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  1. Article ; Online: Melanoma awareness in Jamaican patients at the University Hospital of the West Indies: A cross-sectional study.

    Thomas, Romario D / East-Innis, Althea D C / Charles, Jamee J / Burton, Andrew T W / Liburd, Angela / Ruddock, Rodane / Ho, Jonathan D

    JAAD international

    2024  Volume 15, Page(s) 84–86

    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Applications of Deep Mutational Scanning in Virology.

    Burton, Thomas D / Eyre, Nicholas S

    Viruses

    2021  Volume 13, Issue 6

    Abstract: Several recently developed high-throughput techniques have changed the field of molecular virology. For example, proteomics studies reveal complete interactomes of a viral protein, genome-wide CRISPR knockout and activation screens probe the importance ... ...

    Abstract Several recently developed high-throughput techniques have changed the field of molecular virology. For example, proteomics studies reveal complete interactomes of a viral protein, genome-wide CRISPR knockout and activation screens probe the importance of every single human gene in aiding or fighting a virus, and ChIP-seq experiments reveal genome-wide epigenetic changes in response to infection. Deep mutational scanning is a relatively novel form of protein science which allows the in-depth functional analysis of every nucleotide within a viral gene or genome, revealing regions of importance, flexibility, and mutational potential. In this review, we discuss the application of this technique to RNA viruses including members of the Flaviviridae family, Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2. We also briefly discuss the reverse genetics systems which allow for analysis of viral replication cycles, next-generation sequencing technologies and the bioinformatics tools that facilitate this research.
    MeSH term(s) Computational Biology ; Gene Library ; Genome, Viral/genetics ; High-Throughput Nucleotide Sequencing ; Mutation/genetics ; RNA Viruses/classification ; RNA Viruses/genetics ; RNA Viruses/physiology ; Reverse Genetics ; Sequence Analysis, RNA ; Viral Proteins/genetics
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13061020
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  3. Article ; Online: Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.

    Lenert, Melissa E / Szabo-Pardi, Thomas A / Burton, Michael D

    Molecular pain

    2022  Volume 19, Page(s) 17448069221110691

    Abstract: Fibromyalgia (FM) is a chronic musculoskeletal pain disorder primarily diagnosed in women. Historically, clinical literature focusing on cytokines and immune cells has been inconsistent. However, recent key studies show several layers of immune system ... ...

    Abstract Fibromyalgia (FM) is a chronic musculoskeletal pain disorder primarily diagnosed in women. Historically, clinical literature focusing on cytokines and immune cells has been inconsistent. However, recent key studies show several layers of immune system dysfunction in FM. Preclinically, studies of the immune system have focused on monocytes with little focus on other immune cells. Importantly, T-cells are implicated in the development and resolution of chronic pain states, particularly in females. Our previous work showed that monocytes from women with FM produced more interleukin 5 (IL-5) and systemic treatment of IL-5 reversed mechanical hypersensitivity in a preclinical model of FM. Typically, IL-5 is produced by T
    MeSH term(s) Female ; Mice ; Animals ; T-Lymphocytes, Regulatory ; Interleukin-5/adverse effects ; Myalgia ; Cytokines ; Fibromyalgia ; Chronic Disease
    Chemical Substances Interleukin-5 ; Cytokines
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069221110691
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  4. Article: Applications of Deep Mutational Scanning in Virology

    Burton, Thomas D. / Eyre, Nicholas S.

    Viruses. 2021 May 28, v. 13, no. 6

    2021  

    Abstract: Several recently developed high-throughput techniques have changed the field of molecular virology. For example, proteomics studies reveal complete interactomes of a viral protein, genome-wide CRISPR knockout and activation screens probe the importance ... ...

    Abstract Several recently developed high-throughput techniques have changed the field of molecular virology. For example, proteomics studies reveal complete interactomes of a viral protein, genome-wide CRISPR knockout and activation screens probe the importance of every single human gene in aiding or fighting a virus, and ChIP-seq experiments reveal genome-wide epigenetic changes in response to infection. Deep mutational scanning is a relatively novel form of protein science which allows the in-depth functional analysis of every nucleotide within a viral gene or genome, revealing regions of importance, flexibility, and mutational potential. In this review, we discuss the application of this technique to RNA viruses including members of the Flaviviridae family, Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2. We also briefly discuss the reverse genetics systems which allow for analysis of viral replication cycles, next-generation sequencing technologies and the bioinformatics tools that facilitate this research.
    Keywords Flaviviridae ; Influenza A virus ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; bioinformatics ; chromatin immunoprecipitation ; epigenetics ; genes ; humans ; proteomics ; reverse genetics ; virus replication ; viruses
    Language English
    Dates of publication 2021-0528
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13061020
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: The role of microglia

