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  1. Article ; Online: Effects of cosmetic formulations containing hydroxyacids on sun-exposed skin: current applications and future developments.

    Kornhauser, Andrija / Coelho, Sergio G / Hearing, Vincent J

    Dermatology research and practice

    2012  Volume 2012, Page(s) 710893

    Abstract: This paper describes recent data on the effects of various skin formulations containing hydroxyacids (HAs) and related products on sun-exposed skin. The most frequently used classes of these products, such as α- and β-hydroxyacids, polyhydroxy acids, and ...

    Abstract This paper describes recent data on the effects of various skin formulations containing hydroxyacids (HAs) and related products on sun-exposed skin. The most frequently used classes of these products, such as α- and β-hydroxyacids, polyhydroxy acids, and bionic acids, are reviewed, and their application in cosmetic formulations is described. Special emphasis is devoted to the safety evaluation of these formulations, particularly on the effects of their prolonged use on sun-exposed skin. We also discuss the important contribution of cosmetic vehicles in these types of studies. Data on the effects of HAs on melanogenesis and tanning are also included. Up-to-date methods and techniques used in those explorations, as well as selected future developments in the cosmetic area, are presented.
    Language English
    Publishing date 2012-05-20
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2548952-5
    ISSN 1687-6113 ; 1687-6105
    ISSN (online) 1687-6113
    ISSN 1687-6105
    DOI 10.1155/2012/710893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of Cosmetic Formulations Containing Hydroxyacids on Sun-Exposed Skin

    Vincent J. Hearing / Sergio G. Coelho / Andrija Kornhauser

    Dermatology Research and Practice, Vol

    Current Applications and Future Developments

    2012  Volume 2012

    Keywords Dermatology ; RL1-803 ; Medicine ; R ; DOAJ:Dermatology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Applications of hydroxy acids: classification, mechanisms, and photoactivity.

    Kornhauser, Andrija / Coelho, Sergio G / Hearing, Vincent J

    Clinical, cosmetic and investigational dermatology

    2010  Volume 3, Page(s) 135–142

    Abstract: Hydroxy acids (HAs) represent a class of compounds which have been widely used in a number of cosmetic and therapeutic formulations in order to achieve a variety of beneficial effects for the skin. We review and discuss the most frequently used classes ... ...

    Abstract Hydroxy acids (HAs) represent a class of compounds which have been widely used in a number of cosmetic and therapeutic formulations in order to achieve a variety of beneficial effects for the skin. We review and discuss the most frequently used classes of these compounds, such as α-hydroxy acids, β-hydroxy acids, polyhydroxy acids, and bionic acids, and describe their applications as cosmetic and therapeutic agents. Special emphasis is devoted to the safety evaluation of these formulations, in particular on the effects of their prolonged use on sun-exposed skin. Furthermore, we summarize the very limited number of studies dealing with the modifications evoked by topical application of products containing HAs on photocarcinogenesis. In spite of the large number of reports on the cosmetic and clinical effects of HAs, their biological mechanism(s) of action still require more clarification. Some of these mechanisms are discussed in this article along with important findings on the effect of HAs on melanogenesis and on tanning. We also emphasize the important contribution of cosmetic vehicles in these types of studies. Thus, HAs play an important role in cosmetic formulations, as well as in many dermatologic applications, such as in treating photoaging, acne, ichthyosis, rosacea, pigmentation disorders, and psoriasis.
    Language English
    Publishing date 2010-11-24
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015 ; 1178-7015
    ISSN (online) 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S9042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Applications of hydroxy acids

    Andrija Kornhauser / Sergio G Coelho / Vincent J Hearing

    Clinical, Cosmetic and Investigational Dermatology, Vol 2010, Iss default, Pp 135-

    classification, mechanisms, and photoactivity

    2010  Volume 142

    Abstract: Andrija Kornhauser1, Sergio G Coelho2, Vincent J Hearing21US Food and Drug Administration [retired ...

    Abstract Andrija Kornhauser1, Sergio G Coelho2, Vincent J Hearing21US Food and Drug Administration [retired], Annandale, VA, USA; 2Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAAbstract: Hydroxy acids (HAs) represent a class of compounds which have been widely used in a number of cosmetic and therapeutic formulations in order to achieve a variety of beneficial effects for the skin. We review and discuss the most frequently used classes of these compounds, such as a-hydroxy acids, β-hydroxy acids, polyhydroxy acids, and bionic acids, and describe their applications as cosmetic and therapeutic agents. Special emphasis is devoted to the safety evaluation of these formulations, in particular on the effects of their prolonged use on sun-exposed skin. Furthermore, we summarize the very limited number of studies dealing with the modifications evoked by topical application of products containing HAs on photocarcinogenesis. In spite of the large number of reports on the cosmetic and clinical effects of HAs, their biological mechanism(s) of action still require more clarification. Some of these mechanisms are discussed in this article along with important findings on the effect of HAs on melanogenesis and on tanning. We also emphasize the important contribution of cosmetic vehicles in these types of studies. Thus, HAs play an important role in cosmetic formulations, as well as in many dermatologic applications, such as in treating photoaging, acne, ichthyosis, rosacea, pigmentation disorders, and psoriasis.Keywords: hydroxy acids, glycolic acid, salicylic acid, UV, erythema, cosmetics
    Keywords Dermatology ; RL1-803 ; Medicine ; R ; DOAJ:Dermatology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 540
    Language English
    Publishing date 2010-11-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis.

