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Article ; Online: Primary percutaneous closure of a traumatic ventricular septal defect after stab wound to the chest: a case report.

Solórzano Vázquez, Marco Alejandro / Medina Torres, Oscar Samuel / Tiscareño Villanueva, Ashby Daniel / Villar Valencia, Cristian Adrián

European heart journal. Case reports

2023 Volume 7, Issue 7, Page(s) ytad314

Abstract: Background: Traumatic ventricular septal defects (VSDs) are life-threatening complications of blunt or stab chest trauma. The standard of care is surgical closure or secondary percutaneous closure due to high surgical risk because of recent sternotomy.!# ...

Abstract	Background: Traumatic ventricular septal defects (VSDs) are life-threatening complications of blunt or stab chest trauma. The standard of care is surgical closure or secondary percutaneous closure due to high surgical risk because of recent sternotomy. Case summary: We present a 22-year-old male with an ice pick-related VSD. It was successfully closed by primary percutaneous approach. After 6 months, the echo Doppler shows no residual shunt, normal pulmonary artery pressure, and normal biventricular function. Discussion: To our knowledge, this is one of the first primary percutaneous closures for knife-related VSD. Early diagnosis and treatment can prevent heart failure and long-term complications. Less necrotic tissue surrounding the VSD compared with post-infarction (PI) VSD allows for early and secure treatment. Percutaneous closure is a feasible and effective choice even in patients who had no prior sternotomy or who reject surgery as a primary treatment strategy.
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad314
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Article ; Online: "When I was Younger, My Story Belonged to Everyone Else": Co-production of Resources for Adults Living with Craniosynostosis.

Stock, Nicola M / Costa, Bruna / Bannister, William / Ashby, Charlotte / Matthews, Nammie / Hebden, Louise / Melles, Laura / Hilton-Webb, Zoe / Smith, Sally / Kane, Kristian / Carter, Lewis / Kearney, Anna / Piggott, Katie / Russell, Charlotte / Wilkinson-Bell, Karen

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2024 , Page(s) 10556656241236580

Abstract: Objective: Despite growing recognition that congenital craniofacial conditions have lifelong implications, psychological support for adults is currently lacking. The aim of this project was to produce a series of short films about living with ... ...

Abstract	Objective: Despite growing recognition that congenital craniofacial conditions have lifelong implications, psychological support for adults is currently lacking. The aim of this project was to produce a series of short films about living with craniosynostosis in adulthood, alongside a psychoeducational booklet. Design: The resources were developed using multiple focus groups and meetings attended by researchers, patient representatives, a leading charitable organisation, an award-winning film production company, clinicians, and other experts in the field. Results: An online mixed-methods survey was developed based on prior work to request feedback on the acceptability and utility of the resources from the craniosynostosis community. While data collection to evaluate the resources is ongoing, preliminary results ( Conclusions: The resources developed represent a step forward in addressing the unmet information and support needs of adults with craniosynostosis and highlight the benefits of co-production in research.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656241236580
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Article ; Online: Health care's response to climate change: a carbon footprint assessment of the NHS in England.

Tennison, Imogen / Roschnik, Sonia / Ashby, Ben / Boyd, Richard / Hamilton, Ian / Oreszczyn, Tadj / Owen, Anne / Romanello, Marina / Ruyssevelt, Paul / Sherman, Jodi D / Smith, Andrew Z P / Steele, Kristian / Watts, Nicholas / Eckelman, Matthew J

The Lancet. Planetary health

2021 Volume 5, Issue 2, Page(s) e84–e92

Abstract: Background: Climate change threatens to undermine the past 50 years of gains in public health. In response, the National Health Service (NHS) in England has been working since 2008 to quantify and reduce its carbon footprint. This Article presents the ... ...

