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Article: Venous thromboembolism in two adolescents with Down syndrome.

Kurokami, Tsunehiko / Takasawa, Reiko / Takeda, Sayaka / Kurobe, Masashi / Takasawa, Kei / Nishioka, Masato / Shimohira, Masayuki

The Turkish journal of pediatrics

2019 Volume 60, Issue 4, Page(s) 429–432

Abstract: Kurokami T, Takasawa R, Takeda S, Kurobe M, Takasawa K, Nishioka M, Shimohira M ...

Abstract	Kurokami T, Takasawa R, Takeda S, Kurobe M, Takasawa K, Nishioka M, Shimohira M. Venous thromboembolism in two adolescents with Down syndrome. Turk J Pediatr 2018; 60: 429-432. Although venous thromboembolic events are relatively rare in children, they are an increasingly recognized clinical entity in pediatric tertiary care hospitals. Although vascular disorders are prevalent with Down syndrome, it remains unclear whether Down syndrome patients are at higher risk for venous thromboembolic events. We report two adolescent cases with Down syndrome who unexpectedly developed venous thromboembolism in a general care unit. Our cases had a few risk factors; laparoscopic radical surgery for Hirschsprung's disease with central venous catheterisation in Case 1, and bacterial hepatic abscess in Case 2. Despite preventive heparinization with catheterisation and minor surgery in Case 1 and non-sepsis in Case 2, bed rest for only a few days triggered sudden onset of deep vein thrombosis in lower limbs with pulmonary thromboembolism in both cases. We speculate that the characteristics of Down syndrome, including physical and behavioural problems, might cause venous thromboembolic events. Thus, we should pay more attention to the relationship specifically between venous thromboembolism and Down syndrome, especially in adolescents, and increase prevention, early detection and treatment efforts.
MeSH term(s)	Adolescent ; Down Syndrome/complications ; Humans ; Laparoscopy ; Lower Extremity/blood supply ; Male ; Pulmonary Embolism/etiology ; Risk Factors ; Tomography, X-Ray Computed ; Venous Thromboembolism/etiology ; Venous Thrombosis/etiology
Language	English
Publishing date	2019-04-01
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
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Article ; Online: TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells.

Cell death & disease

2023 Volume 14, Issue 7, Page(s) 424

Abstract: Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development. To identify dysregulated lncRNAs in gastric cancer (GC), we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for transcriptionally active lncRNA genes in ...

Abstract	Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development. To identify dysregulated lncRNAs in gastric cancer (GC), we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for transcriptionally active lncRNA genes in the non-tumorous gastric mucosa of patients with GC and healthy individuals. We found that H3K4me3 at TM4SF1-AS1 was specifically upregulated in GC patients and that the expression of TM4SF1-AS1 was significantly elevated in primary and cultured GC cells. TM4SF1-AS1 contributes to GC cell growth in vitro and in vivo, and its oncogenic function is mediated, at least in part, through interactions with purine-rich element-binding protein α (Pur-α) and Y-box binding protein 1 (YB-1). TM4SF1-AS1 also activates interferon signaling in GC cells, which is dependent on Pur-α and RIG-I. Chromatin isolation by RNA purification (ChIRP)-mass spectrometry demonstrated that TM4SF1-AS1 was associated with several stress granule (SG)-related proteins, including G3BP2, RACK1, and DDX3. Notably, TM4SF1-AS1 promoted SG formation and inhibited apoptosis in GC cells by sequestering RACK1, an activator of the stress-responsive MAPK pathway, within SGs. TM4SF1-AS1-induced SG formation and apoptosis inhibition are dependent on Pur-α and YB-1. These findings suggested that TM4SF1-AS1 contributes to tumorigenesis by enhancing SG-mediated stress adaptation.
MeSH term(s)	Humans ; Cell Line, Tumor ; RNA, Long Noncoding/genetics ; Stress Granules ; Apoptosis/genetics ; Stomach Neoplasms/pathology ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Antigens, Surface ; Neoplasm Proteins/metabolism
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; TM4SF1 protein, human (147016-68-0) ; Antigens, Surface ; Neoplasm Proteins
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-05953-3
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Article ; Online: Uncovering Prognosis-Related Genes and Pathways by Multi-Omics Analysis in Lung Cancer.

Asada, Ken / Kobayashi, Kazuma / Joutard, Samuel / Tubaki, Masashi / Takahashi, Satoshi / Takasawa, Ken / Komatsu, Masaaki / Kaneko, Syuzo / Sese, Jun / Hamamoto, Ryuji

Biomolecules

2020 Volume 10, Issue 4

Abstract: Lung cancer is one of the leading causes of death worldwide. Therefore, understanding the factors linked to patient survival is essential. Recently, multi-omics analysis has emerged, allowing for patient groups to be classified according to prognosis and ...