    Yamaguchi, Yuji / Takahashi, Kaoruko / Zmudzka, Barbara Z / Kornhauser, Andrija / Miller, Sharon A / Tadokoro, Taketsugu / Berens, Werner / Beer, Janusz Z / Hearing, Vincent J

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2006  Volume 20, Issue 9, Page(s) 1486–1488

    Abstract: Melanin plays an important role in protecting the skin against UV radiation, and melanomas and basal/squamous cell carcinomas occur more frequently in individuals with fair/light skin. We previously reported that levels of melanin correlate inversely ... ...

    Abstract Melanin plays an important role in protecting the skin against UV radiation, and melanomas and basal/squamous cell carcinomas occur more frequently in individuals with fair/light skin. We previously reported that levels of melanin correlate inversely with amounts of DNA damage induced by UV in normal human skin of different racial/ethnic groups. We have now separately examined DNA damage in the upper and lower epidermal layers in various types of skin before and after exposure to UV and have measured subsequent apoptosis and phosphorylation of p53. The results show that two major mechanisms underlie the increased photocarcinogenesis in fair/light skin. First, UV-induced DNA damage in the lower epidermis (including keratinocyte stem cells and melanocytes) is more effectively prevented in darker skin, suggesting that the pigmented epidermis is an efficient UV filter. Second, UV-induced apoptosis is significantly greater in darker skin, which suggests that UV-damaged cells may be removed more efficiently in pigmented epidermis. The combination of decreased DNA damage and more efficient removal of UV-damaged cells may play a critical role in the decreased photocarcinogenesis seen in individuals with darker skin.
    MeSH term(s) Adult ; Apoptosis/radiation effects ; Biopsy ; Continental Population Groups ; DNA Damage ; Dose-Response Relationship, Radiation ; Epidermis/cytology ; Epidermis/physiology ; Epidermis/radiation effects ; Ethnic Groups ; Humans ; Patient Selection ; Pigmentation/radiation effects ; Radiation Protection ; Radionuclide Imaging ; Skin/cytology ; Skin/radiation effects ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/prevention & control ; Ultraviolet Rays
    Language English
    Publishing date 2006-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.06-5725fje
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  6. Article ; Online: The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin.

    Kornhauser, Andrija / Wei, Rong-Rong / Yamaguchi, Yuji / Coelho, Sergio G / Kaidbey, Kays / Barton, Curtis / Takahashi, Kaoruko / Beer, Janusz Z / Miller, Sharon A / Hearing, Vincent J

    Journal of dermatological science

    2009  Volume 55, Issue 1, Page(s) 10–17

    Abstract: Background: alpha-Hydroxy acids (alphaHAs) are reported to reduce signs of aging in the skin and are widely used cosmetic ingredients. Several studies suggest that alphaHA can increase the sensitivity of skin to ultraviolet radiation. More recently, ... ...

    Abstract Background: alpha-Hydroxy acids (alphaHAs) are reported to reduce signs of aging in the skin and are widely used cosmetic ingredients. Several studies suggest that alphaHA can increase the sensitivity of skin to ultraviolet radiation. More recently, beta-hydroxy acids (betaHAs), or combinations of alphaHA and betaHA have also been incorporated into antiaging skin care products. Concerns have also arisen about increased sensitivity to ultraviolet radiation following use of skin care products containing beta-HA.
    Objective: To determine whether topical treatment with glycolic acid, a representative alphaHA, or with salicylic acid, a betaHA, modifies the short-term effects of solar simulated radiation (SSR) in human skin.
    Methods: Fourteen subjects participated in this study. Three of the four test sites on the mid-back of each subject were treated daily Monday-Friday, for a total of 3.5 weeks, with glycolic acid (10%), salicylic acid (2%), or vehicle (control). The fourth site received no treatment. After the last treatment, each site was exposed to SSR, and shave biopsies from all four sites were obtained. The endpoints evaluated in this study were erythema (assessed visually and instrumentally), DNA damage and sunburn cell formation.
    Results: Treatment with glycolic acid resulted in increased sensitivity of human skin to SSR, measured as an increase in erythema, DNA damage and sunburn cell formation. Salicylic acid did not produce significant changes in any of these biomarkers.
    Conclusions: Short-term topical application of glycolic acid in a cosmetic formulation increased the sensitivity of human skin to SSR, while a comparable treatment with salicylic acid did not.
    MeSH term(s) Administration, Topical ; Adult ; DNA Damage ; Erythema/etiology ; Erythema/pathology ; Female ; Glycolates/administration & dosage ; Glycolates/adverse effects ; Humans ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/adverse effects ; Male ; Middle Aged ; Pyrimidine Dimers/metabolism ; Radiation Injuries/chemically induced ; Radiation Injuries/pathology ; Salicylic Acid/administration & dosage ; Salicylic Acid/adverse effects ; Skin/drug effects ; Skin/pathology ; Skin/radiation effects ; Sunburn/etiology ; Sunburn/pathology ; Ultraviolet Rays/adverse effects
    Chemical Substances Glycolates ; Keratolytic Agents ; Pyrimidine Dimers ; glycolic acid (0WT12SX38S) ; Salicylic Acid (O414PZ4LPZ)
    Language English
    Publishing date 2009-05-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2009.03.011
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    Zs.A 2870: Show issues Location:
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  7. Article: Topical glycolic acid enhances photodamage by ultraviolet light.