Abstract	Background: Climate change threatens to undermine the past 50 years of gains in public health. In response, the National Health Service (NHS) in England has been working since 2008 to quantify and reduce its carbon footprint. This Article presents the latest update to its greenhouse gas accounting, identifying interventions for mitigation efforts and describing an approach applicable to other health systems across the world. Methods: A hybrid model was used to quantify emissions within Scopes 1, 2, and 3 of the Greenhouse Gas Protocol, as well as patient and visitor travel emissions, from 1990 to 2019. This approach complements the broad coverage of top-down economic modelling with the high accuracy of bottom-up data wherever available. Available data were backcasted or forecasted to cover all years. To enable the identification of measures to reduce carbon emissions, results were disaggregated by organisation type. Findings: In 2019, the health service's emissions totalled 25 megatonnes of carbon dioxide equivalent, a reduction of 26% since 1990, and a decrease of 64% in the emissions per inpatient finished admission episode. Of the 2019 footprint, 62% came from the supply chain, 24% from the direct delivery of care, 10% from staff commute and patient and visitor travel, and 4% from private health and care services commissioned by the NHS. Interpretation: This work represents the longest and most comprehensive accounting of national health-care emissions globally, and underscores the importance of incorporating bottom-up data to improve the accuracy of top-down modelling and enabling detailed monitoring of progress as health systems act to reduce emissions. Funding: Wellcome Trust.
MeSH term(s)	Carbon Dioxide/analysis ; Carbon Footprint/statistics & numerical data ; Climate Change ; Delivery of Health Care ; England ; Greenhouse Gases/analysis ; Health Care Sector ; Humans ; State Medicine/statistics & numerical data ; Transportation
Chemical Substances	Greenhouse Gases ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-02-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2542-5196
ISSN (online)	2542-5196
DOI	10.1016/S2542-5196(20)30271-0
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Article: The Problem of “Us” Versus “Them” and AIDS Stigma

DEVINE, PATRICIA G / HARRISON, KRISTEN / PLANT, E. ASHBY

American behavioral scientist. 1999 Apr., v. 42, no. 7

1999

Abstract: This article has two goals. The first is to consider what the social-psychological literature on social identity, ingroup-outgroup perception, and prejudice contributes to the understanding of AIDS-related stigma. The second is to address ways to make ... ...

Abstract	This article has two goals. The first is to consider what the social-psychological literature on social identity, ingroup-outgroup perception, and prejudice contributes to the understanding of AIDS-related stigma. The second is to address ways to make the world more comfortable and compassionate for people with AIDS (PWAs). At the core of AIDS-related stigma is the perception that PWAs are members of an outgroup threatening one's social identity as a member of the nondeviant ingroup. A variety of psychological principles operate to heighten this perception and to make the boundaries between “us” and “them” seemingly impenetrable. Furthermore, reactions to PWAs are strongly affective and often involve multiple and conflicting emotional experiences. Models that consider the multifaceted, symbolic aspects of AIDS-related stigma may inform strategies for reducing the stigma. However, because many people may be resistant to direct attitude change tactics, the authors suggest an additional strategy that seeks to change attitudes indirectly by first changing behaviors.
Keywords	attitudes and opinions ; models ; people ; social identification
Language	English
Dates of publication	1999-04
Size	p. 1212-1228.
Publishing place	Sage Publications, Inc.
Document type	Article
ZDB-ID	206867-9
ISSN	0002-7642
ISSN	0002-7642
DOI	10.1177/00027649921954732
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Promising Success of Project Extension for Community Healthcare Outcomes (ECHO) Diabetes: Case Series.

Figg, Lauren / Addala, Ananta / Jain, Ishaan / Anez, Claudia / Midney, Paul / DeChirico, Corin / Symanski, Colleen / Fitzgerald, Brian C / Colbert, Kristi / Raymer, Terry / Stockton-Joreteg, Candy / Murphy, Elizabeth / Collins, Leah / Bernstein, Cyd / Hechavarria, Melanie / Sheehan, Eleni P / Bernier, Angelina / Westen, Sarah C / Hood, Korey K /

Zaharieva, Dessi P / Basina, Marina / Cuttriss, Nicolas / Filipp, Stephanie L / Gurka, Matthew J / Walker, Ashby F / Maahs, David M / Haller, Michael J / Lal, Rayhan A

JMIR diabetes

2023 Volume 8, Page(s) e46050

Abstract: Background: In the United States, there are over 37 million people with diabetes but only 8000 endocrinologists. Therefore, many people with diabetes receive care exclusively from primary care providers (PCPs). To democratize knowledge regarding insulin- ...

