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  1. Article ; Online: Flurofamide Prevention and Treatment of

    Fleming, Derek / Patel, Robin

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0192722

    Abstract: Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia ( ... ...

    Abstract Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia (NH
    MeSH term(s) Mice ; Animals ; Ureaplasma ; Hyperammonemia/drug therapy ; Hyperammonemia/prevention & control ; Hyperammonemia/complications ; Urease/pharmacology ; Ammonia/pharmacology ; Ureaplasma Infections/complications ; Ureaplasma Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Urea/pharmacology
    Chemical Substances flurofamide (599XHU06GH) ; Urease (EC 3.5.1.5) ; Ammonia (7664-41-7) ; Anti-Bacterial Agents ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01927-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of Treatment of Methicillin-Resistant

    Islam Anoy, Md Monzurul / Kim, Won-Jun / Gelston, Suzanne / Fleming, Derek / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced ... ...

    Abstract Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced H
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of shunt valves used for treating hydrocephalus: comparison with endoscopy treatment.

    Fleming, Charles H / Ritter, Ann M / Bruce, Derek A

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 39, Issue 10, Page(s) 2709–2717

    Abstract: The pathophysiology of hydrocephalus is not clearly defined. Thus, treatment will remain empirical until a fuller understanding of the various forms of hydrocephalus is achieved. Valve-controlled shunting has been the mainstay of therapy since the late ... ...

    Abstract The pathophysiology of hydrocephalus is not clearly defined. Thus, treatment will remain empirical until a fuller understanding of the various forms of hydrocephalus is achieved. Valve-controlled shunting has been the mainstay of therapy since the late 1950s. Initially, shunting occurred from the ventricular system to the atrium. In the 1970s, VA shunts were replaced by ventriculoperitoneal shunts as the primary location for the distal end. Multiple types of one-way valve systems have been developed in the pursuit of draining the appropriate amount of CSF that avoids either overdrainage or underdrainage while preserving normal brain development and cognition. These valves are reviewed and compared as to their function. Other locations for the distal end of the shunting system are reviewed to include pleural space and gallbladder. The lumbar subarachnoid space as the proximal location for a shunt is also reviewed. The only other surgical alternative for treating hydrocephalus is endoscopic third ventriculostomy. Since 2000, approximately 50% of children with hydrocephalus have been shown to be candidates for ETV. The benefits are the lack of need for an artificial shunt system and thus lower rates of infection and over time fewer reoperations. Future progress is dependent on improved shunt valve systems that are affordable worldwide and ready availability of ETV in developing countries. Anatomic and molecular causes of hydrocephalus need to be defined so that medications or genetic modifications become available for potential cure of hydrocephalus.
    MeSH term(s) Child ; Humans ; Infant ; Third Ventricle/surgery ; Hydrocephalus/etiology ; Ventriculostomy/adverse effects ; Brain/surgery ; Endoscopy ; Ventriculoperitoneal Shunt/adverse effects ; Cerebrospinal Fluid Shunts/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-06-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06049-1
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    Zs.A 2036: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: DUAL ACTION ELECTROCHEMICAL BANDAGE OPERATED by a PROGRAMMABLE MULTIMODAL WEARABLE POTENTIOSTAT.

    Bozyel, Ibrahim / Fleming, Derek / Kim, Won-Jun / Rosen, Peter F / Gelston, Suzanne / Ozdemir, Dilara / Ay, Suat U / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide ( ... ...

    Abstract Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide (H
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contribution of Uremia to

    Fleming, Derek / Cunningham, Scott A / Patel, Robin

    Microbiology spectrum

    2022  Volume 10, Issue 1, Page(s) e0194221

    Abstract: Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the ... ...

    Abstract Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the respiratory tract, although it is not well understood what makes LTRs preferentially susceptible to HS compared to other immunocompromised hosts. Ureaplasma species harbor highly active ureases, and postoperative LTRs commonly experience uremia. We hypothesized that uremia could be a potentiating comorbidity, providing increased substrate for ureaplasmal ureases. Using a novel dialyzed flow system, the ammonia-producing capacities of four isolates of Ureaplasma parvum and six isolates of Ureaplasma urealyticum in media formulations relating to normal and uremic host conditions were tested. For all isolates, growth under simulated uremic conditions resulted in increased ammonia production over 24 h, despite similar endpoint bacterial quantities. Further, transcripts of
    MeSH term(s) Ammonia/metabolism ; Animals ; Humans ; Hyperammonemia/complications ; Hyperammonemia/microbiology ; Immunocompromised Host ; Lung ; Lung Transplantation ; Mice ; Transplant Recipients ; Ureaplasma ; Ureaplasma urealyticum/isolation & purification ; Uremia/complications ; Uremia/microbiology ; Urinary Tract
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01942-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dealing With Surrogate Conflict: A Student's Perspective.

