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Article ; Online: VR Training System to Help Improve Photography Skills

Hiroki Kobayashi / Katashi Nagao

Applied Sciences, Vol 13, Iss 7817, p

2023 Volume 7817

Abstract: People aspiring to enhance their photography skills face multiple challenges, such as finding subjects and understanding camera-specific parameters. To address this, we present the VR Photo Training System. This system allows users to practice ... ...

Abstract	People aspiring to enhance their photography skills face multiple challenges, such as finding subjects and understanding camera-specific parameters. To address this, we present the VR Photo Training System. This system allows users to practice photography in a virtual space and provides feedback on user-taken photos using machine-learning models. These models, trained on datasets from the virtual environment, evaluate the aesthetics, composition, and color of photos. The system also includes a feature offering composition advice, which further aids in skill development. The evaluation and recommendation functions of our system have shown sufficient accuracy, proving its effectiveness for photography training.
Keywords	virtual reality ; self-training system for photography ; aesthetic assessment ; composition assessment and recommendation ; deep learning ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: pH-Dependent Regulation of Electron Flow in Photosystem II by a Histidine Residue at the Stromal Surface.

Kobayashi, Tomoyuki / Shimada, Yuichiro / Nagao, Ryo / Noguchi, Takumi

Biochemistry

2022 Volume 61, Issue 13, Page(s) 1351–1362

Abstract: In photosystem II (PSII), the secondary plastoquinone electron acceptor ... ...

Abstract	In photosystem II (PSII), the secondary plastoquinone electron acceptor Q
MeSH term(s)	Electron Transport ; Electrons ; Histidine/genetics ; Histidine/metabolism ; Hydrogen-Ion Concentration ; Photosystem II Protein Complex/chemistry ; Plastoquinone/metabolism
Chemical Substances	Photosystem II Protein Complex ; Histidine (4QD397987E) ; Plastoquinone (OAC30J69CN)
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.2c00150
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Article ; Online: FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5.

Takeda, Kengo / Ohta, Satoshi / Nagao, Miu / Kobayashi, Erika / Tago, Kenji / Funakoshi-Tago, Megumi

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Chronic myeloid leukemia (CML) is induced by the expression of the fused tyrosine kinase BCR-ABL, which is caused by a chromosomal translocation. BCR-ABL inhibitors have been used to treat CML; however, the acquisition of resistance by CML cells during ... ...

Abstract	Chronic myeloid leukemia (CML) is induced by the expression of the fused tyrosine kinase BCR-ABL, which is caused by a chromosomal translocation. BCR-ABL inhibitors have been used to treat CML; however, the acquisition of resistance by CML cells during treatment is a serious issue. We herein demonstrated that BCR-ABL induced the expression of the RNA helicase DDX5 in K562 cells derived from CML patients in a manner that was dependent on its kinase activity, which resulted in cell proliferation and survival. The knockout of DDX5 decreased the expression of BIRC5 (survivin) and activated caspase 3, leading to apoptosis in K562 cells. Similar results were obtained in cells treated with FL118, an inhibitor of DDX5 and a derivative compound of camptothecin (CPT). Furthermore, FL118 potently induced apoptosis not only in Ba/F3 cells expressing BCR-ABL, but also in those expressing the BCR-ABL T315I mutant, which is resistant to BCR-ABL inhibitors. Collectively, these results revealed that DDX5 is a critical therapeutic target in CML and that FL118 is an effective candidate compound for the treatment of BCR-ABL inhibitor-resistant CML.
MeSH term(s)	Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myeloid ; Indolizines ; Benzodioxoles ; Protein Kinase Inhibitors/pharmacology
Chemical Substances	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione ; Indolizines ; Benzodioxoles ; Protein Kinase Inhibitors
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073693
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Article ; Online: Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60.

Fujiwara, Kazuki / Tanaka, Takayuki / Kobayashi, Hisamine / Nagao, Kenji / Ishikawa-Takata, Kazuko

Nutrients

2024 Volume 16, Issue 8

Abstract: With advancements in medical technology, the structure of disease is shifting from acute illnesses to chronic conditions, such as Alzheimer's disease (AD). Consequently, there is an escalating need for evaluations that discourse on the potential effects ... ...