Abstract	Background: In the United States, there are over 37 million people with diabetes but only 8000 endocrinologists. Therefore, many people with diabetes receive care exclusively from primary care providers (PCPs). To democratize knowledge regarding insulin-requiring diabetes through tele-education, Stanford University and the University of Florida developed Project Extension for Community Healthcare Outcomes (ECHO) Diabetes. Objective: ECHO Diabetes uses a Hub and Spoke model connecting specialists (the "Hub") with PCPs (the "Spokes"). One-hour, weekly sessions include Hub diabetes didactic presentations and Spoke deidentified case presentations. Lessons learned during these sessions target provider knowledge and confidence surrounding diabetes management and patient care. Methods: Spokes were asked to provide short descriptions of people with diabetes whose diabetes management improved directly or indirectly from their providers' participation or their involvement with a Diabetes Support Coach (DSC). We provide a case series to describe individuals and outcomes. Because this study was not a randomized controlled trial and was a prospective observation of patients with the intervention delivered to providers, the trial is not registered in a public trials registry. Results: A case series of 11 people with diabetes was compiled from 10 PCPs and 1 DSC from California and Florida between 2021 and 2022. The principal impact of ECHO Diabetes is the education amplified from PCPs and DSCs to people with diabetes. In all cases, people with diabetes reported increased engagement and improved diabetes management. Several cases reflected increased access to diabetes technology, improvement in glycemic outcomes, and positive trends in mental health measures. Conclusions: This case series elucidates the potential value of the ECHO Diabetes program to people with diabetes who receive their diabetes care from PCPs. Those matched with a DSC saw clinically significant improvements in hemoglobin A
Language	English
Publishing date	2023-08-03
Publishing country	Canada
Document type	Journal Article
ISSN	2371-4379
ISSN (online)	2371-4379
DOI	10.2196/46050
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Article ; Online: Health care's response to climate change

Imogen Tennison, MEng / Sonia Roschnik, MSc / Ben Ashby, MEng / Richard Boyd, MEng / Ian Hamilton, PhD / Tadj Oreszczyn, ProfPhD / Anne Owen, PhD / Marina Romanello, PhD / Paul Ruyssevelt, ProfPhD / Jodi D Sherman, MD / Andrew Z P Smith, MSc / Kristian Steele, EngD / Nicholas Watts, MBBS / Matthew J Eckelman, PhD

The Lancet Planetary Health, Vol 5, Iss 2, Pp e84-e

a carbon footprint assessment of the NHS in England

2021 Volume 92

Abstract: Summary: Background: Climate change threatens to undermine the past 50 years of gains in public health. In response, the National Health Service (NHS) in England has been working since 2008 to quantify and reduce its carbon footprint. This Article ... ...

Abstract	Summary: Background: Climate change threatens to undermine the past 50 years of gains in public health. In response, the National Health Service (NHS) in England has been working since 2008 to quantify and reduce its carbon footprint. This Article presents the latest update to its greenhouse gas accounting, identifying interventions for mitigation efforts and describing an approach applicable to other health systems across the world. Methods: A hybrid model was used to quantify emissions within Scopes 1, 2, and 3 of the Greenhouse Gas Protocol, as well as patient and visitor travel emissions, from 1990 to 2019. This approach complements the broad coverage of top-down economic modelling with the high accuracy of bottom-up data wherever available. Available data were backcasted or forecasted to cover all years. To enable the identification of measures to reduce carbon emissions, results were disaggregated by organisation type. Findings: In 2019, the health service's emissions totalled 25 megatonnes of carbon dioxide equivalent, a reduction of 26% since 1990, and a decrease of 64% in the emissions per inpatient finished admission episode. Of the 2019 footprint, 62% came from the supply chain, 24% from the direct delivery of care, 10% from staff commute and patient and visitor travel, and 4% from private health and care services commissioned by the NHS. Interpretation: This work represents the longest and most comprehensive accounting of national health-care emissions globally, and underscores the importance of incorporating bottom-up data to improve the accuracy of top-down modelling and enabling detailed monitoring of progress as health systems act to reduce emissions. Funding: Wellcome Trust.
Keywords	Environmental sciences ; GE1-350
Subject code	360
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats.

