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  1. Article ; Online: Honokiol: Treatment for malignant peripheral nerve sheath tumors.

    Joshi, Megha Rajeev

    Journal of cancer research and therapeutics

    2023  Volume 19, Issue 5, Page(s) 1485–1486

    MeSH term(s) Humans ; Neurofibrosarcoma ; Nerve Sheath Neoplasms/drug therapy ; Nerve Sheath Neoplasms/pathology ; Neurilemmoma ; Biphenyl Compounds
    Chemical Substances honokiol (11513CCO0N) ; Biphenyl Compounds
    Language English
    Publishing date 2023-10-03
    Publishing country India
    Document type Letter
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_1742_21
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  2. Article: Unusual findings on fine-needle aspiration cytology of a retroperitoneal mass.

    Joshi, Mihir Jejurkar / Joshi, Megha Govind

    CytoJournal

    2023  Volume 20, Page(s) 40

    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2158838-7
    ISSN 1742-6413 ; 0974-5963
    ISSN (online) 1742-6413
    ISSN 0974-5963
    DOI 10.25259/Cytojournal_28_2022
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  3. Article: Rare infection diagnosed by cytology in a bronchoalveolar lavage specimen in a patient with massive pulmonary hemorrhage.

    Joshi, Megha / Scarff, Geetanjali

    CytoJournal

    2020  Volume 17, Page(s) 23

    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2158838-7
    ISSN 1742-6413 ; 0974-5963
    ISSN (online) 1742-6413
    ISSN 0974-5963
    DOI 10.25259/Cytojournal_86_2019
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  4. Article ; Online: Evidence for visceral leishmaniasis elimination in Nepal.

    Banjara, Megha Raj / Joshi, Anand Ballabh

    The Lancet. Global health

    2020  Volume 8, Issue 2, Page(s) e161–e162

    MeSH term(s) Humans ; Leishmania donovani ; Leishmaniasis, Visceral ; Nepal ; Surveys and Questionnaires
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(19)30538-8
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  5. Article ; Online: Application of Pediatric Risk of Mortality (PRISM) III Score in Predicting Mortality Outcomes.

    Joshi, Prakash / Agrawal, Sumit / Ghimire, Jagat Jeevan / Shrestha, Pun Narayan / Khatun, Najala / Banjara, Megha Raj

    Journal of Nepal Health Research Council

    2024  Volume 21, Issue 3, Page(s) 450–457

    Abstract: Background: Children admitted in a pediatric intensive care unit have a high risk of mortality. Pediatric risk of mortality III score in first 24 hours of admission has increasingly been used to predict mortality. The objective of this study was to ... ...

    Abstract Background: Children admitted in a pediatric intensive care unit have a high risk of mortality. Pediatric risk of mortality III score in first 24 hours of admission has increasingly been used to predict mortality. The objective of this study was to evaluate the validity of Pediatric risk of mortality score in prediction of mortality among the patient admitted in pediatric intensive care unit.
    Methods: This prospective observational study was conducted at pediatric intensive care unit of a government pediatric hospital from January to June 2021. Patients between 1 month to 14 years of age and meeting the inclusion criteria were enrolled. Pediatric risk of mortality III score was calculated within 24 hours of admission. Patients were followed up for outcome measure as survivors and non survivors. Chi square test and logistic regression analysis were used to find the association of predictors and the score.
    Results: The mean Pediatric risk of mortality III score was lower in survivors than in non-survivors (4.67 ± 3.8 versus 14.10 ± 6.07; p<0.001). Those requiring inotropic and ventilator support have significantly higher mortality [49.4 versus 0.6 (p<0.001) and 81.8 versus 1.5 (p<0.001) respectively]. Minimum systolic blood pressure, abnormal pupillary reflex, increased blood urea nitrogen and decreased platelet were the significant (p<0.001) risk factors. The area under the Receiver Operating Characteristic curve was 0.916±0.024 (p<0.001) and goodness-of-fit test showed no significant difference between observed and expected mortalities (p=0.186).
    Conclusions: The Pediatric risk of mortality score constitutes a useful prognostic tool in predicting the mortality.
    Key words: Mortality; pediatrics; pediatric intensive care unit; risk score.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Blood Pressure ; Hospitalization ; Hospitals, Public ; Intensive Care Units, Pediatric ; Nepal/epidemiology ; Prospective Studies
    Language English
    Publishing date 2024-03-22
    Publishing country Nepal
    Document type Observational Study ; Journal Article
    ZDB-ID 2551251-1
    ISSN 1999-6217 ; 1999-6217
    ISSN (online) 1999-6217
    ISSN 1999-6217
    DOI 10.33314/jnhrc.v21i3.4662
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  6. Article: Clinical and Radiographic Evaluation of Different Glass Ionomer Restorative Materials in Primary Molars: A Comparative Randomized Clinical Trial.