    Kaidbey, Kays / Sutherland, Betsy / Bennett, Paula / Wamer, Wayne G / Barton, Curtis / Dennis, Donna / Kornhauser, Andrija

    Photodermatology, photoimmunology & photomedicine

    2003  Volume 19, Issue 1, Page(s) 21–27

    Abstract: Background: Alpha-hydroxy acids (AHAs) are widely used as ingredients in cosmetics. Several studies suggest that AHAs can increase the sensitivity of skin to ultraviolet (UV) light.: Purpose: This study was performed in order to determine whether ... ...

    Abstract Background: Alpha-hydroxy acids (AHAs) are widely used as ingredients in cosmetics. Several studies suggest that AHAs can increase the sensitivity of skin to ultraviolet (UV) light.
    Purpose: This study was performed in order to determine whether short-term dermal treatment with glycolic acid, a representative AHA, can enhance the damaging effects of UV light. The duration of the effect of AHAs on the sensitivity of skin to UV light was also examined.
    Methods: The backs of 29 Caucasian subjects were treated, once daily, 6 days per week with either 10% glycolic acid (pH 3.5) or placebo in a randomized double-blinded study. At the end of 4 weeks, sites within each treated area were exposed to 1.5 MED of UV light, determined on previously untreated skin. Specimens were obtained for enumeration of sunburn cells (SBCs) in the first group of subjects (n = 16), whereas cyclobutyl pyrimidine dimers (CPDs) in DNA were determined in the second group (n = 13). The minimal erythema dose (MED) in each site was also determined in the first group of subjects. Sunburn cells and MEDs were re-evaluated in the first group 1 week after discontinuing AHA applications.
    Results: Glycolic acid caused enhanced sensitivity to UV light measured as increased SBC induction and lowered MEDs. Cyclobutyl pyrimidine dimers were elevated but not to a statistically significant level. No differences in SBCs or MEDs were evident after a week of discontinued treatments.
    Conclusion: Short-term application of 10% glycolic acid sensitizes the skin to the damaging effects of UV light. This photosensitivity is reversed within a week of terminating treatments.
    MeSH term(s) Administration, Cutaneous ; Adult ; Cosmetics/administration & dosage ; Cosmetics/adverse effects ; Double-Blind Method ; European Continental Ancestry Group ; Female ; Humans ; Hydroxy Acids/administration & dosage ; Hydroxy Acids/adverse effects ; Male ; Middle Aged ; Skin Pigmentation/drug effects ; Skin Pigmentation/radiation effects ; Sunburn/etiology ; Sunburn/pathology ; Ultraviolet Rays
    Chemical Substances Cosmetics ; Hydroxy Acids
    Language English
    Publishing date 2003-04-23
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0905-4383 ; 0108-9684
    ISSN (online) 1600-0781
    ISSN 0905-4383 ; 0108-9684
    DOI 10.1034/j.1600-0781.2003.00013.x
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    Zs.A 1951: Show issues Location:
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  8. Book ; Conference proceedings: Photochemical toxicity

    Zervos, Constantine / Andersen, F. Alan / Kornhauser, Andrija

    toxic, allergic, and carcinogenic aspects with emphasis on predicting effects in humans : proceedings of the seventh in the series of Food and Drug Administration Science Symposia, held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, March 16-17, 1981

    1982  

    Title variant JNCI
    Event/congress Food and Drug Administration Science Symposia (7th, 1981, UniformedServicesUniversityoftheHealthSciences)
    Author's details edited by F. Alan Andersen, Andrija Kornhauser, Constantine Zervos ; symposium coordinator and technical editor, Janet E. Cunningham
    MeSH term(s) Photosensitivity Disorders/chemically induced
    Language English
    Size p. 151-316 :, ill.
    Publisher U.S. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration
    Publishing place Rockville, Md
    Document type Book ; Conference proceedings
    Note Reprinted from: JNCI, v. 69, no. 1, July 1982.
    Database Catalogue of the US National Library of Medicine (NLM)

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