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  1. Article ; Online: SGLT2 Inhibitors and Diuresis: A Small Piece of the Puzzle.

    Vardeny, Orly

    JACC. Heart failure

    2023  Volume 12, Issue 1, Page(s) 47–49

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Heart Failure/drug therapy ; Diabetes Mellitus, Type 2 ; Diuresis ; Stroke Volume
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Influenza vaccine in cardiovascular disease: time to move the needle.

    Vardeny, Orly

    European heart journal

    2022  Volume 43, Issue 41, Page(s) 4389–4391

    MeSH term(s) Humans ; Influenza Vaccines/therapeutic use ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Cardiovascular Diseases/prevention & control ; Acute Coronary Syndrome ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac491
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 640: Show issues

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  3. Article ; Online: Patient selection for mineralocorticoid receptor antagonists in heart failure with mildly reduced or preserved ejection fraction.

    Vardeny, Orly / Houle, Hailee

    Pharmacotherapy

    2023  Volume 43, Issue 6, Page(s) 563–569

    Abstract: The mineralocorticoid receptor is a steroid hormone receptor that contributes to cardiac tissue inflammation, fibrosis, and cardiac dysfunction and plays an important role in the pathophysiology of heart failure. Mineralocorticoid receptor antagonists ( ... ...

    Abstract The mineralocorticoid receptor is a steroid hormone receptor that contributes to cardiac tissue inflammation, fibrosis, and cardiac dysfunction and plays an important role in the pathophysiology of heart failure. Mineralocorticoid receptor antagonists (MRA) are an important component of guideline-directed medical therapy for heart failure to improve clinical outcomes. Clinical trial evidence in heart failure with reduced ejection fraction (HFrEF) informed a strong guideline recommendation for use of MRA in symptomatic patients, barring contraindications. In heart failure with mildly reduced ejection fraction (HFmrEF) and in heart failure with preserved ejection fraction (HFpEF), data are less robust, and this drug class received a weaker recommendation in the heart failure treatment guidelines. Thus, careful selection of patients with HFmrEF/HFpEF who are most likely to benefit from MRA is paramount to better optimize use of these medications. The purpose of this narrative review is to outline the rationale for the use of MRA in heart failure, summarize the clinical trial evidence for MRA in HFmrEF/HFpEF, discuss clinical considerations for their use, and describe investigations of nonsteroidal MRA in HFmrEF/HFpEF.
    MeSH term(s) Humans ; Heart Failure/drug therapy ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Patient Selection ; Stroke Volume/physiology ; Prognosis
    Chemical Substances Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.2801
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1738: Show issues Location:
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    Zs.MO 585: Show issues

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  4. Article ; Online: The Sweet Spot: Heart Failure Prevention with SGLT2 Inhibitors.

    Vardeny, Orly

    The American journal of medicine

    2019  Volume 133, Issue 2, Page(s) 182–185

    Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of medications that reduce plasma glucose concentrations through an insulin-independent mechanism of increased urinary glucose excretion, with concomitant natriuresis and diuresis. ... ...

    Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of medications that reduce plasma glucose concentrations through an insulin-independent mechanism of increased urinary glucose excretion, with concomitant natriuresis and diuresis. Clinical outcomes trials with SGLT2 inhibitors revealed a cardioprotective benefit among patients with diabetes mellitus, with a consistent reduction in hospitalization for heart failure. As such, the 2018 updated US and European treatment guidelines for diabetes mellitus incorporated SGLT2 inhibitors as second-line glucose-lowering agents after metformin. Although well tolerated, there are known adverse effects with SGLT2 inhibitors that require clinical monitoring, such as genital mycotic infections, diabetic ketoacidosis, volume depletion particularly in the setting of concomitant diuretic use, and lower limb amputations with canagliflozin. Ongoing clinical trials will uncover the potential benefit of SGLT2 inhibitors in patients with prevalent heart failure with or without diabetes mellitus.
    MeSH term(s) Cardiovascular Agents/therapeutic use ; Heart Failure/drug therapy ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Cardiovascular Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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  5. Article ; Online: Optimizing Heart Failure Therapy Requires All-Hands-on-Deck and a DASH of Technology.