Spiller, Krista / Xi, Zheng-Xiong / Li, Xia / Ashby, Charles R / Callahan, Patrick M / Tehim, Ashok / Gardner, Eliot L

Neuropharmacology

2009 Volume 57, Issue 1, Page(s) 60–66

Abstract: Varenicline, a partial alpha4beta2 and full alpha7 nicotinic receptor agonist, has been shown to inhibit nicotine self-administration and nicotine-induced increases in extracellular dopamine in the nucleus accumbens. In the present study, we investigated ...

Abstract	Varenicline, a partial alpha4beta2 and full alpha7 nicotinic receptor agonist, has been shown to inhibit nicotine self-administration and nicotine-induced increases in extracellular dopamine in the nucleus accumbens. In the present study, we investigated whether varenicline inhibits nicotine-enhanced electrical brain-stimulation reward (BSR), and if so, which receptor subtypes are involved. Systemic administration of nicotine (0.25-1.0 mg/kg, i.p.) or varenicline (0.03-3 mg/kg, i.p.) produced biphasic effects, with low doses producing enhancement (e.g., decreased BSR threshold), and high doses inhibiting BSR. Pretreatment with low dose (0.03-1.0 mg/kg) varenicline dose-dependently attenuated nicotine (0.25 or 0.5 mg/kg)-enhanced BSR. The BSR-enhancing effect produced by varenicline was blocked by mecamylamine (a high affinity nicotinic receptor antagonist) or dihydro-beta-erythroidine (a relatively selective nicotinic alpha4-containing receptor antagonist), but not methyllycaconitine (a selective alpha7 receptor antagonist), suggesting an effect mediated by activation of alpha4beta2 receptors. This suggestion is supported by findings that the alpha4beta2 receptor agonist SIB-1765F produced a dose-dependent enhancement of BSR, while pretreatment with SIB-1765F attenuated nicotine (0.5 mg/kg)-enhanced BSR. In contrast, the selective alpha7 receptor agonist ARR-17779, altered neither BSR itself nor nicotine-enhanced BSR, at any dose tested. These findings suggest that: 1) varenicline inhibits nicotine-enhanced BSR, supporting its use as a smoking cessation aid; and 2) varenicline-enhanced BSR by itself and varenicline's anti-nicotine effects are mediated by activation of alpha4beta2, but not alpha7, receptors.
MeSH term(s)	Animals ; Benzazepines/pharmacology ; Conditioning, Operant/drug effects ; Conditioning, Operant/physiology ; Dose-Response Relationship, Drug ; Drug Interactions ; Electric Stimulation/methods ; Male ; Medial Forebrain Bundle/drug effects ; Medial Forebrain Bundle/physiology ; Nicotine/pharmacology ; Nicotinic Agonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Quinoxalines/pharmacology ; Rats ; Rats, Long-Evans ; Receptors, Nicotinic/metabolism ; Reward ; Varenicline
Chemical Substances	Benzazepines ; Nicotinic Agonists ; Nicotinic Antagonists ; Quinoxalines ; Receptors, Nicotinic ; nicotinic receptor alpha4beta2 ; Nicotine (6M3C89ZY6R) ; Varenicline (W6HS99O8ZO)
Language	English
Publishing date	2009-04-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2009.04.006
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Article: The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats.

Spiller, Krista / Xi, Zheng-Xiong / Peng, Xiao-Qing / Newman, Amy H / Ashby, Charles R / Heidbreder, Christian / Gaál, József / Gardner, Eliot L

Psychopharmacology

2007 Volume 196, Issue 4, Page(s) 533–542

Abstract: Rationale: We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR).: Objective: In the present study, we investigated ... ...

