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Article ; Online: Synthesis and formulation of [

Green, Mark A / Mathias, Carla J

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2022 Volume 182, Page(s) 110119

Abstract: Purpose: The [: Methods: The [: Results: The [: Conclusions: The approach to [ ...

Abstract	Purpose: The [ Methods: The [ Results: The [ Conclusions: The approach to [
MeSH term(s)	Animals ; Copper Radioisotopes ; Models, Animal ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Perfusion Imaging ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry ; Rodentia ; Thiosemicarbazones/chemical synthesis ; Thiosemicarbazones/chemistry
Chemical Substances	Copper Radioisotopes ; Organometallic Compounds ; Radiopharmaceuticals ; Thiosemicarbazones ; copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex (19976-14-8)
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2022.110119
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Article ; Online: Impact of early, weekly drinking on latent classes of alcohol involvement progression and recovery: Evidence from the NESARC Waves 1 and 2.

Green, Kerry M / Reboussin, Beth A / Storr, Carla L / Mojtabai, Ramin / Susukida, Ryoko / Young, Andrea S / Cullen, Bernadette A / Luken, Amanda / Amin-Esmaeili, Masoumeh / Crum, Rosa M

Addictive behaviors reports

2022 Volume 15, Page(s) 100410

Abstract: Introduction: Early drinkers have been found to have higher risk of developing alcohol use disorder; however, the association of early drinking with progression to problematic alcohol involvement that does not meet disorder criteria (i.e., subclinical ... ...

Abstract	Introduction: Early drinkers have been found to have higher risk of developing alcohol use disorder; however, the association of early drinking with progression to problematic alcohol involvement that does not meet disorder criteria (i.e., subclinical problems) or to severe stages of alcohol involvement, sex-specific associations, and relationship of early drinking with alcohol recovery have rarely been investigated. Methods: Using data from Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), we applied latent transition analyses to investigate the impact of weekly drinking before age 18 on alcohol progression and recovery operationalized as three classes of alcohol involvement using abuse and dependence indicators. We analyzed data separately for male (n = 12,276) and female (n = 14,750) drinkers and applied propensity score methods to address confounding. Results: We observed significant associations between early, weekly drinking and alcohol involvement class membership at Wave 1 for both males and females. For males, early, weekly drinking was also associated with greater odds of transitioning from moderate to severe alcohol problems (aOR = 3.19, 95% CI = 1.72, 5.35). For females, early, weekly drinking predicted the transition from no to severe problems (aOR = 2.98, 95% CI = 1.11-8.00). Contrary to our hypothesis, early, weekly drinking was associated with greater likelihood of transition from severe to no problems for males (aOR = 3.23, 95% CI = 1.26, 8.26). Discussion: Frequent, early drinking seems to be an important indicator of drinking progression with differential associations by sex. This information is useful to identify those at greater risk of progressing to severe drinking problems to intervene appropriately.
Language	English
Publishing date	2022-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831558-3
ISSN	2352-8532 ; 2352-8532
ISSN (online)	2352-8532
ISSN	2352-8532
DOI	10.1016/j.abrep.2022.100410
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Article ; Online: Pharmacokinetics of Voxelotor in Patients With Renal and Hepatic Impairment.

Preston, Richard A / Marbury, Thomas / Balaratnam, Ganesh / Green, Michelle / Dixon, Sandy / Lehrer-Graiwer, Josh / Washington, Carla

Journal of clinical pharmacology

2020 Volume 61, Issue 4, Page(s) 493–505

Abstract: Two open-label studies assessed the safety, tolerability, and pharmacokinetics of Oxbryta (voxelotor) in subjects with hepatic or renal impairment. Eight subjects with severe renal impairment (estimated glomerular filtration rate <30 mL/min/1.73 ... ...

Abstract	Two open-label studies assessed the safety, tolerability, and pharmacokinetics of Oxbryta (voxelotor) in subjects with hepatic or renal impairment. Eight subjects with severe renal impairment (estimated glomerular filtration rate <30 mL/min/1.73 m
MeSH term(s)	Adult ; Aged ; Area Under Curve ; Benzaldehydes/pharmacokinetics ; Body Mass Index ; Dose-Response Relationship, Drug ; Female ; Glomerular Filtration Rate ; Half-Life ; Hematologic Agents/pharmacokinetics ; Hepatic Insufficiency/metabolism ; Humans ; Male ; Middle Aged ; Pyrazines/pharmacokinetics ; Pyrazoles/pharmacokinetics ; Renal Insufficiency/metabolism
Chemical Substances	Benzaldehydes ; Hematologic Agents ; Pyrazines ; Pyrazoles ; voxelotor (3ZO554A4Q8)
Language	English
Publishing date	2020-10-20
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1757
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Article ; Online: Developing public health tools for combating the opioid epidemic.

