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  1. Article ; Online: Increased solar-driven chemical transformations through surface-induced benzoperylene aggregation in dye-sensitized photoanodes.

    Bruggeman, Didjay F / Detz, Remko J / Mathew, Simon / Reek, Joost N H

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  Volume 23, Issue 3, Page(s) 503–516

    Abstract: The impact of benzo[ghi]perylenetriimide (BPTI) dye aggregation on the performance of photoelectrochemical devices was explored, through imide-substitution with either alkyl (BPTI-A, 2-ethylpropyl) or bulky aryl (BPTI-B, 2,6-diisopropylphenyl) moieties, ... ...

    Abstract The impact of benzo[ghi]perylenetriimide (BPTI) dye aggregation on the performance of photoelectrochemical devices was explored, through imide-substitution with either alkyl (BPTI-A, 2-ethylpropyl) or bulky aryl (BPTI-B, 2,6-diisopropylphenyl) moieties, to, respectively, enable or suppress aggregation. While both dyes demonstrated similar monomeric optoelectronic properties in solution, adsorption onto mesoporous SnO
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00534-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Escherichia coli robustly expresses ATP synthase at growth rate-maximizing concentrations.

    Rabbers, Iraes / Bruggeman, Frank J

    The FEBS journal

    2022  Volume 289, Issue 16, Page(s) 4925–4934

    Abstract: ... for future conditions. To address this question, we focus on the ATP-producing enzyme F ...

    Abstract Fitness-enhancing adaptations of protein expression and its regulation are an important aspect of bacterial evolution. A key question is whether evolution has led to optimal protein expression that maximizes immediate growth rate (short-term fitness) in a robust manner (consistently across diverse conditions). Alternatively, they could display suboptimal short-term fitness, because they cannot do better or because they instead strive for long-term fitness maximization by, for instance, preparing for future conditions. To address this question, we focus on the ATP-producing enzyme F
    MeSH term(s) Adenosine Triphosphate/metabolism ; Bacteria/metabolism ; Escherichia coli ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Proton-Translocating ATPases (EC 3.6.3.14)
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Population niche width is driven by within-individual niche expansion and individual specialization in introduced brook trout in mountain lakes.

    Baker, H K / Bruggeman, C E F / Shurin, J B

    Oecologia

    2022  Volume 200, Issue 1-2, Page(s) 1–10

    Abstract: The width of a population's resource-use niche is determined by individual diet breadth ("within-individual component") and the degree of niche partitioning between individuals ("between-individual component"). The balance between these two factors ... ...

    Abstract The width of a population's resource-use niche is determined by individual diet breadth ("within-individual component") and the degree of niche partitioning between individuals ("between-individual component"). The balance between these two factors affects ecological stability and evolutionary trajectories, and may shift as ecological opportunity permits broader population niches. Lakes in California's Sierra Nevada Mountains vary in resource diversity for introduced brook trout (Salvelinus fontinalis) due to elevation, lake morphometry, and watershed features. We compared the relative contributions of within- and between-individual niche components to two measures of the dietary niches of thirteen populations of brook trout: prey taxonomic composition and prey size distribution. For both taxonomic and size diversity of fish diets, population niche width was positively related to both the within- and between-individual components. For taxonomic diversity, the two components increased in parallel, while for size diversity, the between-individual component became more important relative to the within-individual component in populations with the greatest niche widths. Our results support the Niche Variation Hypothesis that populations with broader niches are more heterogeneous among individuals and show that individual niche width and individual specialization can operate in parallel to expand the population niche.
    MeSH term(s) Animals ; Biological Evolution ; Diet ; Lakes ; Trout
    Language English
    Publishing date 2022-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123369-5
    ISSN 1432-1939 ; 0029-8549
    ISSN (online) 1432-1939
    ISSN 0029-8549
    DOI 10.1007/s00442-022-05201-z
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    In stock of ZB MED Bonn / Germany

    Z 70/109: Show issues

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  4. Book ; Online: Chapter Strengths and Weaknesses for Climate Change: Adaptation in Water Governance: A Comparison Across Six European Regions

    Bergsma, Emmy / Alphen, H. Van / Bruggeman, A. / Giannakis, E. / Koti, J. / Kristvik, E. / Loza, P. / Martinez, M. / Muthanna, T.M. / Rocha, F. / Viseu, T. / Zoumides, C.

    2018  

    Keywords Limnology (freshwater) ; water governance, climate change, regional impacts, adaptation
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021051277
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Blue Circle Health: A Novel Patient-Centered Model of Health Care Delivery for Low-Income Patients With Type 1 Diabetes.