Abstract	Rationale: We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR). Objective: In the present study, we investigated whether the selective D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 agonist BP-897 similarly reduce methamphetamine (METH)-enhanced BSR. Materials and methods: Rats were trained to respond for rewarding electrical self-stimulation of the medial forebrain bundle. To assess the degree of drug-induced changes in BSR, a rate-frequency curve shift paradigm was used to measure brain-reward threshold (theta 0). Results: METH (0.1-0.65 mg/kg, i.p.) dose-dependently lowered ( approximately 10-50%) BSR thresholds, producing an enhancement of BSR. Pretreatment with SB-277011A (12 mg/kg, but not 24 mg/kg, i.p.) significantly attenuated METH-enhanced BSR. NGB 2904 (0.1-1.0 mg/kg, but not 10 mg/kg) also attenuated METH-enhanced BSR. SB-277011A or NGB 2904 alone, at the doses tested, had no effect on BSR. Pretreatment with BP-897 (0.1-5 mg/kg) dose-dependently attenuated METH-enhanced BSR. However, when the dose was increased to 10 mg/kg, BP-897 shifted the stimulation-response curve to the right (inhibited BSR itself) in the presence or absence of METH. Conclusions: Selective antagonism of D3 receptors by SB-277011A or NGB 2904 attenuates METH-enhanced BSR in rats, while the METH-enhanced BSR attenuation produced by BP-897 may involve both D3 and non-D3 receptors. These findings support a potential use of selective D3 receptor antagonists for the treatment of METH addiction.
MeSH term(s)	Analysis of Variance ; Animals ; Brain/drug effects ; Brain/physiology ; Central Nervous System Stimulants/pharmacology ; Dose-Response Relationship, Drug ; Electric Stimulation ; Fluorenes/pharmacology ; Male ; Methamphetamine/pharmacology ; Nitriles/pharmacology ; Piperazines/pharmacology ; Rats ; Rats, Long-Evans ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/antagonists & inhibitors ; Reward ; Tetrahydroisoquinolines/pharmacology
Chemical Substances	Central Nervous System Stimulants ; Fluorenes ; NGB 2904 ; Nitriles ; Piperazines ; Receptors, Dopamine D3 ; SB 277011 ; Tetrahydroisoquinolines ; BP 897 (20PLE5W821) ; Methamphetamine (44RAL3456C)
Language	English
Publishing date	2007-11-06
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-007-0986-6
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Article: The effectiveness of 3 stretching techniques on hamstring flexibility using consistent stretching parameters.

Davis, D Scott / Ashby, Paul E / McCale, Kristi L / McQuain, Jerry A / Wine, Jaime M

Journal of strength and conditioning research

2005 Volume 19, Issue 1, Page(s) 27–32

Abstract: This study compares the effects of 3 common stretching techniques on the length of the hamstring muscle group during a 4-week training program. Subjects were 19 young adults between the ages of 21 and 35. The criterion for subject inclusion was tight ... ...

Abstract	This study compares the effects of 3 common stretching techniques on the length of the hamstring muscle group during a 4-week training program. Subjects were 19 young adults between the ages of 21 and 35. The criterion for subject inclusion was tight hamstrings as defined by a knee extension angle greater than 20 degrees while supine with the hip flexed 90 degrees . The participants were randomly assigned to 1 of 4 groups. Group 1 (n = 5) was self-stretching, group 2 (n = 5) was static stretching, group 3 (n = 5) was proprioceptive neuromuscular facilitation incorporating the theory of reciprocal inhibition (PNF-R), and group 4 (n = 4) was control. Each group received the same stretching dose of a single 30-second stretch 3 days per week for 4 weeks. Knee extension angle was measured before the start of the stretching program, at 2 weeks, and at 4 weeks. Statistical analysis (p < or = 0.05) revealed a significant interaction of stretching technique and duration of stretch. Post hoc analysis showed that all 3 stretching techniques increase hamstring length from the baseline value during a 4-week training program; however, only group 2 (static stretching) was found to be significantly greater than the control at 4 weeks. These data indicate that static stretching 1 repetition for 30 seconds 3 days per week increased hamstring length in young healthy subjects. These data also suggest that active self-stretching and PNF-R stretching 1 repetition for 30 seconds 3 days per week is not sufficient to significantly increase hamstring length in this population.
MeSH term(s)	Adult ; Female ; Humans ; Knee Joint/physiology ; Male ; Muscle, Skeletal/physiology ; Pliability ; Range of Motion, Articular/physiology ; Thigh ; Time Factors
Language	English
Publishing date	2005-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/14273.1
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Article ; Online: The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats.