    Kataria, Vishakha G / Patel, Megha C / Bhatt, Rohan / Patel, Foram C / Makwani, Disha G / Joshi, Kaushal

    International journal of clinical pediatric dentistry

    2024  Volume 16, Issue 6, Page(s) 829–836

    Abstract: Aim: The study aimed to evaluate and compare the clinical and radiographic success rate of Ketac Universal (3M), GC 9 EXTRA (GC), and Cention N (Ivoclar) restorative materials in primary molars.: Materials and methods: The study was conducted as ... ...

    Abstract Aim: The study aimed to evaluate and compare the clinical and radiographic success rate of Ketac Universal (3M), GC 9 EXTRA (GC), and Cention N (Ivoclar) restorative materials in primary molars.
    Materials and methods: The study was conducted as randomized clinical trial in children aged 3-8 years old, out of which a total of 75 primary molars were selected in 43 patients who met the inclusion criteria. The sample size was further divided into three groups of restorative materials, which included group I-Ketac Universal (
    Results: On intercomparison of three groups at 12 months, there was no significant difference found, while on pairwise comparison of Ketac Universal and Cention N, there was a significant difference in relation to surface texture (
    Conclusion: Newly introduced restorative material Cention N exhibited improved physical and mechanical properties and can be recommended as a cost-effective restorative and easy-to-use material in posterior load-bearing primary molars.
    Clinical significance: Restoration of primary teeth continues to be an important aspect of restorative dentistry. The longevity of restorations in primary teeth is significantly different for all materials compared to permanent dentition. This makes the assessment of these restorations as a separate group meaningful.
    How to cite this article: Kataria VG, Patel MC, Bhatt R,
    Language English
    Publishing date 2024-01-25
    Publishing country India
    Document type Journal Article
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-2709
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  7. Article ; Online: Cluster wild bootstrapping to handle dependent effect sizes in meta-analysis with a small number of studies.

    Joshi, Megha / Pustejovsky, James E / Beretvas, S Natasha

    Research synthesis methods

    2022  Volume 13, Issue 4, Page(s) 457–477

    Abstract: The most common and well-known meta-regression models work under the assumption that there is only one effect size estimate per study and that the estimates are independent. However, meta-analytic reviews of social science research often include multiple ...

    Abstract The most common and well-known meta-regression models work under the assumption that there is only one effect size estimate per study and that the estimates are independent. However, meta-analytic reviews of social science research often include multiple effect size estimates per primary study, leading to dependence in the estimates. Some meta-analyses also include multiple studies conducted by the same lab or investigator, creating another potential source of dependence. An increasingly popular method to handle dependence is robust variance estimation (RVE), but this method can result in inflated Type I error rates when the number of studies is small. Small-sample correction methods for RVE have been shown to control Type I error rates adequately but may be overly conservative, especially for tests of multiple-contrast hypotheses. We evaluated an alternative method for handling dependence, cluster wild bootstrapping, which has been examined in the econometrics literature but not in the context of meta-analysis. Results from two simulation studies indicate that cluster wild bootstrapping maintains adequate Type I error rates and provides more power than extant small-sample correction methods, particularly for multiple-contrast hypothesis tests. We recommend using cluster wild bootstrapping to conduct hypothesis tests for meta-analyses with a small number of studies. We have also created an R package that implements such tests.
    MeSH term(s) Computer Simulation ; Data Interpretation, Statistical ; Humans ; Meta-Analysis as Topic ; Research Design ; Sample Size
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2548499-0
    ISSN 1759-2887 ; 1759-2879
    ISSN (online) 1759-2887
    ISSN 1759-2879
    DOI 10.1002/jrsm.1554
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  8. Article ; Online: Utilization of Truenat chips in defining XDR, pre-XDR and MDR in tuberculous meningitis.

    Sharma, Kusum / Sharma, Megha / Shree, Ritu / Singla, Neeraj / Joshi, Himanshu / Modi, Tanish / Goyal, Manoj / Sharma, Aman / Sharma, Navneet / Modi, Manish

    Tuberculosis (Edinburgh, Scotland)

    2024  Volume 147, Page(s) 102513

    Abstract: Setting and objective: To develop and evaluate newer molecular tests that identify drug resistance according to contemporary definitions in Tuberculous meningitis (TBM), the most severe form of EPTB.: Design: 93 cerebrospinal fluid (CSF) specimens [ ... ...