    Bruggeman, Brittany S / Walker, Ashby F / Peters, Anne L / D'Avolio, Leonard W / Haller, Michael J

    Journal of diabetes science and technology

    2023  Volume 17, Issue 4, Page(s) 925–934

    Abstract: Analog insulins, insulin pumps, and continuous glucose monitors (CGM) have revolutionized type 1 diabetes (T1D) treatment over the last 50 years. Nevertheless, less than 20% of patients in the United States reach guideline-based HbA1c targets. The ... ...

    Abstract Analog insulins, insulin pumps, and continuous glucose monitors (CGM) have revolutionized type 1 diabetes (T1D) treatment over the last 50 years. Nevertheless, less than 20% of patients in the United States reach guideline-based HbA1c targets. The dysfunctional delivery of U.S. health care has further worsened glycemic outcomes among structurally disadvantaged groups such as non-Hispanic Black and low-income populations. Administrative complexities resulting from mixed insurance coverage and delivery systems, incongruity between effective policies and reimbursement, structural racism, and implicit biases have led to high diabetes care-related costs, provider scarcity and burnout, and patient diabetes distress. The Extension for Community Healthcare Outcomes (ECHO) Diabetes tele-education outreach model was created to increase self-efficacy among primary care providers through a combination of weekly didactic sessions led by a team of diabetes experts and access to community-based peer coaches. As an evolution of ECHO Diabetes, Blue Circle Health has been established as a philanthropically funded health care delivery system, using a whole-person, individualized approach to T1D care for adults living in underserved communities. The program will provide direct-to-patient telehealth services, including diabetes education, management, and related psychological care regardless of ability to pay. Community-based diabetes support coaches will serve as the primary point of contact, or guide on the "Blue Circle Health Member Journey." Access to needed insulins, supplies, and CGMs will be provided at no cost to the individual. Through a continuous learning and improvement model, a person-centered, equitable, accessible, and effective health care delivery model will be built for people living with T1D.
    MeSH term(s) Adult ; Humans ; United States ; Diabetes Mellitus, Type 1/therapy ; Blood Glucose ; Poverty ; Insulin/therapeutic use ; Delivery of Health Care ; Patient-Centered Care
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/19322968221149008
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  6. Article ; Online: Comparison of homogeneous and heterogeneous catalysts in dye-sensitised photoelectrochemical cells for alcohol oxidation coupled to dihydrogen formation.

    Bruggeman, D F / Mathew, S / Detz, R J / Reek, J N H

    Sustainable energy & fuels

    2021  Volume 5, Issue 22, Page(s) 5707–5716

    Abstract: This study examines two strategies-homo- and heterogeneous approaches for the light-driven oxidation of benzyl alcohol in dye-sensitised photoelectrochemical cells (DSPECs). The DSPEC consists of a mesoporous anatase ... ...

    Abstract This study examines two strategies-homo- and heterogeneous approaches for the light-driven oxidation of benzyl alcohol in dye-sensitised photoelectrochemical cells (DSPECs). The DSPEC consists of a mesoporous anatase TiO
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 2398-4902
    ISSN (online) 2398-4902
    DOI 10.1039/d1se01275d
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  7. Article ; Online: Aqueous Biphasic Dye-Sensitized Photosynthesis Cells for TEMPO-Based Oxidation of Glycerol.

    Bruggeman, Didjay F / Laporte, Annechien A H / Detz, Remko J / Mathew, Simon / Reek, Joost N H

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 21, Page(s) e202200175

    Abstract: This work reports an aqueous dye-sensitized photoelectrochemical cell (DSPEC) capable of oxidizing glycerol (an archetypical biobased compound) coupled with ... ...

    Abstract This work reports an aqueous dye-sensitized photoelectrochemical cell (DSPEC) capable of oxidizing glycerol (an archetypical biobased compound) coupled with H
    MeSH term(s) Acetonitriles ; Coloring Agents/chemistry ; Cyclic N-Oxides ; Glycerol ; Oxidation-Reduction ; Photosynthesis ; Solar Energy ; Water/chemistry
    Chemical Substances Acetonitriles ; Coloring Agents ; Cyclic N-Oxides ; Water (059QF0KO0R) ; Glycerol (PDC6A3C0OX) ; TEMPO (VQN7359ICQ)
    Language English
    Publishing date 2022-03-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202200175
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  8. Article ; Online: Thyroid Storm Caused by Hyperemesis Gravidarum.

    Zimmerman, Chelsea F / Ilstad-Minnihan, Alexandra B / Bruggeman, Brittany S / Bruggeman, Bradley J / Dayton, Kristin J / Joseph, Nancy / Moas, Daniel I / Rohrs, Henry J

    AACE clinical case reports

    2022  Volume 8, Issue 3, Page(s) 124–127

    Abstract: Background: Transient thyrotoxicosis has been documented in the setting of hyperemesis gravidarum (HG) with elevated human chorionic gonadotropin (hCG) levels. Thyroid storm in pregnancy is rarer and typically associated with autoimmune hyperthyroidism. ...