Abstract	With advancements in medical technology, the structure of disease is shifting from acute illnesses to chronic conditions, such as Alzheimer's disease (AD). Consequently, there is an escalating need for evaluations that discourse on the potential effects on healthy life years, as well as disease onset. We aimed to evaluate the associations with AD disability-adjusted life year (AD-DALY) rates and protein intake by sex and age group. For the analysis, we used representative values for males and females in their 60s and aged over 70, extracted from the public dataset of the Global Burden of Disease Study and the National Health and Nutrition Survey in Japan, covering the years 1990 to 2019. In order to evaluate the association between AD-DALY rates and protein intake, we analyzed correlations and stratified multiple regression models. Additionally, we simulated alterations in AD-DALY rates associated with changes in protein intake by utilizing stratified multiple regression models. AD-DALY rates and protein intake indicated significant negative correlations across all sex and age groups. In stratified multiple regression models, significant associations were found between higher protein intake and lower AD-DALY rates in females. In the simulation, when protein intake was increased to 1.5 g/kg/day, AD-DALY rates decreased by 5-9 percent compared with 2019. However, the association between intake of animal and plant protein and AD-DALY rates were found to vary based on sex and age group. The present study suggests the possibility to improve AD-DALY rates by increasing population average protein intake levels in a recommended range.
MeSH term(s)	Humans ; Female ; Male ; Japan/epidemiology ; Aged ; Alzheimer Disease/epidemiology ; Dietary Proteins/administration & dosage ; Middle Aged ; Aged, 80 and over ; Disability-Adjusted Life Years ; Nutrition Surveys ; Sex Factors ; East Asian People
Chemical Substances	Dietary Proteins
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081221
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Article ; Online: Classifying presence or absence of calcifications on mammography using generative contribution mapping.

Kobayashi, Tatsuaki / Haraguchi, Takafumi / Nagao, Tomoharu

Radiological physics and technology

2022 Volume 15, Issue 4, Page(s) 340–348

Abstract: The purpose of this study was to verify the efficacy of generative contribution mapping (GCM), an explainable deep learning model for images, in classifying the presence or absence of calcifications on mammography. The learning dataset consisted of 303 ... ...

Abstract	The purpose of this study was to verify the efficacy of generative contribution mapping (GCM), an explainable deep learning model for images, in classifying the presence or absence of calcifications on mammography. The learning dataset consisted of 303 full-field digital mammography (FFDM) images labeled with microcalcifications obtained from the public INbreast database without extremely dense images. FFDM images were divided into calcification and non-calcification patch images using a sliding window method with 25% overlap. The patch images of the mediolateral oblique (MLO) and craniocaudal (CC) views were divided into a training set of 70%, a validation set of 10%, and a testing set of 20%. The classification performance of GCM classifiers was evaluated and compared with that of EfficientNet classifiers. Visualization maps of GCM highlighted regions of interest more clearly than EfficientNet's gradient-weighted class activation maps. The results showed that GCM classifiers yielded an accuracy of 0.92 (CC), 0.91 (MLO), and an area under the receiver operating characteristic curve of 0.92 (CC), 0.94 (MLO). In conclusion, GCM could accurately classify the presence or absence of calcifications on mammograms and explain intuitively reasonable grounds for their classification with visualization maps highlighting regions of interest.
MeSH term(s)	Humans ; Mammography/methods ; Calcinosis/diagnostic imaging ; ROC Curve ; Databases, Factual
Language	English
Publishing date	2022-08-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2433581-2
ISSN	1865-0341 ; 1865-0333
ISSN (online)	1865-0341
ISSN	1865-0333
DOI	10.1007/s12194-022-00673-3
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Article ; Online: Phosphorus(V) Tetraazaporphyrin with an Intense, Broad CT Band in the Near-IR Region.

Yoshida, Takuya / Okada, Yusuke / Namikawa, Tomotaka / Furuyama, Taniyuki / Kamada, Kenji / Kobayashi, Nagao

Organic letters

2024 Volume 26, Issue 9, Page(s) 1931–1935

Abstract: In phosphorus tetraazaporphyrins (PTAPs), the Q- and charge-transfer (CT) bands appear as a result of configuration interaction between their excited states. On the basis of this concept, a PTAP with an intense, broad CT band in the near-IR region has ... ...