    Abstract Setting and objective: To develop and evaluate newer molecular tests that identify drug resistance according to contemporary definitions in Tuberculous meningitis (TBM), the most severe form of EPTB.
    Design: 93 cerebrospinal fluid (CSF) specimens [41 culture-positive and 52 culture-negative], were subjected to Truenat MTB Plus assay along with chips for rifampicin, isoniazid, fluoroquinolones and bedaquiline resistance. The performance was compared against phenotypic drug susceptibility testing (pDST), Line probe assay (LPA) and gene sequencing.
    Results: Against pDST, Truenat chips had a sensitivity and specificity of 100%; 94.47%, 100%; 94.47%, 100%; 97.14% and 100%; 100%, respectively for rifampicin, isoniazid, fluoroquinolones and bedaquiline. Against LPA, all Truenat chips detected resistant isolates with 100% sensitivity; but 2 cases each of false-rifampicin and false-isoniazid resistance and 1 case of false-fluoroquinolone resistance was reported. Truenat drug chips gave indeterminate results in ∼25% cases, which were excluded. All cases reported indeterminate were found to be susceptible by pDST/LPA.
    Conclusion: The strategic drug resistance chips of Truenat Plus assay can contribute greatly to TB elimination by providing rapid and reliable detection of drug resistance pattern in TBM. Cases reported indeterminate require confirmation by other phenotypic and genotypic methods.
    Language English
    Publishing date 2024-03-24
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2024.102513
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  9. Article ; Online: Knowledge and Attitude about Labor Epidural Analgesia among Pregnant Women Attending Antenatal Clinic.

    Parajuli, Bashu Dev / Koirala, Megha / Joshi, Pankaj / Katuwal, Neeta / Shrestha, Amit / Singh, Shreejana / Rawal, Suniti / Shrestha, Anil

    Journal of Nepal Health Research Council

    2024  Volume 21, Issue 4, Page(s) 623–628

    Abstract: Background: Labour pain is one of the most painful experiences that a woman faces in her lifetime. There are various options for labour pain management. Epidural analgesia is the gold standard method for pain management during labour. In developing and ... ...

    Abstract Background: Labour pain is one of the most painful experiences that a woman faces in her lifetime. There are various options for labour pain management. Epidural analgesia is the gold standard method for pain management during labour. In developing and under-developed countries there are many challenges to provide this service, a very important one being knowledge about epidural analgesia among the parturients and the physicians.
    Methods: A prospective cross-sectional study was carried out among 384 pregnant women attending Antenatal clinic of a tertiary level teaching hospital using pretested structured questionnaire prepared by a team of anaesthesiologists and obstetricians. Non-probability purposive sampling technique was used. The data was analysed by using SPSS version 20.0. Descriptive and inferential statistical methods were used for analysis.
    Results: Of the 384 pregnant women, only 29.4% had knowledge about some form of labour analgesia techniques and only 16% of the participants were aware of labour epidural analgesia. Also, only 6.2% were aware that epidural service is available at our hospital. Regarding acceptance, only 42.4% were willing to use epidural analgesia in their present pregnancy.
    Conclusions: The present study findings revealed that a significant number of participants had very limited knowledge about labour epidural analgesia and were also unaware of the availability of the service in our hospital. Educational programs need to be provided to all the pregnant women for enhancement of knowledge and awareness about epidural labour analgesia to increase its acceptability among them.
    MeSH term(s) Female ; Humans ; Pregnancy ; Analgesia, Epidural ; Cross-Sectional Studies ; Pregnant Women ; Prospective Studies ; Nepal ; Hospitals, Teaching ; Labor Pain/therapy
    Language English
    Publishing date 2024-03-31
    Publishing country Nepal
    Document type Journal Article
    ZDB-ID 2551251-1
    ISSN 1999-6217 ; 1999-6217
    ISSN (online) 1999-6217
    ISSN 1999-6217
    DOI 10.33314/jnhrc.v21i4.4862
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  10. Article ; Online: Anaesthetic Management of a Patient with Fontan Circulation for Laparoscopic Cholecystectomy

    Bashu Dev Parajuli / Allen Suwal / Amit Sharma Bhattrai / Basanta Ghimire / Pankaj Joshi / Megha Koirala / Prasan Bir Singh Kansakar

    Journal of Nepal Health Research Council, Vol 20, Iss

    2023  Volume 3

    Abstract: ...

    Abstract .
    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nepal Health Research Council
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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