    Abstract Background: Transient thyrotoxicosis has been documented in the setting of hyperemesis gravidarum (HG) with elevated human chorionic gonadotropin (hCG) levels. Thyroid storm in pregnancy is rarer and typically associated with autoimmune hyperthyroidism. We described thyroid storm in a primigravid 18-year-old patient due to hCG level elevation secondary to HG, which resolved in the second trimester of pregnancy.
    Case report: Our patient presented with vomiting, hyperthyroidism, and cardiac and renal dysfunction at 16 weeks' gestation. She was clinically found to have a thyroid storm, with undetectable thyroid-stimulating hormone (TSH) and a free thyroxine level of >6.99 ng/dL. The hCG level was elevated at 246 030 mIU/L (9040-56 451 mIU/L). She was treated with methimazole, saturated solution potassium iodide, and propranolol. Because thyroid autoantibodies were absent, thyroid ultrasound yielded normal results, and thyroid function testing results rapidly improved as the hCG level decreased, the medications were tapered and ultimately discontinued by day 10 of hospitalization. The thyroid function remained normal after discharge.
    Discussion: Because hCG and TSH have identical alfa subunits and similar beta subunits, hCG can bind to the TSH receptor and stimulate thyroxine production. The hCG level peaks at around 8-14 weeks of gestation, correlating with decreased TSH levels in this same time frame. This case emphasizes the relevant physiology and importance of timely and thorough evaluation to determine the appropriate management, prognosis, and follow-up for patients with thyroid storm in the setting of HG.
    Conclusion: Although transient thyrotoxicosis is documented in patients with HG, thyroid storm is rare, and our case illustrates a severe example of these comorbidities.
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.1016/j.aace.2021.12.005
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  9. Article ; Online: Quantification of the NA dependent change of shape in the image formation of a z-polarized fluorescent molecule using vectorial diffraction simulations.

    Ströhl, Florian / Bruggeman, Ezra / Rowlands, Christopher J / Wolfson, Deanna L / Ahluwalia, Balpreet S

    Microscopy research and technique

    2022  Volume 85, Issue 5, Page(s) 2016–2022

    Abstract: The point spread function of a fixed fluorophore with its dipole axis colinear to the optical axis appears donut-shaped when seen through a microscope, and its light distribution in the pupil plane is radially polarized. Yet other techniques, such as ... ...

    Abstract The point spread function of a fixed fluorophore with its dipole axis colinear to the optical axis appears donut-shaped when seen through a microscope, and its light distribution in the pupil plane is radially polarized. Yet other techniques, such as photolithography, report that this same light distribution in the pupil plane appears as a solid spot. How can this same distribution lead to a spot in one case but a donut in the other? Here, we show how the tube lens of the system plays a critical role in determining this shape. Using a vectorial treatment of image formation, we simulate the relative contributions of both longitudinal and radial components to the image of a dipole emitter and thus show how the donut (typically reported for z-polarized single molecule fluorescence microscopy) transforms into a solid spot (as commonly reported for photolithography) as the numerical aperture of the tube lens increases. We find that the transition point occurs around 0.7 NA, which is significantly higher than used for most microscopy systems and lower than for common photolithography systems, thus resolving the seeming paradox of dipole shape.
    MeSH term(s) Algorithms ; Lenses ; Microscopy/methods
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24060
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: High-density volumetric super-resolution microscopy.

    Daly, Sam / Ferreira Fernandes, João / Bruggeman, Ezra / Handa, Anoushka / Peters, Ruby / Benaissa, Sarah / Zhang, Boya / Beckwith, Joseph S / Sanders, Edward W / Sims, Ruth R / Klenerman, David / Davis, Simon J / O'Holleran, Kevin / Lee, Steven F

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1940

    Abstract: Volumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and complex PSF spatial ...

    Abstract Volumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and complex PSF spatial footprints reduce biological throughput and applicability by requiring lower labeling densities to avoid overlapping fluorescent signals. We quantitatively compare the density dependence of single-molecule light field microscopy (SMLFM) to other 3D PSFs (astigmatism, double helix and tetrapod) showing that SMLFM enables an order-of-magnitude speed improvement compared to the double helix PSF by resolving overlapping emitters through parallax. We demonstrate this optical robustness experimentally with high accuracy ( > 99.2 ± 0.1%, 0.1 locs μm
    MeSH term(s) Microscopy/methods ; Imaging, Three-Dimensional/methods ; Single Molecule Imaging/methods ; Nanotechnology
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45828-5
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