Abstract	Lung cancer is one of the leading causes of death worldwide. Therefore, understanding the factors linked to patient survival is essential. Recently, multi-omics analysis has emerged, allowing for patient groups to be classified according to prognosis and at a more individual level, to support the use of precision medicine. Here, we combined RNA expression and miRNA expression with clinical information, to conduct a multi-omics analysis, using publicly available datasets (the cancer genome atlas (TCGA) focusing on lung adenocarcinoma (LUAD)). We were able to successfully subclass patients according to survival. The classifiers we developed, using inferred labels obtained from patient subtypes showed that a support vector machine (SVM), gave the best classification results, with an accuracy of 0.82 with the test dataset. Using these subtypes, we ranked genes based on RNA expression levels. The top 25 genes were investigated, to elucidate the mechanisms that underlie patient prognosis. Bioinformatics analyses showed that the expression levels of six out of 25 genes (
MeSH term(s)	Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/genetics ; Aged ; Female ; Genomics ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Support Vector Machine ; Unsupervised Machine Learning
Language	English
Publishing date	2020-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10040524
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Article ; Online: Colonoscopic diagnosis and reduction of recurrent intussusception owing to Henoch-Schönlein purpura without purpura.

Shimoyama, Teruyoshi / Matsuda, Nozomi / Kurobe, Masashi / Hayakawa, Takehiko / Nishioka, Masato / Shimohira, Masayuki / Takasawa, Kei

Paediatrics and international child health

2018 Volume 39, Issue 3, Page(s) 219–223

Abstract: About 50-75% of patients with Henoch-Schönlein purpura (HSP) develop gastro-intestinal symptoms with surgical complications such as intussusception occurring in 0.7-13.6%. In 10-40% of patients, however, gastro-intestinal manifestations may precede the ... ...

Abstract	About 50-75% of patients with Henoch-Schönlein purpura (HSP) develop gastro-intestinal symptoms with surgical complications such as intussusception occurring in 0.7-13.6%. In 10-40% of patients, however, gastro-intestinal manifestations may precede the onset of purpura. In patients with gastro-intestinal tract involvement without purpura, confirming the diagnosis of HSP and determining the appropriate treatment remains difficult. A seven-year-old boy presented with recurrent intussusception owing to HSP without purpura. It was confirmed pathologically and treated via colonoscopy. Early colonoscopic intervention can contribute to the early diagnosis of HSP and its subsequent management by avoiding unnecessary surgical invasion.
MeSH term(s)	Child ; Colonoscopy/methods ; Humans ; Intussusception/diagnosis ; Intussusception/prevention & control ; Male ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/diagnosis ; Secondary Prevention
Language	English
Publishing date	2018-04-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2649065-1
ISSN	2046-9055 ; 2046-9047
ISSN (online)	2046-9055
ISSN	2046-9047
DOI	10.1080/20469047.2018.1457273
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Article ; Online: Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury.

Tamai, Koji / Terai, Hidetomi / Nakamura, Hiroaki / Yokogawa, Noriaki / Sasagawa, Takeshi / Nakashima, Hiroaki / Segi, Naoki / Ito, Sadayuki / Funayama, Toru / Eto, Fumihiko / Yamaji, Akihiro / Watanabe, Kota / Yamane, Junichi / Takeda, Kazuki / Furuya, Takeo / Yunde, Atsushi / Nakajima, Hideaki / Yamada, Tomohiro / Hasegawa, Tomohiko /

Terashima, Yoshinori / Hirota, Ryosuke / Suzuki, Hidenori / Imajo, Yasuaki / Ikegami, Shota / Uehara, Masashi / Tonomura, Hitoshi / Sakata, Munehiro / Hashimoto, Ko / Onoda, Yoshito / Kawaguchi, Kenichi / Haruta, Yohei / Suzuki, Nobuyuki / Kato, Kenji / Uei, Hiroshi / Sawada, Hirokatsu / Nakanishi, Kazuo / Misaki, Kosuke / Kuroda, Akiyoshi / Inoue, Gen / Kakutani, Kenichiro / Kakiuchi, Yuji / Kiyasu, Katsuhito / Tominaga, Hiroyuki / Tokumoto, Hiroto / Iizuka, Yoichi / Takasawa, Eiji / Akeda, Koji / Takegami, Norihiko / Funao, Haruki / Oshima, Yasushi / Kaito, Takashi / Sakai, Daisuke / Yoshii, Toshitaka / Ohba, Tetsuro / Otsuki, Bungo / Seki, Shoji / Miyazaki, Masashi / Ishihara, Masayuki / Okada, Seiji / Imagama, Shiro / Kato, Satoshi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5853

Abstract: This retrospective cohort study established malnutrition's impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or ... ...

