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Article: Olfactory training with essential oils for patients with post-COVID-19 smell dysfunction: A case series.

Donelli, Davide / Antonelli, Michele / Valussi, Marco

European journal of integrative medicine

2023 Volume 60, Page(s) 102253

Abstract: Introduction: It is estimated that up to one third of COVID-19 patients can develop long-lasting smell dysfunction. Viral infections, especially COVID-19, can cause anosmia through different pathomechanisms, and different strategies have been proposed ... ...

Abstract	Introduction: It is estimated that up to one third of COVID-19 patients can develop long-lasting smell dysfunction. Viral infections, especially COVID-19, can cause anosmia through different pathomechanisms, and different strategies have been proposed for effectively managing post-COVID-19 olfactory dysfunction in clinical practice, with olfactory training being recommended as a first-line treatment option. Methods: This report describes a non-consecutive series of clinical cases. After COVID-19, eight cases (5 females, 3 males) of adult patients with long-lasting (3+ months) post-viral smell dysfunction followed a 30-day olfactory training protocol with a set of plant-derived essential oils. At baseline and at the end of the treatment, the patients were administered the Assessment of Self-reported Olfactory Functioning (ASOF) questionnaire, an inventory used to measure olfactory dysfunction and health-related quality of life. Results: For any of the outcomes assessed with the ASOF scale, a significant improvement from baseline was reported, even though mean value ameliorations were more pronounced for olfactory function per se (Subjective Olfactory Capability: from 3.6 to 5.6 out of 10; Self-Reported capability of Perceiving specific odors: from 1.8 to 3.0 out of 5), rather than for health-related quality of life (Olfactory-Related Quality of life: from 2.9 to 3.9 out of 6). Conclusions: It was observed that patients with long-lasting COVID-19-related smell dysfunction improved after a 30-day olfactory training protocol. Further controlled clinical studies would be useful to better investigate the role of olfactory training in patients with postviral smell dysfunction.
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2467260-9
ISSN	1876-3839 ; 1876-3820
ISSN (online)	1876-3839
ISSN	1876-3820
DOI	10.1016/j.eujim.2023.102253
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Appropriate use of essential oils and their components in the management of upper respiratory tract symptoms in patients with COVID-19.

Valussi, Marco / Antonelli, Michele / Donelli, Davide / Firenzuoli, Fabio

Journal of herbal medicine

2021 Volume 28, Page(s) 100451

Abstract: Introduction: The involvement of the upper respiratory tract is common in COVID-19, and the majority of patients are treated at home with a mild-to-moderate form of the disease. Many approaches based on essential oils have been proposed for the ... ...

Abstract	Introduction: The involvement of the upper respiratory tract is common in COVID-19, and the majority of patients are treated at home with a mild-to-moderate form of the disease. Many approaches based on essential oils have been proposed for the symptomatic treatment of COVID-19. This work aims to outline the potential and safe evidence-based uses of essential oils and their major components for the clinical management of mild respiratory symptoms caused by uncomplicated coronavirus infections, including SARS-CoV-2. Due to their wide use, a focus on the constituents eucalyptol and menthol has been provided. Methods: An overview of the scientific literature with a critical discussion of retrieved evidence and clinical recommendations. Results: In general, eucalyptol and essential oils or blends whose content is rich in it, may be used as an integrative remedy for the symptomatic improvement of patients with mild and uncomplicated infections caused by coronaviruses. Menthol is not recommended in patients with COVID-19, due to a potential reduction of the self-perception of dyspnea, which can lead infected patients to underestimate the actual disease severity and to delay medical attention. Discussion: Based on available evidence, symptomatic remedies for COVID-19, such as essential oils and their isolated compounds, can be useful, but are not an alternative to standard medical therapy and do not exempt patients from following precautionary measures issued by health authorities. Clinical recommendations on the appropriate use of essential oils for the management of upper airway symptoms of COVID-19 are provided. Further studies on the topic are advised.
Language	English
Publishing date	2021-03-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2210-8033
ISSN	2210-8033
DOI	10.1016/j.hermed.2021.100451
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Appropriate use of essential oils and their components in the management of upper respiratory tract symptoms in patients with COVID-19

Valussi, Marco / Antonelli, Michele / Donelli, Davide / Firenzuoli, Fabio

Journal of herbal medicine. 2021 Aug., v. 28

2021

Abstract: The involvement of the upper respiratory tract is common in COVID-19, and the majority of patients are treated at home with a mild-to-moderate form of the disease. Many approaches based on essential oils have been proposed for the symptomatic treatment ... ...