    Szabo-Pardi, Thomas A / Agalave, Nilesh M / Burton, Michael D

    Neural regeneration research

    2020  Volume 16, Issue 6, Page(s) 1202–1203

    Language English
    Publishing date 2020-12-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.300438
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  6. Article ; Online: Sex-specific differences in alcohol-induced pain sensitization.

    Alexander, Shevon N / Jeong, Han S / Szabo-Pardi, Thomas A / Burton, Michael D

    Neuropharmacology

    2022  Volume 225, Page(s) 109354

    Abstract: Pain sensitization is a phenomenon that occurs to protect tissues from damage and recent studies have shown how a variety of non-noxious stimuli included in our everyday lives can lead to pain sensitization. Consumption of large amounts of alcohol over a ...

    Abstract Pain sensitization is a phenomenon that occurs to protect tissues from damage and recent studies have shown how a variety of non-noxious stimuli included in our everyday lives can lead to pain sensitization. Consumption of large amounts of alcohol over a long period of time invokes alcohol use disorder (AUD), a complex pathological state that has many manifestations, including alcohol peripheral neuropathy (neuropathic pain). We asked if 'non-pathological' alcohol consumption can cause pain sensitization in the absence of other pathology? Studies have pointed to glia and other immune cells and their role in pain sensitization that results in cell and sex-specific responses. Using a low-dose and short-term ethanol exposure model, we investigated whether this exposure would sensitize mice to a subthreshold dose of an inflammatory mediator that normally does not induce pain. We observed female mice exhibited specific mechanical and higher thermal sensitivity than males. We also observed an increase in CD68
    MeSH term(s) Animals ; Female ; Male ; Mice ; Ethanol/adverse effects ; Ganglia, Spinal/pathology ; Hyperalgesia/chemically induced ; Macrophages/drug effects ; Macrophages/pathology ; Microglia/drug effects ; Microglia/pathology ; Neuralgia/chemically induced ; Neuralgia/pathology ; Neuroglia/drug effects ; Neuroglia/pathology ; Alcoholism/complications ; Sex Characteristics
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109354
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    Ui I Zs.242: Show issues Location:
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  7. Article ; Online: Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb.

    Burton, Shawn D / Brown, Audrey / Eiting, Thomas P / Youngstrom, Isaac A / Rust, Thomas C / Schmuker, Michael / Wachowiak, Matt

    eLife

    2022  Volume 11

    Abstract: In olfactory systems, convergence of sensory neurons onto glomeruli generates a map of odorant receptor identity. How glomerular maps relate to sensory space remains unclear. We sought to better characterize this relationship in the mouse olfactory ... ...

    Abstract In olfactory systems, convergence of sensory neurons onto glomeruli generates a map of odorant receptor identity. How glomerular maps relate to sensory space remains unclear. We sought to better characterize this relationship in the mouse olfactory system by defining glomeruli in terms of the odorants to which they are most sensitive. Using high-throughput odorant delivery and ultrasensitive imaging of sensory inputs, we imaged responses to 185 odorants presented at concentrations determined to activate only one or a few glomeruli across the dorsal olfactory bulb. The resulting datasets defined the tuning properties of glomeruli - and, by inference, their cognate odorant receptors - in a low-concentration regime, and yielded consensus maps of glomerular sensitivity across a wide range of chemical space. Glomeruli were extremely narrowly tuned, with ~25% responding to only one odorant, and extremely sensitive, responding to their effective odorants at sub-picomolar to nanomolar concentrations. Such narrow tuning in this concentration regime allowed for reliable functional identification of many glomeruli based on a single diagnostic odorant. At the same time, the response spectra of glomeruli responding to multiple odorants was best predicted by straightforward odorant structural features, and glomeruli sensitive to distinct odorants with common structural features were spatially clustered. These results define an underlying structure to the primary representation of sensory space by the mouse olfactory system.
    MeSH term(s) Animals ; Mice ; Odorants ; Olfactory Bulb/physiology ; Olfactory Receptor Neurons/physiology ; Receptors, Odorant/metabolism ; Smell/physiology
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.80470
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  8. Article: Antihistamines for Postacute Sequelae of SARS-CoV-2 Infection.