Abstract	This retrospective cohort study established malnutrition's impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan-Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale ≥ 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p < 0.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1 year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1 year post-injury than matched controls.
MeSH term(s)	Humans ; Aged ; Activities of Daily Living ; Retrospective Studies ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/therapy ; Malnutrition/complications ; Nutritional Status ; Recovery of Function
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56527-y
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Article ; Online: Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population.

Spinal cord

2024 Volume 62, Issue 4, Page(s) 149–155

Abstract: Study design: Retrospective cohort study.: Objectives: To define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade ...

Abstract	Study design: Retrospective cohort study. Objectives: To define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade C (AIS-C). Settings: Multi-institutions in Japan. Methods: We included patients aged ≥65 years with traumatic SCI of AIS-C who were treated conservatively or surgically with >3 follow-up months. To identify factors related to neurological improvement, patients were divided into three groups according to their neurological status at the final follow-up, with univariate among-group comparisons of demographics, radiographic, and therapeutic factors. Significant variables were included in the multivariate logistic regression analysis. Results: Overall, 296 older patients with SCI of AIS-C on admission were identified (average age: 75.2 years, average follow-up: 18.7 months). Among them, 190 (64.2%) patients improved to AIS-D and 21 (7.1%) patients improved to AIS-E at final follow-up. There were significant among-group differences in age (p = 0.026), body mass index (p = 0.007), status of pre-traumatic activities of daily living (ADL) (p = 0.037), and serum albumin concentrations (p = 0.011). Logistic regression analysis showed no significant differences in variables in the stratified group of patients who improved to AIS-D. Meanwhile, serum albumin was a significant variable in patients who improved to AIS-E (p = 0.026; OR: 6.20, pre-traumatic ADL was omitted due to data skewness). Conclusions: Most older patients with incomplete AIS-C SCI demonstrated at least 1 grade of neurological improvement. However, <10% of patients achieved complete recovery. Key predictors of complete recovery were high serum albumin levels on admission and independent pre-traumatic ADL. Sponsorship: No funding was received for this study.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Spinal Cord Injuries/diagnosis ; Spinal Cord Injuries/epidemiology ; Spinal Cord Injuries/therapy ; Retrospective Studies ; Activities of Daily Living ; Recovery of Function ; Serum Albumin
Chemical Substances	Serum Albumin
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1316161-1
ISSN	1476-5624 ; 1362-4393
ISSN (online)	1476-5624
ISSN	1362-4393
DOI	10.1038/s41393-024-00963-0
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Article ; Online: Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency.

Human molecular genetics

2022 Volume 31, Issue 13, Page(s) 2223–2235

Abstract: The genetic regulation of ovarian development remains largely unclear. Indeed, in most cases of impaired ovarian development-such as 46,XX disorders of sex development (DSD) without SRY, and premature ovarian insufficiency (POI)-the genetic causes have ... ...

Abstract	The genetic regulation of ovarian development remains largely unclear. Indeed, in most cases of impaired ovarian development-such as 46,XX disorders of sex development (DSD) without SRY, and premature ovarian insufficiency (POI)-the genetic causes have not been identified, and the vast majority of disease-associated sequence variants could lie within non-coding regulatory sequences. In this study, we aimed to identify enhancers of five ovarian genes known to play key roles in early ovarian development, basing our analysis on the expression of enhancer derived transcripts (eRNAs), which are considered to characterize active enhancers. Temporal expression profile changes in mouse WT1-positive ovarian cells were obtained from cap analysis of gene expression at E13.5, E16.5 and P0. We compared the chronological expression profiles of ovarian-specific eRNA with expression profiles for each of the ovarian-specific genes, yielding two candidate sequences for enhancers of Wnt4 and Rspo1. Both sequences are conserved between mouse and human, and we confirmed their enhancer activities using transient expression assays in murine granulosa cells. Furthermore, by sequencing the region in patients with impaired ovarian development in 24 patients, such as POI, gonadal dysgenesis and 46,XX DSD, we identified rare single nucleotide variants in both sequences. Our results demonstrate that combined analysis of the temporal expression profiles of eRNA and mRNA of target genes presents a powerful tool for locating cis-element enhancers, and a means of identifying disease-associated sequence variants that lie within non-coding regulatory sequences, thus advancing an important unmet need in forward human genetics.
MeSH term(s)	Animals ; Enhancer Elements, Genetic/genetics ; Female ; Genetic Variation ; Humans ; Menopause, Premature/genetics ; Mice ; Primary Ovarian Insufficiency/genetics ; Primary Ovarian Insufficiency/metabolism ; RNA/genetics ; Time Factors
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddac023
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Zs.A 3469: Show issues

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Article: Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan.

