Article ; Online: K
2021 Volume 11, Issue 1, Page(s) 18330
Abstract: ... TKIs), but patients develop inevitably a resistance against these drugs. On the other hand, K ...
Abstract | Non-small cell lung cancer (NSCLC) has a poor prognosis with a 5 year survival rate of only ~ 10%. Important driver mutations underlying NSCLC affect the epidermal growth factor receptor (EGFR) causing the constitutive activation of its tyrosine kinase domain. There are efficient EGFR tyrosine kinase inhibitors (TKIs), but patients develop inevitably a resistance against these drugs. On the other hand, K |
---|---|
MeSH term(s) | A549 Cells ; Carcinoma, Non-Small-Cell Lung ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Erlotinib Hydrochloride/pharmacology ; Gene Expression Profiling ; Humans ; Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors ; Lung Neoplasms ; Potassium Channel Blockers/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Single-Cell Analysis/methods |
Chemical Substances | Large-Conductance Calcium-Activated Potassium Channels ; Potassium Channel Blockers ; Protein Kinase Inhibitors ; Erlotinib Hydrochloride (DA87705X9K) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) |
Language | English |
Publishing date | 2021-09-15 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-021-97406-0 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.