Green, Carla A / Hazlehurst, Brian

Pharmacoepidemiology and drug safety

2019 Volume 28, Issue 8, Page(s) 1125–1126

MeSH term(s)	Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Humans ; Opioid Epidemic/prevention & control ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/prevention & control ; Public Health
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2019-08-02
Publishing country	England
Document type	Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.4871
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Article ; Online: Synbiotics and Surgery: Can Prebiotics and Probiotics Affect Inflammatory Surgical Outcomes?

Trone, Kristin / Rahman, Shahrose / Green, Caitlin Homberger / Venegas, Carla / Martindale, Robert / Stroud, Andrea

Current nutrition reports

2023 Volume 12, Issue 2, Page(s) 238–246

Abstract: Purpose of review: Prebiotics, probiotics, and synbiotics have received increasing attention over the years for their beneficial impact on the gut microbiome and for their systemic anti-inflammatory effects. They have also been shown to improve surgical ...

Abstract	Purpose of review: Prebiotics, probiotics, and synbiotics have received increasing attention over the years for their beneficial impact on the gut microbiome and for their systemic anti-inflammatory effects. They have also been shown to improve surgical outcomes. Here, we review the inflammatory effects of surgery as well as the data which suggests a benefit of prebiotics, probiotics, and synbiotics taken in the perioperative period. Recent findings: Synbiotics and fermented foods may have an even greater anti-inflammatory effect than probiotics or prebiotics alone. Recent data suggest that the anti-inflammatory effects and microbiome changes brought on by prebiotics, probiotics, and synbiotics have the potential to improve surgical outcomes. We highlight the potential to alter systemic inflammation, surgical and hospital-acquired infections, colorectal cancer formation, recurrence, and anastomotic leak. Synbiotics could also impact metabolic syndrome. Prebiotics, probiotics, and especially synbiotics may be extremely beneficial when taken in the perioperative period. Even short-term gut microbiome pre-habilitation could alter surgical outcomes significantly.
MeSH term(s)	Humans ; Prebiotics ; Synbiotics ; Probiotics/pharmacology ; Treatment Outcome ; Anti-Inflammatory Agents
Chemical Substances	Prebiotics ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2161-3311
ISSN (online)	2161-3311
DOI	10.1007/s13668-023-00464-1
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Article ; Online: The Effects of Marijuana Use on Transitions through Stages of Alcohol Involvement for Men and Women in the NESARC I and II.

Green, Kerry M / Reboussin, Beth A / Pacek, Lauren R / Storr, Carla L / Mojtabai, Ramin / Cullen, Bernadette A / Crum, Rosa M

Substance use & misuse

2019 Volume 54, Issue 13, Page(s) 2167–2176

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/psychology ; Alcoholism/psychology ; Disease Progression ; Female ; Humans ; Male ; Marijuana Use/psychology ; Middle Aged ; Risk Factors ; Young Adult
Language	English
Publishing date	2019-07-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2019.1638408
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Article ; Online: Patient perspectives on how living with a mental illness affects making and maintaining healthy lifestyle changes.

Yarborough, Bobbi Jo H / Stumbo, Scott P / Cavese, Julie A / Yarborough, Micah T / Green, Carla A

Patient education and counseling

2018 Volume 102, Issue 2, Page(s) 346–351

Abstract: Objective: To understand the ways that mental health symptoms interfere with achieving health goals.: Methods: Individuals with mental illness diagnoses and varying levels of preventive service use were recruited from federally qualified health ... ...

Abstract	Objective: To understand the ways that mental health symptoms interfere with achieving health goals. Methods: Individuals with mental illness diagnoses and varying levels of preventive service use were recruited from federally qualified health centers and an integrated health care delivery system and interviewed. Thematic analysis was used to characterize descriptions of how mental illness experiences influenced lifestyle change efforts. Results: Three themes described patients' (n = 163) perspectives on barriers to making healthy lifestyle changes: 1) Thinking about making lifestyle changes is overwhelming for individuals already managing the burdens of mental illnesses; 2) Depression makes it difficult to care about a healthy future; and 3) When mental illness symptoms are not adequately treated unhealthy behaviors that provide relief are unlikely to be discontinued. Participants also made suggestions for improving health care delivery to facilitate positive behavior change. Conclusion: Patients with mental illnesses need their clinicians to be empathic, help them envision a healthier future, address unmet mental health needs, and provide resources. Practice implications: Primary care clinicians should encourage their patients with mental illnesses to make healthy lifestyle changes within the context of a supportive relationship. Lifestyle change can be overwhelming; clinicians should acknowledge progress and provide ongoing tangible support.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Depression/psychology ; Female ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Healthy Lifestyle ; Humans ; Interviews as Topic ; Male ; Mental Disorders/diagnosis ; Mental Disorders/psychology ; Mentally Ill Persons/psychology ; Middle Aged ; Obesity ; Qualitative Research
Language	English
Publishing date	2018-09-01
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605590-4
ISSN	1873-5134 ; 0738-3991
ISSN (online)	1873-5134
ISSN	0738-3991
DOI	10.1016/j.pec.2018.08.036
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Article ; Online: Stressful life events and transitions in problematic alcohol use involvement among US adults.

