein thrombosis (DVT) is a common complication in orthopedic patients. Previous studies have focused on major orthopedic surgery.There are few studies with multiple trauma. We aimed to describe the prevalence of DVT and compare the predictive power of the different risk assessment scales in patients with multiple trauma.
    Methods: This prospective cohort study involved multiple trauma patients admitted to our hospital between October 2021 and December 2022. Data were prospectively collected for thrombotic risk assessments using the Risk Assessment Profile for thromboembolism(RAPT), the DVT risk assessment score (DRAS), and the Trauma Embolic Scoring System (TESS), respectively. The receiver operation characteristic (ROC) curve and the area under the curve (AUC) were evaluated to compare the predictive power. The whole leg duplex ultrasound of both lower extremities Doppler ultrasound was used to determine DVT incidence.
    Results: A total of 210 patients were included, and the incidence of DVT was 26.19%. Distal DVT accounted for 87.27%; postoperative DVT, 72.73%; and bilateral lower extremity thrombosis, 30.91%. There were significant differences in age, education degree, pelvic fracture, surgery, ISS, D-dimer level, length of hospital stay and ICU stay between the thrombosis group and the non-thrombosis group. The AUCs for RAPT, DRAS, and TESS were 0.737, 0.710, and 0.683, respectively. There were no significant differences between the three ROC curves.
    Conclusions: The incidence of DVT was relatively high during hospitalization. We prospectively validated the tests to predict risk of DVT among patients with multiple trauma to help trauma surgeons in the clinical administration of DVT prophylaxis.
    MeSH term(s) Humans ; Prospective Studies ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Risk Assessment ; Risk Factors ; Thrombosis/complications ; Multiple Trauma/complications ; Lower Extremity/diagnostic imaging ; Retrospective Studies
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050431-7
    ISSN 1471-227X ; 1471-227X
    ISSN (online) 1471-227X
    ISSN 1471-227X
    DOI 10.1186/s12873-023-00914-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [A case of laryngeal carcinoma complicated with Hodgkin's lymphoma].

    Chen, Mo / Yu, Tingting / Teng, Yongliang / Cui, Xiangyan / Wang, Xin

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2023  Volume 37, Issue 8, Page(s) 667–670

    Abstract: A case of laryngeal cancer complicated with Hodgkin's lymphoma treated in the Department of Otolaryngology Head and neck surgery of the First Hospital of Jilin University was reported. Under general anesthesia, right vertical partial laryngectomy, ... ...

    Abstract A case of laryngeal cancer complicated with Hodgkin's lymphoma treated in the Department of Otolaryngology Head and neck surgery of the First Hospital of Jilin University was reported. Under general anesthesia, right vertical partial laryngectomy, bilateral neck lymph node functional dissection and temporary tracheotomy were performed. No recurrence was found in laryngoscope and color Doppler ultrasound of neck lymph nodes 3 and 5 months after operation.
    MeSH term(s) Humans ; Laryngeal Neoplasms/surgery ; Hodgkin Disease/complications ; Neck/pathology ; Neck Dissection ; Lymph Nodes/pathology ; Laryngectomy ; Carcinoma/pathology
    Language Chinese
    Publishing date 2023-08-07
    Publishing country China
    Document type Case Reports ; English Abstract ; Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2023.08.014
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  9. Article ; Online: ROS-Responsive Poly(α-l-lysine)-Based Nanoparticles Loaded with Doxycycline Combat Oxidative Stress and Bacterial Infection.

    Wang, Yuanchao / Li, Ying / Liu, Wen / Li, Chen / Duo, Xinghong / Meng, Xiangyan / Feng, Yakai

    Macromolecular bioscience

    2024  , Page(s) e2300580

    Abstract: Bacterial pneumonia is one of the major threats in clinical practice, and the reactive oxygen species (ROS) generated at the infection site can exacerbate the damage. Currently, conventional antibiotic therapies have low utilization, and their excessive ... ...

    Abstract Bacterial pneumonia is one of the major threats in clinical practice, and the reactive oxygen species (ROS) generated at the infection site can exacerbate the damage. Currently, conventional antibiotic therapies have low utilization, and their excessive use can result in substantial toxicity. Nanocarrier systems provide an ideal approach for treating bacterial infection by facilitating more efficient utilization of antibiotics. In this study, the ROS-responsive amphiphilic nanoparticles (NPs) are developed and used to encapsulate the antibiotic doxycycline (DOXY) to achieve antibacterial and antioxidant functionalities. The NPs are prepared from poly(α-l-lysine) (α-PLL) and phenylboronic acid pinacol ester simultaneously conjugated carbonyldiimidazole (abbreviated as CDIPB). The phenylboronic acid ester groups on CDIPB could react with excessive ROS to suppress oxidative damage at the infection site. The ROS-responsive degradation of CDIPB also facilitates the rapid release of internal DOXY, effectively killing the accumulated bacteria. Additionally, in vitro cell experiments demonstrate the good biocompatibility of the NPs. These results suggest that the ROS-responsive amphiphilic nanoparticles can serve as a novel nanoplatform for the treatment of bacterial pneumonia.
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039130-4
    ISSN 1616-5195 ; 1616-5187
    ISSN (online) 1616-5195
    ISSN 1616-5187
    DOI 10.1002/mabi.202300580
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  10. Article: Recent Advances in Investigating Functional Dynamics of Chromatin.

    Shi, Xiangyan / Zhai, Ziwei / Chen, Yinglu / Li, Jindi / Nordenskiöld, Lars

    Frontiers in genetics

    2022  Volume 13, Page(s) 870640

    Abstract: Dynamics spanning the picosecond-minute time domain and the atomic-subcellular spatial window have been observed for ... ...

    Abstract Dynamics spanning the picosecond-minute time domain and the atomic-subcellular spatial window have been observed for chromatin
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.870640
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