    Pinto, Melissa D / Lambert, Natalie / Downs, Charles A / Abrahim, Heather / Hughes, Thomas D / Rahmani, Amir M / Burton, Candace W / Chakraborty, Rana

    The journal for nurse practitioners : JNP

    2022  Volume 18, Issue 3, Page(s) 335–338

    Abstract: Postacute sequelae of SARS-CoV2 (PASC) infection is an emerging global health crisis, variably affecting millions worldwide. PASC has no established treatment. We describe 2 cases of PASC in response to opportune administration of over-the-counter ... ...

    Abstract Postacute sequelae of SARS-CoV2 (PASC) infection is an emerging global health crisis, variably affecting millions worldwide. PASC has no established treatment. We describe 2 cases of PASC in response to opportune administration of over-the-counter antihistamines, with significant improvement in symptoms and ability to perform activities of daily living. Future studies are warranted to understand the potential role of histamine in the pathogenesis of PASC and explore the clinical benefits of antihistamines in the treatment of PASC.
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2202063-9
    ISSN 1878-058X ; 1555-4155
    ISSN (online) 1878-058X
    ISSN 1555-4155
    DOI 10.1016/j.nurpra.2021.12.016
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  9. Article ; Online: Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb

    Shawn D Burton / Audrey Brown / Thomas P Eiting / Isaac A Youngstrom / Thomas C Rust / Michael Schmuker / Matt Wachowiak

    eLife, Vol

    2022  Volume 11

    Abstract: In olfactory systems, convergence of sensory neurons onto glomeruli generates a map of odorant receptor identity. How glomerular maps relate to sensory space remains unclear. We sought to better characterize this relationship in the mouse olfactory ... ...

    Abstract In olfactory systems, convergence of sensory neurons onto glomeruli generates a map of odorant receptor identity. How glomerular maps relate to sensory space remains unclear. We sought to better characterize this relationship in the mouse olfactory system by defining glomeruli in terms of the odorants to which they are most sensitive. Using high-throughput odorant delivery and ultrasensitive imaging of sensory inputs, we imaged responses to 185 odorants presented at concentrations determined to activate only one or a few glomeruli across the dorsal olfactory bulb. The resulting datasets defined the tuning properties of glomeruli - and, by inference, their cognate odorant receptors - in a low-concentration regime, and yielded consensus maps of glomerular sensitivity across a wide range of chemical space. Glomeruli were extremely narrowly tuned, with ~25% responding to only one odorant, and extremely sensitive, responding to their effective odorants at sub-picomolar to nanomolar concentrations. Such narrow tuning in this concentration regime allowed for reliable functional identification of many glomeruli based on a single diagnostic odorant. At the same time, the response spectra of glomeruli responding to multiple odorants was best predicted by straightforward odorant structural features, and glomeruli sensitive to distinct odorants with common structural features were spatially clustered. These results define an underlying structure to the primary representation of sensory space by the mouse olfactory system.
    Keywords imaging ; coding ; odor ; olfactometry ; chemoinformatics ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 006
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice.

    Szabo-Pardi, Thomas A / Barron, Luz R / Lenert, Melissa E / Burton, Michael D

    Brain, behavior, and immunity

    2021  Volume 97, Page(s) 42–60

    Abstract: Recent studies have brought to light the necessity to discern sex-specific differences in various pain states and different cell-types that mediate these differences. These studies have uncovered the role of neuroimmune interactions to mediate pain ... ...

    Abstract Recent studies have brought to light the necessity to discern sex-specific differences in various pain states and different cell-types that mediate these differences. These studies have uncovered the role of neuroimmune interactions to mediate pain states in a sex-specific fashion. While investigating immune function in pain development, we discovered that females utilize immune components of sensory neurons to mediate neuropathic pain development. We utilized two novel transgenic mouse models that eitherrestore expression of toll-like receptor (TLR) 4 inNa
    MeSH term(s) Animals ; Female ; Hyperalgesia ; Male ; Mice ; Mice, Transgenic ; Neuralgia ; Sensory Receptor Cells ; Toll-Like Receptor 4/genetics
    Chemical Substances Tlr4 protein, mouse ; Toll-Like Receptor 4
    Language English
    Publishing date 2021-06-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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