Peng, Xiao-Qing / Ashby, Charles R / Spiller, Krista / Li, Xia / Li, Jie / Thomasson, Nitza / Millan, Mark J / Mocaër, Elisabeth / Muńoz, Carmen / Gardner, Eliot L / Xi, Zheng-Xiong

Neuropharmacology

2008 Volume 56, Issue 4, Page(s) 752–760

Abstract: We have previously reported that selective dopamine (DA) D3 receptor antagonists are effective in a number of animal models of drug addiction, but not in intravenous drug self-administration, suggesting a limited ability to modify drug reward. In the ... ...

Abstract	We have previously reported that selective dopamine (DA) D3 receptor antagonists are effective in a number of animal models of drug addiction, but not in intravenous drug self-administration, suggesting a limited ability to modify drug reward. In the present study, we evaluated the actions ofS33138, a novel partially selective D3 receptor antagonist, in animal models relevant to drug addiction. S33138, at doses of 0.156 or 0.625 mg/kg (i.p.), attenuated cocaine-enhanced brain-stimulation reward (BSR), and the highest dose tested (2.5 mg/kg) produced a significant aversive-like rightward shift in BSR rate-frequency reward functions. Further, S33138 produced biphasic effects on cocaine self-administration, i.e., a moderate dose (2.5 mg/kg, p.o.) increased, while a higher dose (5 mg/kg, p.o.) inhibited, cocaine self-administration. The increase in cocaine self-administration likely reflects a compensatory response to a partial reduction in drug reward after S33138. In addition, S33138 (0.156-2.5 mg/kg, p.o.) also dose-dependently inhibited cocaine-induced reinstatement of drug-seeking behavior. The reduction in cocaine-enhanced BSR and cocaine-triggered reinstatement produced by lower effective doses (e.g., 0.156 or 0.625 mg/kg) of 533138 is unlikely due to impaired locomotion, as lower effective doses of S33138 decreased neither Ymax levels in the BSR paradigm, rotarod performance, nor locomotion. However, the higher doses (2.5 or 5 mg/kg) of S33138 also significantly inhibited sucrose self-administration and rotarod performance, suggesting non-D3 receptor-mediated effects on non-drug reward and locomotion. These data suggest that lower doses of S33138 interacting essentially with D3 receptors have pharmacotherapeutic potential in treatment of cocaine addiction, while higher doses occupying D2 receptors may influence locomotion and non-drug reward.
MeSH term(s)	Acetanilides/pharmacology ; Animals ; Benzopyrans/pharmacology ; Cocaine/administration & dosage ; Cocaine/antagonists & inhibitors ; Cocaine/pharmacology ; Cocaine-Related Disorders/drug therapy ; Cocaine-Related Disorders/psychology ; Dopamine Antagonists/pharmacology ; Dopamine Uptake Inhibitors/administration & dosage ; Dopamine Uptake Inhibitors/antagonists & inhibitors ; Dopamine Uptake Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Electric Stimulation ; Extinction, Psychological/drug effects ; Injections, Intravenous ; Male ; Motor Activity/drug effects ; Postural Balance/drug effects ; Psychomotor Performance/drug effects ; Rats ; Rats, Long-Evans ; Receptors, Dopamine D3/antagonists & inhibitors ; Recurrence ; Reinforcement Schedule ; Self Administration ; Self Stimulation ; Sucrose/pharmacology
Chemical Substances	Acetanilides ; Benzopyrans ; Dopamine Antagonists ; Dopamine Uptake Inhibitors ; N-(4-(2-(8-cyano-1,3a,4,9b-tetrahydro(1)benzopyrano(3,4-c)pyrrol-2(3H)-yl)ethyl)phenyl)acetamide ; Receptors, Dopamine D3 ; Sucrose (57-50-1) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2008-12-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2008.12.007
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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