Segi, Naoki / Nakashima, Hiroaki / Machino, Masaaki / Ito, Sadayuki / Yokogawa, Noriaki / Sasagawa, Takeshi / Funayama, Toru / Eto, Fumihiko / Watanabe, Kota / Nori, Satoshi / Furuya, Takeo / Yunde, Atsushi / Nakajima, Hideaki / Hasegawa, Tomohiko / Yamada, Tomohiro / Terashima, Yoshinori / Hirota, Ryosuke / Suzuki, Hidenori / Imajo, Yasuaki /

Ikegami, Shota / Uehara, Masashi / Tonomura, Hitoshi / Sakata, Munehiro / Hashimoto, Ko / Onoda, Yoshito / Kawaguchi, Kenichi / Haruta, Yohei / Suzuki, Nobuyuki / Kato, Kenji / Uei, Hiroshi / Sawada, Hirokatsu / Nakanishi, Kazuo / Misaki, Kosuke / Terai, Hidetomi / Tamai, Koji / Inoue, Gen / Shirasawa, Eiki / Kakutani, Kenichiro / Iizuka, Yoichi / Takasawa, Eiji / Akeda, Koji / Kiyasu, Katsuhito / Tominaga, Hiroyuki / Tokumoto, Hiroto / Funao, Haruki / Oshima, Yasushi / Yoshii, Toshitaka / Kaito, Takashi / Sakai, Daisuke / Ohba, Tetsuro / Seki, Shoji / Otsuki, Bungo / Ishihara, Masayuki / Miyazaki, Masashi / Okada, Seiji / Imagama, Shiro / Kato, Satoshi

Global spine journal

2023 , Page(s) 21925682231151643

Abstract: Study design: Retrospective multicenter study.: Objectives: To investigate changes over a 10-years period in the profile of cervical spine and spinal cord injuries among the elderly in Japan.: Methods: The current multicenter study was a ... ...

Abstract	Study design: Retrospective multicenter study. Objectives: To investigate changes over a 10-years period in the profile of cervical spine and spinal cord injuries among the elderly in Japan. Methods: The current multicenter study was a retrospective analysis of inpatients aged ≥65 years, suffering cervical fracture (CF) and/or cervical spinal cord injury (CSCI). We analyzed 1413 patients' epidemiology (from 2010 to 2019). Moreover, 727 patients who underwent surgical treatment were analyzed in 2 groups: the early (2010-2014) and late period (2015-2019). Results: Both the number of patients and number of surgical patients showed a significant increasing trend ( Conclusions: Both the number of elderly CF and/or CSCI patients and number of patients undergoing surgery increased dramatically over the decade without any change in profile. Instrumentation surgeries with screws increased, without an increase in systemic complications.
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682231151643
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Article: Effects of Dementia on Outcomes after Cervical Spine Injuries in Elderly Patients: Evaluation of 1512 Cases in a Nationwide Multicenter Study in Japan.

Yamada, Yohei / Yokogawa, Noriaki / Kato, Satoshi / Sasagawa, Takeshi / Tsuchiya, Hiroyuki / Nakashima, Hiroaki / Segi, Naoki / Ito, Sadayuki / Funayama, Toru / Eto, Fumihiko / Yamaji, Akihiro / Yamane, Junichi / Nori, Satoshi / Furuya, Takeo / Yunde, Atsushi / Nakajima, Hideaki / Yamada, Tomohiro / Hasegawa, Tomohiko / Terashima, Yoshinori /

Hirota, Ryosuke / Suzuki, Hidenori / Imajo, Yasuaki / Ikegami, Shota / Uehara, Masashi / Tonomura, Hitoshi / Sakata, Munehiro / Hashimoto, Ko / Onoda, Yoshito / Kawaguchi, Kenichi / Haruta, Yohei / Suzuki, Nobuyuki / Kato, Kenji / Uei, Hiroshi / Sawada, Hirokatsu / Nakanishi, Kazuo / Misaki, Kosuke / Terai, Hidetomi / Tamai, Koji / Kuroda, Akiyoshi / Inoue, Gen / Kakutani, Kenichiro / Kakiuchi, Yuji / Kiyasu, Katsuhito / Tominaga, Hiroyuki / Tokumoto, Hiroto / Iizuka, Yoichi / Takasawa, Eiji / Akeda, Koji / Takegami, Norihiko / Funao, Haruki / Oshima, Yasushi / Kaito, Takashi / Sakai, Daisuke / Yoshii, Toshitaka / Ohba, Tetsuro / Otsuki, Bungo / Seki, Shoji / Miyazaki, Masashi / Ishihara, Masayuki / Okada, Seiji / Imagama, Shiro / Watanabe, Kota