Abstract	The involvement of the upper respiratory tract is common in COVID-19, and the majority of patients are treated at home with a mild-to-moderate form of the disease. Many approaches based on essential oils have been proposed for the symptomatic treatment of COVID-19. This work aims to outline the potential and safe evidence-based uses of essential oils and their major components for the clinical management of mild respiratory symptoms caused by uncomplicated coronavirus infections, including SARS-CoV-2. Due to their wide use, a focus on the constituents eucalyptol and menthol has been provided.An overview of the scientific literature with a critical discussion of retrieved evidence and clinical recommendations.In general, eucalyptol and essential oils or blends whose content is rich in it, may be used as an integrative remedy for the symptomatic improvement of patients with mild and uncomplicated infections caused by coronaviruses. Menthol is not recommended in patients with COVID-19, due to a potential reduction of the self-perception of dyspnea, which can lead infected patients to underestimate the actual disease severity and to delay medical attention.Based on available evidence, symptomatic remedies for COVID-19, such as essential oils and their isolated compounds, can be useful, but are not an alternative to standard medical therapy and do not exempt patients from following precautionary measures issued by health authorities. Clinical recommendations on the appropriate use of essential oils for the management of upper airway symptoms of COVID-19 are provided. Further studies on the topic are advised.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; cineole ; disease severity ; dyspnea ; herbal medicines ; menthol ; respiratory system ; self-perception ; therapeutics
Language	English
Dates of publication	2021-08
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-light
ISSN	2210-8033
DOI	10.1016/j.hermed.2021.100451
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Functional foods with digestion-enhancing properties.

Valussi, Marco

International journal of food sciences and nutrition

2012 Volume 63 Suppl 1, Page(s) 82–89

Abstract: On analyzing the traditional societies' plant lore by treatment and plant categories, one cannot but notice the greater weight given to treatment of digestive disturbances and ailments compared to modern Western pharmacopoeias, and the blurred boundaries ...

Abstract	On analyzing the traditional societies' plant lore by treatment and plant categories, one cannot but notice the greater weight given to treatment of digestive disturbances and ailments compared to modern Western pharmacopoeias, and the blurred boundaries between medicines and foods, in contrast to the clear-cut distinction made in contemporary industrialized societies. Hence, there is an interest in exploring the issue of multifunctional food and traditional ingredients with digestive properties. In this paper, I examine the coevolutionary foundations for digestive activities, the problems and ambiguities that emerge in the analysis of traditional data, and the possible biological mechanisms underlying the actions of bitter, aromatic and pungent compounds. After these premises, this paper presents a short review of those plants with a significant body of research supporting the claims that they have a digestive action, with particular emphasis on clinical data. The plants that have a substantial body of data in support of their digestion-enhancing activities mainly belong to one of three groups: bitter, aromatic and pungent plants. Amongst the most important we can find ginger, peppermint, aniseed and fennel, citrus fruits, dandelion and artichoke, melissa and chamomile, but many more have a significant body of experimental data available.
MeSH term(s)	Animals ; Apiaceae/chemistry ; Asteraceae/chemistry ; Digestion ; Food, Fortified/analysis ; Functional Food/analysis ; Gastroenteritis/diet therapy ; Gastrointestinal Agents/therapeutic use ; Humans ; Lamiaceae/chemistry ; Medicine, Traditional
Chemical Substances	Gastrointestinal Agents
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1121877-0
ISSN	1465-3478 ; 0963-7486
ISSN (online)	1465-3478
ISSN	0963-7486
DOI	10.3109/09637486.2011.627841
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Article ; Online: ESCUELA PÚBLICA DE GESTIÓN SOCIAL EN LA PROVINCIA DEL CHACO

Norma Elena Bregagnolo / Melina Gonzalez / Mayra Elena Valussi

Revista Binacional Brasil - Argentina, Vol 12, Iss

UNA ALTERNATIVA PEDAGÓGICA CON PERSPECTIVA DE DERECHOS

2023 Volume 01

Abstract: ... Argentina. Desde esta modalidad, la escuela asume un formato pedagógico “alternativo” en el marco ...