Abstract	In phosphorus tetraazaporphyrins (PTAPs), the Q- and charge-transfer (CT) bands appear as a result of configuration interaction between their excited states. On the basis of this concept, a PTAP with an intense, broad CT band in the near-IR region has been rationally designed and realized by introducing eight diphenylaminophenyl (dPAP) groups. The order of the CT and Q-bands in ascending energy was supported by magnetic circular dichroism (MCD) spectroscopy and theoretical calculations. An intense two-photon absorption was also found in the deep near-IR region.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c00298
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Article ; Online: "Deepening" Insight on Skin Aging and Anti-microbial Immunity.

Kobayashi, Tetsuro / Nagao, Keisuke

Cell metabolism

2019 Volume 29, Issue 3, Page(s) 515–517

Abstract: Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling ... ...

Abstract	Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired anti-bacterial host defense.
MeSH term(s)	Anti-Infective Agents ; Fibroblasts ; Immunity, Innate ; Signal Transduction/drug effects ; Skin ; Skin Aging ; Transforming Growth Factor beta
Chemical Substances	Anti-Infective Agents ; Transforming Growth Factor beta
Language	English
Publishing date	2019-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2019.02.006
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Article ; Online: Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie's Disease.

Mitsui, Yozo / Yamabe, Fumito / Hori, Shunsuke / Uetani, Masato / Kobayashi, Hideyuki / Nagao, Koichi / Nakajima, Koichi

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: Peyronie's disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. ... ...

Abstract	Peyronie's disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions.
MeSH term(s)	Male ; Humans ; Penile Induration/etiology ; Penile Induration/pathology ; Phosphatidylinositol 3-Kinases ; Quality of Life ; Penis/metabolism ; Risk Factors
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241210133
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Article ; Online: Mapping regulatory circuits in allergic skin inflammation.

Kobayashi, Tetsuro / Nagao, Keisuke

Science immunology

2018 Volume 3, Issue 21

Abstract: ... ...

Abstract	RORα
MeSH term(s)	Dermatitis, Atopic ; Humans ; Immunity, Innate ; Inflammation ; Lymphocytes ; Skin
Language	English
Publishing date	2018-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.aar7655
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Article ; Online: Botulinum Toxin Therapy for Spasmodic Dysphonia in Japan: The History and an Update.

Hyodo, Masamitsu / Hirose, Kahori / Nagao, Asuka / Nakahira, Maya / Kobayashi, Taisuke

Toxins

2022 Volume 14, Issue 7

Abstract: ... by Kobayashi et al. in 1989. The group developed an objective mora (syllable) method to evaluate SD severity ...

Abstract	Spasmodic dysphonia (SD) is a rare neurological disorder that impairs phonatory function by triggering involuntary and intermittent contractions of the intrinsic laryngeal muscles. SD is classified into three types: adductor SD (AdSD), abductor SD (AbSD), and mixed SD. Of these, AdSD accounts for 90-95% of disease; younger females are predominantly affected. Botulinum toxin injection into the laryngeal muscles is safe, minimally invasive, and very effective. Here, we review the history of clinical research for SD conducted in Japan. The first use of botulinum toxin injection therapy to treat SD in Japan was by Kobayashi et al. in 1989. The group developed an objective mora (syllable) method to evaluate SD severity. Recently, we conducted a placebo-controlled, randomized, double-blinded clinical trial of botulinum toxin therapy for AdSD and an open-label trial for AbSD to obtain the approval of such therapy by the Japanese medical insurance system. The mora method revealed significant voice improvement and the evidence was of high quality. Additionally, a clinical trial of type 2 thyroplasty using titanium bridges confirmed the efficacy and safety of such therapy. These studies broadened the SD treatment options and have significantly benefited patients.
MeSH term(s)	Botulinum Toxins/adverse effects ; Botulinum Toxins, Type A/adverse effects ; Dysphonia/drug therapy ; Dysphonia/surgery ; Female ; Humans ; Injections ; Japan ; Laryngeal Muscles/surgery ; Randomized Controlled Trials as Topic ; Treatment Outcome
Chemical Substances	Botulinum Toxins (EC 3.4.24.69) ; Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins14070451
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