Storr, Carla L / Reboussin, Beth A / Green, Kerry M / Mojtabai, Ramin / Susukida, Ryoko / Young, Andrea S / Cullen, Bernadette A / Alvanzo, Anika A H / Crum, Rosa M

Substance use & misuse

2021 Volume 56, Issue 14, Page(s) 2171–2180

Abstract: Objective: We investigated the impact of stressful life events (SLEs) for males and females on transitions in problematic alcohol involvement, both progression and recovery, over a 3-year interval.: Method: Participants of both Wave 1 (2001-2002) and ...

Abstract	Objective: We investigated the impact of stressful life events (SLEs) for males and females on transitions in problematic alcohol involvement, both progression and recovery, over a 3-year interval. Method: Participants of both Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were stratified by sex (14,233 males and 19,550 females). Latent transition analysis estimated the impact of experiencing ≥3 SLE in the year preceding the Wave 1 interview on the probability of transitioning between three empirically-derived stages of alcohol involvement (patterns of alcohol use disorder [AUD] symptoms), across waves. Propensity score methods adjusted for confounding. Results: For males, three or more SLEs were associated with progression from the moderate to the severe problem stage (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.17, 4.26). Among those in the severe problem stage, SLEs negatively impacted recovery regardless of sex. Employment/Financial SLEs were associated with a higher odds of transition from the moderate to the no problem stage (OR = 1.60, 95% CI = 1.03, 2.46) and lower odds of transitions from the severe to the moderate problem stage (OR = 0.40, 95% CI = 0.16, 0.99) among males, and from the severe to the no problem stage (OR = 0.26, 95% CI = 0.07, 0.88) among females. Conclusion: Stressful life events appear to affect transitions in alcohol involvement over time among those who already have alcohol problems, rather than impacting a transition among those without AUD problems.
MeSH term(s)	Adult ; Alcohol Drinking/epidemiology ; Alcohol-Related Disorders/epidemiology ; Alcoholism/epidemiology ; Female ; Humans ; Life Change Events ; Male ; Odds Ratio
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2021.1975748
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Article ; Online: The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics.

Wickramaratne, Anushka C / Li, Li / Hopkins, Jesse B / Joachimiak, Lukasz A / Green, Carla B

Biochemistry

2022

Abstract: Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin ( ...

Abstract	Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin (
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.2c00072
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Article ; Online: Buprenorphine use and setting type among reproductive-aged women self-reporting nonmedical prescription opioid use.

DeSisto, Carla L / Terplan, Mishka / Kacha-Ochana, Akadia / Green, Jody L / Mueller, Trisha / Cox, Shanna / Ko, Jean Y

Journal of substance use and addiction treatment

2023 Volume 155, Page(s) 209083

Abstract: Introduction: Screening for opioid misuse and treatment for opioid use disorder are critical for reducing morbidity and mortality. We sought to understand the extent of self-reported past 30-day buprenorphine use in various settings among women of ... ...

Abstract	Introduction: Screening for opioid misuse and treatment for opioid use disorder are critical for reducing morbidity and mortality. We sought to understand the extent of self-reported past 30-day buprenorphine use in various settings among women of reproductive age with self-reported nonmedical prescription opioid use being assessed for substance use problems. Methods: The study collected data from individuals being assessed for substance use problems using the Addiction Severity Index-Multimedia Version in 2018-2020. We stratified the sample of 10,196 women ages 12-55 self-reporting past 30-day nonmedical prescription opioid use by buprenorphine use and setting type. We categorized setting types as: buprenorphine in specialty addiction treatment, buprenorphine in office-based opioid treatment, and diverted buprenorphine. We included each woman's first intake assessment during the study period. The study assessed number of buprenorphine products, reasons for using buprenorphine, and sources of buprenorphine procurement. The study calculated frequency of reasons for using buprenorphine to treat opioid use disorder outside of a doctor-managed treatment, overall and by race/ethnicity. Results: Overall, 25.5 % of the sample used buprenorphine in specialty addiction treatment, 6.1 % used buprenorphine prescribed in office-based treatment, 21.7 % used diverted buprenorphine, and 46.7 % reported no buprenorphine use during the past 30 days. Among women who reported using buprenorphine to treat opioid use disorder, but not as part of a doctor-managed treatment, 72.3 % could not find a provider or get into a treatment program, 21.8 % did not want to be part of a program or see a provider, and 6.0 % reported both; a higher proportion of American Indian/Alaska Native women (92.1 %) reported that they could not find a provider or get into a treatment program versus non-Hispanic White (78.0 %), non-Hispanic Black (76.0 %), and Hispanic (75.0 %) women. Conclusions: Appropriate screening for nonmedical prescription opioid use to assess need for treatment with medication for opioid use disorder is important for all women of reproductive age. Our data highlight opportunities to improve treatment program accessibility and availability and support the need to increase equitable access for all women.
MeSH term(s)	Humans ; Female ; Adult ; Male ; Buprenorphine/therapeutic use ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Reproduction ; Prescriptions
Chemical Substances	Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2023.209083
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