    DiDomenico, Robert J / Vardeny, Orly

    Circulation. Heart failure

    2023  Volume 16, Issue 9, Page(s) e010886

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/therapy ; Quality Improvement ; Stroke Volume ; Hypertension ; Technology
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.123.010886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6745: Show issues Location:
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  6. Article ; Online: Words Matter: How the Universal Definition of Heart Failure Will Influence Research.

    Solomon, Scott D / Vardeny, Orly

    Journal of cardiac failure

    2021  Volume 27, Issue 10, Page(s) 1042–1044

    MeSH term(s) Heart Failure/diagnosis ; Humans
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2021.08.011
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    Zs.A 4340: Show issues Location:
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  7. Article ; Online: Angiotensin receptor-neprilysin inhibitors in heart failure: a shifting paradigm.

    Vardeny, Orly

    Evidence-based medicine

    2015  Volume 20, Issue 2, Page(s) 61

    MeSH term(s) Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Enalapril/therapeutic use ; Female ; Heart Failure/drug therapy ; Humans ; Male ; Neprilysin/antagonists & inhibitors ; Tetrazoles/therapeutic use
    Chemical Substances Aminobutyrates ; Angiotensin Receptor Antagonists ; Tetrazoles ; Enalapril (69PN84IO1A) ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1324346-9
    ISSN 1473-6810 ; 1356-5524
    ISSN (online) 1473-6810
    ISSN 1356-5524
    DOI 10.1136/ebmed-2014-110112
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    Zs.A 4793: Show issues Location:
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  8. Article ; Online: Influenza and Heart Failure: A Catchy Comorbid Combination.

    Vardeny, Orly / Solomon, Scott D

    JACC. Heart failure

    2019  Volume 7, Issue 2, Page(s) 118–120

    MeSH term(s) Comorbidity ; Heart Failure/epidemiology ; Humans ; Influenza, Human/epidemiology ; Vaccination
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2018.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Complications in Patients With COVID-19-Reply.

    Madjid, Mohammad / Solomon, Scott D / Vardeny, Orly

    JAMA cardiology

    2020  Volume 6, Issue 3, Page(s) 360

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.5794
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  10. Article ; Online: Practical Guide to Prescribing Sodium-Glucose Cotransporter 2 Inhibitors for Cardiologists.

    Vardeny, Orly / Vaduganathan, Muthiah

    JACC. Heart failure

    2019  Volume 7, Issue 2, Page(s) 169–172

    Abstract: The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of glucose-lowering therapies that have been shown to reduce risks of heart failure (HF) events in patients with type 2 diabetes mellitus (T2DM) at high-risk for or with cardiovascular ... ...

    Abstract The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of glucose-lowering therapies that have been shown to reduce risks of heart failure (HF) events in patients with type 2 diabetes mellitus (T2DM) at high-risk for or with cardiovascular disease. The United States Food and Drug Administration has expanded the regulatory label for empagliflozin and canagliflozin for use to lower cardiovascular risk in patients with T2DM and cardiovascular disease. SGLT2 inhibitors are being actively studied in the treatment of patients with HF, including in those without diabetes mellitus. Despite the accumulating data supporting this class of therapies in HF prevention, cardiologists infrequently prescribe SGLT2 inhibitors, potentially due to lack of familiarity with their use. We provide an up-to-date practical guide highlighting important elements for treatment initiation, dosing, anticipated adverse effects, and barriers to uptake.
    MeSH term(s) Cardiologists/standards ; Comorbidity ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Drug Prescriptions/standards ; Global Health ; Heart Failure/epidemiology ; Heart Failure/prevention & control ; Humans ; Practice Guidelines as Topic ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2018.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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