Abstract	En este trabajo presentamos los avances de una investigación que se realiza de forma articulada con acciones de docencia y extensión, consideraremos en la discusión rasgos y peculiaridades de la conformación de la Escuela Jardín Infantil de una Escuela Pública de Gestión Social de la ciudad de Resistencia, Chaco, Argentina. Desde esta modalidad, la escuela asume un formato pedagógico “alternativo” en el marco de su proyecto fundacional, donde se asume como anticapitalista, antiimperialista y actualmente como antipatriarcal. Se priorizan los derechos de la niñez, apoyando la educación como “valor fundamental en todos los niveles, el trabajo como sinónimo de dignidad y respeto a los valores de la humanidad frente a la adversidad”, de esta forma se fortalece, genera formas de autodeterminación. -organizacion, de autogobierno. La metodología es de tipo etnográfico, se llevó a cabo con observaciones participantes y entrevistas en profundidad a actores escolares. La publicación se inscribe en el Proyecto de Investigación Estudios de los procesos de construcción de ciudadanía en el nivel universitario e inicial, desde perspectivas epistemológicas latinoamericanas - Grupo de Investigación Consolidado Formación Docente y Educación Infantil – FODEI – SGCyT – UNNE.
Keywords	Educación Infantil - Derechos - Gestión Social ; Educación Infantil ; Derechos ; Gestión Social ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	Spanish
Publishing date	2023-06-01T00:00:00Z
Publisher	Universidade Estadual do Sudoeste da Bahia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy, safety and tolerability of Tiger Balm® ointments

Michele Antonelli / Davide Donelli / Marco Valussi

Journal of Pharmacy & Pharmacognosy Research, Vol 8, Iss 1, Pp 1-

a systematic review and a meta-analysis of prevalence

2020 Volume 17

Abstract: Context: Tiger Balm® (TB®) ointments are multi-purpose branded Chinese topical remedies, often used for pain relief and purchasable in many countries as over-the-counter medications. Aims: To assess the efficacy, safety and tolerability of TB® ointments. ...

Abstract	Context: Tiger Balm® (TB®) ointments are multi-purpose branded Chinese topical remedies, often used for pain relief and purchasable in many countries as over-the-counter medications. Aims: To assess the efficacy, safety and tolerability of TB® ointments. Methods: Medline, Scopus, EMBASE, Cochrane Library, Web of Science, Google Scholar, PEDro, and the Chinese Clinical Trial Registry were systematically searched for relevant articles. The quality of included studies on the efficacy of TB® ointments was evaluated with dedicated NIH tools. Retrieved evidence was then summarized and critically appraised. Results: After article screening and selection, 12 studies were finally included in the present review (five on TB® ointments efficacy, whereas seven on their safety and tolerability). Two cases of dermatitis and one of cheilitis likely ascribable to the use of TB® ointments have been reported. Based on available studies, it might be estimated that around 4% [95% CI, 3%-5%] of patients with history of contact skin allergy could be positive if patch tested with TB® ointments, therefore caution is recommended in the use of TB® among these subjects. Conclusions: According to retrieved evidence, TB® ointments might be useful for the management of pain due to tension headache, and they seem capable of increasing leg blood flow if combined with massage. Considering available evidence on topical products with camphor, TB® ointments shouldn’t be used in children, as well as in pregnant or lactating women. Chronic use, large amounts of balm, and the application on damaged skin must be avoided too. Further studies are recommended.
Keywords	drug efficacy ; drug safety ; systematic review ; traditional chinese medicine ; Therapeutics. Pharmacology ; RM1-950 ; Pharmacy and materia medica ; RS1-441
Subject code	306
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	GarVal Editorial Ltda.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Functional foods with digestion-enhancing properties

Valussi, Marco

International journal of food sciences and nutrition. 2012 Mar. 1, v. 63, no. sup1