    Su, Derek / Fleming, David A

    Southern medical journal

    2019  Volume 112, Issue 6, Page(s) 315–317

    MeSH term(s) Advance Care Planning ; Conflict, Psychological ; Decision Making/ethics ; Humans ; Negotiating/methods ; Patient Preference ; Proxy
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000000981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.117: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 336: Show issues

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  7. Article: HOCl-producing Electrochemical Bandage is Active in Murine Polymicrobial Wound Infection.

    Fleming, Derek / Bozyel, Ibrahim / Koscianski, Christina A / Ozdemir, Dilara / Karau, Melissa J / Cuello, Luz / Anoy, Md Monzurul Islam / Gelston, Suzanne / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often ... ...

    Abstract Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often involving
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.19.585100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A novel bioreactor for the stable growth of Ureaplasma parvum and Ureaplasma urealyticum.

    Fleming, Derek / Karau, Melissa / Patel, Robin

    Journal of microbiological methods

    2020  Volume 181, Page(s) 106131

    Abstract: Ureaplasma species, including Ureaplasma parvum and Ureaplasma urealyticum, are challenging to culture and maintain. Here, we describe a novel bioreactor for growing high-titer liquid Ureaplasma cultures in a stable manner. ...

    Abstract Ureaplasma species, including Ureaplasma parvum and Ureaplasma urealyticum, are challenging to culture and maintain. Here, we describe a novel bioreactor for growing high-titer liquid Ureaplasma cultures in a stable manner.
    MeSH term(s) Bioreactors/microbiology ; Humans ; Ureaplasma/growth & development ; Ureaplasma Infections/microbiology ; Ureaplasma urealyticum/growth & development
    Language English
    Publishing date 2020-12-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2020.106131
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    Zs.A 1849: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: HOCl-producing electrochemical bandage for treating

    Fleming, Derek / Bozyel, Ibrahim / Ozdemir, Dilara / Otero, Judith Alvarez / Karau, Melissa J / Anoy, Md Monzurul Islam / Koscianski, Christina / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    Antimicrobial agents and chemotherapy

    2024  Volume 68, Issue 2, Page(s) e0121623

    Abstract: The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel ... ...

    Abstract The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel electrochemical bandage (e-bandage) delivering low-levels of hypochlorous acid (HOCl) was evaluated against
    MeSH term(s) Animals ; Mice ; Pseudomonas aeruginosa ; Hypochlorous Acid ; Amikacin ; Pseudomonas Infections/microbiology ; Wound Infection/microbiology ; Bandages ; Anti-Bacterial Agents ; Biofilms
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; Amikacin (84319SGC3C) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01216-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  10. Article ; Online: The biofilm community resurfaces: new findings and post-pandemic progress.

    Greenwich, Jennifer L / Fleming, Derek / Banin, Ehud / Häussler, Susanne / Kjellerup, Birthe V / Sauer, Karin / Visick, Karen L / Fuqua, Clay

    Journal of bacteriology

    2023  Volume 205, Issue 10, Page(s) e0016623

    Abstract: The ninth American Society for Microbiology Conference on Biofilms was convened in-person on 13-17 November 2022 in Charlotte, NC. As the first of these conferences since prior to the start of the COVID-19 pandemic, the energy among the participants of ... ...

    Abstract The ninth American Society for Microbiology Conference on Biofilms was convened in-person on 13-17 November 2022 in Charlotte, NC. As the first of these conferences since prior to the start of the COVID-19 pandemic, the energy among the participants of the conference was clear, and the meeting was a tremendous success. The mixture of >330 oral and poster presentations resoundingly embodied the vitality of biofilm research across a wide range of topics and multiple scientific disciplines. Special activities, including a pre-conference symposium for early career researchers, further enhanced the attendee experience. As a general theme, the conference was deliberately structured to provide high levels of participation and engagement among early career scientists.
    MeSH term(s) Humans ; United States ; Pandemics ; Societies, Scientific ; Biofilms
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00166-23
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