Journal of clinical medicine

2023 Volume 12, Issue 5

Abstract: We aimed to retrospectively investigate the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. We enrolled 1512 patients aged ≥ 65 years with traumatic cervical injuries registered in a ... ...

Abstract	We aimed to retrospectively investigate the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. We enrolled 1512 patients aged ≥ 65 years with traumatic cervical injuries registered in a multicenter study database. Patients were divided into two groups according to the presence of dementia, and 95 patients (6.3%) had dementia. Univariate analysis revealed that the dementia group comprised patients who were older and predominantly female and had lower body mass index, higher modified 5-item frailty index (mFI-5), lower pre-injury activities of daily living (ADLs), and a larger number of comorbidities than patients without dementia. Furthermore, 61 patient pairs were selected through propensity score matching with adjustments for age, sex, pre-injury ADLs, American Spinal Injury Association Impairment Scale score at the time of injury, and the administration of surgical treatment. In the univariate analysis of the matched groups, patients with dementia had significantly lower ADLs at 6 months and a higher incidence of dysphagia up to 6 months than patients without dementia. Kaplan-Meier analysis revealed that patients with dementia had a higher mortality than those without dementia until the last follow-up. Dementia was associated with poor ADLs and higher mortality rates after traumatic cervical spine injuries in elderly patients.
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12051867
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Article: Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture.

Segi, Naoki / Nakashima, Hiroaki / Machino, Masaaki / Ito, Sadayuki / Yokogawa, Noriaki / Sasagawa, Takeshi / Funayama, Toru / Eto, Fumihiko / Yamaji, Akihiro / Watanabe, Kota / Nori, Satoshi / Takeda, Kazuki / Furuya, Takeo / Yunde, Atsushi / Nakajima, Hideaki / Yamada, Tomohiro / Hasegawa, Tomohiko / Terashima, Yoshinori / Hirota, Ryosuke /

Suzuki, Hidenori / Imajo, Yasuaki / Ikegami, Shota / Uehara, Masashi / Tonomura, Hitoshi / Sakata, Munehiro / Hashimoto, Ko / Onoda, Yoshito / Kawaguchi, Kenichi / Haruta, Yohei / Suzuki, Nobuyuki / Kato, Kenji / Uei, Hiroshi / Sawada, Hirokatsu / Nakanishi, Kazuo / Misaki, Kosuke / Terai, Hidetomi / Tamai, Koji / Shirasawa, Eiki / Inoue, Gen / Kakutani, Kenichiro / Kakiuchi, Yuji / Iizuka, Yoichi / Takasawa, Eiji / Akeda, Koji / Takegami, Norihiko / Kiyasu, Katsuhito / Tominaga, Hiroyuki / Tokumoto, Hiroto / Funao, Haruki / Oshima, Yasushi / Yoshii, Toshitaka / Kaito, Takashi / Sakai, Daisuke / Ohba, Tetsuro / Seki, Shoji / Otsuki, Bungo / Ishihara, Masayuki / Miyazaki, Masashi / Okada, Seiji / Imagama, Shiro / Kato, Satoshi

Global spine journal

2023 , Page(s) 21925682231186757

Abstract: Study design: Retrospective multicenter study.: Objective: The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, ...

Abstract	Study design: Retrospective multicenter study. Objective: The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures. Methods: The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified. Propensity score-matched cohorts from 1363 patients without cDISH were generated and compared. Logistic regression analysis was performed to determine the risk of early mortality for patients with cDISH-related injury. Results: Patients with cDISH-related injuries with fracture did not differ significantly in the incidence of each complication and ambulation or severity of paralysis compared to matched controls. In patients with cDISH-related injury without fracture, those who were nonambulatory at discharge comprised 55% vs 34% of controls, indicating significantly poorer ambulation in those with cDISH-related injuries ( Conclusions: The current study showed no significant differences in the incidence of complications, ambulation outcomes between patients with cDISH-related injury with fracture and matched controls, and that the ambulation at discharge for patients with cDISH-related injury without fractures were significantly inferior to those of matched controls.
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682231186757
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Kategorien

Order via subito

More links

Kategorien

Order via subito