2012

Abstract	On analyzing the traditional societies' plant lore by treatment and plant categories, one cannot but notice the greater weight given to treatment of digestive disturbances and ailments compared to modern Western pharmacopoeias, and the blurred boundaries between medicines and foods, in contrast to the clear-cut distinction made in contemporary industrialized societies. Hence, there is an interest in exploring the issue of multifunctional food and traditional ingredients with digestive properties. In this paper, I examine the coevolutionary foundations for digestive activities, the problems and ambiguities that emerge in the analysis of traditional data, and the possible biological mechanisms underlying the actions of bitter, aromatic and pungent compounds. After these premises, this paper presents a short review of those plants with a significant body of research supporting the claims that they have a digestive action, with particular emphasis on clinical data. The plants that have a substantial body of data in support of their digestion-enhancing activities mainly belong to one of three groups: bitter, aromatic and pungent plants. Amongst the most important we can find ginger, peppermint, aniseed and fennel, citrus fruits, dandelion and artichoke, melissa and chamomile, but many more have a significant body of experimental data available.
Keywords	Citrus ; Mentha piperita nothosubsp. piperita ; Taraxacum ; anise ; artichokes ; chamomile ; clearcutting ; fennel ; ginger ; industrialization ; nutrition
Language	English
Dates of publication	2012-0301
Size	p. 82-89.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1121877-0
ISSN	1465-3478 ; 0963-7486
ISSN (online)	1465-3478
ISSN	0963-7486
DOI	10.3109/09637486.2011.627841
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review.

Antonelli, Michele / Donelli, Davide / Barbieri, Grazia / Valussi, Marco / Maggini, Valentina / Firenzuoli, Fabio

International journal of environmental research and public health

2020 Volume 17, Issue 18

Abstract: The aim of this research work is to analyze the chemistry and diversity of forest VOCs (volatile organic compounds) and to outline their evidence-based effects on health. This research work was designed as a narrative overview of the scientific ... ...

Abstract	The aim of this research work is to analyze the chemistry and diversity of forest VOCs (volatile organic compounds) and to outline their evidence-based effects on health. This research work was designed as a narrative overview of the scientific literature. Inhaling forest VOCs like limonene and pinene can result in useful antioxidant and anti-inflammatory effects on the airways, and the pharmacological activity of some terpenes absorbed through inhalation may be also beneficial to promote brain functions by decreasing mental fatigue, inducing relaxation, and improving cognitive performance and mood. The tree composition can markedly influence the concentration of specific VOCs in the forest air, which also exhibits cyclic diurnal variations. Moreover, beneficial psychological and physiological effects of visiting a forest cannot be solely attributed to VOC inhalation but are due to a global and integrated stimulation of the five senses, induced by all specific characteristics of the natural environment, with the visual component probably playing a fundamental role in the overall effect. Globally, these findings can have useful implications for individual wellbeing, public health, and landscape design. Further clinical and environmental studies are advised, since the majority of the existing evidence is derived from laboratory findings.
MeSH term(s)	Air Pollutants/analysis ; Environmental Health ; Environmental Monitoring ; Forests ; Humans ; Trees ; Volatile Organic Compounds/analysis
Chemical Substances	Air Pollutants ; Volatile Organic Compounds
Language	English
Publishing date	2020-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17186506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization and Phytotoxicity Assessment of Essential Oils from Plant Byproducts.

Smeriglio, Antonella / Trombetta, Domenico / Cornara, Laura / Valussi, Marco / De Feo, Vincenzo / Caputo, Lucia

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 16

Abstract: The present work describes the chemical characterization and the phytotoxicity assessment of essential oils (EOs) obtained from spent materials or pruning waste of four plant species: ...

Abstract	The present work describes the chemical characterization and the phytotoxicity assessment of essential oils (EOs) obtained from spent materials or pruning waste of four plant species:
MeSH term(s)	Antioxidants/chemistry ; Antioxidants/pharmacology ; Antioxidants/toxicity ; Gas Chromatography-Mass Spectrometry ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Oils, Volatile/toxicity ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/toxicity ; Plant Oils/chemistry ; Plant Oils/pharmacology ; Plant Oils/toxicity ; Plants/chemistry ; Plants/ultrastructure ; Portulaca/drug effects
Chemical Substances	Antioxidants ; Oils, Volatile ; Phytochemicals ; Plant Oils
Language	English
Publishing date	2019-08-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24162941
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Article: Comparative and Functional Screening of Three Species Traditionally used as Antidepressants:

Cornara, Laura / Ambu, Gabriele / Trombetta, Domenico / Denaro, Marcella / Alloisio, Susanna / Frigerio, Jessica / Labra, Massimo / Ghimire, Govinda / Valussi, Marco / Smeriglio, Antonella

Plants (Basel, Switzerland)

2020 Volume 9, Issue 8

Abstract: The essential oils (EOs) of three Caprifoliaceae species, the ... ...

Abstract	The essential oils (EOs) of three Caprifoliaceae species, the Eurasiatic
Keywords	covid19
Language	English
Publishing date	2020-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants9080994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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